Factors predicting outcome after allogeneic transplant in refractory acute myeloid leukemia: a retrospective analysis of Gruppo Italiano Trapianto di Midollo ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-01-09

AUTHORS

E Todisco, F Ciceri, C Boschini, F Giglio, A Bacigalupo, F Patriarca, I Donnini, E P Alessandrino, W Arcese, A P Iori, P Marenco, I Cavattoni, P Chiusolo, E Terruzzi, L Castagna, A Santoro, A Bosi, E Oldani, B Bruno, F Bonifazi, A Rambaldi

ABSTRACT

The clinical outcome of primary refractory (PRF) AML patients is poor and only a minor proportion of patients is rescued by allogenic hematopoietic stem cell transplantation (HSCT). The identification of pre-HSCT variables may help to determine PRF AML patients who can most likely benefit from HSCT. We analyzed PRF AML patients transplanted between 1999 and 2012 from a sibling, unrelated donor or a cord blood unit. Overall, 227 patients from 26 Gruppo Italiano Trapianto di Midollo Osseo e Terapia cellulare centers were included in the analysis. At 3 years, the overall survival was 14%. By multivariate analysis, the number of chemotherapy cycles, (hazard ratio (HR): 1.87; 95% confidence interval (CI): 1.24–2.85; P=0.0028), the percentage of bone marrow or peripheral blood blasts (HR: 1.75; 95% CI: 1.16–2.64; P=0.0078), the adverse cytogenetic (HR: 1.44; 95% CI: 1.00–2.07; P=0.0508) and the age of patients (HR: 1.77; 95% CI: 1.08–2.88; P=0.0223) remained significantly associated with survival. Thus, we set up a new score predicting at 3 years after transplantation, an overall survival probability of 32% for patients with score 0 (no or 1 prognostic factor), 10% for patients with score 1 (2 prognostic factors) and 3% for patients with score 2 (3 or 4 prognostic factors). More... »

PAGES

955-961

Journal

TITLE

Bone Marrow Transplantation

ISSUE

7

VOLUME

52

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bmt.2016.325

DOI

http://dx.doi.org/10.1038/bmt.2016.325

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005559108

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28067875


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362 grid-institutes:grid.416200.1 schema:alternateName Department of Hematology Oncology, Ospedale Niguarda Ca' Granda, Milano, Italy
363 schema:name Department of Hematology Oncology, Ospedale Niguarda Ca' Granda, Milano, Italy
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365 grid-institutes:grid.417728.f schema:alternateName Department of Hematology and Oncology, Humanitas Cancer Center, Rozzano-Milano, Italy
366 schema:name Department of Hematology and Oncology, Humanitas Cancer Center, Rozzano-Milano, Italy
367 rdf:type schema:Organization
368 grid-institutes:grid.460094.f schema:alternateName Hematology and BMT Unit, Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy
369 schema:name Hematology and BMT Unit, Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy
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371 grid-institutes:grid.6292.f schema:alternateName Bologna University, S. Orsola-Malpighi Hospital-Institute of Hematology & Medical Oncology L & A Seràgnoli, Bologna, Italy
372 schema:name Bologna University, S. Orsola-Malpighi Hospital-Institute of Hematology & Medical Oncology L & A Seràgnoli, Bologna, Italy
373 rdf:type schema:Organization
374 grid-institutes:grid.7563.7 schema:alternateName Department of Clinical Medicine and Prevention, University of Milano Bicocca, Monza, Italy
375 schema:name Department of Clinical Medicine and Prevention, University of Milano Bicocca, Monza, Italy
376 rdf:type schema:Organization
377 grid-institutes:grid.7841.a schema:alternateName Department of Cellular Biotechnologies and Hematology, Sapienza University, Rome, Italy
378 schema:name Department of Cellular Biotechnologies and Hematology, Sapienza University, Rome, Italy
379 rdf:type schema:Organization
380 grid-institutes:grid.8404.8 schema:alternateName Department of Hematology, BMT Unit, Univeristy of Firenze, Firenze, Italy
381 schema:name Department of Hematology, BMT Unit, Univeristy of Firenze, Firenze, Italy
382 rdf:type schema:Organization
383 grid-institutes:grid.8982.b schema:alternateName Department of Hematology Oncology, IRCCS Fondazione Policlinico San Matteo & University of Pavia, Pavia, Italy
384 schema:name Department of Hematology Oncology, IRCCS Fondazione Policlinico San Matteo & University of Pavia, Pavia, Italy
385 rdf:type schema:Organization
 




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