Revised diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a new classification from the European Society ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-07

AUTHORS

M Mohty, F Malard, M Abecassis, E Aerts, A S Alaskar, M Aljurf, M Arat, P Bader, F Baron, A Bazarbachi, D Blaise, F Ciceri, S Corbacioglu, J-H Dalle, F Dignan, T Fukuda, A Huynh, T Masszi, M Michallet, A Nagler, M NiChonghaile, S Okamoto, A Pagliuca, C Peters, F B Petersen, P G Richardson, T Ruutu, B N Savani, E Wallhult, I Yakoub-Agha, R F Duarte, E Carreras

ABSTRACT

Sinusoidal obstruction syndrome, also known as veno-occlusive disease (SOS/VOD), is a potentially life threatening complication that can develop after hematopoietic cell transplantation. Although SOS/VOD progressively resolves within a few weeks in most patients, the most severe forms result in multi-organ dysfunction and are associated with a high mortality rate (>80%). Therefore, careful attention must be paid to allow an early detection of SOS/VOD, particularly as drugs have now proven to be effective and licensed for its treatment. Unfortunately, current criteria lack sensitivity and specificity, making early identification and severity assessment of SOS/VOD difficult. The aim of this work is to propose a new definition for diagnosis, and a severity-grading system for SOS/VOD in adult patients, on behalf of the European Society for Blood and Marrow Transplantation. More... »

PAGES

906

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/bmt.2016.130

    DOI

    http://dx.doi.org/10.1038/bmt.2016.130

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1017627248

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27183098


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