Unmanipulated haploidentical BMT following non-myeloablative conditioning and post-transplantation CY for advanced Hodgkin’s lymphoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-11-04

AUTHORS

A Raiola, A Dominietto, R Varaldo, A Ghiso, F Galaverna, S Bramanti, E Todisco, B Sarina, L Giordano, A Ibatici, A Santoro, M Clavio, A Bacigalupo, L Castagna

ABSTRACT

Twenty-six patients with advanced Hodgkin’s disease received a related HLA haploidentical unmanipulated BMT, following a non-myeloablative conditioning with low-dose TBI, proposed by the Baltimore group; GvHD prophylaxis consisted of high-dose post-transplantation CY (PT-CY), mycophenolate and a calcineurin inhibitor. All patients had received a previous autograft, and 65% had active disease at the time of BMT. Sustained engraftment of donor cells occurred in 25 patients (96%), with a median time to neutrophil recovery (>0.5 × 109/L) and platelet recovery (>20 × 109/L) of +18 and +23 days from BMT. The incidence of grade II–IV acute GVHD and of chronic GVHD was 24% and 8%, respectively. With a median follow-up of 24 months (range 18–44) 21 patients are alive, 20 disease free. The cumulative incidence of TRM and relapse was 4% and 31%, respectively. The actuarial 3-year survival is 77%, the actuarial 3-year PFS is 63%. In conclusion, we confirm that high-dose PT-CY is effective as prophylaxis of GVHD after HLA haploidentical BMT, can prevent rejection and does not appear to eliminate the allogeneic graft versus lymphoma effect. More... »

PAGES

190-194

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bmt.2013.166

DOI

http://dx.doi.org/10.1038/bmt.2013.166

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004741171

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24185585


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