Second auto-SCT is safe and effective salvage therapy for relapsed multiple myeloma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-10-13

AUTHORS

R L Olin, D T Vogl, D L Porter, S M Luger, S J Schuster, D E Tsai, D L Siegel, R J Cook, P A Mangan, K Cunningham, E A Stadtmauer

ABSTRACT

Therapeutic options for patients with multiple myeloma whose disease has relapsed after a prior auto-SCT include novel biologic therapies, traditional chemotherapy or a second transplant, with no clear standard of care. Few published studies address the safety and efficacy of a second auto-SCT for relapsed disease. We reviewed the Abramson Cancer Center experience with salvage auto-SCT for relapsed multiple myeloma. Forty-one patients had received a salvage auto-SCT at our institution; the median time between transplants was 37 months (range 3–91). The overall response rate in assessable patients was 55%, and treatment-related mortality was 7%. With a median follow-up time of 15 months, the median PFS was 8.5 months and the median overall survival (OS) was 20.7 months. In a multivariate analysis of OS, independent prognostic factors were ⩾5 prior lines of therapy and time to progression after initial auto-SCT of ⩽12 months. We conclude that in well-selected patients, salvage auto-SCT is safe and effective for relapsed myeloma. More... »

PAGES

417-422

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bmt.2008.334

DOI

http://dx.doi.org/10.1038/bmt.2008.334

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021521647

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18850013


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