Extensive chronic GVHD is associated with donor blood CD34+ cell count after G-CSF mobilization in non-myeloablative allogeneic PBSC transplantation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-05-21

AUTHORS

N Dhédin, T Prébet, R Peffault De Latour, S Katsahian, M Kuentz, N Piard, D Réa, F Norol, J P Jouet, J A Ribeil, R Tabrizi, B Rio, B Lioure, P Tiberghien, J H Bourhis, A Sirvent, P Bordigoni, D Blaise, M Michallet, J P Vernant

ABSTRACT

The correlation between the incidence of GVHD and the number of infused CD34+ cells remains controversial for PBSC transplantation after a reduced-intensity-conditioning (RIC) regimen. We evaluated 99 patients transplanted with an HLA-identical sibling after the same RIC (2-Gy-TBI/fludarabine). Donor and recipient characteristics, donor’s blood G-CSF-mobilized CD34+ cell count, and number of infused CD34+ and CD3+ cells were analyzed as risk factors for acute and chronic GVHD There was a trend for an increased incidence of extensive chronic GVHD in the quartile of patients receiving more than 10 × 106 CD34+ cells/kg (P=0.05). Interestingly, the number of donor's blood CD34+ cells at day 5 of G-CSF mobilization was closely associated with the incidence of extensive chronic GVHD, that is, 48% (95% CI: 28–68) at 24-months in the quartile of patients whose donors had the highest CD34+ cell counts versus 24.3% (95% CI: 14–34) in the other patients (P=0.007). In multivariate analysis, the only factor correlating with extensive chronic GVHD (cGVHD) was the donor’s blood CD34+ cell count after G-CSF (HR 2.49; 95% CI: 1.16–5.35, P=0.019). This study shows that the incidence of cGVHD is more strongly associated with the donor's ability to mobilize CD34+ cells than with the number of infused CD34+ cells. More... »

PAGES

1564-1568

Journal

TITLE

Bone Marrow Transplantation

ISSUE

12

VOLUME

47

Author Affiliations

  • Service de Greffe de Moelle, Unité Adolescents et Jeunes Adultes (AJA), Paris, France
  • Unité de Transplantation, Médullaire Institut Paoli Calmettes, Marseille, France
  • Service de Greffe de Moelle, Hôpital Saint-Louis, Paris, France
  • Unité de Biostatistique, Hôpital Henri Mondor, Creteil, France
  • Service d’Hématologie, Hôpital Henri Mondor, Creteil, France
  • Etablissement Français du Sang, Pays de la Loire-Site d’Angers, Angers, France
  • Unité de Thérapie Cellulaire et de Clinique Transfusionnelle, Hôpital Saint-Louis, Paris, France
  • Centre de Transfusion Sanguine, Groupe, Hospitalier, Pitié-Salpêtrière, Paris, France
  • Service des Maladies du Sang, Hôpital Claude Huriez CHRU, Lille, France
  • Département de biothérapie, Groupe Hospitalier Necker-Enfants Malades, Paris, France
  • Service des Maladies du Sang, GH du Haut Levêque, Pessac, France
  • Service d’Hématologie, Hôtel Dieu, Paris, France
  • Service d’Onco-Hématologie, CHU Hautepierre, Strasbourg, France
  • Unité de Thérapie Cellulaire, Etablissement Français du sang, Bourgogne Franche-Comté, Besancon, France
  • Service d’Hématologie, Institut Gustave Roussy, Villejuif, France
  • Service d’Hématologie et d’Oncologie Médicale Hôpital Lapeyronie CHU Avenue du Doyen Giraud, Montpellier, France
  • Unité de Transplantation Médullaire, Hôpital Brabois- Hôpital d’Enfants, Nancy, France
  • Unité de Transplantation Médullaire, Institut Paoli Calmettes, Marseille, France
  • Service d’Hématologie Pavillon E, Hôpital Edouard Herriot 5, Lyon, France
  • Service d’Hématologie GH Pitié-Salpêtrière, Paris, France
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/bmt.2012.75

    DOI

    http://dx.doi.org/10.1038/bmt.2012.75

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1006774435

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22609881


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