Fasciitis and myositis: an analysis of muscle-related complications caused by chronic GVHD after allo-SCT View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-09-01

AUTHORS

K Oda, C Nakaseko, S Ozawa, M Nishimura, Y Saito, F Yoshiba, T Yamashita, H Fujita, H Takasaki, H Kanamori, A Maruta, H Sakamaki, S Okamoto

ABSTRACT

The muscle-related complications of fasciitis and myositis, caused by chronic GVHD after Allo-SCT are relatively rare, but at times will severely impair a patient's quality of life (QOL). We performed a retrospective analysis in Japanese Allo-SCT recipients to identify the incidence, risk factors and clinical features of fasciitis and myositis. In 1967 patients who underwent Allo-SCT between January 1994 and March 2005 and survived beyond 90 days post transplantation, eight patients developed fasciitis and nine patients developed myositis, with a 5-year cumulative incidence of 0.55% and 0.54%, respectively. The median time from SCT to the development of fasciitis and myositis was 991 and 660 days, respectively. PBSCT was a risk factor for developing fasciitis, but no risk factors were found for myositis. The response to immunosuppressive treatment was better in patients with myositis than fasciitis, and the overall survival after developing these symptoms was better in patients with myositis than those with fasciitis. An early diagnosis by a biopsy, which includes fascia and muscle or magnetic resonance imaging (MRI) and prompt treatment may be important to prevent an impairment of the patient's QOL with persistent disability. More... »

PAGES

159-167

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bmt.2008.297

DOI

http://dx.doi.org/10.1038/bmt.2008.297

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023017715

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18762758


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63 life
64 magnetic resonance imaging
65 median time
66 muscle
67 myositis
68 overall survival
69 patients
70 patients' QoL
71 patients' quality
72 persistent disability
73 post transplantation
74 prompt treatment
75 quality
76 recipients
77 resonance imaging
78 response
79 retrospective analysis
80 risk factors
81 survival
82 symptoms
83 time
84 transplantation
85 treatment
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