Clinical impact of NK-cell reconstitution after reduced intensity conditioned unrelated cord blood transplantation in patients with acute myeloid leukemia: analysis ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-06-26

AUTHORS

S Nguyen, A Achour, L Souchet, S Vigouroux, P Chevallier, S Furst, A Sirvent, J-O Bay, G Socié, P Ceballos, A Huynh, J Cornillon, S Francois, F Legrand, I Yakoub-Agha, G Michel, N Maillard, G Margueritte, S Maury, M Uzunov, C-E Bulabois, M Michallet, L Clement, C Dauriac, K Bilger, J Lejeune, V Béziat, V Rocha, B Rio, S Chevret, V Vieillard

ABSTRACT

Unrelated cord blood transplantation (UCBT) after a reduced intensity conditioning regimen (RIC) has extended the use of UCB in elderly patients and those with co-morbidities without an HLA-identical donor, although post-transplant relapse remains a concern in high-risk acute myeloid leukemia (AML) patients. HLA incompatibilities between donor and recipient might enhance the alloreactivity of natural killer (NK) cells after allogeneic hematopoietic stem-cell transplantation (HSCT). We studied the reconstitution of NK cells and KIR-L mismatch in 54 patients who underwent a RIC-UCBT for AML in CR in a prospective phase II clinical trial. After RIC-UCBT, NK cells displayed phenotypic features of both activation and immaturity. Restoration of their polyfunctional capacities depended on the timing of their acquisition of phenotypic markers of maturity. The incidence of treatment-related mortality (TRM) was correlated with low CD16 expression (P=0.043) and high HLA-DR expression (P=0.0008), whereas overall survival was associated with increased frequency of NK-cell degranulation (P=0.001). These features reflect a general impairment of the NK licensing process in HLA-mismatched HSCT and may aid the development of future strategies for selecting optimal UCB units and enhancing immune recovery. More... »

PAGES

1428-1435

Journal

TITLE

Bone Marrow Transplantation

ISSUE

10

VOLUME

52

Author Affiliations

  • Sorbonne Universités, UPMC Univ Paris 06, INSERM U1135, CNRS ERL8255, Centre d’Immunologie et des Maladies Infectieuses (CIMI-Paris), Paris, France
  • AP-HP, Hôpital Pitié Salpêtrière (AP-HP), Service d’Hématologie Clinique, Paris, France
  • CHU de Bordeaux Hôpital du Haut-Lévèque, Service d'hématologie clinique et de thérapie cellulaire, Pessac, France
  • Hematology Department, CHU de Nantes, Nantes, France
  • Institut Paoli Calmettes, Service de greffe de moelle, Marseille, France
  • Centre Hospitalier Universitaire de Montpellier, Montpellier, France
  • CHU Estaing Service d’Hématologie Clinique, Clermont-Ferrand, France
  • AP-HP, Hôpital Saint-Louis, Service d’Hématologie et de Transplantation, Paris, France
  • Hôpital Lapeyronie, Montpellier, France
  • CHU de Toulouse, Hématologie Clinique, Toulouse, France
  • Institut de Cancérologie de la Loire, Service d’Hématologie, Saint-Priest-en-Jarez, France
  • CHU de Angers, Angers, France
  • CHU de Nice, Service d’Hématologie, Nice, France
  • CHU de Lille, Service d’Hématologie Lille, France
  • Department of Pediatric Hematology and Oncology, Timone Enfants Hospital and Research Unit EA 3279 Aix-Marseille University, Marseille, France
  • CHU de Poitiers, Poitiers, France
  • CHU Montpellier Pédiatrie, Montpellier, France
  • Hôpital Henri Mondor, Service d'Hématologie, Créteil, France
  • CHU Grenoble, Grenoble, France
  • Hôpital Edouard Herriot, Lyon, France
  • University Hospital de Bordeaux, Bordeaux, France
  • CHU de Rennes, Rennes, France
  • CHRU de Strasbourg, Strasbourg, France
  • Department de Bioinformatique et Statistique Médicale, Hôpital Saint-Louis, Paris, France
  • Eurocord Office, Hôpital Saint-Louis, Paris, France
  • Hôpital Saint-Antoine, Hématologie Clinique et Thérapie Cellulaire, Paris, France
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/bmt.2017.122

    DOI

    http://dx.doi.org/10.1038/bmt.2017.122

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1086159114

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28650455


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Immunology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Allografts", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cord Blood Stem Cell Transplantation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Disease-Free Survival", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Killer Cells, Natural", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Leukemia, Myeloid, Acute", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prospective Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Recovery of Function", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Registries", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Survival Rate", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transplantation Conditioning", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Sorbonne Universit\u00e9s, UPMC Univ Paris 06, INSERM U1135, CNRS ERL8255, Centre d\u2019Immunologie et des Maladies Infectieuses (CIMI-Paris), Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.463810.8", 
              "name": [
                "AP-HP, H\u00f4pital Piti\u00e9 Salp\u00eatri\u00e8re (AP-HP), Service d\u2019H\u00e9matologie Clinique, Paris, France", 
                "Sorbonne Universit\u00e9s, UPMC Univ Paris 06, INSERM U1135, CNRS ERL8255, Centre d\u2019Immunologie et des Maladies Infectieuses (CIMI-Paris), Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nguyen", 
            "givenName": "S", 
            "id": "sg:person.01171607431.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171607431.53"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Sorbonne Universit\u00e9s, UPMC Univ Paris 06, INSERM U1135, CNRS ERL8255, Centre d\u2019Immunologie et des Maladies Infectieuses (CIMI-Paris), Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.463810.8", 
              "name": [
                "Sorbonne Universit\u00e9s, UPMC Univ Paris 06, INSERM U1135, CNRS ERL8255, Centre d\u2019Immunologie et des Maladies Infectieuses (CIMI-Paris), Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Achour", 
            "givenName": "A", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "AP-HP, H\u00f4pital Piti\u00e9 Salp\u00eatri\u00e8re (AP-HP), Service d\u2019H\u00e9matologie Clinique, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.411439.a", 
              "name": [
                "AP-HP, H\u00f4pital Piti\u00e9 Salp\u00eatri\u00e8re (AP-HP), Service d\u2019H\u00e9matologie Clinique, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Souchet", 
            "givenName": "L", 
            "id": "sg:person.011773213421.92", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011773213421.92"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "CHU de Bordeaux H\u00f4pital du Haut-L\u00e9v\u00e8que, Service d'h\u00e9matologie clinique et de th\u00e9rapie cellulaire, Pessac, France", 
              "id": "http://www.grid.ac/institutes/grid.42399.35", 
              "name": [
                "CHU de Bordeaux H\u00f4pital du Haut-L\u00e9v\u00e8que, Service d'h\u00e9matologie clinique et de th\u00e9rapie cellulaire, Pessac, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Vigouroux", 
            "givenName": "S", 
            "id": "sg:person.0722016554.90", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722016554.90"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hematology Department, CHU de Nantes, Nantes, France", 
              "id": "http://www.grid.ac/institutes/grid.277151.7", 
              "name": [
                "Hematology Department, CHU de Nantes, Nantes, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chevallier", 
            "givenName": "P", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institut Paoli Calmettes, Service de greffe de moelle, Marseille, France", 
              "id": "http://www.grid.ac/institutes/grid.418443.e", 
              "name": [
                "Institut Paoli Calmettes, Service de greffe de moelle, Marseille, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Furst", 
            "givenName": "S", 
            "id": "sg:person.01070244016.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070244016.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Centre Hospitalier Universitaire de Montpellier, Montpellier, France", 
              "id": "http://www.grid.ac/institutes/grid.157868.5", 
              "name": [
                "Centre Hospitalier Universitaire de Montpellier, Montpellier, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sirvent", 
            "givenName": "A", 
            "id": "sg:person.01262560655.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262560655.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "CHU Estaing Service d\u2019H\u00e9matologie Clinique, Clermont-Ferrand, France", 
              "id": "http://www.grid.ac/institutes/grid.411163.0", 
              "name": [
                "CHU Estaing Service d\u2019H\u00e9matologie Clinique, Clermont-Ferrand, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bay", 
            "givenName": "J-O", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "AP-HP, H\u00f4pital Saint-Louis, Service d\u2019H\u00e9matologie et de Transplantation, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.413328.f", 
              "name": [
                "AP-HP, H\u00f4pital Saint-Louis, Service d\u2019H\u00e9matologie et de Transplantation, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Soci\u00e9", 
            "givenName": "G", 
            "id": "sg:person.015747476457.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015747476457.00"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "H\u00f4pital Lapeyronie, Montpellier, France", 
              "id": "http://www.grid.ac/institutes/grid.411572.4", 
              "name": [
                "H\u00f4pital Lapeyronie, Montpellier, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ceballos", 
            "givenName": "P", 
            "id": "sg:person.01041606055.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041606055.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "CHU de Toulouse, H\u00e9matologie Clinique, Toulouse, France", 
              "id": "http://www.grid.ac/institutes/grid.411175.7", 
              "name": [
                "CHU de Toulouse, H\u00e9matologie Clinique, Toulouse, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Huynh", 
            "givenName": "A", 
            "id": "sg:person.0622277623.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622277623.22"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institut de Canc\u00e9rologie de la Loire, Service d\u2019H\u00e9matologie, Saint-Priest-en-Jarez, France", 
              "id": "http://www.grid.ac/institutes/grid.488279.8", 
              "name": [
                "Institut de Canc\u00e9rologie de la Loire, Service d\u2019H\u00e9matologie, Saint-Priest-en-Jarez, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cornillon", 
            "givenName": "J", 
            "id": "sg:person.0773366521.67", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773366521.67"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "CHU de Angers, Angers, France", 
              "id": "http://www.grid.ac/institutes/grid.411147.6", 
              "name": [
                "CHU de Angers, Angers, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Francois", 
            "givenName": "S", 
            "id": "sg:person.0710767661.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710767661.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "CHU de Nice, Service d\u2019H\u00e9matologie, Nice, France", 
              "id": "http://www.grid.ac/institutes/grid.410528.a", 
              "name": [
                "CHU de Nice, Service d\u2019H\u00e9matologie, Nice, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Legrand", 
            "givenName": "F", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "CHU de Lille, Service d\u2019H\u00e9matologie Lille, France", 
              "id": "http://www.grid.ac/institutes/grid.410463.4", 
              "name": [
                "CHU de Lille, Service d\u2019H\u00e9matologie Lille, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yakoub-Agha", 
            "givenName": "I", 
            "id": "sg:person.0631077726.87", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631077726.87"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pediatric Hematology and Oncology, Timone Enfants Hospital and Research Unit EA 3279 Aix-Marseille University, Marseille, France", 
              "id": "http://www.grid.ac/institutes/grid.5399.6", 
              "name": [
                "Department of Pediatric Hematology and Oncology, Timone Enfants Hospital and Research Unit EA 3279 Aix-Marseille University, Marseille, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Michel", 
            "givenName": "G", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "CHU de Poitiers, Poitiers, France", 
              "id": "http://www.grid.ac/institutes/grid.411162.1", 
              "name": [
                "CHU de Poitiers, Poitiers, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Maillard", 
            "givenName": "N", 
            "id": "sg:person.01067470361.59", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067470361.59"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "CHU Montpellier P\u00e9diatrie, Montpellier, France", 
              "id": "http://www.grid.ac/institutes/grid.157868.5", 
              "name": [
                "CHU Montpellier P\u00e9diatrie, Montpellier, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Margueritte", 
            "givenName": "G", 
            "id": "sg:person.0653007001.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653007001.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "H\u00f4pital Henri Mondor, Service d'H\u00e9matologie, Cr\u00e9teil, France", 
              "id": "http://www.grid.ac/institutes/grid.412116.1", 
              "name": [
                "H\u00f4pital Henri Mondor, Service d'H\u00e9matologie, Cr\u00e9teil, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Maury", 
            "givenName": "S", 
            "id": "sg:person.0762115262.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762115262.49"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "AP-HP, H\u00f4pital Piti\u00e9 Salp\u00eatri\u00e8re (AP-HP), Service d\u2019H\u00e9matologie Clinique, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.411439.a", 
              "name": [
                "AP-HP, H\u00f4pital Piti\u00e9 Salp\u00eatri\u00e8re (AP-HP), Service d\u2019H\u00e9matologie Clinique, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Uzunov", 
            "givenName": "M", 
            "id": "sg:person.01034023327.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034023327.28"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "CHU Grenoble, Grenoble, France", 
              "id": "http://www.grid.ac/institutes/grid.410529.b", 
              "name": [
                "CHU Grenoble, Grenoble, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bulabois", 
            "givenName": "C-E", 
            "id": "sg:person.0575776213.94", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0575776213.94"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "H\u00f4pital Edouard Herriot, Lyon, France", 
              "id": "http://www.grid.ac/institutes/grid.412180.e", 
              "name": [
                "H\u00f4pital Edouard Herriot, Lyon, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Michallet", 
            "givenName": "M", 
            "id": "sg:person.01264301106.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264301106.83"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospital de Bordeaux, Bordeaux, France", 
              "id": "http://www.grid.ac/institutes/grid.42399.35", 
              "name": [
                "University Hospital de Bordeaux, Bordeaux, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Clement", 
            "givenName": "L", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "CHU de Rennes, Rennes, France", 
              "id": "http://www.grid.ac/institutes/grid.411154.4", 
              "name": [
                "CHU de Rennes, Rennes, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dauriac", 
            "givenName": "C", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "CHRU de Strasbourg, Strasbourg, France", 
              "id": "http://www.grid.ac/institutes/grid.412220.7", 
              "name": [
                "CHRU de Strasbourg, Strasbourg, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bilger", 
            "givenName": "K", 
            "id": "sg:person.01255345560.63", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255345560.63"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department de Bioinformatique et Statistique M\u00e9dicale, H\u00f4pital Saint-Louis, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.413328.f", 
              "name": [
                "Department de Bioinformatique et Statistique M\u00e9dicale, H\u00f4pital Saint-Louis, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lejeune", 
            "givenName": "J", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Sorbonne Universit\u00e9s, UPMC Univ Paris 06, INSERM U1135, CNRS ERL8255, Centre d\u2019Immunologie et des Maladies Infectieuses (CIMI-Paris), Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.463810.8", 
              "name": [
                "Sorbonne Universit\u00e9s, UPMC Univ Paris 06, INSERM U1135, CNRS ERL8255, Centre d\u2019Immunologie et des Maladies Infectieuses (CIMI-Paris), Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "B\u00e9ziat", 
            "givenName": "V", 
            "id": "sg:person.01040042621.92", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040042621.92"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Eurocord Office, H\u00f4pital Saint-Louis, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.413328.f", 
              "name": [
                "Eurocord Office, H\u00f4pital Saint-Louis, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rocha", 
            "givenName": "V", 
            "id": "sg:person.01143444261.94", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143444261.94"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "H\u00f4pital Saint-Antoine, H\u00e9matologie Clinique et Th\u00e9rapie Cellulaire, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.412370.3", 
              "name": [
                "H\u00f4pital Saint-Antoine, H\u00e9matologie Clinique et Th\u00e9rapie Cellulaire, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rio", 
            "givenName": "B", 
            "id": "sg:person.01245127334.86", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245127334.86"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department de Bioinformatique et Statistique M\u00e9dicale, H\u00f4pital Saint-Louis, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.413328.f", 
              "name": [
                "Department de Bioinformatique et Statistique M\u00e9dicale, H\u00f4pital Saint-Louis, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chevret", 
            "givenName": "S", 
            "id": "sg:person.0625147223.89", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625147223.89"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Sorbonne Universit\u00e9s, UPMC Univ Paris 06, INSERM U1135, CNRS ERL8255, Centre d\u2019Immunologie et des Maladies Infectieuses (CIMI-Paris), Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.463810.8", 
              "name": [
                "Sorbonne Universit\u00e9s, UPMC Univ Paris 06, INSERM U1135, CNRS ERL8255, Centre d\u2019Immunologie et des Maladies Infectieuses (CIMI-Paris), Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Vieillard", 
            "givenName": "V", 
            "id": "sg:person.01344140455.98", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344140455.98"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/ng2077", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025357588", 
              "https://doi.org/10.1038/ng2077"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/leu.2008.343", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037682121", 
              "https://doi.org/10.1038/leu.2008.343"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bmt.1705014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044849485", 
              "https://doi.org/10.1038/sj.bmt.1705014"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00251-013-0724-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029634343", 
              "https://doi.org/10.1007/s00251-013-0724-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/leu.2008.365", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017064265", 
              "https://doi.org/10.1038/leu.2008.365"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.3518", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002722764", 
              "https://doi.org/10.1038/ni.3518"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/leu.2015.98", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044650418", 
              "https://doi.org/10.1038/leu.2015.98"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri3044", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012854808", 
              "https://doi.org/10.1038/nri3044"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2405041", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044220803", 
              "https://doi.org/10.1038/sj.leu.2405041"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-06-26", 
        "datePublishedReg": "2017-06-26", 
        "description": "Unrelated cord blood transplantation (UCBT) after a reduced intensity conditioning regimen (RIC) has extended the use of UCB in elderly patients and those with co-morbidities without an HLA-identical donor, although post-transplant relapse remains a concern in high-risk acute myeloid leukemia (AML) patients. HLA incompatibilities between donor and recipient might enhance the alloreactivity of natural killer (NK) cells after allogeneic hematopoietic stem-cell transplantation (HSCT). We studied the reconstitution of NK cells and KIR-L mismatch in 54 patients who underwent a RIC-UCBT for AML in CR in a prospective phase II clinical trial. After RIC-UCBT, NK cells displayed phenotypic features of both activation and immaturity. Restoration of their polyfunctional capacities depended on the timing of their acquisition of phenotypic markers of maturity. The incidence of treatment-related mortality (TRM) was correlated with low CD16 expression (P=0.043) and high HLA-DR expression (P=0.0008), whereas overall survival was associated with increased frequency of NK-cell degranulation (P=0.001). These features reflect a general impairment of the NK licensing process in HLA-mismatched HSCT and may aid the development of future strategies for selecting optimal UCB units and enhancing immune recovery.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/bmt.2017.122", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1096890", 
            "issn": [
              "0268-3369", 
              "1476-5365"
            ], 
            "name": "Bone Marrow Transplantation", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "10", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "52"
          }
        ], 
        "keywords": [
          "unrelated cord blood transplantation", 
          "hematopoietic stem cell transplantation", 
          "reduced intensity conditioning regimen", 
          "treatment-related mortality", 
          "cord blood transplantation", 
          "blood transplantation", 
          "NK cells", 
          "high-risk acute myeloid leukemia patients", 
          "prospective phase II clinical trial", 
          "prospective phase II multicenter trial", 
          "allogeneic hematopoietic stem cell transplantation", 
          "high HLA-DR expression", 
          "phase II multicenter trial", 
          "acute myeloid leukemia patients", 
          "phase II clinical trial", 
          "post-transplant relapse", 
          "lower CD16 expression", 
          "NK cell reconstitution", 
          "HLA-identical donor", 
          "HLA-DR expression", 
          "NK cell degranulation", 
          "intensity conditioning regimen", 
          "natural killer cells", 
          "stem cell transplantation", 
          "myeloid leukemia patients", 
          "acute myeloid leukemia", 
          "use of UCB", 
          "immune recovery", 
          "conditioning regimen", 
          "elderly patients", 
          "overall survival", 
          "HLA incompatibility", 
          "multicenter trial", 
          "killer cells", 
          "CD16 expression", 
          "clinical trials", 
          "leukemia patients", 
          "polyfunctional capacity", 
          "myeloid leukemia", 
          "UCB units", 
          "clinical impact", 
          "patients", 
          "Soci\u00e9t\u00e9 Fran\u00e7aise", 
          "transplantation", 
          "phenotypic markers", 
          "phenotypic features", 
          "general impairment", 
          "trials", 
          "future strategies", 
          "cells", 
          "Eurocord", 
          "regimen", 
          "alloreactivity", 
          "relapse", 
          "HLA", 
          "expression", 
          "degranulation", 
          "AML", 
          "leukemia", 
          "mortality", 
          "Greffe", 
          "donors", 
          "incidence", 
          "reconstitution", 
          "impairment", 
          "recipients", 
          "UCB", 
          "survival", 
          "immaturity", 
          "markers", 
          "activation", 
          "restoration", 
          "recovery", 
          "timing", 
          "features", 
          "use", 
          "concern", 
          "frequency", 
          "development", 
          "strategies", 
          "units", 
          "impact", 
          "analysis", 
          "capacity", 
          "acquisition", 
          "intensity", 
          "Fran\u00e7aise", 
          "incompatibility", 
          "maturity", 
          "licensing process", 
          "behalf", 
          "Cr", 
          "mismatch", 
          "process"
        ], 
        "name": "Clinical impact of NK-cell reconstitution after reduced intensity conditioned unrelated cord blood transplantation in patients with acute myeloid leukemia: analysis of a prospective phase II multicenter trial on behalf of the Soci\u00e9t\u00e9 Fran\u00e7aise de Greffe de Moelle Osseuse et Th\u00e9rapie Cellulaire and Eurocord", 
        "pagination": "1428-1435", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1086159114"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/bmt.2017.122"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "28650455"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/bmt.2017.122", 
          "https://app.dimensions.ai/details/publication/pub.1086159114"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-09-02T16:01", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_746.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/bmt.2017.122"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/bmt.2017.122'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/bmt.2017.122'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/bmt.2017.122'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/bmt.2017.122'


     

    This table displays all metadata directly associated to this object as RDF triples.

    525 TRIPLES      21 PREDICATES      143 URIs      126 LITERALS      22 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/bmt.2017.122 schema:about N227f32615847421186aa01a1e965241f
    2 N2fdecdaf5b61419e88d6fb6c2c07c053
    3 N3637edceee6e4a5ba2f9e3db3c8f5a53
    4 N3d34a9d1583a49d182676f59cd20fd9a
    5 N443401271aa44d5885b6b2e0e0d89579
    6 N6d5aa244dfd24b96a39a58dd9171ae63
    7 N7f1249e9cecc471690773ffd1cac5c7e
    8 N847b9b39a9714fc0a7fffc0cae2d2646
    9 N8d7499240b96427aa386a3dbbd022498
    10 N8d7cd514c05e4499951693d6659e20c4
    11 N9ba171beb13a4dd68cc83c139c24a26c
    12 N9f4523a92c8f441583174f65ee51d40e
    13 Na14a11b1d5a84a928ab8a5044dc367c0
    14 Ncc297b506f2a483d87c1fcf4dc1072de
    15 Nd6ed28d12ba84be0b25b964913b40c92
    16 anzsrc-for:11
    17 anzsrc-for:1107
    18 schema:author N9eea5d35c54b4b7884d3263061a83db6
    19 schema:citation sg:pub.10.1007/s00251-013-0724-7
    20 sg:pub.10.1038/leu.2008.343
    21 sg:pub.10.1038/leu.2008.365
    22 sg:pub.10.1038/leu.2015.98
    23 sg:pub.10.1038/ng2077
    24 sg:pub.10.1038/ni.3518
    25 sg:pub.10.1038/nri3044
    26 sg:pub.10.1038/sj.bmt.1705014
    27 sg:pub.10.1038/sj.leu.2405041
    28 schema:datePublished 2017-06-26
    29 schema:datePublishedReg 2017-06-26
    30 schema:description Unrelated cord blood transplantation (UCBT) after a reduced intensity conditioning regimen (RIC) has extended the use of UCB in elderly patients and those with co-morbidities without an HLA-identical donor, although post-transplant relapse remains a concern in high-risk acute myeloid leukemia (AML) patients. HLA incompatibilities between donor and recipient might enhance the alloreactivity of natural killer (NK) cells after allogeneic hematopoietic stem-cell transplantation (HSCT). We studied the reconstitution of NK cells and KIR-L mismatch in 54 patients who underwent a RIC-UCBT for AML in CR in a prospective phase II clinical trial. After RIC-UCBT, NK cells displayed phenotypic features of both activation and immaturity. Restoration of their polyfunctional capacities depended on the timing of their acquisition of phenotypic markers of maturity. The incidence of treatment-related mortality (TRM) was correlated with low CD16 expression (P=0.043) and high HLA-DR expression (P=0.0008), whereas overall survival was associated with increased frequency of NK-cell degranulation (P=0.001). These features reflect a general impairment of the NK licensing process in HLA-mismatched HSCT and may aid the development of future strategies for selecting optimal UCB units and enhancing immune recovery.
    31 schema:genre article
    32 schema:isAccessibleForFree false
    33 schema:isPartOf N322995d7960046ca8d6ec91da1ebbfb6
    34 N99e4d5f46c8847d0925b1597a204f7a0
    35 sg:journal.1096890
    36 schema:keywords AML
    37 CD16 expression
    38 Cr
    39 Eurocord
    40 Française
    41 Greffe
    42 HLA
    43 HLA incompatibility
    44 HLA-DR expression
    45 HLA-identical donor
    46 NK cell degranulation
    47 NK cell reconstitution
    48 NK cells
    49 Société Française
    50 UCB
    51 UCB units
    52 acquisition
    53 activation
    54 acute myeloid leukemia
    55 acute myeloid leukemia patients
    56 allogeneic hematopoietic stem cell transplantation
    57 alloreactivity
    58 analysis
    59 behalf
    60 blood transplantation
    61 capacity
    62 cells
    63 clinical impact
    64 clinical trials
    65 concern
    66 conditioning regimen
    67 cord blood transplantation
    68 degranulation
    69 development
    70 donors
    71 elderly patients
    72 expression
    73 features
    74 frequency
    75 future strategies
    76 general impairment
    77 hematopoietic stem cell transplantation
    78 high HLA-DR expression
    79 high-risk acute myeloid leukemia patients
    80 immaturity
    81 immune recovery
    82 impact
    83 impairment
    84 incidence
    85 incompatibility
    86 intensity
    87 intensity conditioning regimen
    88 killer cells
    89 leukemia
    90 leukemia patients
    91 licensing process
    92 lower CD16 expression
    93 markers
    94 maturity
    95 mismatch
    96 mortality
    97 multicenter trial
    98 myeloid leukemia
    99 myeloid leukemia patients
    100 natural killer cells
    101 overall survival
    102 patients
    103 phase II clinical trial
    104 phase II multicenter trial
    105 phenotypic features
    106 phenotypic markers
    107 polyfunctional capacity
    108 post-transplant relapse
    109 process
    110 prospective phase II clinical trial
    111 prospective phase II multicenter trial
    112 recipients
    113 reconstitution
    114 recovery
    115 reduced intensity conditioning regimen
    116 regimen
    117 relapse
    118 restoration
    119 stem cell transplantation
    120 strategies
    121 survival
    122 timing
    123 transplantation
    124 treatment-related mortality
    125 trials
    126 units
    127 unrelated cord blood transplantation
    128 use
    129 use of UCB
    130 schema:name Clinical impact of NK-cell reconstitution after reduced intensity conditioned unrelated cord blood transplantation in patients with acute myeloid leukemia: analysis of a prospective phase II multicenter trial on behalf of the Société Française de Greffe de Moelle Osseuse et Thérapie Cellulaire and Eurocord
    131 schema:pagination 1428-1435
    132 schema:productId N83af350575314e61ab2f706915f7f4bb
    133 Nca7187c5bb8e4a52a7ebe09fec2e0b12
    134 Nfb550e19b6664bcf8640f26a43df44d3
    135 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086159114
    136 https://doi.org/10.1038/bmt.2017.122
    137 schema:sdDatePublished 2022-09-02T16:01
    138 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    139 schema:sdPublisher Ndeb570509fca4695ba2edd3dff64c919
    140 schema:url https://doi.org/10.1038/bmt.2017.122
    141 sgo:license sg:explorer/license/
    142 sgo:sdDataset articles
    143 rdf:type schema:ScholarlyArticle
    144 N0ee12f669a834de0a2ffd7bbb75c9336 rdf:first sg:person.01041606055.08
    145 rdf:rest Nb87aedeff80b4100ba24d3597398a92f
    146 N1227fe46e6264d4b92596c5f7b4e8f4a rdf:first N5b58bd83430f41cba373d8a3eb59d2c1
    147 rdf:rest N7d7e750e57cd46e898e1dede0342b75a
    148 N16042ad900b244b2b554a1908946ded4 rdf:first sg:person.0625147223.89
    149 rdf:rest N502da70a732d4bd1ac9bd93fddb33bd0
    150 N1d5cf3d0caa240c9b2657ea587d3dc32 rdf:first sg:person.01040042621.92
    151 rdf:rest Nbee956b28c404595b4fe74e2ab4c14ab
    152 N1e47add0e85b4b7784ebac32f3dd8ed2 rdf:first sg:person.0710767661.03
    153 rdf:rest Ne179a0a9efe54a859602d7bde96b2b4e
    154 N227f32615847421186aa01a1e965241f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    155 schema:name Leukemia, Myeloid, Acute
    156 rdf:type schema:DefinedTerm
    157 N237222644eb244019fb70cd0ef04a035 rdf:first N36e1f8410f14464db71d0529405ab842
    158 rdf:rest Nc060ce63c9454d32ab01c2624eb2280f
    159 N262a2c5129ca4671a064c5ec3262e46e rdf:first sg:person.0631077726.87
    160 rdf:rest N4560faf434eb4c14aea301e7fe8e9664
    161 N2bd06ad4fc1041a39571afb17f45a08d rdf:first sg:person.01264301106.83
    162 rdf:rest N237222644eb244019fb70cd0ef04a035
    163 N2df2782a6bd84a7dbb1cab41b869476b schema:affiliation grid-institutes:grid.411154.4
    164 schema:familyName Dauriac
    165 schema:givenName C
    166 rdf:type schema:Person
    167 N2fdecdaf5b61419e88d6fb6c2c07c053 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    168 schema:name Allografts
    169 rdf:type schema:DefinedTerm
    170 N3035a93ca7894b8eaf23a7ebfd3723be rdf:first sg:person.01245127334.86
    171 rdf:rest N16042ad900b244b2b554a1908946ded4
    172 N322995d7960046ca8d6ec91da1ebbfb6 schema:issueNumber 10
    173 rdf:type schema:PublicationIssue
    174 N3637edceee6e4a5ba2f9e3db3c8f5a53 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    175 schema:name Transplantation Conditioning
    176 rdf:type schema:DefinedTerm
    177 N36e1f8410f14464db71d0529405ab842 schema:affiliation grid-institutes:grid.42399.35
    178 schema:familyName Clement
    179 schema:givenName L
    180 rdf:type schema:Person
    181 N386bbe6027044d37841b4a4fa07bff20 rdf:first Ndda17b99b1224cab9eb30410b1e7901c
    182 rdf:rest N989f8de1cff64a24b36a049a3612eeb0
    183 N39047761cf7645ef884f6fbe28e94b0e schema:affiliation grid-institutes:grid.5399.6
    184 schema:familyName Michel
    185 schema:givenName G
    186 rdf:type schema:Person
    187 N3d34a9d1583a49d182676f59cd20fd9a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    188 schema:name Disease-Free Survival
    189 rdf:type schema:DefinedTerm
    190 N3dba9c7fc49448aba68df985b2a4519c rdf:first sg:person.0653007001.30
    191 rdf:rest N9814e09cd854467ba1b845b9d1592cb8
    192 N416b2e5b16914cb7b66a414143bd9c32 rdf:first sg:person.01262560655.33
    193 rdf:rest N1227fe46e6264d4b92596c5f7b4e8f4a
    194 N443401271aa44d5885b6b2e0e0d89579 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    195 schema:name Female
    196 rdf:type schema:DefinedTerm
    197 N4443a1f226d64a83b5e0b74f4863300d rdf:first sg:person.0575776213.94
    198 rdf:rest N2bd06ad4fc1041a39571afb17f45a08d
    199 N4560faf434eb4c14aea301e7fe8e9664 rdf:first N39047761cf7645ef884f6fbe28e94b0e
    200 rdf:rest N85df578a60a946a3b7511ff33afcfe60
    201 N4eb6be4921004eeda3586c1f3508be99 rdf:first Nf66adfd577ce49e0a6a56c6207cc5911
    202 rdf:rest Nf6ed1a24185a4ec48f4000daa4273008
    203 N502da70a732d4bd1ac9bd93fddb33bd0 rdf:first sg:person.01344140455.98
    204 rdf:rest rdf:nil
    205 N53c45fb1040244028576fcc581c5b382 rdf:first Naf12fe95fa4a4b6eb48e8caa81268de0
    206 rdf:rest N1d5cf3d0caa240c9b2657ea587d3dc32
    207 N5b58bd83430f41cba373d8a3eb59d2c1 schema:affiliation grid-institutes:grid.411163.0
    208 schema:familyName Bay
    209 schema:givenName J-O
    210 rdf:type schema:Person
    211 N6d5aa244dfd24b96a39a58dd9171ae63 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    212 schema:name Adult
    213 rdf:type schema:DefinedTerm
    214 N7d7e750e57cd46e898e1dede0342b75a rdf:first sg:person.015747476457.00
    215 rdf:rest N0ee12f669a834de0a2ffd7bbb75c9336
    216 N7e97864f580d430090ed554b66a2c2ce rdf:first sg:person.01255345560.63
    217 rdf:rest N53c45fb1040244028576fcc581c5b382
    218 N7f1249e9cecc471690773ffd1cac5c7e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    219 schema:name Survival Rate
    220 rdf:type schema:DefinedTerm
    221 N83af350575314e61ab2f706915f7f4bb schema:name dimensions_id
    222 schema:value pub.1086159114
    223 rdf:type schema:PropertyValue
    224 N847b9b39a9714fc0a7fffc0cae2d2646 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    225 schema:name Registries
    226 rdf:type schema:DefinedTerm
    227 N85df578a60a946a3b7511ff33afcfe60 rdf:first sg:person.01067470361.59
    228 rdf:rest N3dba9c7fc49448aba68df985b2a4519c
    229 N8d7499240b96427aa386a3dbbd022498 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    230 schema:name Humans
    231 rdf:type schema:DefinedTerm
    232 N8d7cd514c05e4499951693d6659e20c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    233 schema:name Killer Cells, Natural
    234 rdf:type schema:DefinedTerm
    235 N93c25bb102194249b92acc4c5af5a5ba schema:affiliation grid-institutes:grid.410528.a
    236 schema:familyName Legrand
    237 schema:givenName F
    238 rdf:type schema:Person
    239 N9814e09cd854467ba1b845b9d1592cb8 rdf:first sg:person.0762115262.49
    240 rdf:rest Ncaa60e972bc449cd9ab2a0d755ce0e7e
    241 N989f8de1cff64a24b36a049a3612eeb0 rdf:first sg:person.01070244016.45
    242 rdf:rest N416b2e5b16914cb7b66a414143bd9c32
    243 N99e4d5f46c8847d0925b1597a204f7a0 schema:volumeNumber 52
    244 rdf:type schema:PublicationVolume
    245 N9ba171beb13a4dd68cc83c139c24a26c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    246 schema:name Cord Blood Stem Cell Transplantation
    247 rdf:type schema:DefinedTerm
    248 N9eea5d35c54b4b7884d3263061a83db6 rdf:first sg:person.01171607431.53
    249 rdf:rest N4eb6be4921004eeda3586c1f3508be99
    250 N9f4523a92c8f441583174f65ee51d40e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    251 schema:name Prospective Studies
    252 rdf:type schema:DefinedTerm
    253 Na14a11b1d5a84a928ab8a5044dc367c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    254 schema:name Recovery of Function
    255 rdf:type schema:DefinedTerm
    256 Naf12fe95fa4a4b6eb48e8caa81268de0 schema:affiliation grid-institutes:grid.413328.f
    257 schema:familyName Lejeune
    258 schema:givenName J
    259 rdf:type schema:Person
    260 Nb87aedeff80b4100ba24d3597398a92f rdf:first sg:person.0622277623.22
    261 rdf:rest Ne820db2e6d514d498bf5e97199802d0e
    262 Nbe228a6d7237425aa1fbe734134c0f8a rdf:first sg:person.0722016554.90
    263 rdf:rest N386bbe6027044d37841b4a4fa07bff20
    264 Nbee956b28c404595b4fe74e2ab4c14ab rdf:first sg:person.01143444261.94
    265 rdf:rest N3035a93ca7894b8eaf23a7ebfd3723be
    266 Nc060ce63c9454d32ab01c2624eb2280f rdf:first N2df2782a6bd84a7dbb1cab41b869476b
    267 rdf:rest N7e97864f580d430090ed554b66a2c2ce
    268 Nca7187c5bb8e4a52a7ebe09fec2e0b12 schema:name doi
    269 schema:value 10.1038/bmt.2017.122
    270 rdf:type schema:PropertyValue
    271 Ncaa60e972bc449cd9ab2a0d755ce0e7e rdf:first sg:person.01034023327.28
    272 rdf:rest N4443a1f226d64a83b5e0b74f4863300d
    273 Ncc297b506f2a483d87c1fcf4dc1072de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    274 schema:name Male
    275 rdf:type schema:DefinedTerm
    276 Nd6ed28d12ba84be0b25b964913b40c92 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    277 schema:name Middle Aged
    278 rdf:type schema:DefinedTerm
    279 Ndda17b99b1224cab9eb30410b1e7901c schema:affiliation grid-institutes:grid.277151.7
    280 schema:familyName Chevallier
    281 schema:givenName P
    282 rdf:type schema:Person
    283 Ndeb570509fca4695ba2edd3dff64c919 schema:name Springer Nature - SN SciGraph project
    284 rdf:type schema:Organization
    285 Ne179a0a9efe54a859602d7bde96b2b4e rdf:first N93c25bb102194249b92acc4c5af5a5ba
    286 rdf:rest N262a2c5129ca4671a064c5ec3262e46e
    287 Ne820db2e6d514d498bf5e97199802d0e rdf:first sg:person.0773366521.67
    288 rdf:rest N1e47add0e85b4b7784ebac32f3dd8ed2
    289 Nf66adfd577ce49e0a6a56c6207cc5911 schema:affiliation grid-institutes:grid.463810.8
    290 schema:familyName Achour
    291 schema:givenName A
    292 rdf:type schema:Person
    293 Nf6ed1a24185a4ec48f4000daa4273008 rdf:first sg:person.011773213421.92
    294 rdf:rest Nbe228a6d7237425aa1fbe734134c0f8a
    295 Nfb550e19b6664bcf8640f26a43df44d3 schema:name pubmed_id
    296 schema:value 28650455
    297 rdf:type schema:PropertyValue
    298 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    299 schema:name Medical and Health Sciences
    300 rdf:type schema:DefinedTerm
    301 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
    302 schema:name Immunology
    303 rdf:type schema:DefinedTerm
    304 sg:journal.1096890 schema:issn 0268-3369
    305 1476-5365
    306 schema:name Bone Marrow Transplantation
    307 schema:publisher Springer Nature
    308 rdf:type schema:Periodical
    309 sg:person.01034023327.28 schema:affiliation grid-institutes:grid.411439.a
    310 schema:familyName Uzunov
    311 schema:givenName M
    312 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034023327.28
    313 rdf:type schema:Person
    314 sg:person.01040042621.92 schema:affiliation grid-institutes:grid.463810.8
    315 schema:familyName Béziat
    316 schema:givenName V
    317 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040042621.92
    318 rdf:type schema:Person
    319 sg:person.01041606055.08 schema:affiliation grid-institutes:grid.411572.4
    320 schema:familyName Ceballos
    321 schema:givenName P
    322 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041606055.08
    323 rdf:type schema:Person
    324 sg:person.01067470361.59 schema:affiliation grid-institutes:grid.411162.1
    325 schema:familyName Maillard
    326 schema:givenName N
    327 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067470361.59
    328 rdf:type schema:Person
    329 sg:person.01070244016.45 schema:affiliation grid-institutes:grid.418443.e
    330 schema:familyName Furst
    331 schema:givenName S
    332 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070244016.45
    333 rdf:type schema:Person
    334 sg:person.01143444261.94 schema:affiliation grid-institutes:grid.413328.f
    335 schema:familyName Rocha
    336 schema:givenName V
    337 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143444261.94
    338 rdf:type schema:Person
    339 sg:person.01171607431.53 schema:affiliation grid-institutes:grid.463810.8
    340 schema:familyName Nguyen
    341 schema:givenName S
    342 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171607431.53
    343 rdf:type schema:Person
    344 sg:person.011773213421.92 schema:affiliation grid-institutes:grid.411439.a
    345 schema:familyName Souchet
    346 schema:givenName L
    347 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011773213421.92
    348 rdf:type schema:Person
    349 sg:person.01245127334.86 schema:affiliation grid-institutes:grid.412370.3
    350 schema:familyName Rio
    351 schema:givenName B
    352 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245127334.86
    353 rdf:type schema:Person
    354 sg:person.01255345560.63 schema:affiliation grid-institutes:grid.412220.7
    355 schema:familyName Bilger
    356 schema:givenName K
    357 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255345560.63
    358 rdf:type schema:Person
    359 sg:person.01262560655.33 schema:affiliation grid-institutes:grid.157868.5
    360 schema:familyName Sirvent
    361 schema:givenName A
    362 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262560655.33
    363 rdf:type schema:Person
    364 sg:person.01264301106.83 schema:affiliation grid-institutes:grid.412180.e
    365 schema:familyName Michallet
    366 schema:givenName M
    367 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264301106.83
    368 rdf:type schema:Person
    369 sg:person.01344140455.98 schema:affiliation grid-institutes:grid.463810.8
    370 schema:familyName Vieillard
    371 schema:givenName V
    372 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344140455.98
    373 rdf:type schema:Person
    374 sg:person.015747476457.00 schema:affiliation grid-institutes:grid.413328.f
    375 schema:familyName Socié
    376 schema:givenName G
    377 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015747476457.00
    378 rdf:type schema:Person
    379 sg:person.0575776213.94 schema:affiliation grid-institutes:grid.410529.b
    380 schema:familyName Bulabois
    381 schema:givenName C-E
    382 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0575776213.94
    383 rdf:type schema:Person
    384 sg:person.0622277623.22 schema:affiliation grid-institutes:grid.411175.7
    385 schema:familyName Huynh
    386 schema:givenName A
    387 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622277623.22
    388 rdf:type schema:Person
    389 sg:person.0625147223.89 schema:affiliation grid-institutes:grid.413328.f
    390 schema:familyName Chevret
    391 schema:givenName S
    392 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625147223.89
    393 rdf:type schema:Person
    394 sg:person.0631077726.87 schema:affiliation grid-institutes:grid.410463.4
    395 schema:familyName Yakoub-Agha
    396 schema:givenName I
    397 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631077726.87
    398 rdf:type schema:Person
    399 sg:person.0653007001.30 schema:affiliation grid-institutes:grid.157868.5
    400 schema:familyName Margueritte
    401 schema:givenName G
    402 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653007001.30
    403 rdf:type schema:Person
    404 sg:person.0710767661.03 schema:affiliation grid-institutes:grid.411147.6
    405 schema:familyName Francois
    406 schema:givenName S
    407 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710767661.03
    408 rdf:type schema:Person
    409 sg:person.0722016554.90 schema:affiliation grid-institutes:grid.42399.35
    410 schema:familyName Vigouroux
    411 schema:givenName S
    412 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722016554.90
    413 rdf:type schema:Person
    414 sg:person.0762115262.49 schema:affiliation grid-institutes:grid.412116.1
    415 schema:familyName Maury
    416 schema:givenName S
    417 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762115262.49
    418 rdf:type schema:Person
    419 sg:person.0773366521.67 schema:affiliation grid-institutes:grid.488279.8
    420 schema:familyName Cornillon
    421 schema:givenName J
    422 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773366521.67
    423 rdf:type schema:Person
    424 sg:pub.10.1007/s00251-013-0724-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029634343
    425 https://doi.org/10.1007/s00251-013-0724-7
    426 rdf:type schema:CreativeWork
    427 sg:pub.10.1038/leu.2008.343 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037682121
    428 https://doi.org/10.1038/leu.2008.343
    429 rdf:type schema:CreativeWork
    430 sg:pub.10.1038/leu.2008.365 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017064265
    431 https://doi.org/10.1038/leu.2008.365
    432 rdf:type schema:CreativeWork
    433 sg:pub.10.1038/leu.2015.98 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044650418
    434 https://doi.org/10.1038/leu.2015.98
    435 rdf:type schema:CreativeWork
    436 sg:pub.10.1038/ng2077 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025357588
    437 https://doi.org/10.1038/ng2077
    438 rdf:type schema:CreativeWork
    439 sg:pub.10.1038/ni.3518 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002722764
    440 https://doi.org/10.1038/ni.3518
    441 rdf:type schema:CreativeWork
    442 sg:pub.10.1038/nri3044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012854808
    443 https://doi.org/10.1038/nri3044
    444 rdf:type schema:CreativeWork
    445 sg:pub.10.1038/sj.bmt.1705014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044849485
    446 https://doi.org/10.1038/sj.bmt.1705014
    447 rdf:type schema:CreativeWork
    448 sg:pub.10.1038/sj.leu.2405041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044220803
    449 https://doi.org/10.1038/sj.leu.2405041
    450 rdf:type schema:CreativeWork
    451 grid-institutes:grid.157868.5 schema:alternateName CHU Montpellier Pédiatrie, Montpellier, France
    452 Centre Hospitalier Universitaire de Montpellier, Montpellier, France
    453 schema:name CHU Montpellier Pédiatrie, Montpellier, France
    454 Centre Hospitalier Universitaire de Montpellier, Montpellier, France
    455 rdf:type schema:Organization
    456 grid-institutes:grid.277151.7 schema:alternateName Hematology Department, CHU de Nantes, Nantes, France
    457 schema:name Hematology Department, CHU de Nantes, Nantes, France
    458 rdf:type schema:Organization
    459 grid-institutes:grid.410463.4 schema:alternateName CHU de Lille, Service d’Hématologie Lille, France
    460 schema:name CHU de Lille, Service d’Hématologie Lille, France
    461 rdf:type schema:Organization
    462 grid-institutes:grid.410528.a schema:alternateName CHU de Nice, Service d’Hématologie, Nice, France
    463 schema:name CHU de Nice, Service d’Hématologie, Nice, France
    464 rdf:type schema:Organization
    465 grid-institutes:grid.410529.b schema:alternateName CHU Grenoble, Grenoble, France
    466 schema:name CHU Grenoble, Grenoble, France
    467 rdf:type schema:Organization
    468 grid-institutes:grid.411147.6 schema:alternateName CHU de Angers, Angers, France
    469 schema:name CHU de Angers, Angers, France
    470 rdf:type schema:Organization
    471 grid-institutes:grid.411154.4 schema:alternateName CHU de Rennes, Rennes, France
    472 schema:name CHU de Rennes, Rennes, France
    473 rdf:type schema:Organization
    474 grid-institutes:grid.411162.1 schema:alternateName CHU de Poitiers, Poitiers, France
    475 schema:name CHU de Poitiers, Poitiers, France
    476 rdf:type schema:Organization
    477 grid-institutes:grid.411163.0 schema:alternateName CHU Estaing Service d’Hématologie Clinique, Clermont-Ferrand, France
    478 schema:name CHU Estaing Service d’Hématologie Clinique, Clermont-Ferrand, France
    479 rdf:type schema:Organization
    480 grid-institutes:grid.411175.7 schema:alternateName CHU de Toulouse, Hématologie Clinique, Toulouse, France
    481 schema:name CHU de Toulouse, Hématologie Clinique, Toulouse, France
    482 rdf:type schema:Organization
    483 grid-institutes:grid.411439.a schema:alternateName AP-HP, Hôpital Pitié Salpêtrière (AP-HP), Service d’Hématologie Clinique, Paris, France
    484 schema:name AP-HP, Hôpital Pitié Salpêtrière (AP-HP), Service d’Hématologie Clinique, Paris, France
    485 rdf:type schema:Organization
    486 grid-institutes:grid.411572.4 schema:alternateName Hôpital Lapeyronie, Montpellier, France
    487 schema:name Hôpital Lapeyronie, Montpellier, France
    488 rdf:type schema:Organization
    489 grid-institutes:grid.412116.1 schema:alternateName Hôpital Henri Mondor, Service d'Hématologie, Créteil, France
    490 schema:name Hôpital Henri Mondor, Service d'Hématologie, Créteil, France
    491 rdf:type schema:Organization
    492 grid-institutes:grid.412180.e schema:alternateName Hôpital Edouard Herriot, Lyon, France
    493 schema:name Hôpital Edouard Herriot, Lyon, France
    494 rdf:type schema:Organization
    495 grid-institutes:grid.412220.7 schema:alternateName CHRU de Strasbourg, Strasbourg, France
    496 schema:name CHRU de Strasbourg, Strasbourg, France
    497 rdf:type schema:Organization
    498 grid-institutes:grid.412370.3 schema:alternateName Hôpital Saint-Antoine, Hématologie Clinique et Thérapie Cellulaire, Paris, France
    499 schema:name Hôpital Saint-Antoine, Hématologie Clinique et Thérapie Cellulaire, Paris, France
    500 rdf:type schema:Organization
    501 grid-institutes:grid.413328.f schema:alternateName AP-HP, Hôpital Saint-Louis, Service d’Hématologie et de Transplantation, Paris, France
    502 Department de Bioinformatique et Statistique Médicale, Hôpital Saint-Louis, Paris, France
    503 Eurocord Office, Hôpital Saint-Louis, Paris, France
    504 schema:name AP-HP, Hôpital Saint-Louis, Service d’Hématologie et de Transplantation, Paris, France
    505 Department de Bioinformatique et Statistique Médicale, Hôpital Saint-Louis, Paris, France
    506 Eurocord Office, Hôpital Saint-Louis, Paris, France
    507 rdf:type schema:Organization
    508 grid-institutes:grid.418443.e schema:alternateName Institut Paoli Calmettes, Service de greffe de moelle, Marseille, France
    509 schema:name Institut Paoli Calmettes, Service de greffe de moelle, Marseille, France
    510 rdf:type schema:Organization
    511 grid-institutes:grid.42399.35 schema:alternateName CHU de Bordeaux Hôpital du Haut-Lévèque, Service d'hématologie clinique et de thérapie cellulaire, Pessac, France
    512 University Hospital de Bordeaux, Bordeaux, France
    513 schema:name CHU de Bordeaux Hôpital du Haut-Lévèque, Service d'hématologie clinique et de thérapie cellulaire, Pessac, France
    514 University Hospital de Bordeaux, Bordeaux, France
    515 rdf:type schema:Organization
    516 grid-institutes:grid.463810.8 schema:alternateName Sorbonne Universités, UPMC Univ Paris 06, INSERM U1135, CNRS ERL8255, Centre d’Immunologie et des Maladies Infectieuses (CIMI-Paris), Paris, France
    517 schema:name AP-HP, Hôpital Pitié Salpêtrière (AP-HP), Service d’Hématologie Clinique, Paris, France
    518 Sorbonne Universités, UPMC Univ Paris 06, INSERM U1135, CNRS ERL8255, Centre d’Immunologie et des Maladies Infectieuses (CIMI-Paris), Paris, France
    519 rdf:type schema:Organization
    520 grid-institutes:grid.488279.8 schema:alternateName Institut de Cancérologie de la Loire, Service d’Hématologie, Saint-Priest-en-Jarez, France
    521 schema:name Institut de Cancérologie de la Loire, Service d’Hématologie, Saint-Priest-en-Jarez, France
    522 rdf:type schema:Organization
    523 grid-institutes:grid.5399.6 schema:alternateName Department of Pediatric Hematology and Oncology, Timone Enfants Hospital and Research Unit EA 3279 Aix-Marseille University, Marseille, France
    524 schema:name Department of Pediatric Hematology and Oncology, Timone Enfants Hospital and Research Unit EA 3279 Aix-Marseille University, Marseille, France
    525 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...