Sirolimus and post transplant Cy synergistically maintain mixed chimerism in a mismatched murine model View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-10

AUTHORS

C D Fitzhugh, R P Weitzel, M M Hsieh, O A Phang, C Madison, L Luznik, J D Powell, J F Tisdale

ABSTRACT

Because of the toxicity associated with myeloablative conditioning, nonmyeloablative regimens are increasingly being used in vulnerable patient populations. For patients with sickle cell disease, stable mixed chimerism has proven sufficient to reverse the phenotype. Because the vast majority of patients do not have an HLA-matched sibling, a safe nonmyeloablative regimen that could be applied to the haploidentical setting would be ideal. We employed a mismatched mouse model using BALB/c donors and C57BL/6 recipients. Recipient mice were conditioned with 200 cGy TBI and sirolimus or CSA with or without post transplant Cy (PT-Cy). Our data show that when sirolimus or PT-Cy alone is given to C57BL/6 recipients, donor cells are not detected. However, when sirolimus is administered for 15 or 31 days starting 1 day before or up to 6 days after transplant with PT-Cy, all mice maintain stable mixed chimerism. In contrast, conventional therapy employing CSA with or without PT-Cy does not result in stable mixed chimerism. Lastly, mice with stable mixed chimerism after sirolimus display decreased reactivity to donor Ag both in vitro and in vivo. These data identify a novel strategy for inducing mixed chimerism for the treatment of nonmalignant hematologic diseases. More... »

PAGES

1335

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bmt.2013.60

DOI

http://dx.doi.org/10.1038/bmt.2013.60

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028958110

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23604009


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclophosphamide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Synergism", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunosuppressive Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred BALB C", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred NOD", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sirolimus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Skin Transplantation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transplantation Chimera", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "National Heart Lung and Blood Institute", 
          "id": "https://www.grid.ac/institutes/grid.279885.9", 
          "name": [
            "Molecular and Clinical Hematology Branch, National Heart, Lung, and Blood Institute/National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fitzhugh", 
        "givenName": "C D", 
        "id": "sg:person.01225375732.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225375732.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Heart Lung and Blood Institute", 
          "id": "https://www.grid.ac/institutes/grid.279885.9", 
          "name": [
            "Molecular and Clinical Hematology Branch, National Heart, Lung, and Blood Institute/National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Weitzel", 
        "givenName": "R P", 
        "id": "sg:person.01240725247.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240725247.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Heart Lung and Blood Institute", 
          "id": "https://www.grid.ac/institutes/grid.279885.9", 
          "name": [
            "Molecular and Clinical Hematology Branch, National Heart, Lung, and Blood Institute/National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hsieh", 
        "givenName": "M M", 
        "id": "sg:person.013606765037.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013606765037.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Heart Lung and Blood Institute", 
          "id": "https://www.grid.ac/institutes/grid.279885.9", 
          "name": [
            "Molecular and Clinical Hematology Branch, National Heart, Lung, and Blood Institute/National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Phang", 
        "givenName": "O A", 
        "id": "sg:person.01233420434.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233420434.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Heart Lung and Blood Institute", 
          "id": "https://www.grid.ac/institutes/grid.279885.9", 
          "name": [
            "Molecular and Clinical Hematology Branch, National Heart, Lung, and Blood Institute/National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Madison", 
        "givenName": "C", 
        "id": "sg:person.0664755366.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664755366.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Sidney-Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Luznik", 
        "givenName": "L", 
        "id": "sg:person.01021000274.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021000274.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Sidney-Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Powell", 
        "givenName": "J D", 
        "id": "sg:person.01162106561.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162106561.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Heart Lung and Blood Institute", 
          "id": "https://www.grid.ac/institutes/grid.279885.9", 
          "name": [
            "Molecular and Clinical Hematology Branch, National Heart, Lung, and Blood Institute/National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tisdale", 
        "givenName": "J F", 
        "id": "sg:person.01206574465.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206574465.13"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1097/moh.0b013e32833eaf1b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000234119"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/moh.0b013e32833eaf1b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000234119"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/moh.0b013e32833eaf1b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000234119"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/moh.0b013e32833eaf1b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000234119"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0171-2985(96)80033-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001145185"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bmt.1701291", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001405473", 
          "https://doi.org/10.1038/sj.bmt.1701291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bmt.1701291", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001405473", 
          "https://doi.org/10.1038/sj.bmt.1701291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2007-03-079665", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007980333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.tp.0000164142.98167.4b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010444442"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.tp.0000164142.98167.4b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010444442"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.tp.0000164142.98167.4b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010444442"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.tp.0000164142.98167.4b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010444442"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.exphem.2008.07.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011034757"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-6143.2007.01842.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011080278"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199608083350601", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013378490"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood.v98.12.3456", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015841749"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbmt.2012.08.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016112762"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/bbmt.2002.v8.pm11939602", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018473427"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/bbmt.2001.v7.pm11787529", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019263499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/tp.0b013e318242bddf", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019550174"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/tp.0b013e318242bddf", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019550174"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.tp.0000185299.72295.90", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022196419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.tp.0000185299.72295.90", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022196419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.tp.0000185299.72295.90", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022196419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-6143.2006.01622.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023185927"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbmt.2008.03.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027232719"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2011-01-332510", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028505196"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.tp.0000256158.84418.ff", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030121489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.tp.0000256158.84418.ff", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030121489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bmt.1705628", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030223904", 
          "https://doi.org/10.1038/sj.bmt.1705628"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.trim.2007.01.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032828247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.exphem.2006.08.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032925227"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.178.11.7018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033785474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/tp.0b013e3182241133", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034612737"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/tp.0b013e3182241133", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034612737"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-198708000-00021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036467210"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-198708000-00021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036467210"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.transproceed.2004.12.147", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038221623"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.immuni.2009.04.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039072658"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bmt.2008.203", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039926900", 
          "https://doi.org/10.1038/bmt.2008.203"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood.v99.10.3493", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044074220"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1517/14740330903037156", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045871414"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2004-10-3932", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046923333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3324/haematol.2011.058677", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047566206"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0904971", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051444938"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199702150-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060276428"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199702150-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060276428"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199702150-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060276428"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199702150-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060276428"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-200004150-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060281958"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-200004150-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060281958"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-200004150-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060281958"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074262634", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074802887", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082427383", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082711488", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082739365", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082879435", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082963835", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083014886", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-10", 
    "datePublishedReg": "2013-10-01", 
    "description": "Because of the toxicity associated with myeloablative conditioning, nonmyeloablative regimens are increasingly being used in vulnerable patient populations. For patients with sickle cell disease, stable mixed chimerism has proven sufficient to reverse the phenotype. Because the vast majority of patients do not have an HLA-matched sibling, a safe nonmyeloablative regimen that could be applied to the haploidentical setting would be ideal. We employed a mismatched mouse model using BALB/c donors and C57BL/6 recipients. Recipient mice were conditioned with 200\u2009cGy TBI and sirolimus or CSA with or without post transplant Cy (PT-Cy). Our data show that when sirolimus or PT-Cy alone is given to C57BL/6 recipients, donor cells are not detected. However, when sirolimus is administered for 15 or 31 days starting 1 day before or up to 6 days after transplant with PT-Cy, all mice maintain stable mixed chimerism. In contrast, conventional therapy employing CSA with or without PT-Cy does not result in stable mixed chimerism. Lastly, mice with stable mixed chimerism after sirolimus display decreased reactivity to donor Ag both in vitro and in vivo. These data identify a novel strategy for inducing mixed chimerism for the treatment of nonmalignant hematologic diseases. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/bmt.2013.60", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.3860680", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2725878", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1096890", 
        "issn": [
          "0268-3369", 
          "1476-5365"
        ], 
        "name": "Bone Marrow Transplantation", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "10", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "48"
      }
    ], 
    "name": "Sirolimus and post transplant Cy synergistically maintain mixed chimerism in a mismatched murine model", 
    "pagination": "1335", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "89f34b83c84741e9173deb9a9868682175d1a64c0c683137b664595af845904c"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23604009"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8702459"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/bmt.2013.60"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1028958110"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/bmt.2013.60", 
      "https://app.dimensions.ai/details/publication/pub.1028958110"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T18:58", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8678_00000435.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/bmt201360"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/bmt.2013.60'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/bmt.2013.60'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/bmt.2013.60'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/bmt.2013.60'


 

This table displays all metadata directly associated to this object as RDF triples.

298 TRIPLES      21 PREDICATES      84 URIs      34 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/bmt.2013.60 schema:about N24a85c60c46045a4ba88e8324f2c24b9
2 N2da12626154442c1a5e5da37002e2e14
3 N2e00767620ff4bbc9e181f174476e6aa
4 N3895e4a5874c4172975f59aeebe69103
5 N38effd0908644b71b03df2defbbcc593
6 N4622e8b6dacf4cd29da7b8f9c6b0c34b
7 N7b829174974a4889901dfbe908bf1587
8 N93ea4a3018b8477995aeb1116474cf32
9 Nb05d62070dbc4234abeeaf3439bf79cb
10 Nc59316f92c714e2fbffb37fa1e26f3ff
11 Ne7da951519d345fd89f23ca2c157722a
12 Nea378bfbb3f641ff93bde59b4bf7a0a8
13 Nedf0f2c1646145749d8bf78e8d8bd5f9
14 anzsrc-for:11
15 anzsrc-for:1107
16 schema:author N019c8fe0e8354c32ae28f09aa3de454b
17 schema:citation sg:pub.10.1038/bmt.2008.203
18 sg:pub.10.1038/sj.bmt.1701291
19 sg:pub.10.1038/sj.bmt.1705628
20 https://app.dimensions.ai/details/publication/pub.1074262634
21 https://app.dimensions.ai/details/publication/pub.1074802887
22 https://app.dimensions.ai/details/publication/pub.1082427383
23 https://app.dimensions.ai/details/publication/pub.1082711488
24 https://app.dimensions.ai/details/publication/pub.1082739365
25 https://app.dimensions.ai/details/publication/pub.1082879435
26 https://app.dimensions.ai/details/publication/pub.1082963835
27 https://app.dimensions.ai/details/publication/pub.1083014886
28 https://doi.org/10.1016/j.bbmt.2008.03.005
29 https://doi.org/10.1016/j.bbmt.2012.08.014
30 https://doi.org/10.1016/j.exphem.2006.08.018
31 https://doi.org/10.1016/j.exphem.2008.07.002
32 https://doi.org/10.1016/j.immuni.2009.04.014
33 https://doi.org/10.1016/j.transproceed.2004.12.147
34 https://doi.org/10.1016/j.trim.2007.01.002
35 https://doi.org/10.1016/s0171-2985(96)80033-7
36 https://doi.org/10.1053/bbmt.2001.v7.pm11787529
37 https://doi.org/10.1053/bbmt.2002.v8.pm11939602
38 https://doi.org/10.1056/nejm199608083350601
39 https://doi.org/10.1056/nejmoa0904971
40 https://doi.org/10.1097/00007890-198708000-00021
41 https://doi.org/10.1097/00007890-199702150-00005
42 https://doi.org/10.1097/00007890-200004150-00008
43 https://doi.org/10.1097/01.tp.0000164142.98167.4b
44 https://doi.org/10.1097/01.tp.0000185299.72295.90
45 https://doi.org/10.1097/01.tp.0000256158.84418.ff
46 https://doi.org/10.1097/moh.0b013e32833eaf1b
47 https://doi.org/10.1097/tp.0b013e3182241133
48 https://doi.org/10.1097/tp.0b013e318242bddf
49 https://doi.org/10.1111/j.1600-6143.2006.01622.x
50 https://doi.org/10.1111/j.1600-6143.2007.01842.x
51 https://doi.org/10.1182/blood-2004-10-3932
52 https://doi.org/10.1182/blood-2007-03-079665
53 https://doi.org/10.1182/blood-2011-01-332510
54 https://doi.org/10.1182/blood.v98.12.3456
55 https://doi.org/10.1182/blood.v99.10.3493
56 https://doi.org/10.1517/14740330903037156
57 https://doi.org/10.3324/haematol.2011.058677
58 https://doi.org/10.4049/jimmunol.178.11.7018
59 schema:datePublished 2013-10
60 schema:datePublishedReg 2013-10-01
61 schema:description Because of the toxicity associated with myeloablative conditioning, nonmyeloablative regimens are increasingly being used in vulnerable patient populations. For patients with sickle cell disease, stable mixed chimerism has proven sufficient to reverse the phenotype. Because the vast majority of patients do not have an HLA-matched sibling, a safe nonmyeloablative regimen that could be applied to the haploidentical setting would be ideal. We employed a mismatched mouse model using BALB/c donors and C57BL/6 recipients. Recipient mice were conditioned with 200 cGy TBI and sirolimus or CSA with or without post transplant Cy (PT-Cy). Our data show that when sirolimus or PT-Cy alone is given to C57BL/6 recipients, donor cells are not detected. However, when sirolimus is administered for 15 or 31 days starting 1 day before or up to 6 days after transplant with PT-Cy, all mice maintain stable mixed chimerism. In contrast, conventional therapy employing CSA with or without PT-Cy does not result in stable mixed chimerism. Lastly, mice with stable mixed chimerism after sirolimus display decreased reactivity to donor Ag both in vitro and in vivo. These data identify a novel strategy for inducing mixed chimerism for the treatment of nonmalignant hematologic diseases.
62 schema:genre research_article
63 schema:inLanguage en
64 schema:isAccessibleForFree true
65 schema:isPartOf N13078c48131e47748cfb16fdf7d6dab1
66 Nd9473f53816d40d8aa5c64104387b920
67 sg:journal.1096890
68 schema:name Sirolimus and post transplant Cy synergistically maintain mixed chimerism in a mismatched murine model
69 schema:pagination 1335
70 schema:productId N17ef6324a302463eb038b97367c2dfbb
71 N2caf2a4543244160b4276e3df2d557c2
72 N6d188e9eb4aa4278bee6a4f61517546b
73 N8599f00e26ea4b43b1fed437c4c9674b
74 Nff22792b0fcf44ac93d41beb6c4a578a
75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028958110
76 https://doi.org/10.1038/bmt.2013.60
77 schema:sdDatePublished 2019-04-10T18:58
78 schema:sdLicense https://scigraph.springernature.com/explorer/license/
79 schema:sdPublisher N65863081f5ff4e94a122cdb2a7f4161b
80 schema:url https://www.nature.com/articles/bmt201360
81 sgo:license sg:explorer/license/
82 sgo:sdDataset articles
83 rdf:type schema:ScholarlyArticle
84 N019c8fe0e8354c32ae28f09aa3de454b rdf:first sg:person.01225375732.59
85 rdf:rest N45cea0052d6a4fa08a44e31fca842987
86 N13078c48131e47748cfb16fdf7d6dab1 schema:issueNumber 10
87 rdf:type schema:PublicationIssue
88 N17ef6324a302463eb038b97367c2dfbb schema:name doi
89 schema:value 10.1038/bmt.2013.60
90 rdf:type schema:PropertyValue
91 N24a85c60c46045a4ba88e8324f2c24b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Immunosuppressive Agents
93 rdf:type schema:DefinedTerm
94 N2caf2a4543244160b4276e3df2d557c2 schema:name nlm_unique_id
95 schema:value 8702459
96 rdf:type schema:PropertyValue
97 N2da12626154442c1a5e5da37002e2e14 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Sirolimus
99 rdf:type schema:DefinedTerm
100 N2e00767620ff4bbc9e181f174476e6aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Drug Synergism
102 rdf:type schema:DefinedTerm
103 N3895e4a5874c4172975f59aeebe69103 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Transplantation Chimera
105 rdf:type schema:DefinedTerm
106 N38effd0908644b71b03df2defbbcc593 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Skin Transplantation
108 rdf:type schema:DefinedTerm
109 N45cea0052d6a4fa08a44e31fca842987 rdf:first sg:person.01240725247.13
110 rdf:rest N85223d9e06b7454585f76d4c33ecd6dc
111 N4622e8b6dacf4cd29da7b8f9c6b0c34b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Animals
113 rdf:type schema:DefinedTerm
114 N4917eb1e180243dba0a45952df9f547d rdf:first sg:person.01233420434.30
115 rdf:rest N796ebbfb0f034e97893b6e35fda7178d
116 N65863081f5ff4e94a122cdb2a7f4161b schema:name Springer Nature - SN SciGraph project
117 rdf:type schema:Organization
118 N6d188e9eb4aa4278bee6a4f61517546b schema:name readcube_id
119 schema:value 89f34b83c84741e9173deb9a9868682175d1a64c0c683137b664595af845904c
120 rdf:type schema:PropertyValue
121 N796ebbfb0f034e97893b6e35fda7178d rdf:first sg:person.0664755366.40
122 rdf:rest N866f323dc1cd4f248de263a027427af1
123 N7b829174974a4889901dfbe908bf1587 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Mice, Inbred NOD
125 rdf:type schema:DefinedTerm
126 N85223d9e06b7454585f76d4c33ecd6dc rdf:first sg:person.013606765037.00
127 rdf:rest N4917eb1e180243dba0a45952df9f547d
128 N8599f00e26ea4b43b1fed437c4c9674b schema:name pubmed_id
129 schema:value 23604009
130 rdf:type schema:PropertyValue
131 N866f323dc1cd4f248de263a027427af1 rdf:first sg:person.01021000274.28
132 rdf:rest Nc3622dc7978a46748412cde909bd3a44
133 N93ea4a3018b8477995aeb1116474cf32 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Mice, Inbred BALB C
135 rdf:type schema:DefinedTerm
136 Na89d45bd05a2437fa617bbe60cd2a283 rdf:first sg:person.01206574465.13
137 rdf:rest rdf:nil
138 Nb05d62070dbc4234abeeaf3439bf79cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Cyclophosphamide
140 rdf:type schema:DefinedTerm
141 Nc3622dc7978a46748412cde909bd3a44 rdf:first sg:person.01162106561.71
142 rdf:rest Na89d45bd05a2437fa617bbe60cd2a283
143 Nc59316f92c714e2fbffb37fa1e26f3ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Mice
145 rdf:type schema:DefinedTerm
146 Nd9473f53816d40d8aa5c64104387b920 schema:volumeNumber 48
147 rdf:type schema:PublicationVolume
148 Ne7da951519d345fd89f23ca2c157722a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Female
150 rdf:type schema:DefinedTerm
151 Nea378bfbb3f641ff93bde59b4bf7a0a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Disease Models, Animal
153 rdf:type schema:DefinedTerm
154 Nedf0f2c1646145749d8bf78e8d8bd5f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Mice, Inbred C57BL
156 rdf:type schema:DefinedTerm
157 Nff22792b0fcf44ac93d41beb6c4a578a schema:name dimensions_id
158 schema:value pub.1028958110
159 rdf:type schema:PropertyValue
160 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
161 schema:name Medical and Health Sciences
162 rdf:type schema:DefinedTerm
163 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
164 schema:name Immunology
165 rdf:type schema:DefinedTerm
166 sg:grant.2725878 http://pending.schema.org/fundedItem sg:pub.10.1038/bmt.2013.60
167 rdf:type schema:MonetaryGrant
168 sg:grant.3860680 http://pending.schema.org/fundedItem sg:pub.10.1038/bmt.2013.60
169 rdf:type schema:MonetaryGrant
170 sg:journal.1096890 schema:issn 0268-3369
171 1476-5365
172 schema:name Bone Marrow Transplantation
173 rdf:type schema:Periodical
174 sg:person.01021000274.28 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
175 schema:familyName Luznik
176 schema:givenName L
177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021000274.28
178 rdf:type schema:Person
179 sg:person.01162106561.71 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
180 schema:familyName Powell
181 schema:givenName J D
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162106561.71
183 rdf:type schema:Person
184 sg:person.01206574465.13 schema:affiliation https://www.grid.ac/institutes/grid.279885.9
185 schema:familyName Tisdale
186 schema:givenName J F
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206574465.13
188 rdf:type schema:Person
189 sg:person.01225375732.59 schema:affiliation https://www.grid.ac/institutes/grid.279885.9
190 schema:familyName Fitzhugh
191 schema:givenName C D
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225375732.59
193 rdf:type schema:Person
194 sg:person.01233420434.30 schema:affiliation https://www.grid.ac/institutes/grid.279885.9
195 schema:familyName Phang
196 schema:givenName O A
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233420434.30
198 rdf:type schema:Person
199 sg:person.01240725247.13 schema:affiliation https://www.grid.ac/institutes/grid.279885.9
200 schema:familyName Weitzel
201 schema:givenName R P
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240725247.13
203 rdf:type schema:Person
204 sg:person.013606765037.00 schema:affiliation https://www.grid.ac/institutes/grid.279885.9
205 schema:familyName Hsieh
206 schema:givenName M M
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013606765037.00
208 rdf:type schema:Person
209 sg:person.0664755366.40 schema:affiliation https://www.grid.ac/institutes/grid.279885.9
210 schema:familyName Madison
211 schema:givenName C
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664755366.40
213 rdf:type schema:Person
214 sg:pub.10.1038/bmt.2008.203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039926900
215 https://doi.org/10.1038/bmt.2008.203
216 rdf:type schema:CreativeWork
217 sg:pub.10.1038/sj.bmt.1701291 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001405473
218 https://doi.org/10.1038/sj.bmt.1701291
219 rdf:type schema:CreativeWork
220 sg:pub.10.1038/sj.bmt.1705628 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030223904
221 https://doi.org/10.1038/sj.bmt.1705628
222 rdf:type schema:CreativeWork
223 https://app.dimensions.ai/details/publication/pub.1074262634 schema:CreativeWork
224 https://app.dimensions.ai/details/publication/pub.1074802887 schema:CreativeWork
225 https://app.dimensions.ai/details/publication/pub.1082427383 schema:CreativeWork
226 https://app.dimensions.ai/details/publication/pub.1082711488 schema:CreativeWork
227 https://app.dimensions.ai/details/publication/pub.1082739365 schema:CreativeWork
228 https://app.dimensions.ai/details/publication/pub.1082879435 schema:CreativeWork
229 https://app.dimensions.ai/details/publication/pub.1082963835 schema:CreativeWork
230 https://app.dimensions.ai/details/publication/pub.1083014886 schema:CreativeWork
231 https://doi.org/10.1016/j.bbmt.2008.03.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027232719
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1016/j.bbmt.2012.08.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016112762
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1016/j.exphem.2006.08.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032925227
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1016/j.exphem.2008.07.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011034757
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1016/j.immuni.2009.04.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039072658
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1016/j.transproceed.2004.12.147 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038221623
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1016/j.trim.2007.01.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032828247
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1016/s0171-2985(96)80033-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001145185
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1053/bbmt.2001.v7.pm11787529 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019263499
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1053/bbmt.2002.v8.pm11939602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018473427
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1056/nejm199608083350601 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013378490
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1056/nejmoa0904971 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051444938
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1097/00007890-198708000-00021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036467210
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1097/00007890-199702150-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060276428
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1097/00007890-200004150-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060281958
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1097/01.tp.0000164142.98167.4b schema:sameAs https://app.dimensions.ai/details/publication/pub.1010444442
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1097/01.tp.0000185299.72295.90 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022196419
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1097/01.tp.0000256158.84418.ff schema:sameAs https://app.dimensions.ai/details/publication/pub.1030121489
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1097/moh.0b013e32833eaf1b schema:sameAs https://app.dimensions.ai/details/publication/pub.1000234119
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1097/tp.0b013e3182241133 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034612737
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1097/tp.0b013e318242bddf schema:sameAs https://app.dimensions.ai/details/publication/pub.1019550174
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1111/j.1600-6143.2006.01622.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023185927
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1111/j.1600-6143.2007.01842.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011080278
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1182/blood-2004-10-3932 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046923333
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1182/blood-2007-03-079665 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007980333
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1182/blood-2011-01-332510 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028505196
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1182/blood.v98.12.3456 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015841749
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1182/blood.v99.10.3493 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044074220
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1517/14740330903037156 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045871414
288 rdf:type schema:CreativeWork
289 https://doi.org/10.3324/haematol.2011.058677 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047566206
290 rdf:type schema:CreativeWork
291 https://doi.org/10.4049/jimmunol.178.11.7018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033785474
292 rdf:type schema:CreativeWork
293 https://www.grid.ac/institutes/grid.21107.35 schema:alternateName Johns Hopkins University
294 schema:name Sidney-Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA
295 rdf:type schema:Organization
296 https://www.grid.ac/institutes/grid.279885.9 schema:alternateName National Heart Lung and Blood Institute
297 schema:name Molecular and Clinical Hematology Branch, National Heart, Lung, and Blood Institute/National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
298 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...