Salvage transplantation for allograft failure using fludarabine and alemtuzumab as conditioning regimen View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-03

AUTHORS

J Bolaños-Meade, L Luznik, M Muth, W H Matsui, C A Huff, B D Smith, M Y Levy, Y L Kasamon, L J Swinnen, J D Powell, R A Brodsky, R F Ambinder, R J Jones, E J Fuchs

ABSTRACT

Graft failure after allogeneic blood or marrow transplantation, although generally uncommon, can be a devastating complication. This report includes the outcome of nine patients who received a salvage transplant for failure to engraft after one (n=8) or 2 (n=1) prior transplants. Eight patients received allografts from the original donor. All received fludarabine 30 mg/m(2) i.v. and alemtuzumab 20 mg i.v. daily from days -6 to -2. Daily CYA was begun on day -2, and the allograft was infused on day 0. The therapy was well tolerated with low toxicity, and all nine patients engrafted, recovering neutrophils at a median of 12 days after transplant. Four patients died: two of relapse, one of a fungal infection in the setting of GVHD and one of multiple sclerosis. The combination of fludarabine and alemtuzumab is an effective and well-tolerated salvage conditioning regimen for patients who experience graft failure after blood or marrow transplants. More... »

PAGES

477

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bmt.2008.353

DOI

http://dx.doi.org/10.1038/bmt.2008.353

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048566291

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18978825


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