Risk associations between HLA-DPB1 T-cell epitope matching and outcome of unrelated hematopoietic cell transplantation are independent of HLA-DPA1 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-09

AUTHORS

Katharina Fleischhauer, Marcelo A. Fernandez-Viña, Tao Wang, Michael Haagenson, Minoo Battiwalla, Lee Ann Baxter-Lowe, Fabio Ciceri, Jason Dehn, James Gajewski, Gregory A. Hale, Martin BA Heemskerk, Susana R. Marino, Philip L. McCarthy, David Miklos, Machteld Oudshoorn, Marilyn S. Pollack, Vijay Reddy, David Senitzer, Bronwen E. Shaw, Edmund K. Waller, Stephanie J. Lee, Stephen R. Spellman

ABSTRACT

HLA-DP antigens are beta-alpha heterodimers encoded by polymorphic HLA-DPB1 and -DPA1 alleles, respectively, in strong linkage disequilibrium (LD) with each other. Non-permissive unrelated donor (UD)-recipient HLA-DPB1 mismatches across three different T-cell epitope (TCE) groups are associated with increased mortality after hematopoietic SCT (HCT), but the role of HLA-DPA1 is unclear. We studied 1281 onco-hematologic patients after 10/10 HLA-matched UD-HCT facilitated by the National Marrow Donor Program. Non-permissive mismatches defined solely by HLA-DPB1 TCE groups were associated with significantly higher risks of TRM compared to permissive mismatches (hazard ratio (HR) 1.30, confidence interval (CI) 1.06-1.53; P=0.009) or allele matches. Moreover, non-permissive HLA-DPB1 TCE group mismatches in the graft versus host (GvH) direction significantly decreased the risk of relapse compared to permissive mismatches (HR 0.55, CI 0.37-0.80; P=0.002) or allele matches. Splitting each group into HLA-DPA1*02:01 positive or negative, in frequent LD with HLA-DPB1 alleles from two of the three TCE groups, or into HLA-DPA1 matched or mismatched, did not significantly alter the observed risk associations. Our findings suggest that the effects of clinically non-permissive HLA-DPB1 TCE group mismatches are independent of HLA-DPA1, and that selection of donors with non-permissive DPB1 TCE mismatches in GvH direction might provide some protection from disease recurrence. More... »

PAGES

1176

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bmt.2014.122

DOI

http://dx.doi.org/10.1038/bmt.2014.122

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030475937

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24955785


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child, Preschool", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cohort Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epitope Mapping", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epitopes, T-Lymphocyte", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HLA-DP alpha-Chains", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HLA-DP beta-Chains", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hematopoietic Stem Cell Transplantation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Infant", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transplantation Conditioning", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Unrelated Donors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "San Raffaele Hospital", 
          "id": "https://www.grid.ac/institutes/grid.18887.3e", 
          "name": [
            "Institute of Experimental Cellular Therapy, Essen University Hospital, Essen, Germany", 
            "Unit of Molecular and Functional Immunogenetics, San Raffaele Scientific Institute, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fleischhauer", 
        "givenName": "Katharina", 
        "id": "sg:person.01223223136.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223223136.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stanford University", 
          "id": "https://www.grid.ac/institutes/grid.168010.e", 
          "name": [
            "Histocompatibility, Immunogenetics, and Disease Profiling Laboratory, Stanford University Medical School, Stanford, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fernandez-Vi\u00f1a", 
        "givenName": "Marcelo A.", 
        "id": "sg:person.01127325612.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127325612.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical College of Wisconsin", 
          "id": "https://www.grid.ac/institutes/grid.30760.32", 
          "name": [
            "Division of Biostatistics, Medical College of Wisconsin, Milwaukee, WI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Tao", 
        "id": "sg:person.0706222531.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706222531.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical College of Wisconsin", 
          "id": "https://www.grid.ac/institutes/grid.30760.32", 
          "name": [
            "Center for International Blood and Marrow Transplant Research, Minneapolis, MN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Haagenson", 
        "givenName": "Michael", 
        "id": "sg:person.01135476153.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01135476153.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Heart Lung and Blood Institute", 
          "id": "https://www.grid.ac/institutes/grid.279885.9", 
          "name": [
            "National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Battiwalla", 
        "givenName": "Minoo", 
        "id": "sg:person.01022722420.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022722420.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California San Francisco Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.413077.6", 
          "name": [
            "National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA", 
            "Immunogentics and Transplantation Lab, University of California San Francisco Medical Center, San Francisco, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Baxter-Lowe", 
        "givenName": "Lee Ann", 
        "id": "sg:person.015145562407.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015145562407.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "San Raffaele Hospital", 
          "id": "https://www.grid.ac/institutes/grid.18887.3e", 
          "name": [
            "Hematology and Bone Marrow Transplantation Unit, San Raffaele Scientific Institute, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ciceri", 
        "givenName": "Fabio", 
        "id": "sg:person.01155107736.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155107736.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Marrow Donor Program", 
          "id": "https://www.grid.ac/institutes/grid.422289.7", 
          "name": [
            "National Marrow Donor Program, Minneapolis, MN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dehn", 
        "givenName": "Jason", 
        "id": "sg:person.01340061040.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340061040.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oregon Health & Science University", 
          "id": "https://www.grid.ac/institutes/grid.5288.7", 
          "name": [
            "Oregon Health and Science University, Portland, OR, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gajewski", 
        "givenName": "James", 
        "id": "sg:person.016627600457.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016627600457.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oregon Health & Science University", 
          "id": "https://www.grid.ac/institutes/grid.5288.7", 
          "name": [
            "Oregon Health and Science University, Portland, OR, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hale", 
        "givenName": "Gregory A.", 
        "id": "sg:person.011624737152.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011624737152.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Emory University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412162.2", 
          "name": [
            "Bone Marrow and Stem Cell Transplant Center, Emory University Hospital, Atlanta, GA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Heemskerk", 
        "givenName": "Martin BA", 
        "id": "sg:person.016531470544.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016531470544.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Chicago Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412578.d", 
          "name": [
            "Department of Pathology, University of Chicago Hospitals, Chicago, IL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marino", 
        "givenName": "Susana R.", 
        "id": "sg:person.014411531257.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014411531257.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical College of Wisconsin", 
          "id": "https://www.grid.ac/institutes/grid.30760.32", 
          "name": [
            "Histocompatibility, Immunogenetics, and Disease Profiling Laboratory, Stanford University Medical School, Stanford, CA, USA", 
            "Division of Biostatistics, Medical College of Wisconsin, Milwaukee, WI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "McCarthy", 
        "givenName": "Philip L.", 
        "id": "sg:person.013027767342.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013027767342.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Medicine/Bone Marrow Transplant, Stanford Hospitals and Clinics, Stanford, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miklos", 
        "givenName": "David", 
        "id": "sg:person.01137616010.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137616010.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Leiden University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.10419.3d", 
          "name": [
            "Europdonor Foundation, Leiden University Medical Center, Leiden, Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oudshoorn", 
        "givenName": "Machteld", 
        "id": "sg:person.01147440273.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147440273.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Pathology, University of Texas Health Care System, Veterans Health Care System"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pollack", 
        "givenName": "Marilyn S.", 
        "id": "sg:person.0767423105.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767423105.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Florida", 
          "id": "https://www.grid.ac/institutes/grid.15276.37", 
          "name": [
            "Department of Hemaotology/Oncology, University of Florida, Gainesville, FL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Reddy", 
        "givenName": "Vijay", 
        "id": "sg:person.013170655222.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013170655222.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "City Of Hope National Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.410425.6", 
          "name": [
            "Hematology/Hematopoietic Cell Transplant, City of Hope National Medical Center, Duarte, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Senitzer", 
        "givenName": "David", 
        "id": "sg:person.074407346.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.074407346.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Anthony Nolan", 
          "id": "https://www.grid.ac/institutes/grid.426412.7", 
          "name": [
            "Anthony Nolan Research Institute, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shaw", 
        "givenName": "Bronwen E.", 
        "id": "sg:person.0727054455.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727054455.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Emory University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412162.2", 
          "name": [
            "Bone Marrow and Stem Cell Transplant Center, Emory University Hospital, Atlanta, GA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Waller", 
        "givenName": "Edmund K.", 
        "id": "sg:person.01050305767.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050305767.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Fred Hutchinson Cancer Research Center", 
          "id": "https://www.grid.ac/institutes/grid.270240.3", 
          "name": [
            "Clinical Transplant Research, Fred Hutchinson Cancer Research Center, Seattle, WA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Stephanie J.", 
        "id": "sg:person.011767011574.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011767011574.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical College of Wisconsin", 
          "id": "https://www.grid.ac/institutes/grid.30760.32", 
          "name": [
            "Center for International Blood and Marrow Transplant Research, Minneapolis, MN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Spellman", 
        "givenName": "Stephen R.", 
        "id": "sg:person.01053755630.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053755630.82"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1182/blood-2013-02-481945", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000996858"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2008.90", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005664673", 
          "https://doi.org/10.1038/leu.2008.90"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbmt.2008.05.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007311535"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199810223391701", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007584421"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2007-06-095265", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015712025"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbmt.2012.07.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016213034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molimm.2013.12.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028245034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbmt.2006.05.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029417339"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood.v98.10.2922", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030019336"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1034/j.1399-0039.2003.00089.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030127938"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(12)70004-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033956834"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00251-012-0615-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034538476", 
          "https://doi.org/10.1007/s00251-012-0615-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00251-012-0615-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034538476", 
          "https://doi.org/10.1007/s00251-012-0615-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2009-01-200378", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036570291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0198-8859(99)00004-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044572412"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2007-06-097386", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048103644"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2012-12-470872", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048535923"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bmt.2013.91", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048881899", 
          "https://doi.org/10.1038/bmt.2013.91"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2003-04-1279", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049325961"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-09", 
    "datePublishedReg": "2014-09-01", 
    "description": "HLA-DP antigens are beta-alpha heterodimers encoded by polymorphic HLA-DPB1 and -DPA1 alleles, respectively, in strong linkage disequilibrium (LD) with each other. Non-permissive unrelated donor (UD)-recipient HLA-DPB1 mismatches across three different T-cell epitope (TCE) groups are associated with increased mortality after hematopoietic SCT (HCT), but the role of HLA-DPA1 is unclear. We studied 1281 onco-hematologic patients after 10/10 HLA-matched UD-HCT facilitated by the National Marrow Donor Program. Non-permissive mismatches defined solely by HLA-DPB1 TCE groups were associated with significantly higher risks of TRM compared to permissive mismatches (hazard ratio (HR) 1.30, confidence interval (CI) 1.06-1.53; P=0.009) or allele matches. Moreover, non-permissive HLA-DPB1 TCE group mismatches in the graft versus host (GvH) direction significantly decreased the risk of relapse compared to permissive mismatches (HR 0.55, CI 0.37-0.80; P=0.002) or allele matches. Splitting each group into HLA-DPA1*02:01 positive or negative, in frequent LD with HLA-DPB1 alleles from two of the three TCE groups, or into HLA-DPA1 matched or mismatched, did not significantly alter the observed risk associations. Our findings suggest that the effects of clinically non-permissive HLA-DPB1 TCE group mismatches are independent of HLA-DPA1, and that selection of donors with non-permissive DPB1 TCE mismatches in GvH direction might provide some protection from disease recurrence.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/bmt.2014.122", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2705196", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4381038", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2696275", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2691735", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1096890", 
        "issn": [
          "0268-3369", 
          "1476-5365"
        ], 
        "name": "Bone Marrow Transplantation", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "9", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "49"
      }
    ], 
    "name": "Risk associations between HLA-DPB1 T-cell epitope matching and outcome of unrelated hematopoietic cell transplantation are independent of HLA-DPA1", 
    "pagination": "1176", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "912f5744729bb93342cc76edff788d59524e834e147401db007d062bf6eeac2b"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24955785"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8702459"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/bmt.2014.122"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1030475937"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/bmt.2014.122", 
      "https://app.dimensions.ai/details/publication/pub.1030475937"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T20:34", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000425.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/bmt2014122"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/bmt.2014.122'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/bmt.2014.122'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/bmt.2014.122'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/bmt.2014.122'


 

This table displays all metadata directly associated to this object as RDF triples.

405 TRIPLES      21 PREDICATES      66 URIs      40 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/bmt.2014.122 schema:about N0e844e661eab4d619c43c303d3aa8352
2 N13353c85e4c048b289c284f460c88b24
3 N167f46de694f427db2319c4a317aa67b
4 N1bf285771ecf4861a9a23d75407ce803
5 N3c92c4096fd74dc299b0c5db02d2a338
6 N3f330259ffce4c42b9c0e59d32d42403
7 N5ac962857c6a4fd1a54c2ec350e4a48c
8 N5f2528085bd148c09fb6f211fa8d84e1
9 N693e421ba8974bab973e342f9dada625
10 N6e74de99219547fa9befa4b203d22f1d
11 N79279fcdba67415e85299a87ba03905c
12 N89b30fff2aeb4167b7633072d45e7f9e
13 N91fd4a01341c471083e6ec4449deb913
14 N944c24103cc144d0ac23d5b540945949
15 Na66f21cf03ac4029be74dc3137d31f4e
16 Nc1a74dfe469d41e3a271895cda7b22c7
17 Nd233d6263003454f82da3a61d2c4ec57
18 Nd4daf1c897ef43b0bf5885808de02e66
19 Nedbdc889a59e4487939363ba9cfcc9db
20 anzsrc-for:11
21 anzsrc-for:1107
22 schema:author Nf2d60e4b89d24332b11ed51192341a5b
23 schema:citation sg:pub.10.1007/s00251-012-0615-3
24 sg:pub.10.1038/bmt.2013.91
25 sg:pub.10.1038/leu.2008.90
26 https://doi.org/10.1016/j.bbmt.2006.05.007
27 https://doi.org/10.1016/j.bbmt.2008.05.001
28 https://doi.org/10.1016/j.bbmt.2012.07.020
29 https://doi.org/10.1016/j.molimm.2013.12.006
30 https://doi.org/10.1016/s0198-8859(99)00004-x
31 https://doi.org/10.1016/s1470-2045(12)70004-9
32 https://doi.org/10.1034/j.1399-0039.2003.00089.x
33 https://doi.org/10.1056/nejm199810223391701
34 https://doi.org/10.1182/blood-2003-04-1279
35 https://doi.org/10.1182/blood-2007-06-095265
36 https://doi.org/10.1182/blood-2007-06-097386
37 https://doi.org/10.1182/blood-2009-01-200378
38 https://doi.org/10.1182/blood-2012-12-470872
39 https://doi.org/10.1182/blood-2013-02-481945
40 https://doi.org/10.1182/blood.v98.10.2922
41 schema:datePublished 2014-09
42 schema:datePublishedReg 2014-09-01
43 schema:description HLA-DP antigens are beta-alpha heterodimers encoded by polymorphic HLA-DPB1 and -DPA1 alleles, respectively, in strong linkage disequilibrium (LD) with each other. Non-permissive unrelated donor (UD)-recipient HLA-DPB1 mismatches across three different T-cell epitope (TCE) groups are associated with increased mortality after hematopoietic SCT (HCT), but the role of HLA-DPA1 is unclear. We studied 1281 onco-hematologic patients after 10/10 HLA-matched UD-HCT facilitated by the National Marrow Donor Program. Non-permissive mismatches defined solely by HLA-DPB1 TCE groups were associated with significantly higher risks of TRM compared to permissive mismatches (hazard ratio (HR) 1.30, confidence interval (CI) 1.06-1.53; P=0.009) or allele matches. Moreover, non-permissive HLA-DPB1 TCE group mismatches in the graft versus host (GvH) direction significantly decreased the risk of relapse compared to permissive mismatches (HR 0.55, CI 0.37-0.80; P=0.002) or allele matches. Splitting each group into HLA-DPA1*02:01 positive or negative, in frequent LD with HLA-DPB1 alleles from two of the three TCE groups, or into HLA-DPA1 matched or mismatched, did not significantly alter the observed risk associations. Our findings suggest that the effects of clinically non-permissive HLA-DPB1 TCE group mismatches are independent of HLA-DPA1, and that selection of donors with non-permissive DPB1 TCE mismatches in GvH direction might provide some protection from disease recurrence.
44 schema:genre research_article
45 schema:inLanguage en
46 schema:isAccessibleForFree true
47 schema:isPartOf N7a92721295e040649ddfdb0435c4e454
48 Nf5c8ce93c4c54b819f80dd49be4453ee
49 sg:journal.1096890
50 schema:name Risk associations between HLA-DPB1 T-cell epitope matching and outcome of unrelated hematopoietic cell transplantation are independent of HLA-DPA1
51 schema:pagination 1176
52 schema:productId N39520b7a3aeb4737a475be2539da9ee0
53 N3d41e68691dd4f45a6605ef66860119f
54 N4d3f64df509f4671855b89960b678a54
55 N6e13f45372f141e8b01b54c88a3226c6
56 Naaf9bd1847cb4252a0d9997d8e137b77
57 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030475937
58 https://doi.org/10.1038/bmt.2014.122
59 schema:sdDatePublished 2019-04-10T20:34
60 schema:sdLicense https://scigraph.springernature.com/explorer/license/
61 schema:sdPublisher Nc1b8946f3132406da045fe2fc1b3f7c3
62 schema:url https://www.nature.com/articles/bmt2014122
63 sgo:license sg:explorer/license/
64 sgo:sdDataset articles
65 rdf:type schema:ScholarlyArticle
66 N0261c49d64bd4be2a08799e561f03887 rdf:first sg:person.016627600457.89
67 rdf:rest N080667672ce74a04bef04909ca20dd16
68 N080667672ce74a04bef04909ca20dd16 rdf:first sg:person.011624737152.66
69 rdf:rest Nc6e2179eba164344b70011b3cdcc4009
70 N0e844e661eab4d619c43c303d3aa8352 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
71 schema:name Risk
72 rdf:type schema:DefinedTerm
73 N13353c85e4c048b289c284f460c88b24 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Hematopoietic Stem Cell Transplantation
75 rdf:type schema:DefinedTerm
76 N167f46de694f427db2319c4a317aa67b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Female
78 rdf:type schema:DefinedTerm
79 N1bf285771ecf4861a9a23d75407ce803 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Epitope Mapping
81 rdf:type schema:DefinedTerm
82 N2d9bad15f5a74269ba1d46dfeda3507e rdf:first sg:person.014411531257.35
83 rdf:rest N3ee10f3dd50044fe950996e69018074f
84 N3406c76e83b0411ba10dadeea6324660 rdf:first sg:person.011767011574.08
85 rdf:rest N79ed8eb799a44b8db8cce184df1a12d3
86 N39520b7a3aeb4737a475be2539da9ee0 schema:name pubmed_id
87 schema:value 24955785
88 rdf:type schema:PropertyValue
89 N3c92c4096fd74dc299b0c5db02d2a338 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Infant
91 rdf:type schema:DefinedTerm
92 N3d41e68691dd4f45a6605ef66860119f schema:name dimensions_id
93 schema:value pub.1030475937
94 rdf:type schema:PropertyValue
95 N3ee10f3dd50044fe950996e69018074f rdf:first sg:person.013027767342.86
96 rdf:rest N822c011c112645aebd0a1de9e7e16474
97 N3f330259ffce4c42b9c0e59d32d42403 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Cohort Studies
99 rdf:type schema:DefinedTerm
100 N428112a480a94999b5b8e8fe80eb41f1 rdf:first sg:person.01147440273.79
101 rdf:rest N8ac1826dd81c41ae8695a7da323aa8f4
102 N48c1112d662c436eb58480bab20346a4 schema:name Department of Pathology, University of Texas Health Care System, Veterans Health Care System
103 rdf:type schema:Organization
104 N4d3f64df509f4671855b89960b678a54 schema:name readcube_id
105 schema:value 912f5744729bb93342cc76edff788d59524e834e147401db007d062bf6eeac2b
106 rdf:type schema:PropertyValue
107 N4e522213e6ba4cf4b863791494116a67 rdf:first sg:person.015145562407.54
108 rdf:rest Nfd59ce886e084dafa0bb8b16f7fa1b80
109 N5ac962857c6a4fd1a54c2ec350e4a48c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Transplantation Conditioning
111 rdf:type schema:DefinedTerm
112 N5cab8fd95c144cfa9c86265d5536a1ef schema:name Department of Medicine/Bone Marrow Transplant, Stanford Hospitals and Clinics, Stanford, CA, USA
113 rdf:type schema:Organization
114 N5f2528085bd148c09fb6f211fa8d84e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name HLA-DP alpha-Chains
116 rdf:type schema:DefinedTerm
117 N5fd49410519a49379ec131972529aa27 rdf:first sg:person.0727054455.03
118 rdf:rest Nab52f54b199c4331888186f298670313
119 N693e421ba8974bab973e342f9dada625 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Unrelated Donors
121 rdf:type schema:DefinedTerm
122 N6e13f45372f141e8b01b54c88a3226c6 schema:name doi
123 schema:value 10.1038/bmt.2014.122
124 rdf:type schema:PropertyValue
125 N6e74de99219547fa9befa4b203d22f1d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Middle Aged
127 rdf:type schema:DefinedTerm
128 N70d83e1067594a76ace9a731d34369fc rdf:first sg:person.01127325612.40
129 rdf:rest Na3ced772d1b74c37b49c5ebd2be9d5d1
130 N79279fcdba67415e85299a87ba03905c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Child, Preschool
132 rdf:type schema:DefinedTerm
133 N79ed8eb799a44b8db8cce184df1a12d3 rdf:first sg:person.01053755630.82
134 rdf:rest rdf:nil
135 N7a92721295e040649ddfdb0435c4e454 schema:issueNumber 9
136 rdf:type schema:PublicationIssue
137 N822c011c112645aebd0a1de9e7e16474 rdf:first sg:person.01137616010.60
138 rdf:rest N428112a480a94999b5b8e8fe80eb41f1
139 N89b30fff2aeb4167b7633072d45e7f9e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Male
141 rdf:type schema:DefinedTerm
142 N8ac1826dd81c41ae8695a7da323aa8f4 rdf:first sg:person.0767423105.11
143 rdf:rest Nfbc56fdd220c44acaf248e6a27795f2e
144 N91fd4a01341c471083e6ec4449deb913 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Adult
146 rdf:type schema:DefinedTerm
147 N944c24103cc144d0ac23d5b540945949 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Child
149 rdf:type schema:DefinedTerm
150 N96066e0644424dd9a673ca1b92517a6e rdf:first sg:person.01340061040.03
151 rdf:rest N0261c49d64bd4be2a08799e561f03887
152 Na3ced772d1b74c37b49c5ebd2be9d5d1 rdf:first sg:person.0706222531.98
153 rdf:rest Nf4af6c8c9f0845648ea2f814d1403625
154 Na66f21cf03ac4029be74dc3137d31f4e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Humans
156 rdf:type schema:DefinedTerm
157 Naaf9bd1847cb4252a0d9997d8e137b77 schema:name nlm_unique_id
158 schema:value 8702459
159 rdf:type schema:PropertyValue
160 Nab52f54b199c4331888186f298670313 rdf:first sg:person.01050305767.52
161 rdf:rest N3406c76e83b0411ba10dadeea6324660
162 Nc1a74dfe469d41e3a271895cda7b22c7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Adolescent
164 rdf:type schema:DefinedTerm
165 Nc1b8946f3132406da045fe2fc1b3f7c3 schema:name Springer Nature - SN SciGraph project
166 rdf:type schema:Organization
167 Nc6e2179eba164344b70011b3cdcc4009 rdf:first sg:person.016531470544.62
168 rdf:rest N2d9bad15f5a74269ba1d46dfeda3507e
169 Nc87c8b4aaf9746558c1ecdfc8d943a34 rdf:first sg:person.01022722420.50
170 rdf:rest N4e522213e6ba4cf4b863791494116a67
171 Nd233d6263003454f82da3a61d2c4ec57 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name HLA-DP beta-Chains
173 rdf:type schema:DefinedTerm
174 Nd4daf1c897ef43b0bf5885808de02e66 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Epitopes, T-Lymphocyte
176 rdf:type schema:DefinedTerm
177 Ne3618c7bd8cf4614a6f9e44a8144f344 rdf:first sg:person.074407346.64
178 rdf:rest N5fd49410519a49379ec131972529aa27
179 Nedbdc889a59e4487939363ba9cfcc9db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Young Adult
181 rdf:type schema:DefinedTerm
182 Nf2d60e4b89d24332b11ed51192341a5b rdf:first sg:person.01223223136.80
183 rdf:rest N70d83e1067594a76ace9a731d34369fc
184 Nf4af6c8c9f0845648ea2f814d1403625 rdf:first sg:person.01135476153.37
185 rdf:rest Nc87c8b4aaf9746558c1ecdfc8d943a34
186 Nf5c8ce93c4c54b819f80dd49be4453ee schema:volumeNumber 49
187 rdf:type schema:PublicationVolume
188 Nfbc56fdd220c44acaf248e6a27795f2e rdf:first sg:person.013170655222.94
189 rdf:rest Ne3618c7bd8cf4614a6f9e44a8144f344
190 Nfd59ce886e084dafa0bb8b16f7fa1b80 rdf:first sg:person.01155107736.48
191 rdf:rest N96066e0644424dd9a673ca1b92517a6e
192 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
193 schema:name Medical and Health Sciences
194 rdf:type schema:DefinedTerm
195 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
196 schema:name Immunology
197 rdf:type schema:DefinedTerm
198 sg:grant.2691735 http://pending.schema.org/fundedItem sg:pub.10.1038/bmt.2014.122
199 rdf:type schema:MonetaryGrant
200 sg:grant.2696275 http://pending.schema.org/fundedItem sg:pub.10.1038/bmt.2014.122
201 rdf:type schema:MonetaryGrant
202 sg:grant.2705196 http://pending.schema.org/fundedItem sg:pub.10.1038/bmt.2014.122
203 rdf:type schema:MonetaryGrant
204 sg:grant.4381038 http://pending.schema.org/fundedItem sg:pub.10.1038/bmt.2014.122
205 rdf:type schema:MonetaryGrant
206 sg:journal.1096890 schema:issn 0268-3369
207 1476-5365
208 schema:name Bone Marrow Transplantation
209 rdf:type schema:Periodical
210 sg:person.01022722420.50 schema:affiliation https://www.grid.ac/institutes/grid.279885.9
211 schema:familyName Battiwalla
212 schema:givenName Minoo
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022722420.50
214 rdf:type schema:Person
215 sg:person.01050305767.52 schema:affiliation https://www.grid.ac/institutes/grid.412162.2
216 schema:familyName Waller
217 schema:givenName Edmund K.
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050305767.52
219 rdf:type schema:Person
220 sg:person.01053755630.82 schema:affiliation https://www.grid.ac/institutes/grid.30760.32
221 schema:familyName Spellman
222 schema:givenName Stephen R.
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053755630.82
224 rdf:type schema:Person
225 sg:person.01127325612.40 schema:affiliation https://www.grid.ac/institutes/grid.168010.e
226 schema:familyName Fernandez-Viña
227 schema:givenName Marcelo A.
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127325612.40
229 rdf:type schema:Person
230 sg:person.01135476153.37 schema:affiliation https://www.grid.ac/institutes/grid.30760.32
231 schema:familyName Haagenson
232 schema:givenName Michael
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01135476153.37
234 rdf:type schema:Person
235 sg:person.01137616010.60 schema:affiliation N5cab8fd95c144cfa9c86265d5536a1ef
236 schema:familyName Miklos
237 schema:givenName David
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137616010.60
239 rdf:type schema:Person
240 sg:person.01147440273.79 schema:affiliation https://www.grid.ac/institutes/grid.10419.3d
241 schema:familyName Oudshoorn
242 schema:givenName Machteld
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147440273.79
244 rdf:type schema:Person
245 sg:person.01155107736.48 schema:affiliation https://www.grid.ac/institutes/grid.18887.3e
246 schema:familyName Ciceri
247 schema:givenName Fabio
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155107736.48
249 rdf:type schema:Person
250 sg:person.011624737152.66 schema:affiliation https://www.grid.ac/institutes/grid.5288.7
251 schema:familyName Hale
252 schema:givenName Gregory A.
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011624737152.66
254 rdf:type schema:Person
255 sg:person.011767011574.08 schema:affiliation https://www.grid.ac/institutes/grid.270240.3
256 schema:familyName Lee
257 schema:givenName Stephanie J.
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011767011574.08
259 rdf:type schema:Person
260 sg:person.01223223136.80 schema:affiliation https://www.grid.ac/institutes/grid.18887.3e
261 schema:familyName Fleischhauer
262 schema:givenName Katharina
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223223136.80
264 rdf:type schema:Person
265 sg:person.013027767342.86 schema:affiliation https://www.grid.ac/institutes/grid.30760.32
266 schema:familyName McCarthy
267 schema:givenName Philip L.
268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013027767342.86
269 rdf:type schema:Person
270 sg:person.013170655222.94 schema:affiliation https://www.grid.ac/institutes/grid.15276.37
271 schema:familyName Reddy
272 schema:givenName Vijay
273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013170655222.94
274 rdf:type schema:Person
275 sg:person.01340061040.03 schema:affiliation https://www.grid.ac/institutes/grid.422289.7
276 schema:familyName Dehn
277 schema:givenName Jason
278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340061040.03
279 rdf:type schema:Person
280 sg:person.014411531257.35 schema:affiliation https://www.grid.ac/institutes/grid.412578.d
281 schema:familyName Marino
282 schema:givenName Susana R.
283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014411531257.35
284 rdf:type schema:Person
285 sg:person.015145562407.54 schema:affiliation https://www.grid.ac/institutes/grid.413077.6
286 schema:familyName Baxter-Lowe
287 schema:givenName Lee Ann
288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015145562407.54
289 rdf:type schema:Person
290 sg:person.016531470544.62 schema:affiliation https://www.grid.ac/institutes/grid.412162.2
291 schema:familyName Heemskerk
292 schema:givenName Martin BA
293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016531470544.62
294 rdf:type schema:Person
295 sg:person.016627600457.89 schema:affiliation https://www.grid.ac/institutes/grid.5288.7
296 schema:familyName Gajewski
297 schema:givenName James
298 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016627600457.89
299 rdf:type schema:Person
300 sg:person.0706222531.98 schema:affiliation https://www.grid.ac/institutes/grid.30760.32
301 schema:familyName Wang
302 schema:givenName Tao
303 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706222531.98
304 rdf:type schema:Person
305 sg:person.0727054455.03 schema:affiliation https://www.grid.ac/institutes/grid.426412.7
306 schema:familyName Shaw
307 schema:givenName Bronwen E.
308 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727054455.03
309 rdf:type schema:Person
310 sg:person.074407346.64 schema:affiliation https://www.grid.ac/institutes/grid.410425.6
311 schema:familyName Senitzer
312 schema:givenName David
313 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.074407346.64
314 rdf:type schema:Person
315 sg:person.0767423105.11 schema:affiliation N48c1112d662c436eb58480bab20346a4
316 schema:familyName Pollack
317 schema:givenName Marilyn S.
318 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767423105.11
319 rdf:type schema:Person
320 sg:pub.10.1007/s00251-012-0615-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034538476
321 https://doi.org/10.1007/s00251-012-0615-3
322 rdf:type schema:CreativeWork
323 sg:pub.10.1038/bmt.2013.91 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048881899
324 https://doi.org/10.1038/bmt.2013.91
325 rdf:type schema:CreativeWork
326 sg:pub.10.1038/leu.2008.90 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005664673
327 https://doi.org/10.1038/leu.2008.90
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1016/j.bbmt.2006.05.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029417339
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1016/j.bbmt.2008.05.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007311535
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1016/j.bbmt.2012.07.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016213034
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1016/j.molimm.2013.12.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028245034
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1016/s0198-8859(99)00004-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044572412
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1016/s1470-2045(12)70004-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033956834
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1034/j.1399-0039.2003.00089.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030127938
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1056/nejm199810223391701 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007584421
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1182/blood-2003-04-1279 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049325961
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1182/blood-2007-06-095265 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015712025
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1182/blood-2007-06-097386 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048103644
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1182/blood-2009-01-200378 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036570291
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1182/blood-2012-12-470872 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048535923
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1182/blood-2013-02-481945 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000996858
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1182/blood.v98.10.2922 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030019336
358 rdf:type schema:CreativeWork
359 https://www.grid.ac/institutes/grid.10419.3d schema:alternateName Leiden University Medical Center
360 schema:name Europdonor Foundation, Leiden University Medical Center, Leiden, Netherlands
361 rdf:type schema:Organization
362 https://www.grid.ac/institutes/grid.15276.37 schema:alternateName University of Florida
363 schema:name Department of Hemaotology/Oncology, University of Florida, Gainesville, FL, USA
364 rdf:type schema:Organization
365 https://www.grid.ac/institutes/grid.168010.e schema:alternateName Stanford University
366 schema:name Histocompatibility, Immunogenetics, and Disease Profiling Laboratory, Stanford University Medical School, Stanford, CA, USA
367 rdf:type schema:Organization
368 https://www.grid.ac/institutes/grid.18887.3e schema:alternateName San Raffaele Hospital
369 schema:name Hematology and Bone Marrow Transplantation Unit, San Raffaele Scientific Institute, Milan, Italy
370 Institute of Experimental Cellular Therapy, Essen University Hospital, Essen, Germany
371 Unit of Molecular and Functional Immunogenetics, San Raffaele Scientific Institute, Milan, Italy
372 rdf:type schema:Organization
373 https://www.grid.ac/institutes/grid.270240.3 schema:alternateName Fred Hutchinson Cancer Research Center
374 schema:name Clinical Transplant Research, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
375 rdf:type schema:Organization
376 https://www.grid.ac/institutes/grid.279885.9 schema:alternateName National Heart Lung and Blood Institute
377 schema:name National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA
378 rdf:type schema:Organization
379 https://www.grid.ac/institutes/grid.30760.32 schema:alternateName Medical College of Wisconsin
380 schema:name Center for International Blood and Marrow Transplant Research, Minneapolis, MN, USA
381 Division of Biostatistics, Medical College of Wisconsin, Milwaukee, WI, USA
382 Histocompatibility, Immunogenetics, and Disease Profiling Laboratory, Stanford University Medical School, Stanford, CA, USA
383 rdf:type schema:Organization
384 https://www.grid.ac/institutes/grid.410425.6 schema:alternateName City Of Hope National Medical Center
385 schema:name Hematology/Hematopoietic Cell Transplant, City of Hope National Medical Center, Duarte, CA, USA
386 rdf:type schema:Organization
387 https://www.grid.ac/institutes/grid.412162.2 schema:alternateName Emory University Hospital
388 schema:name Bone Marrow and Stem Cell Transplant Center, Emory University Hospital, Atlanta, GA, USA
389 rdf:type schema:Organization
390 https://www.grid.ac/institutes/grid.412578.d schema:alternateName University of Chicago Medical Center
391 schema:name Department of Pathology, University of Chicago Hospitals, Chicago, IL, USA
392 rdf:type schema:Organization
393 https://www.grid.ac/institutes/grid.413077.6 schema:alternateName University of California San Francisco Medical Center
394 schema:name Immunogentics and Transplantation Lab, University of California San Francisco Medical Center, San Francisco, CA, USA
395 National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA
396 rdf:type schema:Organization
397 https://www.grid.ac/institutes/grid.422289.7 schema:alternateName National Marrow Donor Program
398 schema:name National Marrow Donor Program, Minneapolis, MN, USA
399 rdf:type schema:Organization
400 https://www.grid.ac/institutes/grid.426412.7 schema:alternateName Anthony Nolan
401 schema:name Anthony Nolan Research Institute, London, UK
402 rdf:type schema:Organization
403 https://www.grid.ac/institutes/grid.5288.7 schema:alternateName Oregon Health & Science University
404 schema:name Oregon Health and Science University, Portland, OR, USA
405 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...