Hepatic veno-occlusive disease in children after hematopoietic stem cell transplantation: incidence, risk factors, and outcome View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-08

AUTHORS

S H Lee, K H Yoo, K W Sung, H H Koo, Y J Kwon, M M Kwon, H J Park, B-K Park, Y Y Kim, J A Park, H J Im, J J Seo, H J Kang, H Y Shin, H S Ahn

ABSTRACT

Four hundred and sixty-seven hematopoietic stem cell transplantations (HSCTs) (217 autologous and 250 allogeneic HSCT) were performed in 374 children at four pediatric HSCT centers in Korea from January 2005 to December 2007. Among 467 transplants, veno-occlusive disease (VOD) developed in 72 transplants (15.4%) at a median of 10 days after HSCT. Multivariate analysis showed that BU or TBI-containing regimen (P=0.002), VOD prophylaxis without lipo-prostaglandin E1 (PGE1) (P=0.012), number of previous HSCT (P=0.014), and pretransplant serum ferritin (P=0.018) were independent risk factors for developing VOD. Mean serum ferritin levels were significantly higher in HSCT with VOD (2109.6+/-2842.5 ng/ml) than in HSCT without VOD (1315.9+/-1094.4 ng/ml) (P<0.001). The relative risk of death within 100 days of HSCT in transplants with VOD compared with transplants without VOD was 3.39 (confidence interval: 1.78-6.45). Our results suggest that lipo-PGE1 might have a protective effect against the development of VOD, and pretransplant serum ferritin could act as a risk factor for VOD. A larger prospective study is needed to confirm a possible role of lipo-PGE1 and iron chelation therapy in reducing the incidence of VOD. More... »

PAGES

1287

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/bmt.2009.349

    DOI

    http://dx.doi.org/10.1038/bmt.2009.349

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1040637657

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20010866


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