UGT2B17 minor histocompatibility mismatch and clinical outcome after HLA-identical sibling donor stem cell transplantation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-01

AUTHORS

N Santos, R Rodríguez-Romanos, J B Nieto, I Buño, C Vallejo, A Jiménez-Velasco, S Brunet, E Buces, J López-Jiménez, M González, C Ferrá, A Sampol, R de la Cámara, C Martínez, D Gallardo

ABSTRACT

Minor histocompatibility Ags (mHags) have been implicated in the pathogenesis of GVHD after allogeneic hematopoietic stem cell transplantation (HSCT). Uridine diphospho-glucuronosyltransferase 2B17 (UGT2B17) gene deletion may act as a mHag and its association with acute GVHD (aGVHD) has been described. We retrospectively studied the clinical impact of a UGT2B17 mismatch in a cohort of 1127 patients receiving a HSCT from an HLA-identical sibling donor. UGT2B17 mismatch was present in 69 cases (6.1%). Incidence of severe aGVHD was higher in the UGT2B17 mismatched pairs (22.7% vs 14.6%), but this difference was not statistically significant (P: 0.098). We did not detect differences in chronic GVHD, overall survival, relapse-free survival, transplant-related mortality or relapse. Nevertheless, when we analyzed only those patients receiving grafts from a male donor (616 cases), aGVHD was significantly higher in the UGT2B17 mismatched group (25.1% vs 12.8%; P: 0.005) and this association was confirmed by the multivariate analysis (P: 0.043; hazard ratio: 2.16, 95% confidence interval: 1.03-4.57). Overall survival was worse for patients mismatched for UGT2B17 (P: 0.005). We conclude that UGT2B17 mismatch has a negative clinical impact in allogeneic HSCT from HLA-identical sibling donors only when a male donor is used. These results should be confirmed by other studies. More... »

PAGES

79-82

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bmt.2015.207

DOI

http://dx.doi.org/10.1038/bmt.2015.207

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013613521

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26367234


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Turtle is a human-readable linked data format.

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RDF/XML is a standard XML format for linked data.

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323 schema:name Hematology Department, Hospital Carlos Haya, Málaga, Spain.
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325 https://www.grid.ac/institutes/grid.413396.a schema:alternateName Hospital de Sant Pau
326 schema:name Hematology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
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328 https://www.grid.ac/institutes/grid.418701.b schema:alternateName Institut Català d'Oncologia
329 schema:name Institut Català d'Oncologia, Badalona, Spain.
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331 https://www.grid.ac/institutes/grid.429182.4 schema:alternateName Institut d'Investigació Biomèdica de Girona
332 schema:name Clinical Hematology Department, Institut Català d'Oncologia, IDIBGi, Girona, Spain.
333 rdf:type schema:Organization
 




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