A variant in IRF3 impacts on the clinical outcome of AML patients submitted to Allo-SCT View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-09

AUTHORS

B Martín-Antonio, M Suarez-Lledo, M Arroyes, F Fernández-Avilés, C Martínez, M Rovira, I Espigado, D Gallardo, A Bosch, I Buño, C Martínez-Laperche, A Jiménez-Velasco, R de la Cámara, S Brunet, J B Nieto, Á Urbano-Ispizua

ABSTRACT

Allo-SCT has a strong curative potential for AML patients mainly due to a GVL effect. Unfortunately, GvL and GVHD are intimately linked. IFN regulatory factor-3 (IRF3), by modulating innate immune reactions, could impact on the incidence and intensity of GVL and GVHD. We analyzed two gene variants in IRF3 (rs7251 and rs2304205) on the clinical outcome of 249 AML patients submitted to HLA-identical sibling allo-SCT. Patients with a donor carrying the dominant GG gene variant in rs7251 had, as compared with GC and CC variants, a lower acute GVHD (aGVHD) III-IV incidence (4% vs 11% vs 27%; P=0.0078), a higher relapse incidence (49% vs 35% vs 26%; P=0.018), and lower TRM (7% vs 24% vs 18%; P=0.0065). In functional studies, the GG variant was associated with lower production of IFN-γ, decreased lymphocyte proliferation after antigen presentation by DCs, and lower cytotoxic response of mature natural killer cells. Patients carrying the AA dominant variant in rs2304205 had higher relapse incidence (50% vs 39% vs 18%, P=0.0068). The presence of both variants (GG in rs7251 and AA in rs2304205) in donors and patients resulted in a stronger clinical impact. More... »

PAGES

1205

References to SciGraph publications

  • 1995-09. MIF as a glucocorticoid-induced modulator of cytokine production in NATURE
  • 2010-12. Graft-versus-host disease is enhanced by extracellular ATP activating P2X7R in NATURE MEDICINE
  • 2012-01. Inflammasomes in health and disease in NATURE
  • 2009-12. Transplantation and innate immunity: the lesson of natural killer cells in ITALIAN JOURNAL OF PEDIATRICS
  • 2012-12. Impact of graft-versus-host disease after reduced-intensity conditioning allogeneic stem cell transplantation for acute myeloid leukemia: a report from the Acute Leukemia Working Party of the European group for blood and marrow transplantation in LEUKEMIA
  • 2012-09. A constitutional variant in the transcription factor EP300 strongly influences the clinical outcome of patients submitted to allo-SCT in BONE MARROW TRANSPLANTATION
  • 2007-05. Graft-versus-host disease in NATURE REVIEWS IMMUNOLOGY
  • 2008-04. TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β in NATURE IMMUNOLOGY
  • 2009-02. The EBMT activity survey 2007 with focus on allogeneic HSCT for AML and novel cellular therapies in BONE MARROW TRANSPLANTATION
  • 2008-04. The EBMT activity survey 2006 on hematopoietic stem cell transplantation: focus on the use of cord blood products in BONE MARROW TRANSPLANTATION
  • 2008-06. Analyzing real-time PCR data by the comparative CT method in NATURE PROTOCOLS
  • 2006-11. Interferons, immunity and cancer immunoediting in NATURE REVIEWS IMMUNOLOGY
  • 2003-10. Macrophage migration inhibitory factor: a regulator of innate immunity in NATURE REVIEWS IMMUNOLOGY
  • 2012-07. Cross-interference of RLR and TLR signaling pathways modulates antibacterial T cell responses in NATURE IMMUNOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/bmt.2013.43

    DOI

    http://dx.doi.org/10.1038/bmt.2013.43

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1025166429

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23542224


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