Impact of germinal center and non-germinal center phenotypes on overall and failure-free survival after high-dose chemotherapy and auto-SCT in primary ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-07

AUTHORS

H Nyman, E Jantunen, E Juvonen, E Elonen, J Böhm, V-M Kosma, G Enblad, M-L Karjalainen-Lindsberg, S Leppä

ABSTRACT

Non-germinal center (non-GC) phenotype is an adverse prognostic factor in chemotherapy (CT)-treated diffuse large B-cell lymphoma (DLBCL) patients. To determine how high-dose therapy (HDT) supported with auto-SCT as first line therapy influences GC-associated outcome in young high-risk DLBCL patients GC and non-GC phenotypes were determined immunohistochemically from 63 patients. Of these, 29 primary high-risk DLBCL patients were treated with auto-SCT, whereas 34 CT-treated patients served as a control group. Consistent with previous studies, non-GC phenotype was associated with adverse outcome in CT-treated high-risk patients. In contrast, immunohistochemical classification by cell of origin did not associate with survival after auto-SCT. When the impact of treatment on the predictive value of cell of origin was analyzed, the non-GC patients, who received HDT, had a better failure-free survival (FFS) and overall survival (OS) than the patients treated with CT alone. In multivariate analyses, both age-adjusted International Prognostic Index (aaIPI) and treatment were independent prognostic factors for FFS and OS. For the patients with GC phenotype, the influence of auto-SCT on survival was not significant. The data imply that auto-SCT can overcome the adverse prognostic impact of the non-GC phenotype in patients with high-risk DLBCL and warrant additional prospective studies. More... »

PAGES

bmt200892

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bmt.2008.92

DOI

http://dx.doi.org/10.1038/bmt.2008.92

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014261486

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18391989


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Combined Chemotherapy Protocols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Combined Modality Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Germinal Center", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hematopoietic Stem Cell Transplantation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphoma, Large B-Cell, Diffuse", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Multivariate Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phenotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proportional Hazards Models", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transplantation, Autologous", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Helsinki University Central Hospital", 
          "id": "https://www.grid.ac/institutes/grid.15485.3d", 
          "name": [
            "Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland", 
            "Molecular Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nyman", 
        "givenName": "H", 
        "id": "sg:person.01224432001.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224432001.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kuopio University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.410705.7", 
          "name": [
            "Department of Medicine, Kuopio University Hospital, Kuopio, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jantunen", 
        "givenName": "E", 
        "id": "sg:person.01040342543.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040342543.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Helsinki University Central Hospital", 
          "id": "https://www.grid.ac/institutes/grid.15485.3d", 
          "name": [
            "Department of Hematology, Helsinki University Central Hospital, Helsinki, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Juvonen", 
        "givenName": "E", 
        "id": "sg:person.01165232515.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165232515.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Helsinki University Central Hospital", 
          "id": "https://www.grid.ac/institutes/grid.15485.3d", 
          "name": [
            "Department of Hematology, Helsinki University Central Hospital, Helsinki, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Elonen", 
        "givenName": "E", 
        "id": "sg:person.01130551456.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130551456.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kuopio University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.410705.7", 
          "name": [
            "Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "B\u00f6hm", 
        "givenName": "J", 
        "id": "sg:person.0630625146.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630625146.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kuopio University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.410705.7", 
          "name": [
            "Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland", 
            "Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Kuopio, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kosma", 
        "givenName": "V-M", 
        "id": "sg:person.01240233274.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240233274.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Uppsala University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412354.5", 
          "name": [
            "Department of Oncology, Uppsala University Hospital, Uppsala, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Enblad", 
        "givenName": "G", 
        "id": "sg:person.0662003563.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662003563.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Helsinki", 
          "id": "https://www.grid.ac/institutes/grid.7737.4", 
          "name": [
            "Department of Pathology, Haartman Institute, University of Helsinki, Helsinki, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Karjalainen-Lindsberg", 
        "givenName": "M-L", 
        "id": "sg:person.01305242472.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305242472.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Helsinki University Central Hospital", 
          "id": "https://www.grid.ac/institutes/grid.15485.3d", 
          "name": [
            "Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland", 
            "Molecular Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lepp\u00e4", 
        "givenName": "S", 
        "id": "sg:person.0627751572.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627751572.61"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1023/a:1008392528248", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000975426", 
          "https://doi.org/10.1023/a:1008392528248"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdm012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001524015"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(06)70664-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001953896"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2002-12-3837", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006075661"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35000501", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010898206", 
          "https://doi.org/10.1038/35000501"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35000501", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010898206", 
          "https://doi.org/10.1038/35000501"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199309303291402", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013554742"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/7410", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016228251", 
          "https://doi.org/10.1038/7410"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/7410", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016228251", 
          "https://doi.org/10.1038/7410"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2005-04-1603", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016230743"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa031770", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020205879"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ctrv.2007.02.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020576240"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2006-09-047068", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021851598"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.15.503", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025693649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2003-05-1545", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026049587"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2002-04-1286", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037152866"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.194.12.1861", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037916421"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.194.12.1861", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037916421"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2005-10-4222", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038773934"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa012914", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040112680"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199304083281404", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043239598"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni0302-221", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045237056", 
          "https://doi.org/10.1038/ni0302-221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni0302-221", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045237056", 
          "https://doi.org/10.1038/ni0302-221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2006.05.5897", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049845855"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.3800396", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053221537", 
          "https://doi.org/10.1038/modpathol.3800396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.3800396", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053221537", 
          "https://doi.org/10.1038/modpathol.3800396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.3800396", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053221537", 
          "https://doi.org/10.1038/modpathol.3800396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/2.suppl_1.17", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059393152"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2002.02.125", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064202935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2002.07.075", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064203029"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2003.01.117", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064203292"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.05.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064204242"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2000.18.16.3025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074684756"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077017326", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2008-07", 
    "datePublishedReg": "2008-07-01", 
    "description": "Non-germinal center (non-GC) phenotype is an adverse prognostic factor in chemotherapy (CT)-treated diffuse large B-cell lymphoma (DLBCL) patients. To determine how high-dose therapy (HDT) supported with auto-SCT as first line therapy influences GC-associated outcome in young high-risk DLBCL patients GC and non-GC phenotypes were determined immunohistochemically from 63 patients. Of these, 29 primary high-risk DLBCL patients were treated with auto-SCT, whereas 34 CT-treated patients served as a control group. Consistent with previous studies, non-GC phenotype was associated with adverse outcome in CT-treated high-risk patients. In contrast, immunohistochemical classification by cell of origin did not associate with survival after auto-SCT. When the impact of treatment on the predictive value of cell of origin was analyzed, the non-GC patients, who received HDT, had a better failure-free survival (FFS) and overall survival (OS) than the patients treated with CT alone. In multivariate analyses, both age-adjusted International Prognostic Index (aaIPI) and treatment were independent prognostic factors for FFS and OS. For the patients with GC phenotype, the influence of auto-SCT on survival was not significant. The data imply that auto-SCT can overcome the adverse prognostic impact of the non-GC phenotype in patients with high-risk DLBCL and warrant additional prospective studies.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/bmt.2008.92", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1096890", 
        "issn": [
          "0268-3369", 
          "1476-5365"
        ], 
        "name": "Bone Marrow Transplantation", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "42"
      }
    ], 
    "name": "Impact of germinal center and non-germinal center phenotypes on overall and failure-free survival after high-dose chemotherapy and auto-SCT in primary diffuse large B-cell lymphoma", 
    "pagination": "bmt200892", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "43f0e7919fa7dcaa6bafa1d25dd915f0e39b6bccdd1f83dbef147af92a64f43a"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "18391989"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8702459"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/bmt.2008.92"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1014261486"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/bmt.2008.92", 
      "https://app.dimensions.ai/details/publication/pub.1014261486"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T17:19", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8672_00000422.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/bmt200892"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/bmt.2008.92'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/bmt.2008.92'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/bmt.2008.92'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/bmt.2008.92'


 

This table displays all metadata directly associated to this object as RDF triples.

282 TRIPLES      21 PREDICATES      71 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/bmt.2008.92 schema:about N0c6ba198e153485c9ad84fe8424ef43f
2 N12263436a0ed4b7ca70430e157233cf1
3 N209964e87a5946ceba2add0acbad785f
4 N2a07959e04244825ae3ecac9808997de
5 N3e0481a14f724cb19d3242ca895ab9de
6 N57b34bebf7534022a7cac07a00a46c34
7 N58db33b0017a43459c2c0ef10a460f51
8 N865d3e5e490049de9165d59802df5c91
9 N9b984463e9034235967e2edc9363442c
10 Nb97bbede5a9a41e98da6c94f2efd73f4
11 Nbd960931cf6a42789fdaede7a4193423
12 Nc925ea5648784bcd9640ae6c6d383195
13 Nd4aadbc320aa47d4bae37efea31d12e2
14 Ne9f09b3dc3d8424a8a16574032c3f642
15 anzsrc-for:11
16 anzsrc-for:1112
17 schema:author N478f90898efd4b84af42f5a1ac8a2e37
18 schema:citation sg:pub.10.1023/a:1008392528248
19 sg:pub.10.1038/35000501
20 sg:pub.10.1038/7410
21 sg:pub.10.1038/modpathol.3800396
22 sg:pub.10.1038/ni0302-221
23 https://app.dimensions.ai/details/publication/pub.1077017326
24 https://doi.org/10.1016/j.ctrv.2007.02.002
25 https://doi.org/10.1016/s1470-2045(06)70664-7
26 https://doi.org/10.1056/nejm199304083281404
27 https://doi.org/10.1056/nejm199309303291402
28 https://doi.org/10.1056/nejmoa012914
29 https://doi.org/10.1056/nejmoa031770
30 https://doi.org/10.1084/jem.194.12.1861
31 https://doi.org/10.1093/annonc/2.suppl_1.17
32 https://doi.org/10.1093/annonc/mdm012
33 https://doi.org/10.1182/blood-2002-04-1286
34 https://doi.org/10.1182/blood-2002-12-3837
35 https://doi.org/10.1182/blood-2003-05-1545
36 https://doi.org/10.1182/blood-2005-04-1603
37 https://doi.org/10.1182/blood-2005-10-4222
38 https://doi.org/10.1182/blood-2006-09-047068
39 https://doi.org/10.1200/jco.2000.18.16.3025
40 https://doi.org/10.1200/jco.2002.02.125
41 https://doi.org/10.1200/jco.2002.07.075
42 https://doi.org/10.1200/jco.2003.01.117
43 https://doi.org/10.1200/jco.2005.05.012
44 https://doi.org/10.1200/jco.2005.15.503
45 https://doi.org/10.1200/jco.2006.05.5897
46 schema:datePublished 2008-07
47 schema:datePublishedReg 2008-07-01
48 schema:description Non-germinal center (non-GC) phenotype is an adverse prognostic factor in chemotherapy (CT)-treated diffuse large B-cell lymphoma (DLBCL) patients. To determine how high-dose therapy (HDT) supported with auto-SCT as first line therapy influences GC-associated outcome in young high-risk DLBCL patients GC and non-GC phenotypes were determined immunohistochemically from 63 patients. Of these, 29 primary high-risk DLBCL patients were treated with auto-SCT, whereas 34 CT-treated patients served as a control group. Consistent with previous studies, non-GC phenotype was associated with adverse outcome in CT-treated high-risk patients. In contrast, immunohistochemical classification by cell of origin did not associate with survival after auto-SCT. When the impact of treatment on the predictive value of cell of origin was analyzed, the non-GC patients, who received HDT, had a better failure-free survival (FFS) and overall survival (OS) than the patients treated with CT alone. In multivariate analyses, both age-adjusted International Prognostic Index (aaIPI) and treatment were independent prognostic factors for FFS and OS. For the patients with GC phenotype, the influence of auto-SCT on survival was not significant. The data imply that auto-SCT can overcome the adverse prognostic impact of the non-GC phenotype in patients with high-risk DLBCL and warrant additional prospective studies.
49 schema:genre research_article
50 schema:inLanguage en
51 schema:isAccessibleForFree true
52 schema:isPartOf N2e65fd8790e14dba806034de8a279574
53 N410544933c414552858d44bbafab3c94
54 sg:journal.1096890
55 schema:name Impact of germinal center and non-germinal center phenotypes on overall and failure-free survival after high-dose chemotherapy and auto-SCT in primary diffuse large B-cell lymphoma
56 schema:pagination bmt200892
57 schema:productId N24f6fe4c38214804916f5bc6cee89f26
58 N26705946b0f840d79870b520afe0e1bf
59 N446aa46706104f1c884b48c557d53afb
60 Nbac5d997e4174e0e923246a063d5b048
61 Nf110ec7c268e4af8805a05af5570da08
62 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014261486
63 https://doi.org/10.1038/bmt.2008.92
64 schema:sdDatePublished 2019-04-10T17:19
65 schema:sdLicense https://scigraph.springernature.com/explorer/license/
66 schema:sdPublisher Na61c1aed755d4c20b181e0331446cf1b
67 schema:url http://www.nature.com/articles/bmt200892
68 sgo:license sg:explorer/license/
69 sgo:sdDataset articles
70 rdf:type schema:ScholarlyArticle
71 N001e015953be4a2fb27967d539106588 rdf:first sg:person.01165232515.57
72 rdf:rest Nc85c19dcb1df427289501fda9ebec768
73 N088a670eb7d14b46a5712593957604ba rdf:first sg:person.01240233274.17
74 rdf:rest N961c4a145e1f436aabf3c2ad5f92bb1b
75 N0c6ba198e153485c9ad84fe8424ef43f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Multivariate Analysis
77 rdf:type schema:DefinedTerm
78 N12263436a0ed4b7ca70430e157233cf1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Female
80 rdf:type schema:DefinedTerm
81 N209964e87a5946ceba2add0acbad785f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Transplantation, Autologous
83 rdf:type schema:DefinedTerm
84 N24f6fe4c38214804916f5bc6cee89f26 schema:name readcube_id
85 schema:value 43f0e7919fa7dcaa6bafa1d25dd915f0e39b6bccdd1f83dbef147af92a64f43a
86 rdf:type schema:PropertyValue
87 N26705946b0f840d79870b520afe0e1bf schema:name dimensions_id
88 schema:value pub.1014261486
89 rdf:type schema:PropertyValue
90 N2a07959e04244825ae3ecac9808997de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Combined Modality Therapy
92 rdf:type schema:DefinedTerm
93 N2e65fd8790e14dba806034de8a279574 schema:issueNumber 2
94 rdf:type schema:PublicationIssue
95 N3e0481a14f724cb19d3242ca895ab9de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Humans
97 rdf:type schema:DefinedTerm
98 N410544933c414552858d44bbafab3c94 schema:volumeNumber 42
99 rdf:type schema:PublicationVolume
100 N446aa46706104f1c884b48c557d53afb schema:name doi
101 schema:value 10.1038/bmt.2008.92
102 rdf:type schema:PropertyValue
103 N4644fed0612e4dc7a745513096f15744 rdf:first sg:person.01305242472.47
104 rdf:rest N61bb2efb61b1497a9c9c4f824a5eff21
105 N478f90898efd4b84af42f5a1ac8a2e37 rdf:first sg:person.01224432001.33
106 rdf:rest Nc56ddfa64d39402896903a8fc494806d
107 N57b34bebf7534022a7cac07a00a46c34 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Hematopoietic Stem Cell Transplantation
109 rdf:type schema:DefinedTerm
110 N58db33b0017a43459c2c0ef10a460f51 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Germinal Center
112 rdf:type schema:DefinedTerm
113 N61bb2efb61b1497a9c9c4f824a5eff21 rdf:first sg:person.0627751572.61
114 rdf:rest rdf:nil
115 N83b43406624f44a8af40368d7ca12ee8 rdf:first sg:person.0630625146.64
116 rdf:rest N088a670eb7d14b46a5712593957604ba
117 N865d3e5e490049de9165d59802df5c91 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Phenotype
119 rdf:type schema:DefinedTerm
120 N961c4a145e1f436aabf3c2ad5f92bb1b rdf:first sg:person.0662003563.77
121 rdf:rest N4644fed0612e4dc7a745513096f15744
122 N9b984463e9034235967e2edc9363442c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Adult
124 rdf:type schema:DefinedTerm
125 Na61c1aed755d4c20b181e0331446cf1b schema:name Springer Nature - SN SciGraph project
126 rdf:type schema:Organization
127 Nb97bbede5a9a41e98da6c94f2efd73f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Male
129 rdf:type schema:DefinedTerm
130 Nbac5d997e4174e0e923246a063d5b048 schema:name nlm_unique_id
131 schema:value 8702459
132 rdf:type schema:PropertyValue
133 Nbd960931cf6a42789fdaede7a4193423 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Proportional Hazards Models
135 rdf:type schema:DefinedTerm
136 Nc56ddfa64d39402896903a8fc494806d rdf:first sg:person.01040342543.18
137 rdf:rest N001e015953be4a2fb27967d539106588
138 Nc85c19dcb1df427289501fda9ebec768 rdf:first sg:person.01130551456.99
139 rdf:rest N83b43406624f44a8af40368d7ca12ee8
140 Nc925ea5648784bcd9640ae6c6d383195 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Middle Aged
142 rdf:type schema:DefinedTerm
143 Nd4aadbc320aa47d4bae37efea31d12e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Antineoplastic Combined Chemotherapy Protocols
145 rdf:type schema:DefinedTerm
146 Ne9f09b3dc3d8424a8a16574032c3f642 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Lymphoma, Large B-Cell, Diffuse
148 rdf:type schema:DefinedTerm
149 Nf110ec7c268e4af8805a05af5570da08 schema:name pubmed_id
150 schema:value 18391989
151 rdf:type schema:PropertyValue
152 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
153 schema:name Medical and Health Sciences
154 rdf:type schema:DefinedTerm
155 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
156 schema:name Oncology and Carcinogenesis
157 rdf:type schema:DefinedTerm
158 sg:journal.1096890 schema:issn 0268-3369
159 1476-5365
160 schema:name Bone Marrow Transplantation
161 rdf:type schema:Periodical
162 sg:person.01040342543.18 schema:affiliation https://www.grid.ac/institutes/grid.410705.7
163 schema:familyName Jantunen
164 schema:givenName E
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040342543.18
166 rdf:type schema:Person
167 sg:person.01130551456.99 schema:affiliation https://www.grid.ac/institutes/grid.15485.3d
168 schema:familyName Elonen
169 schema:givenName E
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130551456.99
171 rdf:type schema:Person
172 sg:person.01165232515.57 schema:affiliation https://www.grid.ac/institutes/grid.15485.3d
173 schema:familyName Juvonen
174 schema:givenName E
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165232515.57
176 rdf:type schema:Person
177 sg:person.01224432001.33 schema:affiliation https://www.grid.ac/institutes/grid.15485.3d
178 schema:familyName Nyman
179 schema:givenName H
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224432001.33
181 rdf:type schema:Person
182 sg:person.01240233274.17 schema:affiliation https://www.grid.ac/institutes/grid.410705.7
183 schema:familyName Kosma
184 schema:givenName V-M
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240233274.17
186 rdf:type schema:Person
187 sg:person.01305242472.47 schema:affiliation https://www.grid.ac/institutes/grid.7737.4
188 schema:familyName Karjalainen-Lindsberg
189 schema:givenName M-L
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305242472.47
191 rdf:type schema:Person
192 sg:person.0627751572.61 schema:affiliation https://www.grid.ac/institutes/grid.15485.3d
193 schema:familyName Leppä
194 schema:givenName S
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627751572.61
196 rdf:type schema:Person
197 sg:person.0630625146.64 schema:affiliation https://www.grid.ac/institutes/grid.410705.7
198 schema:familyName Böhm
199 schema:givenName J
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630625146.64
201 rdf:type schema:Person
202 sg:person.0662003563.77 schema:affiliation https://www.grid.ac/institutes/grid.412354.5
203 schema:familyName Enblad
204 schema:givenName G
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662003563.77
206 rdf:type schema:Person
207 sg:pub.10.1023/a:1008392528248 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000975426
208 https://doi.org/10.1023/a:1008392528248
209 rdf:type schema:CreativeWork
210 sg:pub.10.1038/35000501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010898206
211 https://doi.org/10.1038/35000501
212 rdf:type schema:CreativeWork
213 sg:pub.10.1038/7410 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016228251
214 https://doi.org/10.1038/7410
215 rdf:type schema:CreativeWork
216 sg:pub.10.1038/modpathol.3800396 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053221537
217 https://doi.org/10.1038/modpathol.3800396
218 rdf:type schema:CreativeWork
219 sg:pub.10.1038/ni0302-221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045237056
220 https://doi.org/10.1038/ni0302-221
221 rdf:type schema:CreativeWork
222 https://app.dimensions.ai/details/publication/pub.1077017326 schema:CreativeWork
223 https://doi.org/10.1016/j.ctrv.2007.02.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020576240
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/s1470-2045(06)70664-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001953896
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1056/nejm199304083281404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043239598
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1056/nejm199309303291402 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013554742
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1056/nejmoa012914 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040112680
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1056/nejmoa031770 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020205879
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1084/jem.194.12.1861 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037916421
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1093/annonc/2.suppl_1.17 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059393152
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1093/annonc/mdm012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001524015
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1182/blood-2002-04-1286 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037152866
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1182/blood-2002-12-3837 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006075661
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1182/blood-2003-05-1545 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026049587
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1182/blood-2005-04-1603 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016230743
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1182/blood-2005-10-4222 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038773934
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1182/blood-2006-09-047068 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021851598
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1200/jco.2000.18.16.3025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074684756
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1200/jco.2002.02.125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064202935
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1200/jco.2002.07.075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203029
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1200/jco.2003.01.117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203292
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1200/jco.2005.05.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064204242
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1200/jco.2005.15.503 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025693649
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1200/jco.2006.05.5897 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049845855
266 rdf:type schema:CreativeWork
267 https://www.grid.ac/institutes/grid.15485.3d schema:alternateName Helsinki University Central Hospital
268 schema:name Department of Hematology, Helsinki University Central Hospital, Helsinki, Finland
269 Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland
270 Molecular Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
271 rdf:type schema:Organization
272 https://www.grid.ac/institutes/grid.410705.7 schema:alternateName Kuopio University Hospital
273 schema:name Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland
274 Department of Medicine, Kuopio University Hospital, Kuopio, Finland
275 Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Kuopio, Finland
276 rdf:type schema:Organization
277 https://www.grid.ac/institutes/grid.412354.5 schema:alternateName Uppsala University Hospital
278 schema:name Department of Oncology, Uppsala University Hospital, Uppsala, Sweden
279 rdf:type schema:Organization
280 https://www.grid.ac/institutes/grid.7737.4 schema:alternateName University of Helsinki
281 schema:name Department of Pathology, Haartman Institute, University of Helsinki, Helsinki, Finland
282 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...