Efficacy and safety of micafungin for the prophylaxis of invasive fungal infection during neutropenia in children and adolescents undergoing allogeneic ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-09

AUTHORS

H J Park, M Park, M Han, B H Nam, K N Koh, H J Im, J W Lee, N-G Chung, B Cho, H-K Kim, K H Yoo, H H Koo, H J Kang, H Y Shin, H S Ahn, Y T Lim, H Kook, C J Lyu, J O Hah, J E Park, Y J Lim, J J Seo

ABSTRACT

The objective of this study was to evaluate the efficacy and safety of micafungin for the prevention of invasive fungal infection (IFI) during the neutropenic phase of allogeneic hematopoietic SCT (allo-HSCT) in children and adolescents. This was a prospective, multicenter, open-label, single-arm study. Micafungin was administered i.v. at a dose of 1 mg/kg/day (max 50 mg) from the beginning of conditioning until neutrophil engraftment. Treatment success was defined as the absence of proven, probable, possible or suspected IFI through to 4 weeks after therapy. From April 2010 to December 2011, 155 patients were enrolled from 11 institutions in Korea, and 147 patients were analyzed. Of the 147 patients, 121 (82.3%) completed the protocol without premature interruption. Of the 132 patients in whom micafungin efficacy could be evaluated, treatment success was achieved in 119 patients (90.2%). There was no proven fungal infection in any patient. The number of patients with probable, possible and suspected IFI was two, two and nine, respectively. Thirty-five patients (23.8%) experienced 109 adverse events (AEs) possibly related to micafungin. No patients experienced grade IV AEs. Two patients (1.4%) discontinued micafungin administration due to adverse effects. None of the deaths were related to the study drug. More... »

PAGES

1212

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bmt.2014.136

DOI

http://dx.doi.org/10.1038/bmt.2014.136

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047212366

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25000455


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