Azacitidine salvage therapy for relapse of myeloid malignancies following allogeneic hematopoietic SCT View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-04

AUTHORS

B Tessoulin, J Delaunay, P Chevallier, M Loirat, S Ayari, P Peterlin, S Le Gouill, T Gastinne, P Moreau, M Mohty, T Guillaume

ABSTRACT

Patients with hematopoietic malignancies relapsing after allogeneic hematopoietic SCT (allo-HSCT) have a poor prognosis. We retrospectively analyzed the patients who received azacitidine in our center in the course of treatment of their post-transplant relapse. We identified 31 patients. Relapse occurred at a median of 3.7 (1.7-37.6) months following allo-HSCT. Patients received a median number of three cycles (1-12) of azacitidine (7 days, 75 mg/m(2) daily). Thirty-nine percent of patients had either a monosomal karyotype or a complex karyotype. Eleven patients (35%) received at least one DLI. Eleven patients responded to azacitidine, with four patients achieving a CR (13%). Median time to best response was 92 (35-247) days, with a median duration of 209 (64-751) days. One-year estimated survival rate was 14%. In conclusion, azacitidine may reinduce durable remissions in very few patients with AML or myelodysplastic syndrome. The toxicity related to azacitidine was high, although it may be difficult to distinguish between treatment-related side effects, namely due to cytopenia and toxicity due to the relapse or disease progression itself. Early administration of azacitidine after transplant followed by DLI should be considered as a pre-emptive therapy for potential relapse in patients with minimal residual disease or high-risk myeloid malignancies. More... »

PAGES

567

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/bmt.2013.233

    DOI

    http://dx.doi.org/10.1038/bmt.2013.233

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1048090912

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24488048


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