Clinical significance of pretransplant serum ferritin on the outcome of allogeneic hematopoietic SCT: a prospective cohort study by the Kanto ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-03-02

AUTHORS

M Tanaka, H Kanamori, K Matsumoto, T Tachibana, A Numata, K Ohashi, T Kobayashi, C Nakaseko, Y Kanda, E Yamazaki, S Fujisawa, J Ooi, T Sakura, N Aotsuka, M Onoda, S Machida, J Kato, K Usuki, R Watanabe, J Taguchi, S Yano, T Saito, S Takahashi, H Sakamaki, S Okamoto

ABSTRACT

This prospective study aimed to investigate the influence of pretransplant serum ferritin levels on the outcomes of allogeneic hematopoietic SCT (HSCT). In total, 190 patients with acute leukemia or myelodysplastic syndrome were consecutively enrolled. The patients were divided into two groups: low-ferritin group (<1000 ng/mL) and high-ferritin group (⩾1000 ng/mL). The primary end point was the cumulative incidence of infection within 100 days after HSCT, which was similar between the two groups: bloodstream infection, 35 vs 38%, P=0.65; bacterial infection, 44 vs 41%, P=0.68; and fungal infection, 6 vs 8%, P=0.71. The 1-year adjusted probability of OS of the high-ferritin group was significantly lower than that of the low-ferritin group (76 vs 63%, P=0.017). Using receiver operating characteristic curve, the threshold of pretransplant serum ferritin levels for bloodstream infection was 1400 ng/mL; the threshold for OS, EFS and non-relapse mortality was 1349 ng/mL. In conclusion, pretransplant serum ferritin levels of ⩾1000 ng/mL did not influence the incidence of infection but adversely affected OS after HSCT. A higher threshold of pretransplant serum ferritin levels may predict HSCT outcomes. More... »

PAGES

727-733

References to SciGraph publications

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  • <error retrieving object. in <ERROR RETRIEVING OBJECT
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  • Journal

    TITLE

    Bone Marrow Transplantation

    ISSUE

    5

    VOLUME

    50

    Author Affiliations

  • Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan
  • Department of Hematology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
  • Department of Hematology, Yokohama City University Medical Center, Yokohama, Japan
  • Division of Hematology, Tokyo Metropolitan Cancer and Infectious Disease Center Komagome Hospital, Tokyo, Japan
  • Division of Hematology, Department of Clinical Cell Biology, Chiba University Graduate School of Medicine, Chiba, Japan
  • Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan
  • Division of Molecular Therapy, The Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
  • Leukemia Research Center, Saiseikai Maebashi Hospital, Maebashi, Japan
  • Department of Hematology, Narita Red Cross Hospital, Narita, Japan
  • Department of Internal Medicine, Chiba Aoba Municipal Hospital, Chiba, Japan
  • Department of Hematology and Oncology, Tokai University School of Medicine, Isehara, Japan
  • Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
  • Division of Hematology, NTT Medical Center Tokyo, Tokyo, Japan
  • Department of Hematology, Saitama Medical Center, Saitama Medical University, Saitama, Japan
  • Department of Hematology, Shizuoka Red Cross Hospital, Shizuoka, Japan
  • Division of Clinical Oncology and Hematology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
  • Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine, Maebashi, Japan
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/bmt.2015.17

    DOI

    http://dx.doi.org/10.1038/bmt.2015.17

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1035604946

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25730191


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