High-dose melphalan with autologous stem cell support in refractory Hodgkin lymphoma patients as a bridge to second transplant View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-01-26

AUTHORS

L Castagna, R Crocchiolo, L Giordano, S Bramanti, C Carlo-Stella, B Sarina, A Chiti, E Mauro, S Gandolfi, E Todisco, M Balzarotti, A Anastasia, M Magagnoli, E Brusamolino, A Santoro

ABSTRACT

Persistence of disease after salvage therapy among relapsed or refractory Hodgkin lymphoma (HL) patients predicts poor outcome. Here, we report on 41 HL patients with active disease after salvage therapy and who received high-dose melphalan (HD-PAM) and auto-SCT as a bridge to a second autologous or an allogeneic transplantation between 2002 and 2013 at our center. Disease response was based on 18-fluoro-deoxyglucose-positron emission tomography results in all patients. Overall response rate after HD-PAM was 78% and it did not differ among PR or stable/progressive disease patients (P=1.00). Response was associated with better OS: hazard ratio=0.32 (95% confidence interval: 0.13–0.77, P=0.01) irrespective of disease status before HD-PAM. Thirty-three patients (80%) were able to complete the planned treatment, intended as tandem autologous or auto–allo transplant. Hematological and extrahematological toxicity of HD-PAM was manageable, without any treatment-related death. In conclusion, HD-PAM is a valuable therapeutic option in relapsed/refractory HL patients with active disease after salvage therapy, with an impressive 78% overall response rate and 80% rate of proceeding to further transplantation. The present data may be integrated with the growing literature on new drugs in the field of relapsed/refractory HL. More... »

PAGES

499-504

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bmt.2014.304

DOI

http://dx.doi.org/10.1038/bmt.2014.304

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010653468

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25621797


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34 active disease
35 allogeneic transplantation
36 auto-SCT
37 autologous stem cell support
38 better OS
39 bridge
40 cell support
41 center
42 conclusion
43 data
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49 drugs
50 emission tomography
51 extrahematological toxicity
52 field
53 further transplantation
54 hazards
55 high-dose melphalan
56 literature
57 lymphoma patients
58 melphalan
59 new drugs
60 options
61 outcomes
62 overall response rate
63 patients
64 persistence
65 persistence of disease
66 poor outcome
67 positron emission tomography
68 present data
69 proceedings
70 progressive disease patients
71 rate
72 refractory HL
73 refractory HL patients
74 refractory Hodgkin lymphoma patients
75 response
76 response rate
77 salvage therapy
78 second transplant
79 status
80 stem cell support
81 support
82 tandem
83 therapeutic options
84 therapy
85 tomography
86 toxicity
87 transplant
88 transplantation
89 treatment
90 treatment-related deaths
91 valuable therapeutic option
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