Health-related quality of life impact of cobimetinib in combination with vemurafenib in patients with advanced or metastatic BRAFV600 mutation–positive melanoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-03-20

AUTHORS

Brigitte Dréno, Paolo A Ascierto, Victoria Atkinson, Gabriella Liszkay, Michele Maio, Mario Mandalà, Lev Demidov, Daniil Stroyakovskiy, Luc Thomas, Luis de la Cruz-Merino, Caroline Dutriaux, Claus Garbe, Karen Bartley, Thomas Karagiannis, Ilsung Chang, Isabelle Rooney, Daniel O Koralek, James Larkin, Grant A McArthur, Antoni Ribas

ABSTRACT

BACKGROUND: In the coBRIM study, cobimetinib plus vemurafenib (C+V) significantly improved survival outcomes vs placebo and vemurafenib (P+V) in patients with advanced/metastatic BRAFV600-mutated melanoma. An analysis of health-related quality of life (HRQOL) from coBRIM is reported. METHODS: Patients completing the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (QLQ-C30) at baseline and ⩾1 time point thereafter constituted the analysis population. Change from baseline ⩾10 points was considered clinically meaningful. RESULTS: Mean baseline scores for all QLQ-C30 domains were similar between arms. Most on-treatment scores for QLQ-C30 domains were also comparable between arms. A transient deterioration in role function in cycle 1 day 15 (C1D15; -14.7 points) in the P+V arm and improvement in insomnia in the C+V arm at C2D15 (-12.4 points) was observed. Among patients who experienced a ⩾10-point change from baseline (responders), between-group differences were greatest for insomnia (16%), social functioning (10%), fatigue (9%) and pain (7%), all favouring C+V. Diarrhoea, photosensitivity reaction, pyrexia, and rash did not meaningfully affect global health status (GHS). Serous retinopathy was associated with a transient decrease in GHS at C1D15 assessment. CONCLUSIONS: In patients with advanced/metastatic BRAFV600-mutated melanoma, treatment with C+V maintained HRQOL compared with P+V, with superior efficacy. More... »

PAGES

777

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.2017.488

DOI

http://dx.doi.org/10.1038/bjc.2017.488

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1100990088

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29438370


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Nantes", 
          "id": "https://www.grid.ac/institutes/grid.4817.a", 
          "name": [
            "Department of Dermato Cancerology, Nantes University, Nantes 44093, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dr\u00e9no", 
        "givenName": "Brigitte", 
        "id": "sg:person.01146563400.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146563400.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Nazionale dei Tumori", 
          "id": "https://www.grid.ac/institutes/grid.417893.0", 
          "name": [
            "Istituto Nazionale Tumori Fondazione G. Pascale, Naples 80131, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ascierto", 
        "givenName": "Paolo A", 
        "id": "sg:person.01212502023.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212502023.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Princess Alexandra Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412744.0", 
          "name": [
            "Princess Alexandra Hospital, Woolloongabba, QLD 4102, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Atkinson", 
        "givenName": "Victoria", 
        "id": "sg:person.01223761356.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223761356.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute of Oncology", 
          "id": "https://www.grid.ac/institutes/grid.419617.c", 
          "name": [
            "National Institute of Oncology, Budapest 1122, Hungary"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liszkay", 
        "givenName": "Gabriella", 
        "id": "sg:person.01002064006.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002064006.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Azienda Ospedaliera Universitaria Senese", 
          "id": "https://www.grid.ac/institutes/grid.411477.0", 
          "name": [
            "Azienda Ospedaliera Universitaria Senese, Siena 53100, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maio", 
        "givenName": "Michele", 
        "id": "sg:person.01061427172.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061427172.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ospedale Papa Giovanni XXIII", 
          "id": "https://www.grid.ac/institutes/grid.460094.f", 
          "name": [
            "Department of Oncology and Haematology, Papa Giovanni XXIII Hospital, Bergamo 24127, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mandal\u00e0", 
        "givenName": "Mario", 
        "id": "sg:person.01157622404.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157622404.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Russian Cancer Research Center NN Blokhin", 
          "id": "https://www.grid.ac/institutes/grid.466904.9", 
          "name": [
            "N. N. Blokhin Russian Cancer Research Center, Moscow 115478, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Demidov", 
        "givenName": "Lev", 
        "id": "sg:person.01332747155.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01332747155.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Moscow City Oncology Hospital 62, Krasnogorsk 14301, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stroyakovskiy", 
        "givenName": "Daniil", 
        "id": "sg:person.01325746532.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325746532.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier Lyon Sud", 
          "id": "https://www.grid.ac/institutes/grid.411430.3", 
          "name": [
            "Service de Dermatologie, Centre Hospitalier Lyon Sud, Pierre-B\u00e9nite 69495, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thomas", 
        "givenName": "Luc", 
        "id": "sg:person.01034044447.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034044447.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Universitario Virgen Macarena", 
          "id": "https://www.grid.ac/institutes/grid.411375.5", 
          "name": [
            "Hospital Universitario Virgen Macarena, Seville 41009, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de la Cruz-Merino", 
        "givenName": "Luis", 
        "id": "sg:person.01307014706.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307014706.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Saint-Andr\u00e9", 
          "id": "https://www.grid.ac/institutes/grid.414339.8", 
          "name": [
            "H\u00f4pital Saint Andr\u00e9, Bordeaux 33075, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dutriaux", 
        "givenName": "Caroline", 
        "id": "sg:person.0740204011.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740204011.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of T\u00fcbingen", 
          "id": "https://www.grid.ac/institutes/grid.10392.39", 
          "name": [
            "Department of Dermatology, University of T\u00fcbingen, T\u00fcbingen 72074, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Garbe", 
        "givenName": "Claus", 
        "id": "sg:person.01221773122.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221773122.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Roche (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418158.1", 
          "name": [
            "Genentech, Inc., South San Francisco, CA 94080, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bartley", 
        "givenName": "Karen", 
        "id": "sg:person.011137006010.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011137006010.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Roche (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418158.1", 
          "name": [
            "Genentech, Inc., South San Francisco, CA 94080, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Karagiannis", 
        "givenName": "Thomas", 
        "id": "sg:person.012434416233.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012434416233.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Roche (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418158.1", 
          "name": [
            "Genentech, Inc., South San Francisco, CA 94080, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chang", 
        "givenName": "Ilsung", 
        "id": "sg:person.01170102460.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170102460.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Roche (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418158.1", 
          "name": [
            "Genentech, Inc., South San Francisco, CA 94080, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rooney", 
        "givenName": "Isabelle", 
        "id": "sg:person.0613761724.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613761724.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Roche (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418158.1", 
          "name": [
            "Genentech, Inc., South San Francisco, CA 94080, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Koralek", 
        "givenName": "Daniel O", 
        "id": "sg:person.01355044667.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355044667.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal Marsden NHS Foundation Trust", 
          "id": "https://www.grid.ac/institutes/grid.5072.0", 
          "name": [
            "The Royal Marsden NHS Foundation Trust, London SW3 6JJ, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Larkin", 
        "givenName": "James", 
        "id": "sg:person.01255356274.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255356274.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "Peter MacCallum Cancer Centre, East Melbourne, VIC 3002, Australia", 
            "University of Melbourne, Parkville, VIC 3052, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "McArthur", 
        "givenName": "Grant A", 
        "id": "sg:person.01101164743.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101164743.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California Los Angeles", 
          "id": "https://www.grid.ac/institutes/grid.19006.3e", 
          "name": [
            "Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, CA 90095, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ribas", 
        "givenName": "Antoni", 
        "id": "sg:person.0627244670.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627244670.28"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1056/nejmoa1408868", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000859328"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cmr.0000000000000122", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002267720"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cmr.0000000000000122", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002267720"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(15)00087-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002492213"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2015.03.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025118564"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdt580", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025353861"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdu154", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029017193"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/85.5.365", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059818446"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1998.16.1.139", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083201628"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdx040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085285261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2016.34.15_suppl.9533", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106842853"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-03-20", 
    "datePublishedReg": "2018-03-20", 
    "description": "BACKGROUND: In the coBRIM study, cobimetinib plus vemurafenib (C+V) significantly improved survival outcomes vs placebo and vemurafenib (P+V) in patients with advanced/metastatic BRAFV600-mutated melanoma. An analysis of health-related quality of life (HRQOL) from coBRIM is reported.\nMETHODS: Patients completing the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (QLQ-C30) at baseline and \u2a7e1 time point thereafter constituted the analysis population. Change from baseline \u2a7e10 points was considered clinically meaningful.\nRESULTS: Mean baseline scores for all QLQ-C30 domains were similar between arms. Most on-treatment scores for QLQ-C30 domains were also comparable between arms. A transient deterioration in role function in cycle 1\u2009day 15 (C1D15; -14.7 points) in the P+V arm and improvement in insomnia in the C+V arm at C2D15 (-12.4 points) was observed. Among patients who experienced a \u2a7e10-point change from baseline (responders), between-group differences were greatest for insomnia (16%), social functioning (10%), fatigue (9%) and pain (7%), all favouring C+V. Diarrhoea, photosensitivity reaction, pyrexia, and rash did not meaningfully affect global health status (GHS). Serous retinopathy was associated with a transient decrease in GHS at C1D15 assessment.\nCONCLUSIONS: In patients with advanced/metastatic BRAFV600-mutated melanoma, treatment with C+V maintained HRQOL compared with P+V, with superior efficacy.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/bjc.2017.488", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1017082", 
        "issn": [
          "0007-0920", 
          "1532-1827"
        ], 
        "name": "British Journal of Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "118"
      }
    ], 
    "name": "Health-related quality of life impact of cobimetinib in combination with vemurafenib in patients with advanced or metastatic BRAFV600 mutation\u2013positive melanoma", 
    "pagination": "777", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "0c937651c79bb086e3a9a2a2ffc273508ad2e9da9b3624f8bd786cd2cccdcefe"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29438370"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0370635"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/bjc.2017.488"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1100990088"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/bjc.2017.488", 
      "https://app.dimensions.ai/details/publication/pub.1100990088"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T11:23", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000355_0000000355/records_53004_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/bjc2017488"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/bjc.2017.488'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/bjc.2017.488'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/bjc.2017.488'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/bjc.2017.488'


 

This table displays all metadata directly associated to this object as RDF triples.

277 TRIPLES      21 PREDICATES      38 URIs      20 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/bjc.2017.488 schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author N24a52f5bfb724807b8098a8cca527c2d
4 schema:citation https://doi.org/10.1016/j.ejca.2015.03.004
5 https://doi.org/10.1016/s1470-2045(15)00087-x
6 https://doi.org/10.1056/nejmoa1408868
7 https://doi.org/10.1093/annonc/mdt580
8 https://doi.org/10.1093/annonc/mdu154
9 https://doi.org/10.1093/annonc/mdx040
10 https://doi.org/10.1093/jnci/85.5.365
11 https://doi.org/10.1097/cmr.0000000000000122
12 https://doi.org/10.1200/jco.1998.16.1.139
13 https://doi.org/10.1200/jco.2016.34.15_suppl.9533
14 schema:datePublished 2018-03-20
15 schema:datePublishedReg 2018-03-20
16 schema:description BACKGROUND: In the coBRIM study, cobimetinib plus vemurafenib (C+V) significantly improved survival outcomes vs placebo and vemurafenib (P+V) in patients with advanced/metastatic BRAFV600-mutated melanoma. An analysis of health-related quality of life (HRQOL) from coBRIM is reported. METHODS: Patients completing the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (QLQ-C30) at baseline and ⩾1 time point thereafter constituted the analysis population. Change from baseline ⩾10 points was considered clinically meaningful. RESULTS: Mean baseline scores for all QLQ-C30 domains were similar between arms. Most on-treatment scores for QLQ-C30 domains were also comparable between arms. A transient deterioration in role function in cycle 1 day 15 (C1D15; -14.7 points) in the P+V arm and improvement in insomnia in the C+V arm at C2D15 (-12.4 points) was observed. Among patients who experienced a ⩾10-point change from baseline (responders), between-group differences were greatest for insomnia (16%), social functioning (10%), fatigue (9%) and pain (7%), all favouring C+V. Diarrhoea, photosensitivity reaction, pyrexia, and rash did not meaningfully affect global health status (GHS). Serous retinopathy was associated with a transient decrease in GHS at C1D15 assessment. CONCLUSIONS: In patients with advanced/metastatic BRAFV600-mutated melanoma, treatment with C+V maintained HRQOL compared with P+V, with superior efficacy.
17 schema:genre research_article
18 schema:inLanguage en
19 schema:isAccessibleForFree true
20 schema:isPartOf N66b2473fb0824b4180e328a555b10620
21 Nd86ecbeebca34e5fbd69ef04d7dddd80
22 sg:journal.1017082
23 schema:name Health-related quality of life impact of cobimetinib in combination with vemurafenib in patients with advanced or metastatic BRAFV600 mutation–positive melanoma
24 schema:pagination 777
25 schema:productId N5d73c65b2b904e60b7f8a00ec8c523e3
26 N8e4d0c5899a842c28db1741808af7a8c
27 Naf6102f763464388a562e76912b61a1d
28 Nc1274df4d9e94e34ba622d8ecfbde0f2
29 Nf72ae4321f834b42a688289bc7dfacda
30 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100990088
31 https://doi.org/10.1038/bjc.2017.488
32 schema:sdDatePublished 2019-04-11T11:23
33 schema:sdLicense https://scigraph.springernature.com/explorer/license/
34 schema:sdPublisher N3101212e982d4925bffccd25c7eaa6e7
35 schema:url https://www.nature.com/articles/bjc2017488
36 sgo:license sg:explorer/license/
37 sgo:sdDataset articles
38 rdf:type schema:ScholarlyArticle
39 N01e25c2f19b440c794f77c1c1b934c60 rdf:first sg:person.0740204011.00
40 rdf:rest N6d3eee79b07d4a8893f92a78be8266ce
41 N0aed1e4346aa4cd5884453660f3dc9b1 rdf:first sg:person.01255356274.07
42 rdf:rest N85687ed2296a46b883cf43245fb958c9
43 N1c448f837e374f558ef0c3a933719a80 rdf:first sg:person.011137006010.21
44 rdf:rest Ncc1e79424fa443f7976d6ffaed54e15f
45 N24a52f5bfb724807b8098a8cca527c2d rdf:first sg:person.01146563400.12
46 rdf:rest Nb437d9c246d7485eb026b9910f936a7a
47 N26cf577973a94d38b2d43fb5861d4b8a rdf:first sg:person.01223761356.54
48 rdf:rest N637c3378af314ab1aeff0747953e340c
49 N26eb1357f18e42dab020b403c0989d19 rdf:first sg:person.01307014706.76
50 rdf:rest N01e25c2f19b440c794f77c1c1b934c60
51 N3101212e982d4925bffccd25c7eaa6e7 schema:name Springer Nature - SN SciGraph project
52 rdf:type schema:Organization
53 N489ef95f8aa549caa492f2d5f8e7c3e7 rdf:first sg:person.01325746532.38
54 rdf:rest N89e13e4cf89844bf91ea5d1ed9fb641c
55 N539f72b03146421c930e3e39c2eb0da7 rdf:first sg:person.01061427172.10
56 rdf:rest N61503255665f4bc894df75ce4c2e9875
57 N548f3fc23ec347539a1d333a2bb504e3 rdf:first sg:person.0627244670.28
58 rdf:rest rdf:nil
59 N5d73c65b2b904e60b7f8a00ec8c523e3 schema:name pubmed_id
60 schema:value 29438370
61 rdf:type schema:PropertyValue
62 N61503255665f4bc894df75ce4c2e9875 rdf:first sg:person.01157622404.07
63 rdf:rest N82aa366315ce4d7f8d017958535c3894
64 N637c3378af314ab1aeff0747953e340c rdf:first sg:person.01002064006.79
65 rdf:rest N539f72b03146421c930e3e39c2eb0da7
66 N66b2473fb0824b4180e328a555b10620 schema:issueNumber 6
67 rdf:type schema:PublicationIssue
68 N6d3eee79b07d4a8893f92a78be8266ce rdf:first sg:person.01221773122.43
69 rdf:rest N1c448f837e374f558ef0c3a933719a80
70 N82aa366315ce4d7f8d017958535c3894 rdf:first sg:person.01332747155.49
71 rdf:rest N489ef95f8aa549caa492f2d5f8e7c3e7
72 N85687ed2296a46b883cf43245fb958c9 rdf:first sg:person.01101164743.35
73 rdf:rest N548f3fc23ec347539a1d333a2bb504e3
74 N89e13e4cf89844bf91ea5d1ed9fb641c rdf:first sg:person.01034044447.78
75 rdf:rest N26eb1357f18e42dab020b403c0989d19
76 N8e4d0c5899a842c28db1741808af7a8c schema:name readcube_id
77 schema:value 0c937651c79bb086e3a9a2a2ffc273508ad2e9da9b3624f8bd786cd2cccdcefe
78 rdf:type schema:PropertyValue
79 N964b0c0a401d4a1bb8eac435c8c6ccef rdf:first sg:person.01355044667.69
80 rdf:rest N0aed1e4346aa4cd5884453660f3dc9b1
81 Naf6102f763464388a562e76912b61a1d schema:name dimensions_id
82 schema:value pub.1100990088
83 rdf:type schema:PropertyValue
84 Nb437d9c246d7485eb026b9910f936a7a rdf:first sg:person.01212502023.44
85 rdf:rest N26cf577973a94d38b2d43fb5861d4b8a
86 Nc1274df4d9e94e34ba622d8ecfbde0f2 schema:name doi
87 schema:value 10.1038/bjc.2017.488
88 rdf:type schema:PropertyValue
89 Nc145f85cecaf4fd0b9a620c17c2a247d rdf:first sg:person.01170102460.78
90 rdf:rest Nda909a0facb34e7690e7fa94ce64446e
91 Nca6d0f14b6024305a5c5307e4caad917 schema:name Moscow City Oncology Hospital 62, Krasnogorsk 14301, Russia
92 rdf:type schema:Organization
93 Ncc1e79424fa443f7976d6ffaed54e15f rdf:first sg:person.012434416233.59
94 rdf:rest Nc145f85cecaf4fd0b9a620c17c2a247d
95 Nd86ecbeebca34e5fbd69ef04d7dddd80 schema:volumeNumber 118
96 rdf:type schema:PublicationVolume
97 Nda909a0facb34e7690e7fa94ce64446e rdf:first sg:person.0613761724.46
98 rdf:rest N964b0c0a401d4a1bb8eac435c8c6ccef
99 Nf72ae4321f834b42a688289bc7dfacda schema:name nlm_unique_id
100 schema:value 0370635
101 rdf:type schema:PropertyValue
102 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
103 schema:name Medical and Health Sciences
104 rdf:type schema:DefinedTerm
105 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
106 schema:name Oncology and Carcinogenesis
107 rdf:type schema:DefinedTerm
108 sg:journal.1017082 schema:issn 0007-0920
109 1532-1827
110 schema:name British Journal of Cancer
111 rdf:type schema:Periodical
112 sg:person.01002064006.79 schema:affiliation https://www.grid.ac/institutes/grid.419617.c
113 schema:familyName Liszkay
114 schema:givenName Gabriella
115 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002064006.79
116 rdf:type schema:Person
117 sg:person.01034044447.78 schema:affiliation https://www.grid.ac/institutes/grid.411430.3
118 schema:familyName Thomas
119 schema:givenName Luc
120 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034044447.78
121 rdf:type schema:Person
122 sg:person.01061427172.10 schema:affiliation https://www.grid.ac/institutes/grid.411477.0
123 schema:familyName Maio
124 schema:givenName Michele
125 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061427172.10
126 rdf:type schema:Person
127 sg:person.01101164743.35 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
128 schema:familyName McArthur
129 schema:givenName Grant A
130 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101164743.35
131 rdf:type schema:Person
132 sg:person.011137006010.21 schema:affiliation https://www.grid.ac/institutes/grid.418158.1
133 schema:familyName Bartley
134 schema:givenName Karen
135 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011137006010.21
136 rdf:type schema:Person
137 sg:person.01146563400.12 schema:affiliation https://www.grid.ac/institutes/grid.4817.a
138 schema:familyName Dréno
139 schema:givenName Brigitte
140 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146563400.12
141 rdf:type schema:Person
142 sg:person.01157622404.07 schema:affiliation https://www.grid.ac/institutes/grid.460094.f
143 schema:familyName Mandalà
144 schema:givenName Mario
145 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157622404.07
146 rdf:type schema:Person
147 sg:person.01170102460.78 schema:affiliation https://www.grid.ac/institutes/grid.418158.1
148 schema:familyName Chang
149 schema:givenName Ilsung
150 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170102460.78
151 rdf:type schema:Person
152 sg:person.01212502023.44 schema:affiliation https://www.grid.ac/institutes/grid.417893.0
153 schema:familyName Ascierto
154 schema:givenName Paolo A
155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212502023.44
156 rdf:type schema:Person
157 sg:person.01221773122.43 schema:affiliation https://www.grid.ac/institutes/grid.10392.39
158 schema:familyName Garbe
159 schema:givenName Claus
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221773122.43
161 rdf:type schema:Person
162 sg:person.01223761356.54 schema:affiliation https://www.grid.ac/institutes/grid.412744.0
163 schema:familyName Atkinson
164 schema:givenName Victoria
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223761356.54
166 rdf:type schema:Person
167 sg:person.012434416233.59 schema:affiliation https://www.grid.ac/institutes/grid.418158.1
168 schema:familyName Karagiannis
169 schema:givenName Thomas
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012434416233.59
171 rdf:type schema:Person
172 sg:person.01255356274.07 schema:affiliation https://www.grid.ac/institutes/grid.5072.0
173 schema:familyName Larkin
174 schema:givenName James
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255356274.07
176 rdf:type schema:Person
177 sg:person.01307014706.76 schema:affiliation https://www.grid.ac/institutes/grid.411375.5
178 schema:familyName de la Cruz-Merino
179 schema:givenName Luis
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307014706.76
181 rdf:type schema:Person
182 sg:person.01325746532.38 schema:affiliation Nca6d0f14b6024305a5c5307e4caad917
183 schema:familyName Stroyakovskiy
184 schema:givenName Daniil
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325746532.38
186 rdf:type schema:Person
187 sg:person.01332747155.49 schema:affiliation https://www.grid.ac/institutes/grid.466904.9
188 schema:familyName Demidov
189 schema:givenName Lev
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01332747155.49
191 rdf:type schema:Person
192 sg:person.01355044667.69 schema:affiliation https://www.grid.ac/institutes/grid.418158.1
193 schema:familyName Koralek
194 schema:givenName Daniel O
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355044667.69
196 rdf:type schema:Person
197 sg:person.0613761724.46 schema:affiliation https://www.grid.ac/institutes/grid.418158.1
198 schema:familyName Rooney
199 schema:givenName Isabelle
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613761724.46
201 rdf:type schema:Person
202 sg:person.0627244670.28 schema:affiliation https://www.grid.ac/institutes/grid.19006.3e
203 schema:familyName Ribas
204 schema:givenName Antoni
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627244670.28
206 rdf:type schema:Person
207 sg:person.0740204011.00 schema:affiliation https://www.grid.ac/institutes/grid.414339.8
208 schema:familyName Dutriaux
209 schema:givenName Caroline
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740204011.00
211 rdf:type schema:Person
212 https://doi.org/10.1016/j.ejca.2015.03.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025118564
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1016/s1470-2045(15)00087-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002492213
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1056/nejmoa1408868 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000859328
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1093/annonc/mdt580 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025353861
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1093/annonc/mdu154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029017193
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1093/annonc/mdx040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085285261
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1093/jnci/85.5.365 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059818446
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1097/cmr.0000000000000122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002267720
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1200/jco.1998.16.1.139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083201628
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1200/jco.2016.34.15_suppl.9533 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106842853
231 rdf:type schema:CreativeWork
232 https://www.grid.ac/institutes/grid.1008.9 schema:alternateName University of Melbourne
233 schema:name Peter MacCallum Cancer Centre, East Melbourne, VIC 3002, Australia
234 University of Melbourne, Parkville, VIC 3052, Australia
235 rdf:type schema:Organization
236 https://www.grid.ac/institutes/grid.10392.39 schema:alternateName University of Tübingen
237 schema:name Department of Dermatology, University of Tübingen, Tübingen 72074, Germany
238 rdf:type schema:Organization
239 https://www.grid.ac/institutes/grid.19006.3e schema:alternateName University of California Los Angeles
240 schema:name Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, CA 90095, USA
241 rdf:type schema:Organization
242 https://www.grid.ac/institutes/grid.411375.5 schema:alternateName Hospital Universitario Virgen Macarena
243 schema:name Hospital Universitario Virgen Macarena, Seville 41009, Spain
244 rdf:type schema:Organization
245 https://www.grid.ac/institutes/grid.411430.3 schema:alternateName Centre Hospitalier Lyon Sud
246 schema:name Service de Dermatologie, Centre Hospitalier Lyon Sud, Pierre-Bénite 69495, France
247 rdf:type schema:Organization
248 https://www.grid.ac/institutes/grid.411477.0 schema:alternateName Azienda Ospedaliera Universitaria Senese
249 schema:name Azienda Ospedaliera Universitaria Senese, Siena 53100, Italy
250 rdf:type schema:Organization
251 https://www.grid.ac/institutes/grid.412744.0 schema:alternateName Princess Alexandra Hospital
252 schema:name Princess Alexandra Hospital, Woolloongabba, QLD 4102, Australia
253 rdf:type schema:Organization
254 https://www.grid.ac/institutes/grid.414339.8 schema:alternateName Hôpital Saint-André
255 schema:name Hôpital Saint André, Bordeaux 33075, France
256 rdf:type schema:Organization
257 https://www.grid.ac/institutes/grid.417893.0 schema:alternateName Istituto Nazionale dei Tumori
258 schema:name Istituto Nazionale Tumori Fondazione G. Pascale, Naples 80131, Italy
259 rdf:type schema:Organization
260 https://www.grid.ac/institutes/grid.418158.1 schema:alternateName Roche (United States)
261 schema:name Genentech, Inc., South San Francisco, CA 94080, USA
262 rdf:type schema:Organization
263 https://www.grid.ac/institutes/grid.419617.c schema:alternateName National Institute of Oncology
264 schema:name National Institute of Oncology, Budapest 1122, Hungary
265 rdf:type schema:Organization
266 https://www.grid.ac/institutes/grid.460094.f schema:alternateName Ospedale Papa Giovanni XXIII
267 schema:name Department of Oncology and Haematology, Papa Giovanni XXIII Hospital, Bergamo 24127, Italy
268 rdf:type schema:Organization
269 https://www.grid.ac/institutes/grid.466904.9 schema:alternateName Russian Cancer Research Center NN Blokhin
270 schema:name N. N. Blokhin Russian Cancer Research Center, Moscow 115478, Russia
271 rdf:type schema:Organization
272 https://www.grid.ac/institutes/grid.4817.a schema:alternateName University of Nantes
273 schema:name Department of Dermato Cancerology, Nantes University, Nantes 44093, France
274 rdf:type schema:Organization
275 https://www.grid.ac/institutes/grid.5072.0 schema:alternateName Royal Marsden NHS Foundation Trust
276 schema:name The Royal Marsden NHS Foundation Trust, London SW3 6JJ, UK
277 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...