Impact of HLA mismatch direction on outcomes after umbilical cord blood transplantation for hematological malignant disorders: a retrospective Eurocord-EBMT analysis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-08-19

AUTHORS

R Cunha, P Loiseau, A Ruggeri, G Sanz, G Michel, A PaolaIori, G Socié, W Arcese, A Picardi, C Dias de Heredia, B Rio, F Locatelli, T A O'Brien, I Yakoub-Agha, M Angel Diaz, N Milpied, H Bittencourt, M Pedro Souza, M Aljurf, D Charron, K Boudjedir, M Labopin, E Gluckman, V Rocha

ABSTRACT

HLA matching is a critical determinant of outcomes for patients who have undergone umbilical cord blood transplantation (UCBT). Data have been published on the importance of donor/recipient HLA mismatch direction on UCBT outcomes. HLA mismatch in the graft-versus-host (GVH) direction is defined as a donor homozygous at an HLA locus, while the recipient shares one HLA Ag with the donor. HLA mismatch in the host-versus-graft (HVG) direction is defined as a recipient homozygous with the donor sharing one HLA Ag. In our study we focused on confirming, using an independent population, whether transplantation outcomes would be different when HLA mismatch direction was considered. We analyzed 1565 patients who received a single-unit UCBT for malignant disease. Median age was 15 years and 72% of patients were transplanted for leukemia. In multivariate analysis, using the 5/6 HLA-matched population as reference, one or two HLA mismatches in the GVH or HVG direction were not associated with non-relapse related mortality and survival. On the basis of our results, there is no evidence to support a change in the current practice for cord blood unit selection. More... »

PAGES

24-29

Journal

TITLE

Bone Marrow Transplantation

ISSUE

1

VOLUME

49

Author Affiliations

  • Eurocord, Hôpital Saint Louis, Paris, France
  • Service d’Immunologie et Histocompatibilité, Hôpital Saint-Louis, AP-HP and Inserm UMRS940, Paris, France
  • Hospital Universitario La Fe, Servicio de Hematologia, Valencia, Spain
  • Hôpital Timone-Enfants, Service Hématologie Pédiatrique, Marseille, France
  • Department of Biotecnologie Cellulari ed Ematologia, Università La Sapienza, Rome, Italy
  • Bone Marrow Transplant Unit, Hôpital Saint Louis, Paris, France
  • Rome Transplant Network, Bone Marrow Transplant Unit, Policlinico Universitario Tor Vergata, Rome, Italy
  • Hospital Vall d'Hebron, Servicio de Hematologia Pediatrica, Barcelona, Spain
  • Hotel Dieu, Service Hématologie, Paris, France
  • Dipartimento di Oncoematologia Pediatrica, Fondazione IRCCS Policlinico San Matteo, IRCCS Ospedale Bambino Gesù and University of Pavia, Rome, Italy
  • Cord & Marrow Transplant Program, Sydney Children's Hospital, Sydney, Australia
  • Hôpital Claude Huriez, Service Hématologie, Lille, France
  • Jesus Children's Hospital, Madrid, Spain
  • CHU Bordeaux, Service Hématologie, Pessac, France
  • Ste-Justine Hospital, Pediatric Hematology Unit, Montreal, Canada
  • Hospital Amaral Carvalho, Bone Marrow Transplant Unit, Jau, Brazil
  • King Faisal Specialist Hospital & Research Centre, Bone Marrow Transplant Unit, Ryad, Saudi Arabia
  • Acute Leukemia Working Party of the European Blood and Marrow Transplant Group, Hôpital Saint Antoine, Université de Paris 7, Service Hématologie, Paris, France
  • Churchill Hospital, Hematology Unit, University of Oxford, Oxford, UK
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/bmt.2013.120

    DOI

    http://dx.doi.org/10.1038/bmt.2013.120

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1019724737

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23955634


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