KRAS mutations in cell-free DNA from preoperative and postoperative sera as a pancreatic cancer marker: a retrospective study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-03-06

AUTHORS

Yutaka Nakano, Minoru Kitago, Sachiko Matsuda, Yuki Nakamura, Yusuke Fujita, Shunichi Imai, Masahiro Shinoda, Hiroshi Yagi, Yuta Abe, Taizo Hibi, Yoko Fujii-Nishimura, Ayano Takeuchi, Yutaka Endo, Osamu Itano, Yuko Kitagawa

ABSTRACT

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) has very poor prognosis despite existing multimodal therapies. This study aimed to investigate whether KRAS mutations at codons 12/13 in cell-free DNA (cfDNA) from preoperative and postoperative sera from patients with PDAC can serve as a predictive biomarker for treatment response and outcomes after surgery. METHODS: Preoperative and postoperative serum samples obtained from 45 patients with PDAC whom underwent curative pancreatectomy at our institution between January 2013 and July 2016 were retrospectively analysed. Peptide nucleic acid-directed PCR clamping was used to identify KRAS mutations in cfDNA. RESULTS: Among the 45 patients enrolled, 11 (24.4%) and 20 (44.4%) had KRAS mutations in cfDNA from preoperative and postoperative sera, respectively. Multivariate analysis revealed that KRAS mutations in postoperative serum (hazard ratio (HR)=2.919; 95% confidence interval (CI)=1.109-5.621; P=0.027) are an independent prognostic factor for disease-free survival. Furthermore, the shift from wild-type KRAS in preoperative to mutant KRAS in postoperative cfDNA (HR=9.419; 95% Cl=2.015-44.036; P=0.004) was an independent prognostic factor for overall survival. CONCLUSIONS: Changes in KRAS mutation status between preoperative and postoperative cfDNA may be a useful predictive biomarker for survival and treatment response. More... »

PAGES

662

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.2017.479

DOI

http://dx.doi.org/10.1038/bjc.2017.479

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1100561708

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29360815


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322 https://www.grid.ac/institutes/grid.411731.1 schema:alternateName International University of Health and Welfare
323 schema:name Hepato-Biliary-Pancreatic and Gastrointestinal Surgery, International University of Health and Welfare School of Medicine, 14-1-6 Kokufudai Ichikawa-shi, Chiba 272-0827, Japan
324 rdf:type schema:Organization
 




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