Impact of MRD and TKI on allogeneic hematopoietic cell transplantation for Ph+ALL: a study from the adult ALL WG of ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-09-21

AUTHORS

S Nishiwaki, K Imai, S Mizuta, H Kanamori, K Ohashi, T Fukuda, Y Onishi, S Takahashi, N Uchida, T Eto, H Nakamae, T Yujiri, S Mori, T Nagamura-Inoue, R Suzuki, Y Atsuta, J Tanaka

ABSTRACT

To assess the impact of minimal residual disease (MRD) and tyrosine kinase inhibitor (TKI) administration on allogeneic hematopoietic cell transplantation (allo-HCT) for Ph-positive ALL (Ph+ALL), we retrospectively analyzed data from a registry database for 432 adult Ph+ALL patients in first CR (CR1) who received pre-transplant TKI administration. Negative MRD (MRD(−)) at allo-HCT was achieved in 277 patients. OS in patients transplanted in MRD(−) was significantly better than that in patients transplanted in MRD(+) (MRD(−): 67% vs MRD(+): 55% at 4 years; P=0.001). MRD(−) at allo-HCT was a significant risk factor for survival along with age at allo-HCT in multivariate analyses. Incidence of relapse in patients transplanted in MRD(−) was significantly lower than that in patients transplanted in MRD(+) (MRD(−): 19% vs MRD(+): 29% at 4 years; P=0.006). In multivariate analyses, MRD(+) at allo-HCT was a significant risk factor for relapse. A post-transplant TKI was administered to 103 patients. In subanalyses regarding the effect of post-transplant TKI administration, post-transplant TKI administration was a significant risk factor for relapse in multivariate analyses (P<0.0001). MRD status at allo-HCT is one of the most important predictive factors for Ph+ALL patients transplanted in CR1. More... »

PAGES

43-50

Journal

TITLE

Bone Marrow Transplantation

ISSUE

1

VOLUME

51

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bmt.2015.217

DOI

http://dx.doi.org/10.1038/bmt.2015.217

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013878219

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26389833


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Public Health and Health Services", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Allografts", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hematopoietic Stem Cell Transplantation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Japan", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm, Residual", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Philadelphia Chromosome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Precursor Cell Lymphoblastic Leukemia-Lymphoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Kinase Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Registries", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan", 
          "id": "http://www.grid.ac/institutes/grid.511247.4", 
          "name": [
            "Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan", 
            "Division of Hematology and Oncology, Toyohashi Municipal Hospital, Toyohashi, Japan", 
            "Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nishiwaki", 
        "givenName": "S", 
        "id": "sg:person.01225143610.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225143610.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Sapporo Hokuyu Hospital, Sappro, Japan", 
          "id": "http://www.grid.ac/institutes/grid.415262.6", 
          "name": [
            "Department of Hematology, Sapporo Hokuyu Hospital, Sappro, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Imai", 
        "givenName": "K", 
        "id": "sg:person.016551375562.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016551375562.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Fujita Health University Hospital, Toyoake, Japan", 
          "id": "http://www.grid.ac/institutes/grid.471500.7", 
          "name": [
            "Department of Hematology, Fujita Health University Hospital, Toyoake, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mizuta", 
        "givenName": "S", 
        "id": "sg:person.01065017243.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065017243.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.414944.8", 
          "name": [
            "Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kanamori", 
        "givenName": "H", 
        "id": "sg:person.01060176576.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060176576.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Hematology, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.415479.a", 
          "name": [
            "Division of Hematology, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ohashi", 
        "givenName": "K", 
        "id": "sg:person.012430503152.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012430503152.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.272242.3", 
          "name": [
            "Division of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fukuda", 
        "givenName": "T", 
        "id": "sg:person.0610272060.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610272060.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology and Rheumatology, Tohoku University Hospital, Sendai, Japan", 
          "id": "http://www.grid.ac/institutes/grid.412757.2", 
          "name": [
            "Department of Hematology and Rheumatology, Tohoku University Hospital, Sendai, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Onishi", 
        "givenName": "Y", 
        "id": "sg:person.01153721575.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153721575.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Molecular Therapy, Institute of Medical Science, The Advanced Clinical Research Center, University of Tokyo, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Division of Molecular Therapy, Institute of Medical Science, The Advanced Clinical Research Center, University of Tokyo, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takahashi", 
        "givenName": "S", 
        "id": "sg:person.0721047700.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721047700.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Toranomon Hospital, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410813.f", 
          "name": [
            "Department of Hematology, Toranomon Hospital, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Uchida", 
        "givenName": "N", 
        "id": "sg:person.010150414102.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010150414102.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.413617.6", 
          "name": [
            "Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Eto", 
        "givenName": "T", 
        "id": "sg:person.014503271162.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014503271162.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Osaka City University Hospital, Osaka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.470114.7", 
          "name": [
            "Department of Hematology, Osaka City University Hospital, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakamae", 
        "givenName": "H", 
        "id": "sg:person.01014223462.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014223462.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Third Department of Internal of Medicine, Yamaguchi University School of Medicine, Ube, Japan", 
          "id": "http://www.grid.ac/institutes/grid.268397.1", 
          "name": [
            "Third Department of Internal of Medicine, Yamaguchi University School of Medicine, Ube, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yujiri", 
        "givenName": "T", 
        "id": "sg:person.01050731510.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050731510.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology and Oncology, St. Luke's International Hospital, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.430395.8", 
          "name": [
            "Department of Hematology and Oncology, St. Luke's International Hospital, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mori", 
        "givenName": "S", 
        "id": "sg:person.012707347012.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012707347012.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cell Processing and Transfusion, Institute of Medical Science, University of Tokyo, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Department of Cell Processing and Transfusion, Institute of Medical Science, University of Tokyo, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nagamura-Inoue", 
        "givenName": "T", 
        "id": "sg:person.0617411273.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617411273.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of HSCT Data Management and Biostatistics, Nagoya University Graduate School of Medicine, Nagoya, Japan", 
          "id": "http://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Department of HSCT Data Management and Biostatistics, Nagoya University Graduate School of Medicine, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Suzuki", 
        "givenName": "R", 
        "id": "sg:person.014632774322.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014632774322.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan", 
          "id": "http://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Department of HSCT Data Management and Biostatistics, Nagoya University Graduate School of Medicine, Nagoya, Japan", 
            "Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Atsuta", 
        "givenName": "Y", 
        "id": "sg:person.01146754030.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146754030.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Tokyo Women's Medical University, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410818.4", 
          "name": [
            "Department of Hematology, Tokyo Women's Medical University, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tanaka", 
        "givenName": "J", 
        "id": "sg:person.0714107337.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714107337.54"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/sj.bmt.1705727", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009895179", 
          "https://doi.org/10.1038/sj.bmt.1705727"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2013.253", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021658729", 
          "https://doi.org/10.1038/leu.2013.253"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2012.164", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033703292", 
          "https://doi.org/10.1038/leu.2012.164"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bmt.2008.296", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033326494", 
          "https://doi.org/10.1038/bmt.2008.296"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2012.352", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021091201", 
          "https://doi.org/10.1038/leu.2012.352"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bcj.2012.18", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016348067", 
          "https://doi.org/10.1038/bcj.2012.18"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-09-21", 
    "datePublishedReg": "2015-09-21", 
    "description": "To assess the impact of minimal residual disease (MRD) and tyrosine kinase inhibitor (TKI) administration on allogeneic hematopoietic cell transplantation (allo-HCT) for Ph-positive ALL (Ph+ALL), we retrospectively analyzed data from a registry database for 432 adult Ph+ALL patients in first CR (CR1) who received pre-transplant TKI administration. Negative MRD (MRD(\u2212)) at allo-HCT was achieved in 277 patients. OS in patients transplanted in MRD(\u2212) was significantly better than that in patients transplanted in MRD(+) (MRD(\u2212): 67% vs MRD(+): 55% at 4 years; P=0.001). MRD(\u2212) at allo-HCT was a significant risk factor for survival along with age at allo-HCT in multivariate analyses. Incidence of relapse in patients transplanted in MRD(\u2212) was significantly lower than that in patients transplanted in MRD(+) (MRD(\u2212): 19% vs MRD(+): 29% at 4 years; P=0.006). In multivariate analyses, MRD(+) at allo-HCT was a significant risk factor for relapse. A post-transplant TKI was administered to 103 patients. In subanalyses regarding the effect of post-transplant TKI administration, post-transplant TKI administration was a significant risk factor for relapse in multivariate analyses (P<0.0001). MRD status at allo-HCT is one of the most important predictive factors for Ph+ALL patients transplanted in CR1.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/bmt.2015.217", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6123246", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6153095", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1096890", 
        "issn": [
          "0268-3369", 
          "1476-5365"
        ], 
        "name": "Bone Marrow Transplantation", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "51"
      }
    ], 
    "keywords": [
      "minimal residual disease", 
      "significant risk factors", 
      "allogeneic hematopoietic cell transplantation", 
      "allo-HCT", 
      "hematopoietic cell transplantation", 
      "TKI administration", 
      "risk factors", 
      "multivariate analysis", 
      "cell transplantation", 
      "impact of MRD", 
      "negative minimal residual disease", 
      "tyrosine kinase inhibitor administration", 
      "incidence of relapse", 
      "important predictive factor", 
      "MRD status", 
      "inhibitor administration", 
      "residual disease", 
      "predictive factors", 
      "registry database", 
      "first CR", 
      "patients", 
      "relapse", 
      "administration", 
      "transplantation", 
      "TKIs", 
      "adults", 
      "subanalyses", 
      "factors", 
      "incidence", 
      "disease", 
      "survival", 
      "age", 
      "CR1", 
      "JSHCT", 
      "status", 
      "OS", 
      "database", 
      "analysis", 
      "study", 
      "impact", 
      "effect", 
      "data", 
      "WG", 
      "pH", 
      "Cr"
    ], 
    "name": "Impact of MRD and TKI on allogeneic hematopoietic cell transplantation for Ph+ALL: a study from the adult ALL WG of the JSHCT", 
    "pagination": "43-50", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1013878219"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/bmt.2015.217"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26389833"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/bmt.2015.217", 
      "https://app.dimensions.ai/details/publication/pub.1013878219"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-08-04T17:04", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_679.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/bmt.2015.217"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/bmt.2015.217'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/bmt.2015.217'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/bmt.2015.217'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/bmt.2015.217'


 

This table displays all metadata directly associated to this object as RDF triples.

354 TRIPLES      21 PREDICATES      91 URIs      77 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/bmt.2015.217 schema:about N0034f12f3d2d4295a9aee4f381e8aaa4
2 N0a32cdad343b4143ab239596b5a7b875
3 N0e60eb14558f4a84a08e53d9c23ce1b0
4 N2b0bfa6eac66475d91d1d36ff8806b7c
5 N3e10bbed15634a70bd8acb827b190346
6 N4e93e4a3afa44d0586aaa0ea40ae14c3
7 N72a64411c5ea4bf2ad4295cf6db49d07
8 N7e73bde0abe54bc3a7cc7f827c41a0d6
9 Nb39d4a7b17864d14b9e3e26e4fa6c94c
10 Nbf8f3a0728ae414eaf94d518cc4378e5
11 Nc5987dafd2f643bda706f7b63e2b9f09
12 Nd5d8568e5c1542d88ff14173ed5de22c
13 Nd86812577a79420d8557ded7187f103d
14 Ne30134f679a748d9b96c932aa785c3d7
15 Neda4a3c606a842dc81e64beed813347d
16 anzsrc-for:11
17 anzsrc-for:1117
18 schema:author N61025c4af4464bdabbe4655a8cc40353
19 schema:citation sg:pub.10.1038/bcj.2012.18
20 sg:pub.10.1038/bmt.2008.296
21 sg:pub.10.1038/leu.2012.164
22 sg:pub.10.1038/leu.2012.352
23 sg:pub.10.1038/leu.2013.253
24 sg:pub.10.1038/sj.bmt.1705727
25 schema:datePublished 2015-09-21
26 schema:datePublishedReg 2015-09-21
27 schema:description To assess the impact of minimal residual disease (MRD) and tyrosine kinase inhibitor (TKI) administration on allogeneic hematopoietic cell transplantation (allo-HCT) for Ph-positive ALL (Ph+ALL), we retrospectively analyzed data from a registry database for 432 adult Ph+ALL patients in first CR (CR1) who received pre-transplant TKI administration. Negative MRD (MRD(−)) at allo-HCT was achieved in 277 patients. OS in patients transplanted in MRD(−) was significantly better than that in patients transplanted in MRD(+) (MRD(−): 67% vs MRD(+): 55% at 4 years; P=0.001). MRD(−) at allo-HCT was a significant risk factor for survival along with age at allo-HCT in multivariate analyses. Incidence of relapse in patients transplanted in MRD(−) was significantly lower than that in patients transplanted in MRD(+) (MRD(−): 19% vs MRD(+): 29% at 4 years; P=0.006). In multivariate analyses, MRD(+) at allo-HCT was a significant risk factor for relapse. A post-transplant TKI was administered to 103 patients. In subanalyses regarding the effect of post-transplant TKI administration, post-transplant TKI administration was a significant risk factor for relapse in multivariate analyses (P<0.0001). MRD status at allo-HCT is one of the most important predictive factors for Ph+ALL patients transplanted in CR1.
28 schema:genre article
29 schema:isAccessibleForFree false
30 schema:isPartOf N469f6e281c614515903ca4555ac28283
31 N563eee70c1124eaab313df42e5b70ddd
32 sg:journal.1096890
33 schema:keywords CR1
34 Cr
35 JSHCT
36 MRD status
37 OS
38 TKI administration
39 TKIs
40 WG
41 administration
42 adults
43 age
44 allo-HCT
45 allogeneic hematopoietic cell transplantation
46 analysis
47 cell transplantation
48 data
49 database
50 disease
51 effect
52 factors
53 first CR
54 hematopoietic cell transplantation
55 impact
56 impact of MRD
57 important predictive factor
58 incidence
59 incidence of relapse
60 inhibitor administration
61 minimal residual disease
62 multivariate analysis
63 negative minimal residual disease
64 pH
65 patients
66 predictive factors
67 registry database
68 relapse
69 residual disease
70 risk factors
71 significant risk factors
72 status
73 study
74 subanalyses
75 survival
76 transplantation
77 tyrosine kinase inhibitor administration
78 schema:name Impact of MRD and TKI on allogeneic hematopoietic cell transplantation for Ph+ALL: a study from the adult ALL WG of the JSHCT
79 schema:pagination 43-50
80 schema:productId N48acfafd8ca24617a129d459bdc42d78
81 Nc7f313feaa9a4d12b793ff97959903b0
82 Ned2c1dda41e640ac8d17c858bc0e8615
83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013878219
84 https://doi.org/10.1038/bmt.2015.217
85 schema:sdDatePublished 2022-08-04T17:04
86 schema:sdLicense https://scigraph.springernature.com/explorer/license/
87 schema:sdPublisher N928019e90cc9458f98f2a5422a8e3eae
88 schema:url https://doi.org/10.1038/bmt.2015.217
89 sgo:license sg:explorer/license/
90 sgo:sdDataset articles
91 rdf:type schema:ScholarlyArticle
92 N0034f12f3d2d4295a9aee4f381e8aaa4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Neoplasm, Residual
94 rdf:type schema:DefinedTerm
95 N0a32cdad343b4143ab239596b5a7b875 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Middle Aged
97 rdf:type schema:DefinedTerm
98 N0e60eb14558f4a84a08e53d9c23ce1b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Aged
100 rdf:type schema:DefinedTerm
101 N0f1fdf1c5c3043faa271ffba4f8ba1e8 rdf:first sg:person.010150414102.18
102 rdf:rest N3fa8064fbbfa43bb843df16e0e6a76b5
103 N16adc18931f64e06914c33b1487493aa rdf:first sg:person.01065017243.50
104 rdf:rest Nd9177045a95d4f969104414d0244e88d
105 N224a09cfae78424ea4a64130bfecb4b2 rdf:first sg:person.01153721575.57
106 rdf:rest N612aca82e59b450ea607ac2f24bb234d
107 N2b0bfa6eac66475d91d1d36ff8806b7c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Male
109 rdf:type schema:DefinedTerm
110 N3498bc530f6847a88d8bb540419afa84 rdf:first sg:person.01146754030.08
111 rdf:rest N4d39e01a84a7491192d79a587986c819
112 N3e10bbed15634a70bd8acb827b190346 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Hematopoietic Stem Cell Transplantation
114 rdf:type schema:DefinedTerm
115 N3fa8064fbbfa43bb843df16e0e6a76b5 rdf:first sg:person.014503271162.26
116 rdf:rest N6d8b628bcde64abeae9ddb820c2a617a
117 N469f6e281c614515903ca4555ac28283 schema:volumeNumber 51
118 rdf:type schema:PublicationVolume
119 N48acfafd8ca24617a129d459bdc42d78 schema:name doi
120 schema:value 10.1038/bmt.2015.217
121 rdf:type schema:PropertyValue
122 N4a4ef10230e24178b5e4bad32a2564c1 rdf:first sg:person.01050731510.22
123 rdf:rest Nb18f2805c34a4e7981bfd4494311424d
124 N4d39e01a84a7491192d79a587986c819 rdf:first sg:person.0714107337.54
125 rdf:rest rdf:nil
126 N4e93e4a3afa44d0586aaa0ea40ae14c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Protein Kinase Inhibitors
128 rdf:type schema:DefinedTerm
129 N563eee70c1124eaab313df42e5b70ddd schema:issueNumber 1
130 rdf:type schema:PublicationIssue
131 N5e0468292e084b8b84bc9800722a3112 rdf:first sg:person.0617411273.34
132 rdf:rest Nb665408eb98346f2898d19ade6331750
133 N61025c4af4464bdabbe4655a8cc40353 rdf:first sg:person.01225143610.34
134 rdf:rest N838ac8d2145540ce9c7f22aa0ed5a41d
135 N612aca82e59b450ea607ac2f24bb234d rdf:first sg:person.0721047700.17
136 rdf:rest N0f1fdf1c5c3043faa271ffba4f8ba1e8
137 N6d8b628bcde64abeae9ddb820c2a617a rdf:first sg:person.01014223462.98
138 rdf:rest N4a4ef10230e24178b5e4bad32a2564c1
139 N72a64411c5ea4bf2ad4295cf6db49d07 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Philadelphia Chromosome
141 rdf:type schema:DefinedTerm
142 N7e73bde0abe54bc3a7cc7f827c41a0d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Japan
144 rdf:type schema:DefinedTerm
145 N838ac8d2145540ce9c7f22aa0ed5a41d rdf:first sg:person.016551375562.50
146 rdf:rest N16adc18931f64e06914c33b1487493aa
147 N8619b2144e1a4383b1971de18b292326 rdf:first sg:person.012430503152.76
148 rdf:rest Nb454d048c2a9452a9b54dcea66c95530
149 N928019e90cc9458f98f2a5422a8e3eae schema:name Springer Nature - SN SciGraph project
150 rdf:type schema:Organization
151 Nb18f2805c34a4e7981bfd4494311424d rdf:first sg:person.012707347012.05
152 rdf:rest N5e0468292e084b8b84bc9800722a3112
153 Nb39d4a7b17864d14b9e3e26e4fa6c94c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Adult
155 rdf:type schema:DefinedTerm
156 Nb454d048c2a9452a9b54dcea66c95530 rdf:first sg:person.0610272060.01
157 rdf:rest N224a09cfae78424ea4a64130bfecb4b2
158 Nb665408eb98346f2898d19ade6331750 rdf:first sg:person.014632774322.04
159 rdf:rest N3498bc530f6847a88d8bb540419afa84
160 Nbf8f3a0728ae414eaf94d518cc4378e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Adolescent
162 rdf:type schema:DefinedTerm
163 Nc5987dafd2f643bda706f7b63e2b9f09 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Female
165 rdf:type schema:DefinedTerm
166 Nc7f313feaa9a4d12b793ff97959903b0 schema:name dimensions_id
167 schema:value pub.1013878219
168 rdf:type schema:PropertyValue
169 Nd5d8568e5c1542d88ff14173ed5de22c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Precursor Cell Lymphoblastic Leukemia-Lymphoma
171 rdf:type schema:DefinedTerm
172 Nd86812577a79420d8557ded7187f103d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Humans
174 rdf:type schema:DefinedTerm
175 Nd9177045a95d4f969104414d0244e88d rdf:first sg:person.01060176576.11
176 rdf:rest N8619b2144e1a4383b1971de18b292326
177 Ne30134f679a748d9b96c932aa785c3d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Allografts
179 rdf:type schema:DefinedTerm
180 Ned2c1dda41e640ac8d17c858bc0e8615 schema:name pubmed_id
181 schema:value 26389833
182 rdf:type schema:PropertyValue
183 Neda4a3c606a842dc81e64beed813347d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Registries
185 rdf:type schema:DefinedTerm
186 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
187 schema:name Medical and Health Sciences
188 rdf:type schema:DefinedTerm
189 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
190 schema:name Public Health and Health Services
191 rdf:type schema:DefinedTerm
192 sg:grant.6123246 http://pending.schema.org/fundedItem sg:pub.10.1038/bmt.2015.217
193 rdf:type schema:MonetaryGrant
194 sg:grant.6153095 http://pending.schema.org/fundedItem sg:pub.10.1038/bmt.2015.217
195 rdf:type schema:MonetaryGrant
196 sg:journal.1096890 schema:issn 0268-3369
197 1476-5365
198 schema:name Bone Marrow Transplantation
199 schema:publisher Springer Nature
200 rdf:type schema:Periodical
201 sg:person.01014223462.98 schema:affiliation grid-institutes:grid.470114.7
202 schema:familyName Nakamae
203 schema:givenName H
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014223462.98
205 rdf:type schema:Person
206 sg:person.010150414102.18 schema:affiliation grid-institutes:grid.410813.f
207 schema:familyName Uchida
208 schema:givenName N
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010150414102.18
210 rdf:type schema:Person
211 sg:person.01050731510.22 schema:affiliation grid-institutes:grid.268397.1
212 schema:familyName Yujiri
213 schema:givenName T
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050731510.22
215 rdf:type schema:Person
216 sg:person.01060176576.11 schema:affiliation grid-institutes:grid.414944.8
217 schema:familyName Kanamori
218 schema:givenName H
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060176576.11
220 rdf:type schema:Person
221 sg:person.01065017243.50 schema:affiliation grid-institutes:grid.471500.7
222 schema:familyName Mizuta
223 schema:givenName S
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065017243.50
225 rdf:type schema:Person
226 sg:person.01146754030.08 schema:affiliation grid-institutes:grid.27476.30
227 schema:familyName Atsuta
228 schema:givenName Y
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146754030.08
230 rdf:type schema:Person
231 sg:person.01153721575.57 schema:affiliation grid-institutes:grid.412757.2
232 schema:familyName Onishi
233 schema:givenName Y
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153721575.57
235 rdf:type schema:Person
236 sg:person.01225143610.34 schema:affiliation grid-institutes:grid.511247.4
237 schema:familyName Nishiwaki
238 schema:givenName S
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225143610.34
240 rdf:type schema:Person
241 sg:person.012430503152.76 schema:affiliation grid-institutes:grid.415479.a
242 schema:familyName Ohashi
243 schema:givenName K
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012430503152.76
245 rdf:type schema:Person
246 sg:person.012707347012.05 schema:affiliation grid-institutes:grid.430395.8
247 schema:familyName Mori
248 schema:givenName S
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012707347012.05
250 rdf:type schema:Person
251 sg:person.014503271162.26 schema:affiliation grid-institutes:grid.413617.6
252 schema:familyName Eto
253 schema:givenName T
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014503271162.26
255 rdf:type schema:Person
256 sg:person.014632774322.04 schema:affiliation grid-institutes:grid.27476.30
257 schema:familyName Suzuki
258 schema:givenName R
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014632774322.04
260 rdf:type schema:Person
261 sg:person.016551375562.50 schema:affiliation grid-institutes:grid.415262.6
262 schema:familyName Imai
263 schema:givenName K
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016551375562.50
265 rdf:type schema:Person
266 sg:person.0610272060.01 schema:affiliation grid-institutes:grid.272242.3
267 schema:familyName Fukuda
268 schema:givenName T
269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610272060.01
270 rdf:type schema:Person
271 sg:person.0617411273.34 schema:affiliation grid-institutes:grid.26999.3d
272 schema:familyName Nagamura-Inoue
273 schema:givenName T
274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617411273.34
275 rdf:type schema:Person
276 sg:person.0714107337.54 schema:affiliation grid-institutes:grid.410818.4
277 schema:familyName Tanaka
278 schema:givenName J
279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714107337.54
280 rdf:type schema:Person
281 sg:person.0721047700.17 schema:affiliation grid-institutes:grid.26999.3d
282 schema:familyName Takahashi
283 schema:givenName S
284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721047700.17
285 rdf:type schema:Person
286 sg:pub.10.1038/bcj.2012.18 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016348067
287 https://doi.org/10.1038/bcj.2012.18
288 rdf:type schema:CreativeWork
289 sg:pub.10.1038/bmt.2008.296 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033326494
290 https://doi.org/10.1038/bmt.2008.296
291 rdf:type schema:CreativeWork
292 sg:pub.10.1038/leu.2012.164 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033703292
293 https://doi.org/10.1038/leu.2012.164
294 rdf:type schema:CreativeWork
295 sg:pub.10.1038/leu.2012.352 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021091201
296 https://doi.org/10.1038/leu.2012.352
297 rdf:type schema:CreativeWork
298 sg:pub.10.1038/leu.2013.253 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021658729
299 https://doi.org/10.1038/leu.2013.253
300 rdf:type schema:CreativeWork
301 sg:pub.10.1038/sj.bmt.1705727 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009895179
302 https://doi.org/10.1038/sj.bmt.1705727
303 rdf:type schema:CreativeWork
304 grid-institutes:grid.268397.1 schema:alternateName Third Department of Internal of Medicine, Yamaguchi University School of Medicine, Ube, Japan
305 schema:name Third Department of Internal of Medicine, Yamaguchi University School of Medicine, Ube, Japan
306 rdf:type schema:Organization
307 grid-institutes:grid.26999.3d schema:alternateName Department of Cell Processing and Transfusion, Institute of Medical Science, University of Tokyo, Tokyo, Japan
308 Division of Molecular Therapy, Institute of Medical Science, The Advanced Clinical Research Center, University of Tokyo, Tokyo, Japan
309 schema:name Department of Cell Processing and Transfusion, Institute of Medical Science, University of Tokyo, Tokyo, Japan
310 Division of Molecular Therapy, Institute of Medical Science, The Advanced Clinical Research Center, University of Tokyo, Tokyo, Japan
311 rdf:type schema:Organization
312 grid-institutes:grid.272242.3 schema:alternateName Division of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan
313 schema:name Division of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan
314 rdf:type schema:Organization
315 grid-institutes:grid.27476.30 schema:alternateName Department of HSCT Data Management and Biostatistics, Nagoya University Graduate School of Medicine, Nagoya, Japan
316 Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan
317 schema:name Department of HSCT Data Management and Biostatistics, Nagoya University Graduate School of Medicine, Nagoya, Japan
318 Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan
319 rdf:type schema:Organization
320 grid-institutes:grid.410813.f schema:alternateName Department of Hematology, Toranomon Hospital, Tokyo, Japan
321 schema:name Department of Hematology, Toranomon Hospital, Tokyo, Japan
322 rdf:type schema:Organization
323 grid-institutes:grid.410818.4 schema:alternateName Department of Hematology, Tokyo Women's Medical University, Tokyo, Japan
324 schema:name Department of Hematology, Tokyo Women's Medical University, Tokyo, Japan
325 rdf:type schema:Organization
326 grid-institutes:grid.412757.2 schema:alternateName Department of Hematology and Rheumatology, Tohoku University Hospital, Sendai, Japan
327 schema:name Department of Hematology and Rheumatology, Tohoku University Hospital, Sendai, Japan
328 rdf:type schema:Organization
329 grid-institutes:grid.413617.6 schema:alternateName Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan
330 schema:name Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan
331 rdf:type schema:Organization
332 grid-institutes:grid.414944.8 schema:alternateName Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan
333 schema:name Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan
334 rdf:type schema:Organization
335 grid-institutes:grid.415262.6 schema:alternateName Department of Hematology, Sapporo Hokuyu Hospital, Sappro, Japan
336 schema:name Department of Hematology, Sapporo Hokuyu Hospital, Sappro, Japan
337 rdf:type schema:Organization
338 grid-institutes:grid.415479.a schema:alternateName Division of Hematology, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan
339 schema:name Division of Hematology, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan
340 rdf:type schema:Organization
341 grid-institutes:grid.430395.8 schema:alternateName Department of Hematology and Oncology, St. Luke's International Hospital, Tokyo, Japan
342 schema:name Department of Hematology and Oncology, St. Luke's International Hospital, Tokyo, Japan
343 rdf:type schema:Organization
344 grid-institutes:grid.470114.7 schema:alternateName Department of Hematology, Osaka City University Hospital, Osaka, Japan
345 schema:name Department of Hematology, Osaka City University Hospital, Osaka, Japan
346 rdf:type schema:Organization
347 grid-institutes:grid.471500.7 schema:alternateName Department of Hematology, Fujita Health University Hospital, Toyoake, Japan
348 schema:name Department of Hematology, Fujita Health University Hospital, Toyoake, Japan
349 rdf:type schema:Organization
350 grid-institutes:grid.511247.4 schema:alternateName Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan
351 schema:name Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
352 Division of Hematology and Oncology, Toyohashi Municipal Hospital, Toyohashi, Japan
353 Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan
354 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...