Incidence and risk factors of post-engraftment invasive fungal disease in adult allogeneic hematopoietic stem cell transplant recipients receiving oral azoles ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-08-17

AUTHORS

P Montesinos, R Rodríguez-Veiga, B Boluda, D Martínez-Cuadrón, I Cano, A Lancharro, J Sanz, M J Arilla, F López-Chuliá, I Navarro, I Lorenzo, M Salavert, J Pemán, P Calvillo, J Martínez, N Carpio, I Jarque, G F Sanz, M A Sanz

ABSTRACT

Studies that analyze the epidemiology and risk factors for invasive fungal disease (IFD) after engraftment in alloSCT are few in number. This single-center retrospective study included 404 alloSCT adult recipients surviving >40 days who engrafted and were discharged without prior IFD. All patients who received ⩾20 mg/day of prednisone were assigned to primary oral prophylaxis (itraconazole or low-dose voriconazole). The primary end point was the cumulative incidence (CI) of probable/proven IFD using the European Organization for Research and Treatment of Cancer and Mycoses Study Group (EORTC/MSG) criteria. The independent prognostic factors after multivariate analyses were used to construct a post-engraftment IFD risk score. The 1-year CI of IFD was 11%. The non-relapse mortality was 40% in those developing IFD and 16% in those who did not. The intent-to-treat analysis showed that 17% of patients abandoned the assigned prophylaxis. Age >40 years, ⩾1 previous SCT, pre-engraftment neutropenia >15 days, extensive chronic GVHD and CMV reactivation were independent risk factors. The post-engraftment IFD score stratified patients into low risk (0–1 factor, CI 0.7%), intermediate risk (2 factors, CI 9.9%) and high risk (3–5 factors, CI 24.7%) (P<0.0001). The antifungal prophylaxis strategy failed to prevent post-engraftment IFD in 11% of alloSCT. Our risk score could be useful to implement risk-adapted strategies using antifungal prophylaxis after engraftment. More... »

PAGES

1465-1472

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bmt.2015.181

DOI

http://dx.doi.org/10.1038/bmt.2015.181

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028117382

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26281032


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Public Health and Health Services", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Administration, Oral", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Allografts", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amphotericin B", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antifungal Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aspergillosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Caspofungin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cause of Death", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Therapy, Combination", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Echinocandins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fungemia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Granulocyte Colony-Stimulating Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hematologic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hematopoietic Stem Cell Transplantation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunocompromised Host", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Incidence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lipopeptides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Medication Adherence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mycoses", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neutropenia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Patient Compliance", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Premedication", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Assessment", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transplantation Conditioning", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Failure", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Triazoles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Hospital Universitari i Polit\u00e8cnic La Fe, Val\u00e8ncia, Spain", 
          "id": "http://www.grid.ac/institutes/grid.84393.35", 
          "name": [
            "Department of Hematology, Hospital Universitari i Polit\u00e8cnic La Fe, Val\u00e8ncia, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Montesinos", 
        "givenName": "P", 
        "id": "sg:person.01172456111.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172456111.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Hospital Universitari i Polit\u00e8cnic La Fe, Val\u00e8ncia, Spain", 
          "id": "http://www.grid.ac/institutes/grid.84393.35", 
          "name": [
            "Department of Hematology, Hospital Universitari i Polit\u00e8cnic La Fe, Val\u00e8ncia, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rodr\u00edguez-Veiga", 
        "givenName": "R", 
        "id": "sg:person.01362315261.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362315261.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Hospital Universitari i Polit\u00e8cnic La Fe, Val\u00e8ncia, Spain", 
          "id": "http://www.grid.ac/institutes/grid.84393.35", 
          "name": [
            "Department of Hematology, Hospital Universitari i Polit\u00e8cnic La Fe, Val\u00e8ncia, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boluda", 
        "givenName": "B", 
        "id": "sg:person.01161564054.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161564054.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Hospital Universitari i Polit\u00e8cnic La Fe, Val\u00e8ncia, Spain", 
          "id": "http://www.grid.ac/institutes/grid.84393.35", 
          "name": [
            "Department of Hematology, Hospital Universitari i Polit\u00e8cnic La Fe, Val\u00e8ncia, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mart\u00ednez-Cuadr\u00f3n", 
        "givenName": "D", 
        "id": "sg:person.01234333123.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234333123.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Hospital Universitari i Polit\u00e8cnic La Fe, Val\u00e8ncia, Spain", 
          "id": "http://www.grid.ac/institutes/grid.84393.35", 
          "name": [
            "Department of Hematology, Hospital Universitari i Polit\u00e8cnic La Fe, Val\u00e8ncia, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cano", 
        "givenName": "I", 
        "id": "sg:person.01026464676.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026464676.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Hospital Universitari i Polit\u00e8cnic La Fe, Val\u00e8ncia, Spain", 
          "id": "http://www.grid.ac/institutes/grid.84393.35", 
          "name": [
            "Department of Hematology, Hospital Universitari i Polit\u00e8cnic La Fe, Val\u00e8ncia, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lancharro", 
        "givenName": "A", 
        "id": "sg:person.0760351476.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760351476.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Hospital Universitari i Polit\u00e8cnic La Fe, Val\u00e8ncia, Spain", 
          "id": "http://www.grid.ac/institutes/grid.84393.35", 
          "name": [
            "Department of Hematology, Hospital Universitari i Polit\u00e8cnic La Fe, Val\u00e8ncia, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sanz", 
        "givenName": "J", 
        "id": "sg:person.01177753461.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177753461.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Hospital Universitari i Polit\u00e8cnic La Fe, Val\u00e8ncia, Spain", 
          "id": "http://www.grid.ac/institutes/grid.84393.35", 
          "name": [
            "Department of Hematology, Hospital Universitari i Polit\u00e8cnic La Fe, Val\u00e8ncia, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Arilla", 
        "givenName": "M J", 
        "id": "sg:person.0624741442.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624741442.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Hospital Universitari i Polit\u00e8cnic La Fe, Val\u00e8ncia, Spain", 
          "id": "http://www.grid.ac/institutes/grid.84393.35", 
          "name": [
            "Department of Hematology, Hospital Universitari i Polit\u00e8cnic La Fe, Val\u00e8ncia, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "L\u00f3pez-Chuli\u00e1", 
        "givenName": "F", 
        "id": "sg:person.01017617741.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017617741.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Hospital Universitari i Polit\u00e8cnic La Fe, Val\u00e8ncia, Spain", 
          "id": "http://www.grid.ac/institutes/grid.84393.35", 
          "name": [
            "Department of Hematology, Hospital Universitari i Polit\u00e8cnic La Fe, Val\u00e8ncia, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Navarro", 
        "givenName": "I", 
        "id": "sg:person.01052441656.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052441656.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Hospital Universitari i Polit\u00e8cnic La Fe, Val\u00e8ncia, Spain", 
          "id": "http://www.grid.ac/institutes/grid.84393.35", 
          "name": [
            "Department of Hematology, Hospital Universitari i Polit\u00e8cnic La Fe, Val\u00e8ncia, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lorenzo", 
        "givenName": "I", 
        "id": "sg:person.01240174223.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240174223.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Infectious Diseases, Hospital Universitari i Polit\u00e8cnic La Fe, Val\u00e8ncia, Spain", 
          "id": "http://www.grid.ac/institutes/grid.84393.35", 
          "name": [
            "Department of Infectious Diseases, Hospital Universitari i Polit\u00e8cnic La Fe, Val\u00e8ncia, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Salavert", 
        "givenName": "M", 
        "id": "sg:person.01076240317.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076240317.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Microbiology, Hospital Universitari i Polit\u00e8cnic La Fe, Val\u00e8ncia, Spain", 
          "id": "http://www.grid.ac/institutes/grid.84393.35", 
          "name": [
            "Department of Microbiology, Hospital Universitari i Polit\u00e8cnic La Fe, Val\u00e8ncia, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pem\u00e1n", 
        "givenName": "J", 
        "id": "sg:person.01014673776.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014673776.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology, Hospital Universitari i Polit\u00e8cnic La Fe, Val\u00e8ncia, Spain", 
          "id": "http://www.grid.ac/institutes/grid.84393.35", 
          "name": [
            "Department of Radiology, Hospital Universitari i Polit\u00e8cnic La Fe, Val\u00e8ncia, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Calvillo", 
        "givenName": "P", 
        "id": "sg:person.01127233122.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127233122.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Hospital Universitari i Polit\u00e8cnic La Fe, Val\u00e8ncia, Spain", 
          "id": "http://www.grid.ac/institutes/grid.84393.35", 
          "name": [
            "Department of Hematology, Hospital Universitari i Polit\u00e8cnic La Fe, Val\u00e8ncia, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mart\u00ednez", 
        "givenName": "J", 
        "id": "sg:person.016204417202.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016204417202.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Hospital Universitari i Polit\u00e8cnic La Fe, Val\u00e8ncia, Spain", 
          "id": "http://www.grid.ac/institutes/grid.84393.35", 
          "name": [
            "Department of Hematology, Hospital Universitari i Polit\u00e8cnic La Fe, Val\u00e8ncia, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Carpio", 
        "givenName": "N", 
        "id": "sg:person.01273172564.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273172564.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Hospital Universitari i Polit\u00e8cnic La Fe, Val\u00e8ncia, Spain", 
          "id": "http://www.grid.ac/institutes/grid.84393.35", 
          "name": [
            "Department of Hematology, Hospital Universitari i Polit\u00e8cnic La Fe, Val\u00e8ncia, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jarque", 
        "givenName": "I", 
        "id": "sg:person.01120371616.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120371616.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Hospital Universitari i Polit\u00e8cnic La Fe, Val\u00e8ncia, Spain", 
          "id": "http://www.grid.ac/institutes/grid.84393.35", 
          "name": [
            "Department of Hematology, Hospital Universitari i Polit\u00e8cnic La Fe, Val\u00e8ncia, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sanz", 
        "givenName": "G F", 
        "id": "sg:person.013151467432.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013151467432.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Departament de Medicina, Universitat de Val\u00e8ncia,, Valencia,, Spain", 
          "id": "http://www.grid.ac/institutes/grid.5338.d", 
          "name": [
            "Department of Hematology, Hospital Universitari i Polit\u00e8cnic La Fe, Val\u00e8ncia, Spain", 
            "Departament de Medicina, Universitat de Val\u00e8ncia,, Valencia,, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sanz", 
        "givenName": "M A", 
        "id": "sg:person.0636400707.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636400707.18"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/bmt.2010.38", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050011141", 
          "https://doi.org/10.1038/bmt.2010.38"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bmt.2009.39", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049041418", 
          "https://doi.org/10.1038/bmt.2009.39"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bmt.1704543", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039018530", 
          "https://doi.org/10.1038/sj.bmt.1704543"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bmt.2013.136", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052679862", 
          "https://doi.org/10.1038/bmt.2013.136"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-08-17", 
    "datePublishedReg": "2015-08-17", 
    "description": "Studies that analyze the epidemiology and risk factors for invasive fungal disease (IFD) after engraftment in alloSCT are few in number. This single-center retrospective study included 404 alloSCT adult recipients surviving >40 days who engrafted and were discharged without prior IFD. All patients who received \u2a7e20\u2009mg/day of prednisone were assigned to primary oral prophylaxis (itraconazole or low-dose voriconazole). The primary end point was the cumulative incidence (CI) of probable/proven IFD using the European Organization for Research and Treatment of Cancer and Mycoses Study Group (EORTC/MSG) criteria. The independent prognostic factors after multivariate analyses were used to construct a post-engraftment IFD risk score. The 1-year CI of IFD was 11%. The non-relapse mortality was 40% in those developing IFD and 16% in those who did not. The intent-to-treat analysis showed that 17% of patients abandoned the assigned prophylaxis. Age >40 years, \u2a7e1 previous SCT, pre-engraftment neutropenia >15 days, extensive chronic GVHD and CMV reactivation were independent risk factors. The post-engraftment IFD score stratified patients into low risk (0\u20131 factor, CI 0.7%), intermediate risk (2 factors, CI 9.9%) and high risk (3\u20135 factors, CI 24.7%) (P<0.0001). The antifungal prophylaxis strategy failed to prevent post-engraftment IFD in 11% of alloSCT. Our risk score could be useful to implement risk-adapted strategies using antifungal prophylaxis after engraftment.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/bmt.2015.181", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1096890", 
        "issn": [
          "0268-3369", 
          "1476-5365"
        ], 
        "name": "Bone Marrow Transplantation", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "11", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "50"
      }
    ], 
    "keywords": [
      "invasive fungal disease", 
      "cumulative incidence", 
      "risk factors", 
      "risk score", 
      "adult allogeneic hematopoietic stem cell transplant recipients", 
      "allogeneic hematopoietic stem cell transplant recipients", 
      "hematopoietic stem cell transplant recipients", 
      "prior IFD", 
      "Mycoses Study Group criteria", 
      "single-center retrospective study", 
      "stem cell transplant recipients", 
      "day of prednisone", 
      "non-relapse mortality", 
      "pre-engraftment neutropenia", 
      "extensive chronic GVHD", 
      "antifungal prophylaxis strategies", 
      "primary end point", 
      "Study Group criteria", 
      "independent risk factor", 
      "cell transplant recipients", 
      "independent prognostic factor", 
      "risk-adapted strategy", 
      "chronic GVHD", 
      "CMV reactivation", 
      "azole prophylaxis", 
      "antifungal prophylaxis", 
      "transplant recipients", 
      "oral prophylaxis", 
      "prognostic factors", 
      "treat analysis", 
      "intermediate risk", 
      "prophylaxis strategies", 
      "retrospective study", 
      "adult recipients", 
      "treatment of cancer", 
      "Group criteria", 
      "high risk", 
      "lower risk", 
      "prophylaxis", 
      "European Organization", 
      "multivariate analysis", 
      "end point", 
      "patients", 
      "alloSCT", 
      "engraftment", 
      "fungal diseases", 
      "disease", 
      "incidence", 
      "scores", 
      "risk", 
      "recipients", 
      "days", 
      "IFD score", 
      "GVHD", 
      "prednisone", 
      "neutropenia", 
      "factors", 
      "cancer", 
      "mortality", 
      "epidemiology", 
      "age", 
      "SCT", 
      "treatment", 
      "study", 
      "reactivation", 
      "years", 
      "criteria", 
      "strategies", 
      "intent", 
      "analysis", 
      "number", 
      "research", 
      "point", 
      "organization", 
      "primary oral prophylaxis", 
      "post-engraftment IFD risk score", 
      "IFD risk score", 
      "previous SCT", 
      "post-engraftment IFD score", 
      "post-engraftment IFD", 
      "oral azoles prophylaxis"
    ], 
    "name": "Incidence and risk factors of post-engraftment invasive fungal disease in adult allogeneic hematopoietic stem cell transplant recipients receiving oral azoles prophylaxis", 
    "pagination": "1465-1472", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1028117382"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/bmt.2015.181"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26281032"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/bmt.2015.181", 
      "https://app.dimensions.ai/details/publication/pub.1028117382"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:36", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_659.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/bmt.2015.181"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/bmt.2015.181'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/bmt.2015.181'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/bmt.2015.181'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/bmt.2015.181'


 

This table displays all metadata directly associated to this object as RDF triples.

435 TRIPLES      22 PREDICATES      146 URIs      134 LITERALS      42 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/bmt.2015.181 schema:about N014453067f274df799a0a8d4ef8d6a7b
2 N18d5fca1f2914d9d90624ceadbc9f384
3 N27afdf8a57a54aeaa7e785321bbbad5e
4 N2b21edfa0b9440aaa42adda216fc03bf
5 N35e88cec58284bfaa37665dcf239129a
6 N39d13844f25c4013a29eaf63cf8b7f58
7 N3b6b4a8df7c749e4a72bc701162465b0
8 N540221e796e3484a85b90a77eb7068e0
9 N54fd9fe8f88d46e4ac167b76f36bc42c
10 N5ac721bbe29d461199da18d4d9ffc155
11 N5c6c9ae4828c456a8d567ec4a93c7b67
12 N632974719712486f9e9a1aa63d8bdc2a
13 N6620f38df9be443a9f59820e3d84c1f4
14 N70417ebbdf2f4742ae42733f48b4eaa9
15 N79d353f9504e40d8b68521590e5a6dbd
16 N7b5dbdfc4c3540dfad510a109d598002
17 N8450591fd3874d61b76cc2e01bcee608
18 N89ec87ddc8fc4234962c3f8aa345b7f8
19 N8c08b491b6e2487297036096de0caa52
20 N921d63dc8cc34522befdfe8a88716843
21 N92ecd6e4339c4fef825cb81f09e01c5f
22 Na16a6ab747d342be82a8a5beb48d0c6d
23 Na459bf0cc920454083d4987d8366b2d1
24 Na9b72861058e40d188660b4d7a63a331
25 Naa186e4e828847c2a35762d87139b476
26 Nabd7ff35e7e34ec39bb32e1f25624f6e
27 Nae87046fa617420a944b121a80f75f18
28 Nb6b0b83aed4240fea484917cd631ddf8
29 Nc4820fc105a145dfa1e3c58234ffeb5a
30 Nd53a1d5656664021b04336e5cc3e2c2e
31 Nd887187edeb94557b701833dd6e4aeb1
32 Ne4348e21cc8d49a499eb7a4d944c9359
33 Ne70cca10b2fa4447ac92e3ce4aa0dd2d
34 Ne747b203d9ac4005b3954d8684087484
35 Nee5483519a694db79d9b0953e64e13c9
36 anzsrc-for:11
37 anzsrc-for:1117
38 schema:author N393749e0355e49b6adfd3635afc80e8c
39 schema:citation sg:pub.10.1038/bmt.2009.39
40 sg:pub.10.1038/bmt.2010.38
41 sg:pub.10.1038/bmt.2013.136
42 sg:pub.10.1038/sj.bmt.1704543
43 schema:datePublished 2015-08-17
44 schema:datePublishedReg 2015-08-17
45 schema:description Studies that analyze the epidemiology and risk factors for invasive fungal disease (IFD) after engraftment in alloSCT are few in number. This single-center retrospective study included 404 alloSCT adult recipients surviving >40 days who engrafted and were discharged without prior IFD. All patients who received ⩾20 mg/day of prednisone were assigned to primary oral prophylaxis (itraconazole or low-dose voriconazole). The primary end point was the cumulative incidence (CI) of probable/proven IFD using the European Organization for Research and Treatment of Cancer and Mycoses Study Group (EORTC/MSG) criteria. The independent prognostic factors after multivariate analyses were used to construct a post-engraftment IFD risk score. The 1-year CI of IFD was 11%. The non-relapse mortality was 40% in those developing IFD and 16% in those who did not. The intent-to-treat analysis showed that 17% of patients abandoned the assigned prophylaxis. Age >40 years, ⩾1 previous SCT, pre-engraftment neutropenia >15 days, extensive chronic GVHD and CMV reactivation were independent risk factors. The post-engraftment IFD score stratified patients into low risk (0–1 factor, CI 0.7%), intermediate risk (2 factors, CI 9.9%) and high risk (3–5 factors, CI 24.7%) (P<0.0001). The antifungal prophylaxis strategy failed to prevent post-engraftment IFD in 11% of alloSCT. Our risk score could be useful to implement risk-adapted strategies using antifungal prophylaxis after engraftment.
46 schema:genre article
47 schema:inLanguage en
48 schema:isAccessibleForFree true
49 schema:isPartOf N77fa808c2cd44140a0f168f4980d1a09
50 N83167b8fb57d4245a09ec99b6575a8a1
51 sg:journal.1096890
52 schema:keywords CMV reactivation
53 European Organization
54 GVHD
55 Group criteria
56 IFD risk score
57 IFD score
58 Mycoses Study Group criteria
59 SCT
60 Study Group criteria
61 adult allogeneic hematopoietic stem cell transplant recipients
62 adult recipients
63 age
64 alloSCT
65 allogeneic hematopoietic stem cell transplant recipients
66 analysis
67 antifungal prophylaxis
68 antifungal prophylaxis strategies
69 azole prophylaxis
70 cancer
71 cell transplant recipients
72 chronic GVHD
73 criteria
74 cumulative incidence
75 day of prednisone
76 days
77 disease
78 end point
79 engraftment
80 epidemiology
81 extensive chronic GVHD
82 factors
83 fungal diseases
84 hematopoietic stem cell transplant recipients
85 high risk
86 incidence
87 independent prognostic factor
88 independent risk factor
89 intent
90 intermediate risk
91 invasive fungal disease
92 lower risk
93 mortality
94 multivariate analysis
95 neutropenia
96 non-relapse mortality
97 number
98 oral azoles prophylaxis
99 oral prophylaxis
100 organization
101 patients
102 point
103 post-engraftment IFD
104 post-engraftment IFD risk score
105 post-engraftment IFD score
106 pre-engraftment neutropenia
107 prednisone
108 previous SCT
109 primary end point
110 primary oral prophylaxis
111 prior IFD
112 prognostic factors
113 prophylaxis
114 prophylaxis strategies
115 reactivation
116 recipients
117 research
118 retrospective study
119 risk
120 risk factors
121 risk score
122 risk-adapted strategy
123 scores
124 single-center retrospective study
125 stem cell transplant recipients
126 strategies
127 study
128 transplant recipients
129 treat analysis
130 treatment
131 treatment of cancer
132 years
133 schema:name Incidence and risk factors of post-engraftment invasive fungal disease in adult allogeneic hematopoietic stem cell transplant recipients receiving oral azoles prophylaxis
134 schema:pagination 1465-1472
135 schema:productId N96f77c574c7a4c90b115189c6a80548c
136 N99177a526001435bb075b85e96b67c6c
137 Nd2d1e5e1bfcf44aa8ab29ead07cc67df
138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028117382
139 https://doi.org/10.1038/bmt.2015.181
140 schema:sdDatePublished 2022-01-01T18:36
141 schema:sdLicense https://scigraph.springernature.com/explorer/license/
142 schema:sdPublisher N406e3d370b604b7b9010782fd4d8842e
143 schema:url https://doi.org/10.1038/bmt.2015.181
144 sgo:license sg:explorer/license/
145 sgo:sdDataset articles
146 rdf:type schema:ScholarlyArticle
147 N00c70c75933c4c7682098516beaf65c8 rdf:first sg:person.01362315261.04
148 rdf:rest Ned63d900317642ea82699e7afcf960d5
149 N014453067f274df799a0a8d4ef8d6a7b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Administration, Oral
151 rdf:type schema:DefinedTerm
152 N048ad113e602464683bc757bf6edf927 rdf:first sg:person.0760351476.54
153 rdf:rest N8bc5f8cd55db4da5acc073f8e85a61c9
154 N18d5fca1f2914d9d90624ceadbc9f384 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Fungemia
156 rdf:type schema:DefinedTerm
157 N27afdf8a57a54aeaa7e785321bbbad5e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Echinocandins
159 rdf:type schema:DefinedTerm
160 N2b21edfa0b9440aaa42adda216fc03bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Allografts
162 rdf:type schema:DefinedTerm
163 N32eeb862214f448fb349c6ed7db431ed rdf:first sg:person.01017617741.90
164 rdf:rest Nf0c254cd85b242f8b06be02cb7f17223
165 N35e88cec58284bfaa37665dcf239129a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Amphotericin B
167 rdf:type schema:DefinedTerm
168 N393749e0355e49b6adfd3635afc80e8c rdf:first sg:person.01172456111.54
169 rdf:rest N00c70c75933c4c7682098516beaf65c8
170 N39d13844f25c4013a29eaf63cf8b7f58 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Caspofungin
172 rdf:type schema:DefinedTerm
173 N3b6b4a8df7c749e4a72bc701162465b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Drug Therapy, Combination
175 rdf:type schema:DefinedTerm
176 N406e3d370b604b7b9010782fd4d8842e schema:name Springer Nature - SN SciGraph project
177 rdf:type schema:Organization
178 N43b6e90149384b3f8daa6a01db8a6ef0 rdf:first sg:person.013151467432.56
179 rdf:rest Na0608808be664eff85b2bd77593f7b8d
180 N500ef5a158ec419fa9a71d5bb35a927f rdf:first sg:person.01014673776.69
181 rdf:rest N9a83269386c849f085715ecd2b0fd642
182 N540221e796e3484a85b90a77eb7068e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Hematopoietic Stem Cell Transplantation
184 rdf:type schema:DefinedTerm
185 N54cb1c59d001438286d094275eecc849 rdf:first sg:person.01026464676.40
186 rdf:rest N048ad113e602464683bc757bf6edf927
187 N54fd9fe8f88d46e4ac167b76f36bc42c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Risk Assessment
189 rdf:type schema:DefinedTerm
190 N5ac721bbe29d461199da18d4d9ffc155 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Antifungal Agents
192 rdf:type schema:DefinedTerm
193 N5c6c9ae4828c456a8d567ec4a93c7b67 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Middle Aged
195 rdf:type schema:DefinedTerm
196 N632974719712486f9e9a1aa63d8bdc2a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Neutropenia
198 rdf:type schema:DefinedTerm
199 N6620f38df9be443a9f59820e3d84c1f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Premedication
201 rdf:type schema:DefinedTerm
202 N70417ebbdf2f4742ae42733f48b4eaa9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Transplantation Conditioning
204 rdf:type schema:DefinedTerm
205 N74373e6d943d4f9abea3d9663947f285 rdf:first sg:person.01273172564.00
206 rdf:rest N7f4191966f554fddbff1a41e10e272a3
207 N77fa808c2cd44140a0f168f4980d1a09 schema:volumeNumber 50
208 rdf:type schema:PublicationVolume
209 N79d353f9504e40d8b68521590e5a6dbd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
210 schema:name Adult
211 rdf:type schema:DefinedTerm
212 N7b5dbdfc4c3540dfad510a109d598002 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
213 schema:name Patient Compliance
214 rdf:type schema:DefinedTerm
215 N7ddf6e7f01954606b4782335efc38077 rdf:first sg:person.01240174223.16
216 rdf:rest N99eab9ab35cf4f3c9dc19758053268bc
217 N7f4191966f554fddbff1a41e10e272a3 rdf:first sg:person.01120371616.34
218 rdf:rest N43b6e90149384b3f8daa6a01db8a6ef0
219 N83167b8fb57d4245a09ec99b6575a8a1 schema:issueNumber 11
220 rdf:type schema:PublicationIssue
221 N8450591fd3874d61b76cc2e01bcee608 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
222 schema:name Treatment Failure
223 rdf:type schema:DefinedTerm
224 N89ec87ddc8fc4234962c3f8aa345b7f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
225 schema:name Cause of Death
226 rdf:type schema:DefinedTerm
227 N8bc5f8cd55db4da5acc073f8e85a61c9 rdf:first sg:person.01177753461.90
228 rdf:rest Ncab4ee96fdaf484d881b55ef0b6f29de
229 N8c08b491b6e2487297036096de0caa52 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
230 schema:name Aspergillosis
231 rdf:type schema:DefinedTerm
232 N921d63dc8cc34522befdfe8a88716843 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
233 schema:name Aged
234 rdf:type schema:DefinedTerm
235 N92ecd6e4339c4fef825cb81f09e01c5f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
236 schema:name Female
237 rdf:type schema:DefinedTerm
238 N96f77c574c7a4c90b115189c6a80548c schema:name doi
239 schema:value 10.1038/bmt.2015.181
240 rdf:type schema:PropertyValue
241 N99177a526001435bb075b85e96b67c6c schema:name dimensions_id
242 schema:value pub.1028117382
243 rdf:type schema:PropertyValue
244 N99eab9ab35cf4f3c9dc19758053268bc rdf:first sg:person.01076240317.06
245 rdf:rest N500ef5a158ec419fa9a71d5bb35a927f
246 N9a3f0b9fe1fa4366999958fcb8f013f0 rdf:first sg:person.016204417202.72
247 rdf:rest N74373e6d943d4f9abea3d9663947f285
248 N9a83269386c849f085715ecd2b0fd642 rdf:first sg:person.01127233122.53
249 rdf:rest N9a3f0b9fe1fa4366999958fcb8f013f0
250 Na0608808be664eff85b2bd77593f7b8d rdf:first sg:person.0636400707.18
251 rdf:rest rdf:nil
252 Na16a6ab747d342be82a8a5beb48d0c6d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
253 schema:name Incidence
254 rdf:type schema:DefinedTerm
255 Na459bf0cc920454083d4987d8366b2d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
256 schema:name Humans
257 rdf:type schema:DefinedTerm
258 Na9b72861058e40d188660b4d7a63a331 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
259 schema:name Immunocompromised Host
260 rdf:type schema:DefinedTerm
261 Naa186e4e828847c2a35762d87139b476 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
262 schema:name Hematologic Neoplasms
263 rdf:type schema:DefinedTerm
264 Nabd7ff35e7e34ec39bb32e1f25624f6e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
265 schema:name Granulocyte Colony-Stimulating Factor
266 rdf:type schema:DefinedTerm
267 Nae87046fa617420a944b121a80f75f18 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
268 schema:name Risk Factors
269 rdf:type schema:DefinedTerm
270 Nb6b0b83aed4240fea484917cd631ddf8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
271 schema:name Retrospective Studies
272 rdf:type schema:DefinedTerm
273 Nc4820fc105a145dfa1e3c58234ffeb5a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
274 schema:name Survival Analysis
275 rdf:type schema:DefinedTerm
276 Ncab4ee96fdaf484d881b55ef0b6f29de rdf:first sg:person.0624741442.29
277 rdf:rest N32eeb862214f448fb349c6ed7db431ed
278 Nd2d1e5e1bfcf44aa8ab29ead07cc67df schema:name pubmed_id
279 schema:value 26281032
280 rdf:type schema:PropertyValue
281 Nd53a1d5656664021b04336e5cc3e2c2e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
282 schema:name Medication Adherence
283 rdf:type schema:DefinedTerm
284 Nd887187edeb94557b701833dd6e4aeb1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
285 schema:name Triazoles
286 rdf:type schema:DefinedTerm
287 Ne4348e21cc8d49a499eb7a4d944c9359 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
288 schema:name Mycoses
289 rdf:type schema:DefinedTerm
290 Ne70cca10b2fa4447ac92e3ce4aa0dd2d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
291 schema:name Lipopeptides
292 rdf:type schema:DefinedTerm
293 Ne747b203d9ac4005b3954d8684087484 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
294 schema:name Young Adult
295 rdf:type schema:DefinedTerm
296 Ne9f07dc9bdd84362a6213e415d2278a2 rdf:first sg:person.01234333123.87
297 rdf:rest N54cb1c59d001438286d094275eecc849
298 Ned63d900317642ea82699e7afcf960d5 rdf:first sg:person.01161564054.49
299 rdf:rest Ne9f07dc9bdd84362a6213e415d2278a2
300 Nee5483519a694db79d9b0953e64e13c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
301 schema:name Male
302 rdf:type schema:DefinedTerm
303 Nf0c254cd85b242f8b06be02cb7f17223 rdf:first sg:person.01052441656.45
304 rdf:rest N7ddf6e7f01954606b4782335efc38077
305 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
306 schema:name Medical and Health Sciences
307 rdf:type schema:DefinedTerm
308 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
309 schema:name Public Health and Health Services
310 rdf:type schema:DefinedTerm
311 sg:journal.1096890 schema:issn 0268-3369
312 1476-5365
313 schema:name Bone Marrow Transplantation
314 schema:publisher Springer Nature
315 rdf:type schema:Periodical
316 sg:person.01014673776.69 schema:affiliation grid-institutes:grid.84393.35
317 schema:familyName Pemán
318 schema:givenName J
319 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014673776.69
320 rdf:type schema:Person
321 sg:person.01017617741.90 schema:affiliation grid-institutes:grid.84393.35
322 schema:familyName López-Chuliá
323 schema:givenName F
324 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017617741.90
325 rdf:type schema:Person
326 sg:person.01026464676.40 schema:affiliation grid-institutes:grid.84393.35
327 schema:familyName Cano
328 schema:givenName I
329 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026464676.40
330 rdf:type schema:Person
331 sg:person.01052441656.45 schema:affiliation grid-institutes:grid.84393.35
332 schema:familyName Navarro
333 schema:givenName I
334 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052441656.45
335 rdf:type schema:Person
336 sg:person.01076240317.06 schema:affiliation grid-institutes:grid.84393.35
337 schema:familyName Salavert
338 schema:givenName M
339 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076240317.06
340 rdf:type schema:Person
341 sg:person.01120371616.34 schema:affiliation grid-institutes:grid.84393.35
342 schema:familyName Jarque
343 schema:givenName I
344 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120371616.34
345 rdf:type schema:Person
346 sg:person.01127233122.53 schema:affiliation grid-institutes:grid.84393.35
347 schema:familyName Calvillo
348 schema:givenName P
349 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127233122.53
350 rdf:type schema:Person
351 sg:person.01161564054.49 schema:affiliation grid-institutes:grid.84393.35
352 schema:familyName Boluda
353 schema:givenName B
354 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161564054.49
355 rdf:type schema:Person
356 sg:person.01172456111.54 schema:affiliation grid-institutes:grid.84393.35
357 schema:familyName Montesinos
358 schema:givenName P
359 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172456111.54
360 rdf:type schema:Person
361 sg:person.01177753461.90 schema:affiliation grid-institutes:grid.84393.35
362 schema:familyName Sanz
363 schema:givenName J
364 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177753461.90
365 rdf:type schema:Person
366 sg:person.01234333123.87 schema:affiliation grid-institutes:grid.84393.35
367 schema:familyName Martínez-Cuadrón
368 schema:givenName D
369 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234333123.87
370 rdf:type schema:Person
371 sg:person.01240174223.16 schema:affiliation grid-institutes:grid.84393.35
372 schema:familyName Lorenzo
373 schema:givenName I
374 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240174223.16
375 rdf:type schema:Person
376 sg:person.01273172564.00 schema:affiliation grid-institutes:grid.84393.35
377 schema:familyName Carpio
378 schema:givenName N
379 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273172564.00
380 rdf:type schema:Person
381 sg:person.013151467432.56 schema:affiliation grid-institutes:grid.84393.35
382 schema:familyName Sanz
383 schema:givenName G F
384 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013151467432.56
385 rdf:type schema:Person
386 sg:person.01362315261.04 schema:affiliation grid-institutes:grid.84393.35
387 schema:familyName Rodríguez-Veiga
388 schema:givenName R
389 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362315261.04
390 rdf:type schema:Person
391 sg:person.016204417202.72 schema:affiliation grid-institutes:grid.84393.35
392 schema:familyName Martínez
393 schema:givenName J
394 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016204417202.72
395 rdf:type schema:Person
396 sg:person.0624741442.29 schema:affiliation grid-institutes:grid.84393.35
397 schema:familyName Arilla
398 schema:givenName M J
399 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624741442.29
400 rdf:type schema:Person
401 sg:person.0636400707.18 schema:affiliation grid-institutes:grid.5338.d
402 schema:familyName Sanz
403 schema:givenName M A
404 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636400707.18
405 rdf:type schema:Person
406 sg:person.0760351476.54 schema:affiliation grid-institutes:grid.84393.35
407 schema:familyName Lancharro
408 schema:givenName A
409 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760351476.54
410 rdf:type schema:Person
411 sg:pub.10.1038/bmt.2009.39 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049041418
412 https://doi.org/10.1038/bmt.2009.39
413 rdf:type schema:CreativeWork
414 sg:pub.10.1038/bmt.2010.38 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050011141
415 https://doi.org/10.1038/bmt.2010.38
416 rdf:type schema:CreativeWork
417 sg:pub.10.1038/bmt.2013.136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052679862
418 https://doi.org/10.1038/bmt.2013.136
419 rdf:type schema:CreativeWork
420 sg:pub.10.1038/sj.bmt.1704543 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039018530
421 https://doi.org/10.1038/sj.bmt.1704543
422 rdf:type schema:CreativeWork
423 grid-institutes:grid.5338.d schema:alternateName Departament de Medicina, Universitat de València,, Valencia,, Spain
424 schema:name Departament de Medicina, Universitat de València,, Valencia,, Spain
425 Department of Hematology, Hospital Universitari i Politècnic La Fe, València, Spain
426 rdf:type schema:Organization
427 grid-institutes:grid.84393.35 schema:alternateName Department of Hematology, Hospital Universitari i Politècnic La Fe, València, Spain
428 Department of Infectious Diseases, Hospital Universitari i Politècnic La Fe, València, Spain
429 Department of Microbiology, Hospital Universitari i Politècnic La Fe, València, Spain
430 Department of Radiology, Hospital Universitari i Politècnic La Fe, València, Spain
431 schema:name Department of Hematology, Hospital Universitari i Politècnic La Fe, València, Spain
432 Department of Infectious Diseases, Hospital Universitari i Politècnic La Fe, València, Spain
433 Department of Microbiology, Hospital Universitari i Politècnic La Fe, València, Spain
434 Department of Radiology, Hospital Universitari i Politècnic La Fe, València, Spain
435 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...