The anti-tumour activity of allogeneic cytokine-induced killer cells in patients who relapse after allogeneic transplant for haematological malignancies View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-07

AUTHORS

Y-C Linn, M Niam, S Chu, A Choong, H-X Yong, K-K Heng, W Hwang, Y Loh, Y-T Goh, G Suck, M Chan, M Koh

ABSTRACT

We performed a Phase I/II clinical trial to study the feasibility, toxicity and efficacy of allogeneic cytokine-induced killer (CIK) cell expansion, and treatment for patients with haematological malignancies who relapsed after allogeneic haemopoietic SCT (allo-HSCT). Allogeneic CIK cells were successfully generated for a total of 24 patients, including those from patients' own leukapheresis products in 5 patients who had no access to further donor cells. The median CD3(+) T-cell expansion was 9.33 (1.3-38.97) fold, and CD3(+)CD56(+) natural killer (NK)-like T-cell expansion was 27.77 (2.59-438.93) fold. A total of 55 infusions were done for 16 patients who had either failed or progressed after initial response to various individualized chemotherapy regimens and donor lymphocyte infusion (DLI), at doses ranging from 10 to 200 million CD3(+) cells/kg. Response attributable to CIK cell infusion was observed in five patients. These included two with ALL, two with Hodgkin's disease (HD) and one with AML, and two of whom had a response sustained for more than 2 years. Acute GVHD occurred in three and was easily treatable. This study provides some evidence suggestive of the efficacy of allogeneic CIK cells even after failure of DLI in some cases. More... »

PAGES

bmt2011202

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bmt.2011.202

DOI

http://dx.doi.org/10.1038/bmt.2011.202

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020019359

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21986635


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytokine-Induced Killer Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hematologic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hematopoietic Stem Cell Transplantation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunotherapy, Adoptive", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recurrence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Singapore General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.163555.1", 
          "name": [
            "Department of Haematology, Singapore General Hospital, Singapore"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Linn", 
        "givenName": "Y-C", 
        "id": "sg:person.01060376017.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060376017.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Health Sciences Authority", 
          "id": "https://www.grid.ac/institutes/grid.413898.f", 
          "name": [
            "Cell Therapy Facility, Blood Services Group, Health Sciences Authority, Singapore"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Niam", 
        "givenName": "M", 
        "id": "sg:person.01107134021.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107134021.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Health Sciences Authority", 
          "id": "https://www.grid.ac/institutes/grid.413898.f", 
          "name": [
            "Cell Therapy Facility, Blood Services Group, Health Sciences Authority, Singapore"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chu", 
        "givenName": "S", 
        "id": "sg:person.01167077626.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167077626.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Health Sciences Authority", 
          "id": "https://www.grid.ac/institutes/grid.413898.f", 
          "name": [
            "Cell Therapy Facility, Blood Services Group, Health Sciences Authority, Singapore"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Choong", 
        "givenName": "A", 
        "id": "sg:person.0662320121.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662320121.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Singapore General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.163555.1", 
          "name": [
            "Department of Haematology, Singapore General Hospital, Singapore"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yong", 
        "givenName": "H-X", 
        "id": "sg:person.0772705421.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772705421.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Singapore General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.163555.1", 
          "name": [
            "Department of Haematology, Singapore General Hospital, Singapore"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Heng", 
        "givenName": "K-K", 
        "id": "sg:person.01066772356.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066772356.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Singapore General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.163555.1", 
          "name": [
            "Department of Haematology, Singapore General Hospital, Singapore"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hwang", 
        "givenName": "W", 
        "id": "sg:person.015476702652.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015476702652.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Singapore General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.163555.1", 
          "name": [
            "Department of Haematology, Singapore General Hospital, Singapore"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Loh", 
        "givenName": "Y", 
        "id": "sg:person.014332116022.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014332116022.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Singapore General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.163555.1", 
          "name": [
            "Department of Haematology, Singapore General Hospital, Singapore"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Goh", 
        "givenName": "Y-T", 
        "id": "sg:person.0745266775.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745266775.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Health Sciences Authority", 
          "id": "https://www.grid.ac/institutes/grid.413898.f", 
          "name": [
            "Cell Therapy Facility, Blood Services Group, Health Sciences Authority, Singapore"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Suck", 
        "givenName": "G", 
        "id": "sg:person.0736422626.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736422626.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Health Sciences Authority", 
          "id": "https://www.grid.ac/institutes/grid.413898.f", 
          "name": [
            "Cell Therapy Facility, Blood Services Group, Health Sciences Authority, Singapore"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chan", 
        "givenName": "M", 
        "id": "sg:person.01116636221.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116636221.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St George's, University of London", 
          "id": "https://www.grid.ac/institutes/grid.264200.2", 
          "name": [
            "Cell Therapy Facility, Blood Services Group, Health Sciences Authority, Singapore", 
            "Department of Haematology, St. George's Hospital and Medical School, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Koh", 
        "givenName": "M", 
        "id": "sg:person.014024057622.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014024057622.17"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1006/mthe.2000.0230", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000471662"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2005-08-3373", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001741322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2003-05-1513", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003184259"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbmt.2007.04.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003493786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2567.2008.02910.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004524332"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00262-004-0505-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005983349", 
          "https://doi.org/10.1007/s00262-004-0505-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2009.24.4590", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009308039"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00262-007-0333-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014677340", 
          "https://doi.org/10.1007/s00262-007-0333-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00262-007-0333-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014677340", 
          "https://doi.org/10.1007/s00262-007-0333-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci25427", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014970383"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3324/haematol.2010.025890", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018009696"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bmt.1705393", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020689372", 
          "https://doi.org/10.1038/sj.bmt.1705393"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bmt.1705393", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020689372", 
          "https://doi.org/10.1038/sj.bmt.1705393"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/cimm.1996.0094", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024041764"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.00.240", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027315638"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-05-2019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029357120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2007-06-092817", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033486629"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.exphem.2011.06.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033772647"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.exphem.2006.05.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035847787"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2141.2002.03247.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038533664"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2141.2003.04728.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041726847"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2006.09.2403", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045509899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.174.1.139", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046330449"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2010-06-290858", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046457918"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1083-8791(01)70014-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046522765"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bmt.1705503", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049508282", 
          "https://doi.org/10.1038/sj.bmt.1705503"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3324/haematol.11132", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050275844"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2004-07-2974", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052161772"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.01.1031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052897396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.01.1031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052897396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.20668", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053297375"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.20.3.674", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064202783"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2000.18.16.3031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074684757"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2001.19.8.2142", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074800002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074894431", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077620906", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078571177", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082395981", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082452272", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1997.15.2.433", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083054534"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083335841", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-07", 
    "datePublishedReg": "2012-07-01", 
    "description": "We performed a Phase I/II clinical trial to study the feasibility, toxicity and efficacy of allogeneic cytokine-induced killer (CIK) cell expansion, and treatment for patients with haematological malignancies who relapsed after allogeneic haemopoietic SCT (allo-HSCT). Allogeneic CIK cells were successfully generated for a total of 24 patients, including those from patients' own leukapheresis products in 5 patients who had no access to further donor cells. The median CD3(+) T-cell expansion was 9.33 (1.3-38.97) fold, and CD3(+)CD56(+) natural killer (NK)-like T-cell expansion was 27.77 (2.59-438.93) fold. A total of 55 infusions were done for 16 patients who had either failed or progressed after initial response to various individualized chemotherapy regimens and donor lymphocyte infusion (DLI), at doses ranging from 10 to 200 million CD3(+) cells/kg. Response attributable to CIK cell infusion was observed in five patients. These included two with ALL, two with Hodgkin's disease (HD) and one with AML, and two of whom had a response sustained for more than 2 years. Acute GVHD occurred in three and was easily treatable. This study provides some evidence suggestive of the efficacy of allogeneic CIK cells even after failure of DLI in some cases.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/bmt.2011.202", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1096890", 
        "issn": [
          "0268-3369", 
          "1476-5365"
        ], 
        "name": "Bone Marrow Transplantation", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "47"
      }
    ], 
    "name": "The anti-tumour activity of allogeneic cytokine-induced killer cells in patients who relapse after allogeneic transplant for haematological malignancies", 
    "pagination": "bmt2011202", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "5f627084198a17fc9c568d9353c5b3c7c2fc7973fbb946a0d2047377c1169f41"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21986635"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8702459"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/bmt.2011.202"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1020019359"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/bmt.2011.202", 
      "https://app.dimensions.ai/details/publication/pub.1020019359"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T19:45", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000424.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/bmt2011202"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/bmt.2011.202'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/bmt.2011.202'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/bmt.2011.202'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/bmt.2011.202'


 

This table displays all metadata directly associated to this object as RDF triples.

309 TRIPLES      21 PREDICATES      78 URIs      32 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/bmt.2011.202 schema:about N032423ac33f84373b611a262b0c812dc
2 N06cd86ab7a05479ba2e782dea3569687
3 N1a610cfa04a343879d0ee417db834e02
4 N1e07dc22c5aa427d92ea0fb25361cba3
5 N20f43ecc1971461db6b8f2056fa13cb7
6 N664d3c3fd985445ca30107ecd3277ab7
7 N6b4dcb1f50ab4640b4087735e8cba16d
8 N838dc23c90954f7880f5488f8fecc5ce
9 Na280b11ae5fa45de8e0b53fc08d2446c
10 Necf6bde37d9a439c8c17f13d5b4786b8
11 Nf9df248e9a624f9a906e41b402cd9e16
12 anzsrc-for:11
13 anzsrc-for:1103
14 schema:author N2d90e88f981545b9a0adcf4fa881c57e
15 schema:citation sg:pub.10.1007/s00262-004-0505-0
16 sg:pub.10.1007/s00262-007-0333-0
17 sg:pub.10.1038/sj.bmt.1705393
18 sg:pub.10.1038/sj.bmt.1705503
19 https://app.dimensions.ai/details/publication/pub.1074894431
20 https://app.dimensions.ai/details/publication/pub.1077620906
21 https://app.dimensions.ai/details/publication/pub.1078571177
22 https://app.dimensions.ai/details/publication/pub.1082395981
23 https://app.dimensions.ai/details/publication/pub.1082452272
24 https://app.dimensions.ai/details/publication/pub.1083335841
25 https://doi.org/10.1002/cncr.20668
26 https://doi.org/10.1006/cimm.1996.0094
27 https://doi.org/10.1006/mthe.2000.0230
28 https://doi.org/10.1016/j.bbmt.2007.04.013
29 https://doi.org/10.1016/j.exphem.2006.05.004
30 https://doi.org/10.1016/j.exphem.2011.06.005
31 https://doi.org/10.1016/s1083-8791(01)70014-6
32 https://doi.org/10.1046/j.1365-2141.2002.03247.x
33 https://doi.org/10.1046/j.1365-2141.2003.04728.x
34 https://doi.org/10.1084/jem.174.1.139
35 https://doi.org/10.1111/j.1365-2567.2008.02910.x
36 https://doi.org/10.1158/1078-0432.ccr-05-2019
37 https://doi.org/10.1172/jci25427
38 https://doi.org/10.1182/blood-2003-05-1513
39 https://doi.org/10.1182/blood-2004-07-2974
40 https://doi.org/10.1182/blood-2005-08-3373
41 https://doi.org/10.1182/blood-2007-06-092817
42 https://doi.org/10.1182/blood-2010-06-290858
43 https://doi.org/10.1200/jco.1997.15.2.433
44 https://doi.org/10.1200/jco.20.3.674
45 https://doi.org/10.1200/jco.2000.18.16.3031
46 https://doi.org/10.1200/jco.2001.19.8.2142
47 https://doi.org/10.1200/jco.2005.00.240
48 https://doi.org/10.1200/jco.2005.01.1031
49 https://doi.org/10.1200/jco.2006.09.2403
50 https://doi.org/10.1200/jco.2009.24.4590
51 https://doi.org/10.3324/haematol.11132
52 https://doi.org/10.3324/haematol.2010.025890
53 schema:datePublished 2012-07
54 schema:datePublishedReg 2012-07-01
55 schema:description We performed a Phase I/II clinical trial to study the feasibility, toxicity and efficacy of allogeneic cytokine-induced killer (CIK) cell expansion, and treatment for patients with haematological malignancies who relapsed after allogeneic haemopoietic SCT (allo-HSCT). Allogeneic CIK cells were successfully generated for a total of 24 patients, including those from patients' own leukapheresis products in 5 patients who had no access to further donor cells. The median CD3(+) T-cell expansion was 9.33 (1.3-38.97) fold, and CD3(+)CD56(+) natural killer (NK)-like T-cell expansion was 27.77 (2.59-438.93) fold. A total of 55 infusions were done for 16 patients who had either failed or progressed after initial response to various individualized chemotherapy regimens and donor lymphocyte infusion (DLI), at doses ranging from 10 to 200 million CD3(+) cells/kg. Response attributable to CIK cell infusion was observed in five patients. These included two with ALL, two with Hodgkin's disease (HD) and one with AML, and two of whom had a response sustained for more than 2 years. Acute GVHD occurred in three and was easily treatable. This study provides some evidence suggestive of the efficacy of allogeneic CIK cells even after failure of DLI in some cases.
56 schema:genre research_article
57 schema:inLanguage en
58 schema:isAccessibleForFree true
59 schema:isPartOf N4f483e7af1f74f0fad885e3d6433425e
60 N7aa74afbcb754582be130151d23a7265
61 sg:journal.1096890
62 schema:name The anti-tumour activity of allogeneic cytokine-induced killer cells in patients who relapse after allogeneic transplant for haematological malignancies
63 schema:pagination bmt2011202
64 schema:productId N3c3760e2f48e4f0599ca1a271195dd88
65 N4c990407f9e54e4386b25c39a2617749
66 N5e000287c86c45a0b0914dbba24ae4c2
67 Nbcd35f780b384e998daaf6c10ceb0fad
68 Ne3ae6a7969454d6cbad4a4a15f2770da
69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020019359
70 https://doi.org/10.1038/bmt.2011.202
71 schema:sdDatePublished 2019-04-10T19:45
72 schema:sdLicense https://scigraph.springernature.com/explorer/license/
73 schema:sdPublisher N3de441131e594dcfa66251c6f865a565
74 schema:url http://www.nature.com/articles/bmt2011202
75 sgo:license sg:explorer/license/
76 sgo:sdDataset articles
77 rdf:type schema:ScholarlyArticle
78 N032423ac33f84373b611a262b0c812dc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Cytokine-Induced Killer Cells
80 rdf:type schema:DefinedTerm
81 N06cd86ab7a05479ba2e782dea3569687 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Middle Aged
83 rdf:type schema:DefinedTerm
84 N0ab8b121f2134dd6b7cca98ed3350330 rdf:first sg:person.01107134021.30
85 rdf:rest Nf3a4bd24017242709259b76967abba68
86 N1991803bd44c4da3b12ce017e44f8a04 rdf:first sg:person.01066772356.28
87 rdf:rest Ncbd9d25ce99f4a479063f626d1f09a65
88 N1a610cfa04a343879d0ee417db834e02 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Immunotherapy, Adoptive
90 rdf:type schema:DefinedTerm
91 N1e07dc22c5aa427d92ea0fb25361cba3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Male
93 rdf:type schema:DefinedTerm
94 N20f43ecc1971461db6b8f2056fa13cb7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Hematologic Neoplasms
96 rdf:type schema:DefinedTerm
97 N2d90e88f981545b9a0adcf4fa881c57e rdf:first sg:person.01060376017.76
98 rdf:rest N0ab8b121f2134dd6b7cca98ed3350330
99 N3c3760e2f48e4f0599ca1a271195dd88 schema:name nlm_unique_id
100 schema:value 8702459
101 rdf:type schema:PropertyValue
102 N3de441131e594dcfa66251c6f865a565 schema:name Springer Nature - SN SciGraph project
103 rdf:type schema:Organization
104 N4c990407f9e54e4386b25c39a2617749 schema:name pubmed_id
105 schema:value 21986635
106 rdf:type schema:PropertyValue
107 N4f483e7af1f74f0fad885e3d6433425e schema:volumeNumber 47
108 rdf:type schema:PublicationVolume
109 N51a37101fb1349e7a7aa8d032d4dfc1e rdf:first sg:person.014024057622.17
110 rdf:rest rdf:nil
111 N5986f570466b431e996fe1c45b968a4e rdf:first sg:person.0736422626.26
112 rdf:rest N85a5499bdddc4d898c3471c418474b42
113 N5e000287c86c45a0b0914dbba24ae4c2 schema:name dimensions_id
114 schema:value pub.1020019359
115 rdf:type schema:PropertyValue
116 N664d3c3fd985445ca30107ecd3277ab7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Young Adult
118 rdf:type schema:DefinedTerm
119 N6b4dcb1f50ab4640b4087735e8cba16d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Hematopoietic Stem Cell Transplantation
121 rdf:type schema:DefinedTerm
122 N731640b15d4b43858319690fb5bb4226 rdf:first sg:person.0662320121.58
123 rdf:rest N8ceaa6f2cb93417ab1016cdc85806849
124 N7aa74afbcb754582be130151d23a7265 schema:issueNumber 7
125 rdf:type schema:PublicationIssue
126 N838dc23c90954f7880f5488f8fecc5ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Recurrence
128 rdf:type schema:DefinedTerm
129 N85a5499bdddc4d898c3471c418474b42 rdf:first sg:person.01116636221.11
130 rdf:rest N51a37101fb1349e7a7aa8d032d4dfc1e
131 N8ceaa6f2cb93417ab1016cdc85806849 rdf:first sg:person.0772705421.36
132 rdf:rest N1991803bd44c4da3b12ce017e44f8a04
133 N97dd1ee1adb54e2aa7ee73a6967ee1a5 rdf:first sg:person.014332116022.48
134 rdf:rest Ne435ea02968a441db16494886f590834
135 Na280b11ae5fa45de8e0b53fc08d2446c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Humans
137 rdf:type schema:DefinedTerm
138 Nbcd35f780b384e998daaf6c10ceb0fad schema:name doi
139 schema:value 10.1038/bmt.2011.202
140 rdf:type schema:PropertyValue
141 Ncbd9d25ce99f4a479063f626d1f09a65 rdf:first sg:person.015476702652.66
142 rdf:rest N97dd1ee1adb54e2aa7ee73a6967ee1a5
143 Ne3ae6a7969454d6cbad4a4a15f2770da schema:name readcube_id
144 schema:value 5f627084198a17fc9c568d9353c5b3c7c2fc7973fbb946a0d2047377c1169f41
145 rdf:type schema:PropertyValue
146 Ne435ea02968a441db16494886f590834 rdf:first sg:person.0745266775.35
147 rdf:rest N5986f570466b431e996fe1c45b968a4e
148 Necf6bde37d9a439c8c17f13d5b4786b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Adult
150 rdf:type schema:DefinedTerm
151 Nf3a4bd24017242709259b76967abba68 rdf:first sg:person.01167077626.23
152 rdf:rest N731640b15d4b43858319690fb5bb4226
153 Nf9df248e9a624f9a906e41b402cd9e16 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Female
155 rdf:type schema:DefinedTerm
156 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
157 schema:name Medical and Health Sciences
158 rdf:type schema:DefinedTerm
159 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
160 schema:name Clinical Sciences
161 rdf:type schema:DefinedTerm
162 sg:journal.1096890 schema:issn 0268-3369
163 1476-5365
164 schema:name Bone Marrow Transplantation
165 rdf:type schema:Periodical
166 sg:person.01060376017.76 schema:affiliation https://www.grid.ac/institutes/grid.163555.1
167 schema:familyName Linn
168 schema:givenName Y-C
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060376017.76
170 rdf:type schema:Person
171 sg:person.01066772356.28 schema:affiliation https://www.grid.ac/institutes/grid.163555.1
172 schema:familyName Heng
173 schema:givenName K-K
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066772356.28
175 rdf:type schema:Person
176 sg:person.01107134021.30 schema:affiliation https://www.grid.ac/institutes/grid.413898.f
177 schema:familyName Niam
178 schema:givenName M
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107134021.30
180 rdf:type schema:Person
181 sg:person.01116636221.11 schema:affiliation https://www.grid.ac/institutes/grid.413898.f
182 schema:familyName Chan
183 schema:givenName M
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116636221.11
185 rdf:type schema:Person
186 sg:person.01167077626.23 schema:affiliation https://www.grid.ac/institutes/grid.413898.f
187 schema:familyName Chu
188 schema:givenName S
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167077626.23
190 rdf:type schema:Person
191 sg:person.014024057622.17 schema:affiliation https://www.grid.ac/institutes/grid.264200.2
192 schema:familyName Koh
193 schema:givenName M
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014024057622.17
195 rdf:type schema:Person
196 sg:person.014332116022.48 schema:affiliation https://www.grid.ac/institutes/grid.163555.1
197 schema:familyName Loh
198 schema:givenName Y
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014332116022.48
200 rdf:type schema:Person
201 sg:person.015476702652.66 schema:affiliation https://www.grid.ac/institutes/grid.163555.1
202 schema:familyName Hwang
203 schema:givenName W
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015476702652.66
205 rdf:type schema:Person
206 sg:person.0662320121.58 schema:affiliation https://www.grid.ac/institutes/grid.413898.f
207 schema:familyName Choong
208 schema:givenName A
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662320121.58
210 rdf:type schema:Person
211 sg:person.0736422626.26 schema:affiliation https://www.grid.ac/institutes/grid.413898.f
212 schema:familyName Suck
213 schema:givenName G
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736422626.26
215 rdf:type schema:Person
216 sg:person.0745266775.35 schema:affiliation https://www.grid.ac/institutes/grid.163555.1
217 schema:familyName Goh
218 schema:givenName Y-T
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745266775.35
220 rdf:type schema:Person
221 sg:person.0772705421.36 schema:affiliation https://www.grid.ac/institutes/grid.163555.1
222 schema:familyName Yong
223 schema:givenName H-X
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772705421.36
225 rdf:type schema:Person
226 sg:pub.10.1007/s00262-004-0505-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005983349
227 https://doi.org/10.1007/s00262-004-0505-0
228 rdf:type schema:CreativeWork
229 sg:pub.10.1007/s00262-007-0333-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014677340
230 https://doi.org/10.1007/s00262-007-0333-0
231 rdf:type schema:CreativeWork
232 sg:pub.10.1038/sj.bmt.1705393 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020689372
233 https://doi.org/10.1038/sj.bmt.1705393
234 rdf:type schema:CreativeWork
235 sg:pub.10.1038/sj.bmt.1705503 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049508282
236 https://doi.org/10.1038/sj.bmt.1705503
237 rdf:type schema:CreativeWork
238 https://app.dimensions.ai/details/publication/pub.1074894431 schema:CreativeWork
239 https://app.dimensions.ai/details/publication/pub.1077620906 schema:CreativeWork
240 https://app.dimensions.ai/details/publication/pub.1078571177 schema:CreativeWork
241 https://app.dimensions.ai/details/publication/pub.1082395981 schema:CreativeWork
242 https://app.dimensions.ai/details/publication/pub.1082452272 schema:CreativeWork
243 https://app.dimensions.ai/details/publication/pub.1083335841 schema:CreativeWork
244 https://doi.org/10.1002/cncr.20668 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053297375
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1006/cimm.1996.0094 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024041764
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1006/mthe.2000.0230 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000471662
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1016/j.bbmt.2007.04.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003493786
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1016/j.exphem.2006.05.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035847787
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1016/j.exphem.2011.06.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033772647
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1016/s1083-8791(01)70014-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046522765
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1046/j.1365-2141.2002.03247.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038533664
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1046/j.1365-2141.2003.04728.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041726847
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1084/jem.174.1.139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046330449
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1111/j.1365-2567.2008.02910.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004524332
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1158/1078-0432.ccr-05-2019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029357120
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1172/jci25427 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014970383
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1182/blood-2003-05-1513 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003184259
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1182/blood-2004-07-2974 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052161772
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1182/blood-2005-08-3373 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001741322
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1182/blood-2007-06-092817 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033486629
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1182/blood-2010-06-290858 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046457918
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1200/jco.1997.15.2.433 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083054534
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1200/jco.20.3.674 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064202783
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1200/jco.2000.18.16.3031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074684757
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1200/jco.2001.19.8.2142 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074800002
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1200/jco.2005.00.240 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027315638
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1200/jco.2005.01.1031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052897396
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1200/jco.2006.09.2403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045509899
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1200/jco.2009.24.4590 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009308039
295 rdf:type schema:CreativeWork
296 https://doi.org/10.3324/haematol.11132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050275844
297 rdf:type schema:CreativeWork
298 https://doi.org/10.3324/haematol.2010.025890 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018009696
299 rdf:type schema:CreativeWork
300 https://www.grid.ac/institutes/grid.163555.1 schema:alternateName Singapore General Hospital
301 schema:name Department of Haematology, Singapore General Hospital, Singapore
302 rdf:type schema:Organization
303 https://www.grid.ac/institutes/grid.264200.2 schema:alternateName St George's, University of London
304 schema:name Cell Therapy Facility, Blood Services Group, Health Sciences Authority, Singapore
305 Department of Haematology, St. George's Hospital and Medical School, London, UK
306 rdf:type schema:Organization
307 https://www.grid.ac/institutes/grid.413898.f schema:alternateName Health Sciences Authority
308 schema:name Cell Therapy Facility, Blood Services Group, Health Sciences Authority, Singapore
309 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...