Distinct clinical outcomes of two CIMP-positive colorectal cancer subtypes based on a revised CIMP classification system View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-04

AUTHORS

Jeong Mo Bae, Jung Ho Kim, Yoonjin Kwak, Dae-Won Lee, Yongjun Cha, Xianyu Wen, Tae Hun Lee, Nam-Yun Cho, Seung-Yong Jeong, Kyu Joo Park, Sae Won Han, Hye Seung Lee, Tae-You Kim, Gyeong Hoon Kang

ABSTRACT

BACKGROUND: Colorectal cancer (CRC) is a heterogeneous disease in terms of molecular carcinogenic pathways. Based on recent findings regarding the multiple serrated neoplasia pathway, we revised an eight-marker panel for a new CIMP classification system. METHODS: 1370 patients who received surgical resection for CRCs were classified into three CIMP subtypes (CIMP-N: 0-4 methylated markers, CIMP-P1: 5-6 methylated markers and CIMP-P2: 7-8 methylated markers). Our findings were validated in a separate set of high-risk stage II or stage III CRCs receiving adjuvant fluoropyrimidine plus oxaliplatin (n=950). RESULTS: A total of 1287/62/21 CRCs cases were classified as CIMP-N/CIMP-P1/CIMP-P2, respectively. CIMP-N showed male predominance, distal location, lower T, N category and devoid of BRAF mutation, microsatellite instability (MSI) and MLH1 methylation. CIMP-P1 showed female predominance, proximal location, advanced TNM stage, mild decrease of CK20 and CDX2 expression, mild increase of CK7 expression, BRAF mutation, MSI and MLH1 methylation. CIMP-P2 showed older age, female predominance, proximal location, advanced T category, markedly reduced CK20 and CDX2 expression, rare KRAS mutation, high frequency of CK7 expression, BRAF mutation, MSI and MLH1 methylation. CIMP-N showed better 5-year cancer-specific survival (CSS; HR=0.47; 95% CI: 0.28-0.78) in discovery set and better 5-year relapse-free survival (RFS; HR=0.50; 95% CI: 0.29-0.88) in validation set compared with CIMP-P1. CIMP-P2 showed marginally better 5-year CSS (HR=0.28, 95% CI: 0.07-1.22) in discovery set and marginally better 5-year RFS (HR=0.21, 95% CI: 0.05-0.92) in validation set compared with CIMP-P1. CONCLUSIONS: CIMP subtypes classified using our revised system showed different clinical outcomes, demonstrating the heterogeneity of multiple serrated precursors of CIMP-positive CRCs. More... »

PAGES

1012

References to SciGraph publications

  • 2016-12. CpG island methylator phenotype is associated with the efficacy of sequential oxaliplatin- and irinotecan-based chemotherapy and EGFR-related gene mutation in Japanese patients with metastatic colorectal cancer in INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
  • 2006-07. CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer in NATURE GENETICS
  • 2016-07. Adverse prognostic impact of the CpG island methylator phenotype in metastatic colorectal cancer in BRITISH JOURNAL OF CANCER
  • 2009-12. Prognostic implications of CpG island hypermethylator phenotype in colorectal cancers in VIRCHOWS ARCHIV
  • 2015-03. A clinicopathological and molecular analysis of 200 traditional serrated adenomas in MODERN PATHOLOGY
  • 2007-05. CpG island methylation, response to combination chemotherapy, and patient survival in advanced microsatellite stable colorectal carcinoma in VIRCHOWS ARCHIV
  • 2012-07. Comprehensive molecular characterization of human colon and rectal cancer in NATURE
  • 2012-09. Serrated Lesions of the Colorectum: Review and Recommendations From an Expert Panel in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2013-08. Prognostic implication of the CpG island methylator phenotype in colorectal cancers depends on tumour location in BRITISH JOURNAL OF CANCER
  • 2014-10. Traditional serrated adenoma has two pathways of neoplastic progression that are distinct from the sessile serrated pathway of colorectal carcinogenesis in MODERN PATHOLOGY
  • 2008-01. Genetic alterations of APC, K-ras, p53, MSI, and MAGE in Korean colorectal cancer patients in INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/bjc.2017.52

    DOI

    http://dx.doi.org/10.1038/bjc.2017.52

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1084127737

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28278514


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged, 80 and over", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Biomarkers, Tumor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Colorectal Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Combined Modality Therapy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "CpG Islands", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA Methylation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Follow-Up Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Immunoenzyme Techniques", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Microsatellite Instability", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mutation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm Recurrence, Local", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm Staging", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Phenotype", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prognosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Survival Rate", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Boramae Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.412479.d", 
              "name": [
                "Laboratory of Epigenetics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea", 
                "Department of Pathology, SMG-SNU Boramae Medical Center, Seoul, South Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bae", 
            "givenName": "Jeong Mo", 
            "id": "sg:person.01161165725.74", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161165725.74"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Seoul National University", 
              "id": "https://www.grid.ac/institutes/grid.31501.36", 
              "name": [
                "Laboratory of Epigenetics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea", 
                "Department of Pathology, Seoul National University College of Medicine, 103 Daehak-ro, Seoul 110-744, South Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kim", 
            "givenName": "Jung Ho", 
            "id": "sg:person.01072751317.56", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072751317.56"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Seoul National University Bundang Hospital", 
              "id": "https://www.grid.ac/institutes/grid.412480.b", 
              "name": [
                "Department of Pathology, Seoul National University College of Medicine, 103 Daehak-ro, Seoul 110-744, South Korea", 
                "Department of Pathology, Seoul National University Bundang Hospital, Seongnam, South Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kwak", 
            "givenName": "Yoonjin", 
            "id": "sg:person.01116610554.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116610554.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Seoul National University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.412484.f", 
              "name": [
                "Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lee", 
            "givenName": "Dae-Won", 
            "id": "sg:person.0660074752.60", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660074752.60"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Seoul National University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.412484.f", 
              "name": [
                "Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cha", 
            "givenName": "Yongjun", 
            "id": "sg:person.01274115701.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274115701.22"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Seoul National University", 
              "id": "https://www.grid.ac/institutes/grid.31501.36", 
              "name": [
                "Laboratory of Epigenetics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wen", 
            "givenName": "Xianyu", 
            "id": "sg:person.0703175125.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703175125.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Seoul National University", 
              "id": "https://www.grid.ac/institutes/grid.31501.36", 
              "name": [
                "Laboratory of Epigenetics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lee", 
            "givenName": "Tae Hun", 
            "id": "sg:person.0714666572.95", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714666572.95"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Seoul National University", 
              "id": "https://www.grid.ac/institutes/grid.31501.36", 
              "name": [
                "Laboratory of Epigenetics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cho", 
            "givenName": "Nam-Yun", 
            "id": "sg:person.01073732430.52", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073732430.52"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Seoul National University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.412484.f", 
              "name": [
                "Department of Surgery, Seoul National University Hospital, Seoul, South Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jeong", 
            "givenName": "Seung-Yong", 
            "id": "sg:person.01160355244.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160355244.12"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Seoul National University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.412484.f", 
              "name": [
                "Department of Surgery, Seoul National University Hospital, Seoul, South Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Park", 
            "givenName": "Kyu Joo", 
            "id": "sg:person.07721337737.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07721337737.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Seoul National University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.412484.f", 
              "name": [
                "Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Han", 
            "givenName": "Sae Won", 
            "id": "sg:person.0626600563.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626600563.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Seoul National University Bundang Hospital", 
              "id": "https://www.grid.ac/institutes/grid.412480.b", 
              "name": [
                "Department of Pathology, Seoul National University College of Medicine, 103 Daehak-ro, Seoul 110-744, South Korea", 
                "Department of Pathology, Seoul National University Bundang Hospital, Seongnam, South Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lee", 
            "givenName": "Hye Seung", 
            "id": "sg:person.014357233714.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014357233714.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Seoul National University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.412484.f", 
              "name": [
                "Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kim", 
            "givenName": "Tae-You", 
            "id": "sg:person.012010335604.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012010335604.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Seoul National University", 
              "id": "https://www.grid.ac/institutes/grid.31501.36", 
              "name": [
                "Laboratory of Epigenetics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea", 
                "Department of Pathology, Seoul National University College of Medicine, 103 Daehak-ro, Seoul 110-744, South Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kang", 
            "givenName": "Gyeong Hoon", 
            "id": "sg:person.014551703117.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014551703117.31"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s10147-016-1017-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001824636", 
              "https://doi.org/10.1007/s10147-016-1017-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10147-016-1017-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001824636", 
              "https://doi.org/10.1007/s10147-016-1017-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pas.0000000000000695", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001892464"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pas.0000000000000695", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001892464"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/modpathol.2014.122", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002044074", 
              "https://doi.org/10.1038/modpathol.2014.122"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.2013.430", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002806672", 
              "https://doi.org/10.1038/bjc.2013.430"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1834", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004242111", 
              "https://doi.org/10.1038/ng1834"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1834", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004242111", 
              "https://doi.org/10.1038/ng1834"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2353/jmoldx.2007.060170", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004648741"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00428-007-0398-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007290505", 
              "https://doi.org/10.1007/s00428-007-0398-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00428-007-0398-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007290505", 
              "https://doi.org/10.1007/s00428-007-0398-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11252", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010619765", 
              "https://doi.org/10.1038/nature11252"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.7374", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011645462"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0704652104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013184871"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1542-3565(04)00673-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014375258"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.96.15.8681", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014931389"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00384-007-0373-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015816841", 
              "https://doi.org/10.1007/s00384-007-0373-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00384-007-0373-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015816841", 
              "https://doi.org/10.1007/s00384-007-0373-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pas.0000000000000253", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017122429"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pas.0000000000000253", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017122429"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pas.0000000000000253", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017122429"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pas.0b013e3181d40cb2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018369077"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pas.0b013e3181d40cb2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018369077"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pas.0b013e3181d40cb2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018369077"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2009.12.066", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019802205"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa022289", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020570290"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(90)90186-i", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020604215"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2014.09.041", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020869438"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/modpathol.2014.35", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026234305", 
              "https://doi.org/10.1038/modpathol.2014.35"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jamaoncol.2015.5225", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029354866"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3393/ac.2014.30.1.28", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029735859"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2559.2006.02549.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030093906"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.humpath.2007.06.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030197560"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2009.12.064", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030932765"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-07-1011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030977087"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pas.0b013e31824430d7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031618732"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pas.0b013e31824430d7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031618732"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2004.02.154", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032168908"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2014.09.038", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032618957"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mds236", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034294500"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mdu149", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035464559"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ajg.2012.161", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035635231", 
              "https://doi.org/10.1038/ajg.2012.161"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ajg.2012.161", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035635231", 
              "https://doi.org/10.1038/ajg.2012.161"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.2016.176", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039762329", 
              "https://doi.org/10.1038/bjc.2016.176"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/his.12788", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039886019"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.117523.110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043274942"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2014.05.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045018017"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2015.63.4238", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045291613"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-08-1171", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047759940"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pas.0b013e318205df36", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047799883"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pas.0b013e318205df36", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047799883"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00428-009-0857-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049046960", 
              "https://doi.org/10.1007/s00428-009-0857-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00428-009-0857-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049046960", 
              "https://doi.org/10.1007/s00428-009-0857-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00428-009-0857-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049046960", 
              "https://doi.org/10.1007/s00428-009-0857-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2010.30.1366", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050703224"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/gut.2008.155473", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052686248"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3748/wjg.v21.i5.1457", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071373327"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075192362", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083350376", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-04", 
        "datePublishedReg": "2017-04-01", 
        "description": "BACKGROUND: Colorectal cancer (CRC) is a heterogeneous disease in terms of molecular carcinogenic pathways. Based on recent findings regarding the multiple serrated neoplasia pathway, we revised an eight-marker panel for a new CIMP classification system.\nMETHODS: 1370 patients who received surgical resection for CRCs were classified into three CIMP subtypes (CIMP-N: 0-4 methylated markers, CIMP-P1: 5-6 methylated markers and CIMP-P2: 7-8 methylated markers). Our findings were validated in a separate set of high-risk stage II or stage III CRCs receiving adjuvant fluoropyrimidine plus oxaliplatin (n=950).\nRESULTS: A total of 1287/62/21 CRCs cases were classified as CIMP-N/CIMP-P1/CIMP-P2, respectively. CIMP-N showed male predominance, distal location, lower T, N category and devoid of BRAF mutation, microsatellite instability (MSI) and MLH1 methylation. CIMP-P1 showed female predominance, proximal location, advanced TNM stage, mild decrease of CK20 and CDX2 expression, mild increase of CK7 expression, BRAF mutation, MSI and MLH1 methylation. CIMP-P2 showed older age, female predominance, proximal location, advanced T category, markedly reduced CK20 and CDX2 expression, rare KRAS mutation, high frequency of CK7 expression, BRAF mutation, MSI and MLH1 methylation. CIMP-N showed better 5-year cancer-specific survival (CSS; HR=0.47; 95% CI: 0.28-0.78) in discovery set and better 5-year relapse-free survival (RFS; HR=0.50; 95% CI: 0.29-0.88) in validation set compared with CIMP-P1. CIMP-P2 showed marginally better 5-year CSS (HR=0.28, 95% CI: 0.07-1.22) in discovery set and marginally better 5-year RFS (HR=0.21, 95% CI: 0.05-0.92) in validation set compared with CIMP-P1.\nCONCLUSIONS: CIMP subtypes classified using our revised system showed different clinical outcomes, demonstrating the heterogeneity of multiple serrated precursors of CIMP-positive CRCs.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/bjc.2017.52", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.7451050", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.7459958", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1017082", 
            "issn": [
              "0007-0920", 
              "1532-1827"
            ], 
            "name": "British Journal of Cancer", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "8", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "116"
          }
        ], 
        "name": "Distinct clinical outcomes of two CIMP-positive colorectal cancer subtypes based on a revised CIMP classification system", 
        "pagination": "1012", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "294b002db9b50fb36a92efa6cb063164824b301bb6b16725228c6daccafa1707"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "28278514"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "0370635"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/bjc.2017.52"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1084127737"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/bjc.2017.52", 
          "https://app.dimensions.ai/details/publication/pub.1084127737"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T13:25", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8659_00000552.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/bjc201752"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/bjc.2017.52'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/bjc.2017.52'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/bjc.2017.52'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/bjc.2017.52'


     

    This table displays all metadata directly associated to this object as RDF triples.

    405 TRIPLES      21 PREDICATES      95 URIs      42 LITERALS      30 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/bjc.2017.52 schema:about N05712cc34a974932b3a4a56550abad31
    2 N09d211db395f4ffa8f118084fe40e0f1
    3 N1f282d0e0c3147cf84570188f2d59d26
    4 N2b080bc7e7a944668b096f6770d6834d
    5 N43baaca517a848a7b0f98d3592e202d4
    6 N46b991e237614837ba874b733589cad7
    7 N4e98f2f90cd442538502d6477c5eb110
    8 N64ac71f3f4d84aee90b2bb7267dd8bba
    9 N68b34bd48e4945e281c0a893565781bf
    10 N80d8a8637d7444e998b798e7b4660ec3
    11 N8140a91912454a33be686b1607c69b49
    12 N8a3d811b716a4faa8dc345a121c3b033
    13 N8abde150bd8b4926ade8a8b3dc731abc
    14 Nb7a0a5fa18784da3a2a7a10a9e829a67
    15 Nc4fa7544052648a5bccff26435a65d8c
    16 Ne34a36ba01c14c13b6ba817addd343df
    17 Ne6408a6d57a84367ba8ff01d267a038a
    18 Neee16f3cc08d442fa1205c2c30a88a35
    19 Nf0ecb2898ece4937a7216dbb1891bf1b
    20 Nf7b608c6652a4917b135b459209f0d59
    21 Nfa13489d42134cb7bc2c352870219861
    22 anzsrc-for:11
    23 anzsrc-for:1112
    24 schema:author N04c024af4c4b493db45ab49a194b0ed2
    25 schema:citation sg:pub.10.1007/s00384-007-0373-0
    26 sg:pub.10.1007/s00428-007-0398-3
    27 sg:pub.10.1007/s00428-009-0857-0
    28 sg:pub.10.1007/s10147-016-1017-6
    29 sg:pub.10.1038/ajg.2012.161
    30 sg:pub.10.1038/bjc.2013.430
    31 sg:pub.10.1038/bjc.2016.176
    32 sg:pub.10.1038/modpathol.2014.122
    33 sg:pub.10.1038/modpathol.2014.35
    34 sg:pub.10.1038/nature11252
    35 sg:pub.10.1038/ng1834
    36 https://app.dimensions.ai/details/publication/pub.1075192362
    37 https://app.dimensions.ai/details/publication/pub.1083350376
    38 https://doi.org/10.1001/jamaoncol.2015.5225
    39 https://doi.org/10.1016/0092-8674(90)90186-i
    40 https://doi.org/10.1016/j.humpath.2007.06.002
    41 https://doi.org/10.1016/s1542-3565(04)00673-1
    42 https://doi.org/10.1053/j.gastro.2009.12.064
    43 https://doi.org/10.1053/j.gastro.2009.12.066
    44 https://doi.org/10.1053/j.gastro.2014.05.009
    45 https://doi.org/10.1053/j.gastro.2014.09.038
    46 https://doi.org/10.1053/j.gastro.2014.09.041
    47 https://doi.org/10.1056/nejmoa022289
    48 https://doi.org/10.1073/pnas.0704652104
    49 https://doi.org/10.1073/pnas.96.15.8681
    50 https://doi.org/10.1093/annonc/mds236
    51 https://doi.org/10.1093/annonc/mdu149
    52 https://doi.org/10.1097/pas.0000000000000253
    53 https://doi.org/10.1097/pas.0000000000000695
    54 https://doi.org/10.1097/pas.0b013e3181d40cb2
    55 https://doi.org/10.1097/pas.0b013e318205df36
    56 https://doi.org/10.1097/pas.0b013e31824430d7
    57 https://doi.org/10.1101/gr.117523.110
    58 https://doi.org/10.1111/his.12788
    59 https://doi.org/10.1111/j.1365-2559.2006.02549.x
    60 https://doi.org/10.1136/gut.2008.155473
    61 https://doi.org/10.1158/0008-5472.can-08-1171
    62 https://doi.org/10.1158/1078-0432.ccr-07-1011
    63 https://doi.org/10.1200/jco.2004.02.154
    64 https://doi.org/10.1200/jco.2010.30.1366
    65 https://doi.org/10.1200/jco.2015.63.4238
    66 https://doi.org/10.18632/oncotarget.7374
    67 https://doi.org/10.2353/jmoldx.2007.060170
    68 https://doi.org/10.3393/ac.2014.30.1.28
    69 https://doi.org/10.3748/wjg.v21.i5.1457
    70 schema:datePublished 2017-04
    71 schema:datePublishedReg 2017-04-01
    72 schema:description BACKGROUND: Colorectal cancer (CRC) is a heterogeneous disease in terms of molecular carcinogenic pathways. Based on recent findings regarding the multiple serrated neoplasia pathway, we revised an eight-marker panel for a new CIMP classification system. METHODS: 1370 patients who received surgical resection for CRCs were classified into three CIMP subtypes (CIMP-N: 0-4 methylated markers, CIMP-P1: 5-6 methylated markers and CIMP-P2: 7-8 methylated markers). Our findings were validated in a separate set of high-risk stage II or stage III CRCs receiving adjuvant fluoropyrimidine plus oxaliplatin (n=950). RESULTS: A total of 1287/62/21 CRCs cases were classified as CIMP-N/CIMP-P1/CIMP-P2, respectively. CIMP-N showed male predominance, distal location, lower T, N category and devoid of BRAF mutation, microsatellite instability (MSI) and MLH1 methylation. CIMP-P1 showed female predominance, proximal location, advanced TNM stage, mild decrease of CK20 and CDX2 expression, mild increase of CK7 expression, BRAF mutation, MSI and MLH1 methylation. CIMP-P2 showed older age, female predominance, proximal location, advanced T category, markedly reduced CK20 and CDX2 expression, rare KRAS mutation, high frequency of CK7 expression, BRAF mutation, MSI and MLH1 methylation. CIMP-N showed better 5-year cancer-specific survival (CSS; HR=0.47; 95% CI: 0.28-0.78) in discovery set and better 5-year relapse-free survival (RFS; HR=0.50; 95% CI: 0.29-0.88) in validation set compared with CIMP-P1. CIMP-P2 showed marginally better 5-year CSS (HR=0.28, 95% CI: 0.07-1.22) in discovery set and marginally better 5-year RFS (HR=0.21, 95% CI: 0.05-0.92) in validation set compared with CIMP-P1. CONCLUSIONS: CIMP subtypes classified using our revised system showed different clinical outcomes, demonstrating the heterogeneity of multiple serrated precursors of CIMP-positive CRCs.
    73 schema:genre research_article
    74 schema:inLanguage en
    75 schema:isAccessibleForFree true
    76 schema:isPartOf N49f1199980d84f6383f65a5e58b9fd73
    77 Ncc624259ede94a99ad183469a3adb563
    78 sg:journal.1017082
    79 schema:name Distinct clinical outcomes of two CIMP-positive colorectal cancer subtypes based on a revised CIMP classification system
    80 schema:pagination 1012
    81 schema:productId N057554dd8fc54b089dd792c89b8a70da
    82 N1a727e2d7bb4480d8bb631f303aa474b
    83 N25520d1671e241a9b893605d74b4f2ff
    84 N5cce26cdf7d4482ebe12d1cc7bc19d44
    85 Nbc5b6b94fcee4f5b970800207bd93209
    86 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084127737
    87 https://doi.org/10.1038/bjc.2017.52
    88 schema:sdDatePublished 2019-04-10T13:25
    89 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    90 schema:sdPublisher N68fdd9542ee94cc6bef2345db6f1f5f2
    91 schema:url https://www.nature.com/articles/bjc201752
    92 sgo:license sg:explorer/license/
    93 sgo:sdDataset articles
    94 rdf:type schema:ScholarlyArticle
    95 N04c024af4c4b493db45ab49a194b0ed2 rdf:first sg:person.01161165725.74
    96 rdf:rest N2603b378a19b40929786f05a90a45ac3
    97 N05712cc34a974932b3a4a56550abad31 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    98 schema:name Mutation
    99 rdf:type schema:DefinedTerm
    100 N057554dd8fc54b089dd792c89b8a70da schema:name dimensions_id
    101 schema:value pub.1084127737
    102 rdf:type schema:PropertyValue
    103 N09d211db395f4ffa8f118084fe40e0f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    104 schema:name Immunoenzyme Techniques
    105 rdf:type schema:DefinedTerm
    106 N1337d69ad70540d98b472be0846742b7 rdf:first sg:person.012010335604.34
    107 rdf:rest Nbba5c73756264b63a6abf0c4c58cdb57
    108 N1a727e2d7bb4480d8bb631f303aa474b schema:name doi
    109 schema:value 10.1038/bjc.2017.52
    110 rdf:type schema:PropertyValue
    111 N1f282d0e0c3147cf84570188f2d59d26 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    112 schema:name Middle Aged
    113 rdf:type schema:DefinedTerm
    114 N25520d1671e241a9b893605d74b4f2ff schema:name pubmed_id
    115 schema:value 28278514
    116 rdf:type schema:PropertyValue
    117 N2603b378a19b40929786f05a90a45ac3 rdf:first sg:person.01072751317.56
    118 rdf:rest Na8ecbd69462e4e748290e568171caa54
    119 N2b080bc7e7a944668b096f6770d6834d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    120 schema:name Biomarkers, Tumor
    121 rdf:type schema:DefinedTerm
    122 N323aeab1fe074ae48de3e64aa6d1a8c2 rdf:first sg:person.014357233714.08
    123 rdf:rest N1337d69ad70540d98b472be0846742b7
    124 N43a874ebf9df49b2a1ecfc38f3c60f34 rdf:first sg:person.01274115701.22
    125 rdf:rest Nbe68e5de9aa248fcb06910f2ac591130
    126 N43baaca517a848a7b0f98d3592e202d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    127 schema:name Colorectal Neoplasms
    128 rdf:type schema:DefinedTerm
    129 N46b991e237614837ba874b733589cad7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    130 schema:name Neoplasm Recurrence, Local
    131 rdf:type schema:DefinedTerm
    132 N49f1199980d84f6383f65a5e58b9fd73 schema:volumeNumber 116
    133 rdf:type schema:PublicationVolume
    134 N4e98f2f90cd442538502d6477c5eb110 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    135 schema:name Male
    136 rdf:type schema:DefinedTerm
    137 N5cce26cdf7d4482ebe12d1cc7bc19d44 schema:name nlm_unique_id
    138 schema:value 0370635
    139 rdf:type schema:PropertyValue
    140 N64ac71f3f4d84aee90b2bb7267dd8bba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    141 schema:name CpG Islands
    142 rdf:type schema:DefinedTerm
    143 N68b34bd48e4945e281c0a893565781bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name Prognosis
    145 rdf:type schema:DefinedTerm
    146 N68fdd9542ee94cc6bef2345db6f1f5f2 schema:name Springer Nature - SN SciGraph project
    147 rdf:type schema:Organization
    148 N71568edbfbce405fa80de79e3fc39b1a rdf:first sg:person.0714666572.95
    149 rdf:rest Nff414c8aac9942f6a9989ae24909ac42
    150 N80d8a8637d7444e998b798e7b4660ec3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    151 schema:name Survival Rate
    152 rdf:type schema:DefinedTerm
    153 N8140a91912454a33be686b1607c69b49 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    154 schema:name Female
    155 rdf:type schema:DefinedTerm
    156 N8a3d811b716a4faa8dc345a121c3b033 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    157 schema:name Phenotype
    158 rdf:type schema:DefinedTerm
    159 N8abde150bd8b4926ade8a8b3dc731abc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    160 schema:name Neoplasm Staging
    161 rdf:type schema:DefinedTerm
    162 Na8ecbd69462e4e748290e568171caa54 rdf:first sg:person.01116610554.13
    163 rdf:rest Nb53709e444684c5d9a02e0743b5a8763
    164 Naede5345cc9e478b8e905296510e4eee rdf:first sg:person.07721337737.19
    165 rdf:rest Nf7dfa799f21c474fb76c48a20fef3bf8
    166 Nb53709e444684c5d9a02e0743b5a8763 rdf:first sg:person.0660074752.60
    167 rdf:rest N43a874ebf9df49b2a1ecfc38f3c60f34
    168 Nb7a0a5fa18784da3a2a7a10a9e829a67 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    169 schema:name Aged, 80 and over
    170 rdf:type schema:DefinedTerm
    171 Nbba5c73756264b63a6abf0c4c58cdb57 rdf:first sg:person.014551703117.31
    172 rdf:rest rdf:nil
    173 Nbc5b6b94fcee4f5b970800207bd93209 schema:name readcube_id
    174 schema:value 294b002db9b50fb36a92efa6cb063164824b301bb6b16725228c6daccafa1707
    175 rdf:type schema:PropertyValue
    176 Nbe68e5de9aa248fcb06910f2ac591130 rdf:first sg:person.0703175125.34
    177 rdf:rest N71568edbfbce405fa80de79e3fc39b1a
    178 Nc4fa7544052648a5bccff26435a65d8c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    179 schema:name Microsatellite Instability
    180 rdf:type schema:DefinedTerm
    181 Ncc624259ede94a99ad183469a3adb563 schema:issueNumber 8
    182 rdf:type schema:PublicationIssue
    183 Ne34a36ba01c14c13b6ba817addd343df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    184 schema:name DNA Methylation
    185 rdf:type schema:DefinedTerm
    186 Ne6408a6d57a84367ba8ff01d267a038a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    187 schema:name Aged
    188 rdf:type schema:DefinedTerm
    189 Ne8d7b0a6652b46429eb145cd90a26774 rdf:first sg:person.01160355244.12
    190 rdf:rest Naede5345cc9e478b8e905296510e4eee
    191 Neee16f3cc08d442fa1205c2c30a88a35 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    192 schema:name Combined Modality Therapy
    193 rdf:type schema:DefinedTerm
    194 Nf0ecb2898ece4937a7216dbb1891bf1b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    195 schema:name Adult
    196 rdf:type schema:DefinedTerm
    197 Nf7b608c6652a4917b135b459209f0d59 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    198 schema:name Follow-Up Studies
    199 rdf:type schema:DefinedTerm
    200 Nf7dfa799f21c474fb76c48a20fef3bf8 rdf:first sg:person.0626600563.08
    201 rdf:rest N323aeab1fe074ae48de3e64aa6d1a8c2
    202 Nfa13489d42134cb7bc2c352870219861 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    203 schema:name Humans
    204 rdf:type schema:DefinedTerm
    205 Nff414c8aac9942f6a9989ae24909ac42 rdf:first sg:person.01073732430.52
    206 rdf:rest Ne8d7b0a6652b46429eb145cd90a26774
    207 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    208 schema:name Medical and Health Sciences
    209 rdf:type schema:DefinedTerm
    210 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    211 schema:name Oncology and Carcinogenesis
    212 rdf:type schema:DefinedTerm
    213 sg:grant.7451050 http://pending.schema.org/fundedItem sg:pub.10.1038/bjc.2017.52
    214 rdf:type schema:MonetaryGrant
    215 sg:grant.7459958 http://pending.schema.org/fundedItem sg:pub.10.1038/bjc.2017.52
    216 rdf:type schema:MonetaryGrant
    217 sg:journal.1017082 schema:issn 0007-0920
    218 1532-1827
    219 schema:name British Journal of Cancer
    220 rdf:type schema:Periodical
    221 sg:person.01072751317.56 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
    222 schema:familyName Kim
    223 schema:givenName Jung Ho
    224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072751317.56
    225 rdf:type schema:Person
    226 sg:person.01073732430.52 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
    227 schema:familyName Cho
    228 schema:givenName Nam-Yun
    229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073732430.52
    230 rdf:type schema:Person
    231 sg:person.01116610554.13 schema:affiliation https://www.grid.ac/institutes/grid.412480.b
    232 schema:familyName Kwak
    233 schema:givenName Yoonjin
    234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116610554.13
    235 rdf:type schema:Person
    236 sg:person.01160355244.12 schema:affiliation https://www.grid.ac/institutes/grid.412484.f
    237 schema:familyName Jeong
    238 schema:givenName Seung-Yong
    239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160355244.12
    240 rdf:type schema:Person
    241 sg:person.01161165725.74 schema:affiliation https://www.grid.ac/institutes/grid.412479.d
    242 schema:familyName Bae
    243 schema:givenName Jeong Mo
    244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161165725.74
    245 rdf:type schema:Person
    246 sg:person.012010335604.34 schema:affiliation https://www.grid.ac/institutes/grid.412484.f
    247 schema:familyName Kim
    248 schema:givenName Tae-You
    249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012010335604.34
    250 rdf:type schema:Person
    251 sg:person.01274115701.22 schema:affiliation https://www.grid.ac/institutes/grid.412484.f
    252 schema:familyName Cha
    253 schema:givenName Yongjun
    254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274115701.22
    255 rdf:type schema:Person
    256 sg:person.014357233714.08 schema:affiliation https://www.grid.ac/institutes/grid.412480.b
    257 schema:familyName Lee
    258 schema:givenName Hye Seung
    259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014357233714.08
    260 rdf:type schema:Person
    261 sg:person.014551703117.31 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
    262 schema:familyName Kang
    263 schema:givenName Gyeong Hoon
    264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014551703117.31
    265 rdf:type schema:Person
    266 sg:person.0626600563.08 schema:affiliation https://www.grid.ac/institutes/grid.412484.f
    267 schema:familyName Han
    268 schema:givenName Sae Won
    269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626600563.08
    270 rdf:type schema:Person
    271 sg:person.0660074752.60 schema:affiliation https://www.grid.ac/institutes/grid.412484.f
    272 schema:familyName Lee
    273 schema:givenName Dae-Won
    274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660074752.60
    275 rdf:type schema:Person
    276 sg:person.0703175125.34 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
    277 schema:familyName Wen
    278 schema:givenName Xianyu
    279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703175125.34
    280 rdf:type schema:Person
    281 sg:person.0714666572.95 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
    282 schema:familyName Lee
    283 schema:givenName Tae Hun
    284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714666572.95
    285 rdf:type schema:Person
    286 sg:person.07721337737.19 schema:affiliation https://www.grid.ac/institutes/grid.412484.f
    287 schema:familyName Park
    288 schema:givenName Kyu Joo
    289 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07721337737.19
    290 rdf:type schema:Person
    291 sg:pub.10.1007/s00384-007-0373-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015816841
    292 https://doi.org/10.1007/s00384-007-0373-0
    293 rdf:type schema:CreativeWork
    294 sg:pub.10.1007/s00428-007-0398-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007290505
    295 https://doi.org/10.1007/s00428-007-0398-3
    296 rdf:type schema:CreativeWork
    297 sg:pub.10.1007/s00428-009-0857-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049046960
    298 https://doi.org/10.1007/s00428-009-0857-0
    299 rdf:type schema:CreativeWork
    300 sg:pub.10.1007/s10147-016-1017-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001824636
    301 https://doi.org/10.1007/s10147-016-1017-6
    302 rdf:type schema:CreativeWork
    303 sg:pub.10.1038/ajg.2012.161 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035635231
    304 https://doi.org/10.1038/ajg.2012.161
    305 rdf:type schema:CreativeWork
    306 sg:pub.10.1038/bjc.2013.430 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002806672
    307 https://doi.org/10.1038/bjc.2013.430
    308 rdf:type schema:CreativeWork
    309 sg:pub.10.1038/bjc.2016.176 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039762329
    310 https://doi.org/10.1038/bjc.2016.176
    311 rdf:type schema:CreativeWork
    312 sg:pub.10.1038/modpathol.2014.122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002044074
    313 https://doi.org/10.1038/modpathol.2014.122
    314 rdf:type schema:CreativeWork
    315 sg:pub.10.1038/modpathol.2014.35 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026234305
    316 https://doi.org/10.1038/modpathol.2014.35
    317 rdf:type schema:CreativeWork
    318 sg:pub.10.1038/nature11252 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010619765
    319 https://doi.org/10.1038/nature11252
    320 rdf:type schema:CreativeWork
    321 sg:pub.10.1038/ng1834 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004242111
    322 https://doi.org/10.1038/ng1834
    323 rdf:type schema:CreativeWork
    324 https://app.dimensions.ai/details/publication/pub.1075192362 schema:CreativeWork
    325 https://app.dimensions.ai/details/publication/pub.1083350376 schema:CreativeWork
    326 https://doi.org/10.1001/jamaoncol.2015.5225 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029354866
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1016/0092-8674(90)90186-i schema:sameAs https://app.dimensions.ai/details/publication/pub.1020604215
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1016/j.humpath.2007.06.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030197560
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1016/s1542-3565(04)00673-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014375258
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1053/j.gastro.2009.12.064 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030932765
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.1053/j.gastro.2009.12.066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019802205
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1053/j.gastro.2014.05.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045018017
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1053/j.gastro.2014.09.038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032618957
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.1053/j.gastro.2014.09.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020869438
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.1056/nejmoa022289 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020570290
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.1073/pnas.0704652104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013184871
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.1073/pnas.96.15.8681 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014931389
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.1093/annonc/mds236 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034294500
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.1093/annonc/mdu149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035464559
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.1097/pas.0000000000000253 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017122429
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.1097/pas.0000000000000695 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001892464
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.1097/pas.0b013e3181d40cb2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018369077
    359 rdf:type schema:CreativeWork
    360 https://doi.org/10.1097/pas.0b013e318205df36 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047799883
    361 rdf:type schema:CreativeWork
    362 https://doi.org/10.1097/pas.0b013e31824430d7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031618732
    363 rdf:type schema:CreativeWork
    364 https://doi.org/10.1101/gr.117523.110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043274942
    365 rdf:type schema:CreativeWork
    366 https://doi.org/10.1111/his.12788 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039886019
    367 rdf:type schema:CreativeWork
    368 https://doi.org/10.1111/j.1365-2559.2006.02549.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030093906
    369 rdf:type schema:CreativeWork
    370 https://doi.org/10.1136/gut.2008.155473 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052686248
    371 rdf:type schema:CreativeWork
    372 https://doi.org/10.1158/0008-5472.can-08-1171 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047759940
    373 rdf:type schema:CreativeWork
    374 https://doi.org/10.1158/1078-0432.ccr-07-1011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030977087
    375 rdf:type schema:CreativeWork
    376 https://doi.org/10.1200/jco.2004.02.154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032168908
    377 rdf:type schema:CreativeWork
    378 https://doi.org/10.1200/jco.2010.30.1366 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050703224
    379 rdf:type schema:CreativeWork
    380 https://doi.org/10.1200/jco.2015.63.4238 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045291613
    381 rdf:type schema:CreativeWork
    382 https://doi.org/10.18632/oncotarget.7374 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011645462
    383 rdf:type schema:CreativeWork
    384 https://doi.org/10.2353/jmoldx.2007.060170 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004648741
    385 rdf:type schema:CreativeWork
    386 https://doi.org/10.3393/ac.2014.30.1.28 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029735859
    387 rdf:type schema:CreativeWork
    388 https://doi.org/10.3748/wjg.v21.i5.1457 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071373327
    389 rdf:type schema:CreativeWork
    390 https://www.grid.ac/institutes/grid.31501.36 schema:alternateName Seoul National University
    391 schema:name Department of Pathology, Seoul National University College of Medicine, 103 Daehak-ro, Seoul 110-744, South Korea
    392 Laboratory of Epigenetics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea
    393 rdf:type schema:Organization
    394 https://www.grid.ac/institutes/grid.412479.d schema:alternateName Boramae Medical Center
    395 schema:name Department of Pathology, SMG-SNU Boramae Medical Center, Seoul, South Korea
    396 Laboratory of Epigenetics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea
    397 rdf:type schema:Organization
    398 https://www.grid.ac/institutes/grid.412480.b schema:alternateName Seoul National University Bundang Hospital
    399 schema:name Department of Pathology, Seoul National University Bundang Hospital, Seongnam, South Korea
    400 Department of Pathology, Seoul National University College of Medicine, 103 Daehak-ro, Seoul 110-744, South Korea
    401 rdf:type schema:Organization
    402 https://www.grid.ac/institutes/grid.412484.f schema:alternateName Seoul National University Hospital
    403 schema:name Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea
    404 Department of Surgery, Seoul National University Hospital, Seoul, South Korea
    405 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...