Nonmyeloablative conditioning, unmanipulated haploidentical SCT and post-infusion CY for advanced lymphomas View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-09-15

AUTHORS

L Castagna, S Bramanti, S Furst, L Giordano, R Crocchiolo, B Sarina, E Mauro, L Morabito, R Bouabdallah, D Coso, M Balzarotti, F Broussais, J El-Cheikh, C C Stella, E Brusamolino, D Blaise, A Santoro

ABSTRACT

Allo-SCT is regularly performed in advanced lymphoma. Haploidentical family donors are a valuable source of hematopoietic stem cells and transplants from these donors, using T-repleted grafts, has recently been successfully reported. We report on 49 patients with refractory lymphoma who received T-repleted haploidentical SCT with a non-myeloablative regimen and post-transplant CY. The median time to recover ANC >0.5 × 10e9/L and transfusion independent plt count >20 × 10e9/L was 20 days (range 14–38) and 26 days (range 14–395). The probability to reach ANC >0.5 × 10e9/L at 30 days was 87% and transfusion independent plt count >20 × 10e9/L at 100 days was 87%. The cumulative incidence of grade 2–4 acute GVHD (aGVHD) was 25.6% (95% confidence interval (CI): 12.9–38.3%) and the cumulative incidence of chronic GVHD (cGVHD) was 5.2% (95% CI: 0–12.4%). The median follow-up is 20.6 months (range 12–54), and the projected 2-year OS and PFS were 71 and 63%. The relapse rate was 18.7% (95% CI: 7.6–29.8%) and the median time to relapse was 4.4 months (range 1.1–8.3). At 2 years, cumulative incidence of NRM was 16.3% (95% CI: 5.9–26.8%). T-repleted Haploidentical transplantation with post-infusion CY is a feasible and effective therapy in the poor prognosis of advanced lymphoma patients. More... »

PAGES

1475-1480

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bmt.2014.197

DOI

http://dx.doi.org/10.1038/bmt.2014.197

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044023524

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25222502


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease-Free Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Graft vs Host Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hodgkin Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunophenotyping", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphoma, Non-Hodgkin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Recurrence, Local", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Platelet Count", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recurrence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stem Cell Transplantation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transplantation Conditioning", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transplantation, Homologous", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Hematology Department, Institut Paoli Calmettes 232, Boulevard S Marguerite, Marseille, France", 
          "id": "http://www.grid.ac/institutes/grid.418443.e", 
          "name": [
            "Hematology Department, Humanitas Cancer Center, Istituto Clinico Humanitas, Milan, Italy", 
            "Hematology Department, Institut Paoli Calmettes 232, Boulevard S Marguerite, Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Castagna", 
        "givenName": "L", 
        "id": "sg:person.0617444457.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617444457.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hematology Department, Humanitas Cancer Center, Istituto Clinico Humanitas, Milan, Italy", 
          "id": "http://www.grid.ac/institutes/grid.417728.f", 
          "name": [
            "Hematology Department, Humanitas Cancer Center, Istituto Clinico Humanitas, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bramanti", 
        "givenName": "S", 
        "id": "sg:person.01366367010.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366367010.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hematology Department, Institut Paoli Calmettes 232, Boulevard S Marguerite, Marseille, France", 
          "id": "http://www.grid.ac/institutes/grid.418443.e", 
          "name": [
            "Hematology Department, Institut Paoli Calmettes 232, Boulevard S Marguerite, Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Furst", 
        "givenName": "S", 
        "id": "sg:person.01070244016.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070244016.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hematology Department, Humanitas Cancer Center, Istituto Clinico Humanitas, Milan, Italy", 
          "id": "http://www.grid.ac/institutes/grid.417728.f", 
          "name": [
            "Hematology Department, Humanitas Cancer Center, Istituto Clinico Humanitas, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Giordano", 
        "givenName": "L", 
        "id": "sg:person.01372004323.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372004323.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hematology Department, Institut Paoli Calmettes 232, Boulevard S Marguerite, Marseille, France", 
          "id": "http://www.grid.ac/institutes/grid.418443.e", 
          "name": [
            "Hematology Department, Institut Paoli Calmettes 232, Boulevard S Marguerite, Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Crocchiolo", 
        "givenName": "R", 
        "id": "sg:person.01301323623.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301323623.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hematology Department, Humanitas Cancer Center, Istituto Clinico Humanitas, Milan, Italy", 
          "id": "http://www.grid.ac/institutes/grid.417728.f", 
          "name": [
            "Hematology Department, Humanitas Cancer Center, Istituto Clinico Humanitas, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sarina", 
        "givenName": "B", 
        "id": "sg:person.0711076110.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711076110.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hematology Department, Humanitas Cancer Center, Istituto Clinico Humanitas, Milan, Italy", 
          "id": "http://www.grid.ac/institutes/grid.417728.f", 
          "name": [
            "Hematology Department, Humanitas Cancer Center, Istituto Clinico Humanitas, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mauro", 
        "givenName": "E", 
        "id": "sg:person.01106603556.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106603556.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hematology Department, Humanitas Cancer Center, Istituto Clinico Humanitas, Milan, Italy", 
          "id": "http://www.grid.ac/institutes/grid.417728.f", 
          "name": [
            "Hematology Department, Humanitas Cancer Center, Istituto Clinico Humanitas, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Morabito", 
        "givenName": "L", 
        "id": "sg:person.01037755247.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037755247.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hematology Department, Institut Paoli Calmettes 232, Boulevard S Marguerite, Marseille, France", 
          "id": "http://www.grid.ac/institutes/grid.418443.e", 
          "name": [
            "Hematology Department, Institut Paoli Calmettes 232, Boulevard S Marguerite, Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bouabdallah", 
        "givenName": "R", 
        "id": "sg:person.0774470430.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774470430.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hematology Department, Institut Paoli Calmettes 232, Boulevard S Marguerite, Marseille, France", 
          "id": "http://www.grid.ac/institutes/grid.418443.e", 
          "name": [
            "Hematology Department, Institut Paoli Calmettes 232, Boulevard S Marguerite, Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Coso", 
        "givenName": "D", 
        "id": "sg:person.01335532730.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335532730.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hematology Department, Humanitas Cancer Center, Istituto Clinico Humanitas, Milan, Italy", 
          "id": "http://www.grid.ac/institutes/grid.417728.f", 
          "name": [
            "Hematology Department, Humanitas Cancer Center, Istituto Clinico Humanitas, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Balzarotti", 
        "givenName": "M", 
        "id": "sg:person.0642762710.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642762710.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hematology Department, Institut Paoli Calmettes 232, Boulevard S Marguerite, Marseille, France", 
          "id": "http://www.grid.ac/institutes/grid.418443.e", 
          "name": [
            "Hematology Department, Institut Paoli Calmettes 232, Boulevard S Marguerite, Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Broussais", 
        "givenName": "F", 
        "id": "sg:person.01334721616.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334721616.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hematology Department, Institut Paoli Calmettes 232, Boulevard S Marguerite, Marseille, France", 
          "id": "http://www.grid.ac/institutes/grid.418443.e", 
          "name": [
            "Hematology Department, Institut Paoli Calmettes 232, Boulevard S Marguerite, Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "El-Cheikh", 
        "givenName": "J", 
        "id": "sg:person.01267004113.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267004113.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hematology Department, Humanitas Cancer Center, Istituto Clinico Humanitas, Milan, Italy", 
          "id": "http://www.grid.ac/institutes/grid.417728.f", 
          "name": [
            "Hematology Department, Humanitas Cancer Center, Istituto Clinico Humanitas, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stella", 
        "givenName": "C C", 
        "id": "sg:person.01140463461.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140463461.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hematology Department, Humanitas Cancer Center, Istituto Clinico Humanitas, Milan, Italy", 
          "id": "http://www.grid.ac/institutes/grid.417728.f", 
          "name": [
            "Hematology Department, Humanitas Cancer Center, Istituto Clinico Humanitas, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brusamolino", 
        "givenName": "E", 
        "id": "sg:person.0624435102.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624435102.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hematology Department, Institut Paoli Calmettes 232, Boulevard S Marguerite, Marseille, France", 
          "id": "http://www.grid.ac/institutes/grid.418443.e", 
          "name": [
            "Hematology Department, Institut Paoli Calmettes 232, Boulevard S Marguerite, Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Blaise", 
        "givenName": "D", 
        "id": "sg:person.0644473065.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644473065.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hematology Department, Humanitas Cancer Center, Istituto Clinico Humanitas, Milan, Italy", 
          "id": "http://www.grid.ac/institutes/grid.417728.f", 
          "name": [
            "Hematology Department, Humanitas Cancer Center, Istituto Clinico Humanitas, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Santoro", 
        "givenName": "A", 
        "id": "sg:person.013724631505.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013724631505.36"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/sj.bmt.1705027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008466637", 
          "https://doi.org/10.1038/sj.bmt.1705027"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2011.11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015066500", 
          "https://doi.org/10.1038/leu.2011.11"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2404822", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019871478", 
          "https://doi.org/10.1038/sj.leu.2404822"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-09-15", 
    "datePublishedReg": "2014-09-15", 
    "description": "Allo-SCT is regularly performed in advanced lymphoma. Haploidentical family donors are a valuable source of hematopoietic stem cells and transplants from these donors, using T-repleted grafts, has recently been successfully reported. We report on 49 patients with refractory lymphoma who received T-repleted haploidentical SCT with a non-myeloablative regimen and post-transplant CY. The median time to recover ANC >0.5 \u00d7 10e9/L and transfusion independent plt count >20 \u00d7 10e9/L was 20 days (range 14\u201338) and 26 days (range 14\u2013395). The probability to reach ANC >0.5 \u00d7 10e9/L at 30 days was 87% and transfusion independent plt count >20 \u00d7 10e9/L at 100 days was 87%. The cumulative incidence of grade 2\u20134 acute GVHD (aGVHD) was 25.6% (95% confidence interval (CI): 12.9\u201338.3%) and the cumulative incidence of chronic GVHD (cGVHD) was 5.2% (95% CI: 0\u201312.4%). The median follow-up is 20.6 months (range 12\u201354), and the projected 2-year OS and PFS were 71 and 63%. The relapse rate was 18.7% (95% CI: 7.6\u201329.8%) and the median time to relapse was 4.4 months (range 1.1\u20138.3). At 2 years, cumulative incidence of NRM was 16.3% (95% CI: 5.9\u201326.8%). T-repleted Haploidentical transplantation with post-infusion CY is a feasible and effective therapy in the poor prognosis of advanced lymphoma patients.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/bmt.2014.197", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1096890", 
        "issn": [
          "0268-3369", 
          "1476-5365"
        ], 
        "name": "Bone Marrow Transplantation", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "12", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "49"
      }
    ], 
    "keywords": [
      "cumulative incidence", 
      "advanced lymphoma", 
      "acute GVHD", 
      "chronic GVHD", 
      "median time", 
      "haploidentical SCT", 
      "PLT count", 
      "non-myeloablative regimen", 
      "post-transplant CY", 
      "advanced lymphoma patients", 
      "haploidentical family donors", 
      "allo-SCT", 
      "haploidentical transplantation", 
      "refractory lymphoma", 
      "family donors", 
      "relapse rate", 
      "nonmyeloablative conditioning", 
      "lymphoma patients", 
      "poor prognosis", 
      "effective therapy", 
      "grade 2", 
      "hematopoietic stem cells", 
      "lymphoma", 
      "incidence", 
      "GVHD", 
      "patients", 
      "stem cells", 
      "months", 
      "days", 
      "SCT", 
      "count", 
      "regimen", 
      "relapse", 
      "transplantation", 
      "prognosis", 
      "ANC", 
      "transplant", 
      "graft", 
      "PFS", 
      "therapy", 
      "donors", 
      "cells", 
      "Cys", 
      "years", 
      "time", 
      "rate", 
      "valuable source", 
      "conditioning", 
      "NRM", 
      "probability", 
      "source"
    ], 
    "name": "Nonmyeloablative conditioning, unmanipulated haploidentical SCT and post-infusion CY for advanced lymphomas", 
    "pagination": "1475-1480", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1044023524"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/bmt.2014.197"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25222502"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/bmt.2014.197", 
      "https://app.dimensions.ai/details/publication/pub.1044023524"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:32", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_644.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/bmt.2014.197"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/bmt.2014.197'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/bmt.2014.197'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/bmt.2014.197'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/bmt.2014.197'


 

This table displays all metadata directly associated to this object as RDF triples.

324 TRIPLES      21 PREDICATES      100 URIs      89 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/bmt.2014.197 schema:about N07e4cf86b8ed4a659185766f2b74301e
2 N19358b71c4684140823427a919bfe4cd
3 N251a5c64b8714a14a0c1c87e479338d1
4 N26db6954babb4ce5a340410f4360d668
5 N343ebe8cb3a94748b20d3f91aa8cddfb
6 N35a2779f7cc740a48b128d2cb1902ce6
7 N3cd8bff2a7a2408fa6e66dfaea9417e5
8 N4a05ba5fccdf4df0bde785187d6e38af
9 N5aab681ab47f4ebc8fb278fe4008e63b
10 N7fc22bf790d04d61aff38879d453b246
11 N8496ce7cdcb2406c8343459a37eacf62
12 N9c495e290712404bb21f4856a7e06efa
13 Na1aff940b5bb40e7ada09dbd9b3a1409
14 Naf5d50f88a0246b6b3da3e5836a2148e
15 Nb07e2b31a3644d21b90aab1cd602792a
16 Nd1c694edd1694090800624070ac3522c
17 Nd56a11cdc9da4fdea780354fb851db4c
18 Ne7bdf56bac3240129705c8fe346f404c
19 Ne96a1074db364ec792f29a9a4282ea13
20 Nf05adf5fef02480ea68394c4dedf49c1
21 Nf7c79d9b50374c87bbdb186191acfa66
22 anzsrc-for:11
23 anzsrc-for:1102
24 schema:author N6b3609852d624f3c8917211a6556bfea
25 schema:citation sg:pub.10.1038/leu.2011.11
26 sg:pub.10.1038/sj.bmt.1705027
27 sg:pub.10.1038/sj.leu.2404822
28 schema:datePublished 2014-09-15
29 schema:datePublishedReg 2014-09-15
30 schema:description Allo-SCT is regularly performed in advanced lymphoma. Haploidentical family donors are a valuable source of hematopoietic stem cells and transplants from these donors, using T-repleted grafts, has recently been successfully reported. We report on 49 patients with refractory lymphoma who received T-repleted haploidentical SCT with a non-myeloablative regimen and post-transplant CY. The median time to recover ANC >0.5 × 10e9/L and transfusion independent plt count >20 × 10e9/L was 20 days (range 14–38) and 26 days (range 14–395). The probability to reach ANC >0.5 × 10e9/L at 30 days was 87% and transfusion independent plt count >20 × 10e9/L at 100 days was 87%. The cumulative incidence of grade 2–4 acute GVHD (aGVHD) was 25.6% (95% confidence interval (CI): 12.9–38.3%) and the cumulative incidence of chronic GVHD (cGVHD) was 5.2% (95% CI: 0–12.4%). The median follow-up is 20.6 months (range 12–54), and the projected 2-year OS and PFS were 71 and 63%. The relapse rate was 18.7% (95% CI: 7.6–29.8%) and the median time to relapse was 4.4 months (range 1.1–8.3). At 2 years, cumulative incidence of NRM was 16.3% (95% CI: 5.9–26.8%). T-repleted Haploidentical transplantation with post-infusion CY is a feasible and effective therapy in the poor prognosis of advanced lymphoma patients.
31 schema:genre article
32 schema:isAccessibleForFree false
33 schema:isPartOf N8b25b7cfd2b04ad2af1b3b602041bbdc
34 Naa8d839421d140e2ab4b2d6162d7b144
35 sg:journal.1096890
36 schema:keywords ANC
37 Cys
38 GVHD
39 NRM
40 PFS
41 PLT count
42 SCT
43 acute GVHD
44 advanced lymphoma
45 advanced lymphoma patients
46 allo-SCT
47 cells
48 chronic GVHD
49 conditioning
50 count
51 cumulative incidence
52 days
53 donors
54 effective therapy
55 family donors
56 grade 2
57 graft
58 haploidentical SCT
59 haploidentical family donors
60 haploidentical transplantation
61 hematopoietic stem cells
62 incidence
63 lymphoma
64 lymphoma patients
65 median time
66 months
67 non-myeloablative regimen
68 nonmyeloablative conditioning
69 patients
70 poor prognosis
71 post-transplant CY
72 probability
73 prognosis
74 rate
75 refractory lymphoma
76 regimen
77 relapse
78 relapse rate
79 source
80 stem cells
81 therapy
82 time
83 transplant
84 transplantation
85 valuable source
86 years
87 schema:name Nonmyeloablative conditioning, unmanipulated haploidentical SCT and post-infusion CY for advanced lymphomas
88 schema:pagination 1475-1480
89 schema:productId N0f05b4bc1b104cd49a3ac8e3c576eae4
90 N2eb088acde9a4d56896d9687b7b192ff
91 N6e70e5466e3240ac88456d76f94254bd
92 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044023524
93 https://doi.org/10.1038/bmt.2014.197
94 schema:sdDatePublished 2022-12-01T06:32
95 schema:sdLicense https://scigraph.springernature.com/explorer/license/
96 schema:sdPublisher N362b2a45ebbd41a08f7bcadb934f5e58
97 schema:url https://doi.org/10.1038/bmt.2014.197
98 sgo:license sg:explorer/license/
99 sgo:sdDataset articles
100 rdf:type schema:ScholarlyArticle
101 N07e4cf86b8ed4a659185766f2b74301e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Stem Cell Transplantation
103 rdf:type schema:DefinedTerm
104 N0f05b4bc1b104cd49a3ac8e3c576eae4 schema:name pubmed_id
105 schema:value 25222502
106 rdf:type schema:PropertyValue
107 N19358b71c4684140823427a919bfe4cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Transplantation, Homologous
109 rdf:type schema:DefinedTerm
110 N1cb34fb1f1f74bf3b9eca8e2a31ec518 rdf:first sg:person.0624435102.12
111 rdf:rest Nef320c1186bc42ff8ad37e6948354714
112 N251a5c64b8714a14a0c1c87e479338d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Immunophenotyping
114 rdf:type schema:DefinedTerm
115 N26db6954babb4ce5a340410f4360d668 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Male
117 rdf:type schema:DefinedTerm
118 N2eb088acde9a4d56896d9687b7b192ff schema:name dimensions_id
119 schema:value pub.1044023524
120 rdf:type schema:PropertyValue
121 N343ebe8cb3a94748b20d3f91aa8cddfb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Aged
123 rdf:type schema:DefinedTerm
124 N35a2779f7cc740a48b128d2cb1902ce6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Adult
126 rdf:type schema:DefinedTerm
127 N362b2a45ebbd41a08f7bcadb934f5e58 schema:name Springer Nature - SN SciGraph project
128 rdf:type schema:Organization
129 N3cb61e23f31b41d78bed05dcb2dd99b0 rdf:first sg:person.01334721616.42
130 rdf:rest N435e627c8d7b49e8b523aeab121dd061
131 N3cd8bff2a7a2408fa6e66dfaea9417e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Follow-Up Studies
133 rdf:type schema:DefinedTerm
134 N435e627c8d7b49e8b523aeab121dd061 rdf:first sg:person.01267004113.75
135 rdf:rest N7e8c55b735b04db8b4b710f4c00719ae
136 N4a05ba5fccdf4df0bde785187d6e38af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Middle Aged
138 rdf:type schema:DefinedTerm
139 N4d7759006b58469096ead7eeafde84de rdf:first sg:person.01301323623.42
140 rdf:rest Ne1a4da3e303c4f90b0fb9d38e76ce535
141 N5aab681ab47f4ebc8fb278fe4008e63b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Treatment Outcome
143 rdf:type schema:DefinedTerm
144 N67ca5d1a78004976847b53154003badf rdf:first sg:person.0642762710.72
145 rdf:rest N3cb61e23f31b41d78bed05dcb2dd99b0
146 N6b3609852d624f3c8917211a6556bfea rdf:first sg:person.0617444457.05
147 rdf:rest Ncb8023764e2d4a618e253a631cac2adf
148 N6e70e5466e3240ac88456d76f94254bd schema:name doi
149 schema:value 10.1038/bmt.2014.197
150 rdf:type schema:PropertyValue
151 N6fbf761323e2428b9ca00a900d103053 rdf:first sg:person.01372004323.05
152 rdf:rest N4d7759006b58469096ead7eeafde84de
153 N73a9ee19b78746f9bd57af50980ad1dd rdf:first sg:person.01335532730.43
154 rdf:rest N67ca5d1a78004976847b53154003badf
155 N7e8c55b735b04db8b4b710f4c00719ae rdf:first sg:person.01140463461.20
156 rdf:rest N1cb34fb1f1f74bf3b9eca8e2a31ec518
157 N7fc22bf790d04d61aff38879d453b246 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Platelet Count
159 rdf:type schema:DefinedTerm
160 N8496ce7cdcb2406c8343459a37eacf62 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Transplantation Conditioning
162 rdf:type schema:DefinedTerm
163 N8b25b7cfd2b04ad2af1b3b602041bbdc schema:volumeNumber 49
164 rdf:type schema:PublicationVolume
165 N961be1bc1b8c4c5aac0e4be9d6c35d91 rdf:first sg:person.0774470430.49
166 rdf:rest N73a9ee19b78746f9bd57af50980ad1dd
167 N9c495e290712404bb21f4856a7e06efa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Graft vs Host Disease
169 rdf:type schema:DefinedTerm
170 Na1aff940b5bb40e7ada09dbd9b3a1409 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Hodgkin Disease
172 rdf:type schema:DefinedTerm
173 Na432d2c8535942bf80b67618daf36e2c rdf:first sg:person.01106603556.11
174 rdf:rest Nd9166e334c79465983e8bba379d40d3c
175 Naa8d839421d140e2ab4b2d6162d7b144 schema:issueNumber 12
176 rdf:type schema:PublicationIssue
177 Naf5d50f88a0246b6b3da3e5836a2148e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Lymphoma, Non-Hodgkin
179 rdf:type schema:DefinedTerm
180 Nb07e2b31a3644d21b90aab1cd602792a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Neoplasm Recurrence, Local
182 rdf:type schema:DefinedTerm
183 Nb0c8d83779574d27a3a612f2adbf1fdc rdf:first sg:person.013724631505.36
184 rdf:rest rdf:nil
185 Ncb8023764e2d4a618e253a631cac2adf rdf:first sg:person.01366367010.53
186 rdf:rest Nfaacbf26f83c467598b64dd13fc3f6f3
187 Nd1c694edd1694090800624070ac3522c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Prognosis
189 rdf:type schema:DefinedTerm
190 Nd56a11cdc9da4fdea780354fb851db4c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Recurrence
192 rdf:type schema:DefinedTerm
193 Nd9166e334c79465983e8bba379d40d3c rdf:first sg:person.01037755247.24
194 rdf:rest N961be1bc1b8c4c5aac0e4be9d6c35d91
195 Ne1a4da3e303c4f90b0fb9d38e76ce535 rdf:first sg:person.0711076110.73
196 rdf:rest Na432d2c8535942bf80b67618daf36e2c
197 Ne7bdf56bac3240129705c8fe346f404c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Disease-Free Survival
199 rdf:type schema:DefinedTerm
200 Ne96a1074db364ec792f29a9a4282ea13 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
201 schema:name Female
202 rdf:type schema:DefinedTerm
203 Nef320c1186bc42ff8ad37e6948354714 rdf:first sg:person.0644473065.59
204 rdf:rest Nb0c8d83779574d27a3a612f2adbf1fdc
205 Nf05adf5fef02480ea68394c4dedf49c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Retrospective Studies
207 rdf:type schema:DefinedTerm
208 Nf7c79d9b50374c87bbdb186191acfa66 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
209 schema:name Humans
210 rdf:type schema:DefinedTerm
211 Nfaacbf26f83c467598b64dd13fc3f6f3 rdf:first sg:person.01070244016.45
212 rdf:rest N6fbf761323e2428b9ca00a900d103053
213 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
214 schema:name Medical and Health Sciences
215 rdf:type schema:DefinedTerm
216 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
217 schema:name Cardiorespiratory Medicine and Haematology
218 rdf:type schema:DefinedTerm
219 sg:journal.1096890 schema:issn 0268-3369
220 1476-5365
221 schema:name Bone Marrow Transplantation
222 schema:publisher Springer Nature
223 rdf:type schema:Periodical
224 sg:person.01037755247.24 schema:affiliation grid-institutes:grid.417728.f
225 schema:familyName Morabito
226 schema:givenName L
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037755247.24
228 rdf:type schema:Person
229 sg:person.01070244016.45 schema:affiliation grid-institutes:grid.418443.e
230 schema:familyName Furst
231 schema:givenName S
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070244016.45
233 rdf:type schema:Person
234 sg:person.01106603556.11 schema:affiliation grid-institutes:grid.417728.f
235 schema:familyName Mauro
236 schema:givenName E
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106603556.11
238 rdf:type schema:Person
239 sg:person.01140463461.20 schema:affiliation grid-institutes:grid.417728.f
240 schema:familyName Stella
241 schema:givenName C C
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140463461.20
243 rdf:type schema:Person
244 sg:person.01267004113.75 schema:affiliation grid-institutes:grid.418443.e
245 schema:familyName El-Cheikh
246 schema:givenName J
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267004113.75
248 rdf:type schema:Person
249 sg:person.01301323623.42 schema:affiliation grid-institutes:grid.418443.e
250 schema:familyName Crocchiolo
251 schema:givenName R
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301323623.42
253 rdf:type schema:Person
254 sg:person.01334721616.42 schema:affiliation grid-institutes:grid.418443.e
255 schema:familyName Broussais
256 schema:givenName F
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334721616.42
258 rdf:type schema:Person
259 sg:person.01335532730.43 schema:affiliation grid-institutes:grid.418443.e
260 schema:familyName Coso
261 schema:givenName D
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335532730.43
263 rdf:type schema:Person
264 sg:person.01366367010.53 schema:affiliation grid-institutes:grid.417728.f
265 schema:familyName Bramanti
266 schema:givenName S
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366367010.53
268 rdf:type schema:Person
269 sg:person.01372004323.05 schema:affiliation grid-institutes:grid.417728.f
270 schema:familyName Giordano
271 schema:givenName L
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372004323.05
273 rdf:type schema:Person
274 sg:person.013724631505.36 schema:affiliation grid-institutes:grid.417728.f
275 schema:familyName Santoro
276 schema:givenName A
277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013724631505.36
278 rdf:type schema:Person
279 sg:person.0617444457.05 schema:affiliation grid-institutes:grid.418443.e
280 schema:familyName Castagna
281 schema:givenName L
282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617444457.05
283 rdf:type schema:Person
284 sg:person.0624435102.12 schema:affiliation grid-institutes:grid.417728.f
285 schema:familyName Brusamolino
286 schema:givenName E
287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624435102.12
288 rdf:type schema:Person
289 sg:person.0642762710.72 schema:affiliation grid-institutes:grid.417728.f
290 schema:familyName Balzarotti
291 schema:givenName M
292 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642762710.72
293 rdf:type schema:Person
294 sg:person.0644473065.59 schema:affiliation grid-institutes:grid.418443.e
295 schema:familyName Blaise
296 schema:givenName D
297 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644473065.59
298 rdf:type schema:Person
299 sg:person.0711076110.73 schema:affiliation grid-institutes:grid.417728.f
300 schema:familyName Sarina
301 schema:givenName B
302 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711076110.73
303 rdf:type schema:Person
304 sg:person.0774470430.49 schema:affiliation grid-institutes:grid.418443.e
305 schema:familyName Bouabdallah
306 schema:givenName R
307 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774470430.49
308 rdf:type schema:Person
309 sg:pub.10.1038/leu.2011.11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015066500
310 https://doi.org/10.1038/leu.2011.11
311 rdf:type schema:CreativeWork
312 sg:pub.10.1038/sj.bmt.1705027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008466637
313 https://doi.org/10.1038/sj.bmt.1705027
314 rdf:type schema:CreativeWork
315 sg:pub.10.1038/sj.leu.2404822 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019871478
316 https://doi.org/10.1038/sj.leu.2404822
317 rdf:type schema:CreativeWork
318 grid-institutes:grid.417728.f schema:alternateName Hematology Department, Humanitas Cancer Center, Istituto Clinico Humanitas, Milan, Italy
319 schema:name Hematology Department, Humanitas Cancer Center, Istituto Clinico Humanitas, Milan, Italy
320 rdf:type schema:Organization
321 grid-institutes:grid.418443.e schema:alternateName Hematology Department, Institut Paoli Calmettes 232, Boulevard S Marguerite, Marseille, France
322 schema:name Hematology Department, Humanitas Cancer Center, Istituto Clinico Humanitas, Milan, Italy
323 Hematology Department, Institut Paoli Calmettes 232, Boulevard S Marguerite, Marseille, France
324 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...