Preoperative chemoradiation with capecitabine, irinotecan and cetuximab in rectal cancer: significance of pre-treatment and post-resection RAS mutations View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-10-24

AUTHORS

Simon Gollins, Nick West, David Sebag-Montefiore, Arthur Sun Myint, Mark Saunders, Shabbir Susnerwala, Phil Quirke, Sharadah Essapen, Leslie Samuel, Bruce Sizer, Jane Worlding, Katie Southward, Gemma Hemmings, Emma Tinkler-Hundal, Morag Taylor, Daniel Bottomley, Philip Chambers, Emma Lawrie, Andre Lopes, Sandy Beare

ABSTRACT

BACKGROUND: The influence of EGFR pathway mutations on cetuximab-containing rectal cancer preoperative chemoradiation (CRT) is uncertain. METHODS: In a prospective phase II trial (EXCITE), patients with magnetic resonance imaging (MRI)-defined non-metastatic rectal adenocarinoma threatening/involving the surgical resection plane received pelvic radiotherapy with concurrent capecitabine, irinotecan and cetuximab. Resection was recommended 8 weeks later. The primary endpoint was histopathologically clear (R0) resection margin. Pre-planned retrospective DNA pyrosequencing (PS) and next generation sequencing (NGS) of KRAS, NRAS, PIK3CA and BRAF was performed on the pre-treatment biopsy and resected specimen. RESULTS: Eighty-two patients were recruited and 76 underwent surgery, with R0 resection in 67 (82%, 90%CI: 73-88%) (four patients with clinical complete response declined surgery). Twenty-four patients (30%) had an excellent clinical or pathological response (ECPR). Using NGS 24 (46%) of 52 matched biopsies/resections were discrepant: ten patients (19%) gained 13 new resection mutations compared to biopsy (12 KRAS, one PIK3CA) and 18 (35%) lost 22 mutations (15 KRAS, 7 PIK3CA). Tumours only ever testing RAS wild-type had significantly greater ECPR than tumours with either biopsy or resection RAS mutations (14/29 [48%] vs 10/51 [20%], P=0.008), with a trend towards increased overall survival (HR 0.23, 95% CI 0.05-1.03, P=0.055). CONCLUSIONS: This regimen was feasible and the primary study endpoint was met. For the first time using pre-operative rectal CRT, emergence of clinically important new resection mutations is described, likely reflecting intratumoural heterogeneity manifesting either as treatment-driven selective clonal expansion or a geographical biopsy sampling miss. More... »

PAGES

1286

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.2017.294

DOI

http://dx.doi.org/10.1038/bjc.2017.294

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1091400472

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28859058


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenocarcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Combined Chemotherapy Protocols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Camptothecin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Capecitabine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cetuximab", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemoradiotherapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Class I Phosphatidylinositol 3-Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Combined Modality Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "GTP Phosphohydrolases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Staging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Postoperative Care", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins B-raf", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins p21(ras)", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rectal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Rate", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Department of Oncology, North Wales Cancer Treatment Centre, Bodelwyddan, Denbighshire LL18 5UJ, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gollins", 
        "givenName": "Simon", 
        "id": "sg:person.01030061632.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030061632.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Leeds", 
          "id": "https://www.grid.ac/institutes/grid.9909.9", 
          "name": [
            "Leeds Institute of Cancer and Pathology, University of Leeds, Leeds LS9 7TF, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "West", 
        "givenName": "Nick", 
        "id": "sg:person.01231610504.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231610504.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Leeds", 
          "id": "https://www.grid.ac/institutes/grid.9909.9", 
          "name": [
            "St James\u2019 Institute of Oncology, University of Leeds, Leeds LS9 7TF, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sebag-Montefiore", 
        "givenName": "David", 
        "id": "sg:person.0645520032.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645520032.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Clatterbridge Cancer Centre NHS Foundation Trust", 
          "id": "https://www.grid.ac/institutes/grid.418624.d", 
          "name": [
            "Clatterbridge Cancer Centre, Clatterbridge Road, Wirral CH63 4JY, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Myint", 
        "givenName": "Arthur Sun", 
        "id": "sg:person.01307134474.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307134474.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Christie Hospital NHS Foundation Trust", 
          "id": "https://www.grid.ac/institutes/grid.412917.8", 
          "name": [
            "The Christie NHS Foundation Trust, Withington, Manchester M20 4BX, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saunders", 
        "givenName": "Mark", 
        "id": "sg:person.01257026230.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257026230.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal Preston Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416204.5", 
          "name": [
            "Royal Preston Hospital, Fulwood, Preston PR2 9HT, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Susnerwala", 
        "givenName": "Shabbir", 
        "id": "sg:person.01371433471.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371433471.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St James's University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.443984.6", 
          "name": [
            "Pathology and Tumour Biology, Level 4 Wellcome Trust Brenner Building, St James University Hospital, Beckett Street, Leeds LS9 7TF, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Quirke", 
        "givenName": "Phil", 
        "id": "sg:person.011373215124.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011373215124.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "St Luke\u2019s Cancer Centre, Egerton Road, Guildford GU2 7XX, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Essapen", 
        "givenName": "Sharadah", 
        "id": "sg:person.01020376324.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020376324.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Aberdeen Royal Infirmary", 
          "id": "https://www.grid.ac/institutes/grid.417581.e", 
          "name": [
            "Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZN, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Samuel", 
        "givenName": "Leslie", 
        "id": "sg:person.0774106122.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774106122.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Colchester General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.414586.a", 
          "name": [
            "Colchester General Hospital, Turner Road, Colchester CO4 5JL, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sizer", 
        "givenName": "Bruce", 
        "id": "sg:person.01262037576.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262037576.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospitals Coventry and Warwickshire NHS Trust", 
          "id": "https://www.grid.ac/institutes/grid.15628.38", 
          "name": [
            "University Hospitals Coventry and Warwickshire NHS Trust, Clifford Bridge Road, Coventry CV2 2DX, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Worlding", 
        "givenName": "Jane", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Leeds", 
          "id": "https://www.grid.ac/institutes/grid.9909.9", 
          "name": [
            "Leeds Institute of Cancer and Pathology, University of Leeds, Leeds LS9 7TF, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Southward", 
        "givenName": "Katie", 
        "id": "sg:person.01012174047.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012174047.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Leeds", 
          "id": "https://www.grid.ac/institutes/grid.9909.9", 
          "name": [
            "Leeds Institute of Cancer and Pathology, University of Leeds, Leeds LS9 7TF, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hemmings", 
        "givenName": "Gemma", 
        "id": "sg:person.01370160323.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370160323.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Leeds", 
          "id": "https://www.grid.ac/institutes/grid.9909.9", 
          "name": [
            "Leeds Institute of Cancer and Pathology, University of Leeds, Leeds LS9 7TF, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tinkler-Hundal", 
        "givenName": "Emma", 
        "id": "sg:person.01124556725.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124556725.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Leeds", 
          "id": "https://www.grid.ac/institutes/grid.9909.9", 
          "name": [
            "Leeds Institute of Cancer and Pathology, University of Leeds, Leeds LS9 7TF, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Taylor", 
        "givenName": "Morag", 
        "id": "sg:person.01002663565.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002663565.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Leeds", 
          "id": "https://www.grid.ac/institutes/grid.9909.9", 
          "name": [
            "Leeds Institute of Cancer and Pathology, University of Leeds, Leeds LS9 7TF, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bottomley", 
        "givenName": "Daniel", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Leeds", 
          "id": "https://www.grid.ac/institutes/grid.9909.9", 
          "name": [
            "Leeds Institute of Cancer and Pathology, University of Leeds, Leeds LS9 7TF, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chambers", 
        "givenName": "Philip", 
        "id": "sg:person.01137103576.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137103576.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University College London", 
          "id": "https://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "Cancer Research UK & UCL Cancer Trials Centre, University College London, 90 Tottenham Court Road, London W1T 4TJ, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lawrie", 
        "givenName": "Emma", 
        "id": "sg:person.015444120047.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015444120047.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University College London", 
          "id": "https://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "Cancer Research UK & UCL Cancer Trials Centre, University College London, 90 Tottenham Court Road, London W1T 4TJ, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lopes", 
        "givenName": "Andre", 
        "id": "sg:person.0603260617.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603260617.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University College London", 
          "id": "https://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "Cancer Research UK & UCL Cancer Trials Centre, University College London, 90 Tottenham Court Road, London W1T 4TJ, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Beare", 
        "givenName": "Sandy", 
        "id": "sg:person.01111333556.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111333556.71"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nature11219", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004846070", 
          "https://doi.org/10.1038/nature11219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2010.29.7697", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004927382"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa053422", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005630380"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.3214", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008423455", 
          "https://doi.org/10.1038/ng.3214"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.suronc.2013.02.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011316789"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2010.06.043", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011463050"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(13)70599-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013224241"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3233/acp-2011-0005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017368181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2011.39.6036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022439548"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2014.59.4812", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026384267"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2009.22.4295", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027962078"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0108247", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029745203"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0108247", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029745203"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2012.03.048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031516034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.radonc.2004.12.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031841398"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mds236", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034294500"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa033025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035161767"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.3870", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035726640", 
          "https://doi.org/10.1038/nm.3870"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1235122", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035954369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(10)70130-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038656599"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2006.06.7629", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040853793"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.02.1329", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042089423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.clon.2015.11.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042194971"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.hoc.2006.01.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042960688"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(13)70136-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045300754"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0805019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045468727"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2011/393521", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063203728"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-16-0032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063225319"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-10-24", 
    "datePublishedReg": "2017-10-24", 
    "description": "BACKGROUND: The influence of EGFR pathway mutations on cetuximab-containing rectal cancer preoperative chemoradiation (CRT) is uncertain.\nMETHODS: In a prospective phase II trial (EXCITE), patients with magnetic resonance imaging (MRI)-defined non-metastatic rectal adenocarinoma threatening/involving the surgical resection plane received pelvic radiotherapy with concurrent capecitabine, irinotecan and cetuximab. Resection was recommended 8 weeks later. The primary endpoint was histopathologically clear (R0) resection margin. Pre-planned retrospective DNA pyrosequencing (PS) and next generation sequencing (NGS) of KRAS, NRAS, PIK3CA and BRAF was performed on the pre-treatment biopsy and resected specimen.\nRESULTS: Eighty-two patients were recruited and 76 underwent surgery, with R0 resection in 67 (82%, 90%CI: 73-88%) (four patients with clinical complete response declined surgery). Twenty-four patients (30%) had an excellent clinical or pathological response (ECPR). Using NGS 24 (46%) of 52 matched biopsies/resections were discrepant: ten patients (19%) gained 13 new resection mutations compared to biopsy (12 KRAS, one PIK3CA) and 18 (35%) lost 22 mutations (15 KRAS, 7 PIK3CA). Tumours only ever testing RAS wild-type had significantly greater ECPR than tumours with either biopsy or resection RAS mutations (14/29 [48%] vs 10/51 [20%], P=0.008), with a trend towards increased overall survival (HR 0.23, 95% CI 0.05-1.03, P=0.055).\nCONCLUSIONS: This regimen was feasible and the primary study endpoint was met. For the first time using pre-operative rectal CRT, emergence of clinically important new resection mutations is described, likely reflecting intratumoural heterogeneity manifesting either as treatment-driven selective clonal expansion or a geographical biopsy sampling miss.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/bjc.2017.294", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1017082", 
        "issn": [
          "0007-0920", 
          "1532-1827"
        ], 
        "name": "British Journal of Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "9", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "117"
      }
    ], 
    "name": "Preoperative chemoradiation with capecitabine, irinotecan and cetuximab in rectal cancer: significance of pre-treatment and post-resection RAS mutations", 
    "pagination": "1286", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "9633ee8f36bdc59cf47db469d821e341e9d79fee6773edf26c3b6532e0be058f"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28859058"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0370635"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/bjc.2017.294"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1091400472"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/bjc.2017.294", 
      "https://app.dimensions.ai/details/publication/pub.1091400472"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T23:12", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000427.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/bjc2017294"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/bjc.2017.294'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/bjc.2017.294'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/bjc.2017.294'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/bjc.2017.294'


 

This table displays all metadata directly associated to this object as RDF triples.

425 TRIPLES      21 PREDICATES      83 URIs      48 LITERALS      37 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/bjc.2017.294 schema:about N05b574246b334494a2d7ddc3c119d6bd
2 N09f90d1a572a44849c3a4879b97c74fc
3 N100129da43c54b3186bee7452dbbbf0c
4 N106f2de3baf848979cf929bc6a8ddf91
5 N12446aebeb5c450d9cd823b1ded84ee6
6 N16cb7e1e25b845eca62af1ada2ffa8bb
7 N1b8369a3af2547219a5610f0f09536cf
8 N23792b1d30324eba92be60a41189dbfe
9 N2f7c040f1f3745049d1e94a67217f6aa
10 N304c66e3f93642298d2336121f1d6b46
11 N33b84da030614428a089eb3af6fa711a
12 N597fd4af43034ce5be7052317a8db2cf
13 N81e23d05fa1a4f93be0f531d08b66cf7
14 N89f95f078bd04acc86f0e4fb87f07094
15 N8b0f57e6d7c44e5c84999202d958e02c
16 N92101d8e94f346119784169518695d9b
17 Na03a53c8a2324a0c9bfd23355d2a159f
18 Na56c276af3294534be5299a0a549ffce
19 Nac5faf730057492d8c8427a8826647d4
20 Nbc4284969e3a4159a38f1e679e453195
21 Nbe2aef1af52449a582007e690f964e57
22 Nbe59553005d64e5dab5c8905e862982d
23 Nc95937c0ffee4cf9b706d2e0cde52b29
24 Ncf28394cae4e4ccbaf319f5ceedf1bcb
25 Nd12e139a6ec548049fb3b5f5530459ea
26 Ndd08139b6b3940d6967b08b9d4c30ae4
27 Nf1ea5f05102643b9a1863a94d0f69ff1
28 Nfe6633c15bad40eaa31dd1de55588384
29 anzsrc-for:11
30 anzsrc-for:1103
31 schema:author N6d724788a7a04e58bafeb46893232ca0
32 schema:citation sg:pub.10.1038/nature11219
33 sg:pub.10.1038/ng.3214
34 sg:pub.10.1038/nm.3870
35 https://doi.org/10.1016/j.clon.2015.11.002
36 https://doi.org/10.1016/j.hoc.2006.01.007
37 https://doi.org/10.1016/j.ijrobp.2010.06.043
38 https://doi.org/10.1016/j.ijrobp.2012.03.048
39 https://doi.org/10.1016/j.radonc.2004.12.021
40 https://doi.org/10.1016/j.suronc.2013.02.001
41 https://doi.org/10.1016/s1470-2045(10)70130-3
42 https://doi.org/10.1016/s1470-2045(13)70136-0
43 https://doi.org/10.1016/s1470-2045(13)70599-0
44 https://doi.org/10.1056/nejmoa033025
45 https://doi.org/10.1056/nejmoa053422
46 https://doi.org/10.1056/nejmoa0805019
47 https://doi.org/10.1093/annonc/mds236
48 https://doi.org/10.1126/science.1235122
49 https://doi.org/10.1155/2011/393521
50 https://doi.org/10.1158/1078-0432.ccr-16-0032
51 https://doi.org/10.1200/jco.2005.02.1329
52 https://doi.org/10.1200/jco.2006.06.7629
53 https://doi.org/10.1200/jco.2009.22.4295
54 https://doi.org/10.1200/jco.2010.29.7697
55 https://doi.org/10.1200/jco.2011.39.6036
56 https://doi.org/10.1200/jco.2014.59.4812
57 https://doi.org/10.1371/journal.pone.0108247
58 https://doi.org/10.3233/acp-2011-0005
59 schema:datePublished 2017-10-24
60 schema:datePublishedReg 2017-10-24
61 schema:description BACKGROUND: The influence of EGFR pathway mutations on cetuximab-containing rectal cancer preoperative chemoradiation (CRT) is uncertain. METHODS: In a prospective phase II trial (EXCITE), patients with magnetic resonance imaging (MRI)-defined non-metastatic rectal adenocarinoma threatening/involving the surgical resection plane received pelvic radiotherapy with concurrent capecitabine, irinotecan and cetuximab. Resection was recommended 8 weeks later. The primary endpoint was histopathologically clear (R0) resection margin. Pre-planned retrospective DNA pyrosequencing (PS) and next generation sequencing (NGS) of KRAS, NRAS, PIK3CA and BRAF was performed on the pre-treatment biopsy and resected specimen. RESULTS: Eighty-two patients were recruited and 76 underwent surgery, with R0 resection in 67 (82%, 90%CI: 73-88%) (four patients with clinical complete response declined surgery). Twenty-four patients (30%) had an excellent clinical or pathological response (ECPR). Using NGS 24 (46%) of 52 matched biopsies/resections were discrepant: ten patients (19%) gained 13 new resection mutations compared to biopsy (12 KRAS, one PIK3CA) and 18 (35%) lost 22 mutations (15 KRAS, 7 PIK3CA). Tumours only ever testing RAS wild-type had significantly greater ECPR than tumours with either biopsy or resection RAS mutations (14/29 [48%] vs 10/51 [20%], P=0.008), with a trend towards increased overall survival (HR 0.23, 95% CI 0.05-1.03, P=0.055). CONCLUSIONS: This regimen was feasible and the primary study endpoint was met. For the first time using pre-operative rectal CRT, emergence of clinically important new resection mutations is described, likely reflecting intratumoural heterogeneity manifesting either as treatment-driven selective clonal expansion or a geographical biopsy sampling miss.
62 schema:genre research_article
63 schema:inLanguage en
64 schema:isAccessibleForFree true
65 schema:isPartOf N519e9aba27df41eb91f2b270080846d4
66 N9eb9da1c1e0749b1a65d65a3bee53eb5
67 sg:journal.1017082
68 schema:name Preoperative chemoradiation with capecitabine, irinotecan and cetuximab in rectal cancer: significance of pre-treatment and post-resection RAS mutations
69 schema:pagination 1286
70 schema:productId N70474c67e614487c9a748b83ab44faa4
71 N8511dbf0babd444b8689bd4bb20b815c
72 N93f7f6b3c35b42cfbf2be1ba831827d0
73 Naede48c4867049c6a6e17defbc3f0a57
74 Ne751cba59e6245718486a8b507608947
75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091400472
76 https://doi.org/10.1038/bjc.2017.294
77 schema:sdDatePublished 2019-04-10T23:12
78 schema:sdLicense https://scigraph.springernature.com/explorer/license/
79 schema:sdPublisher N2abf61b45cfc428b9f458bab9bf372ba
80 schema:url https://www.nature.com/articles/bjc2017294
81 sgo:license sg:explorer/license/
82 sgo:sdDataset articles
83 rdf:type schema:ScholarlyArticle
84 N05b574246b334494a2d7ddc3c119d6bd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Middle Aged
86 rdf:type schema:DefinedTerm
87 N09f90d1a572a44849c3a4879b97c74fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Combined Modality Therapy
89 rdf:type schema:DefinedTerm
90 N0bfbb7c304e2461e98bf7d4b915140b6 rdf:first Nad62badc15b644d886457313c7bb55a5
91 rdf:rest N4793684244a94e2ea0a25a70f3651ae9
92 N0c9856d1ab0a43fb82deb07320c4ede8 rdf:first sg:person.01370160323.58
93 rdf:rest N0e173833bff44030a5a37864898842c0
94 N0e173833bff44030a5a37864898842c0 rdf:first sg:person.01124556725.90
95 rdf:rest N7506a15dbe194427a4c5aed74103c23f
96 N100129da43c54b3186bee7452dbbbf0c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Biomarkers, Tumor
98 rdf:type schema:DefinedTerm
99 N106f2de3baf848979cf929bc6a8ddf91 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Capecitabine
101 rdf:type schema:DefinedTerm
102 N12446aebeb5c450d9cd823b1ded84ee6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Postoperative Care
104 rdf:type schema:DefinedTerm
105 N16cb7e1e25b845eca62af1ada2ffa8bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Mutation
107 rdf:type schema:DefinedTerm
108 N1b8369a3af2547219a5610f0f09536cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Survival Rate
110 rdf:type schema:DefinedTerm
111 N1d24a5074613488fa40e7f29b0ec1f79 rdf:first sg:person.01020376324.61
112 rdf:rest N2d3293316127417481fbce6fe013986f
113 N23792b1d30324eba92be60a41189dbfe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Humans
115 rdf:type schema:DefinedTerm
116 N2abf61b45cfc428b9f458bab9bf372ba schema:name Springer Nature - SN SciGraph project
117 rdf:type schema:Organization
118 N2d3293316127417481fbce6fe013986f rdf:first sg:person.0774106122.06
119 rdf:rest N60cf7100848a4d0b8f90b80c32c33225
120 N2f7c040f1f3745049d1e94a67217f6aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Antineoplastic Combined Chemotherapy Protocols
122 rdf:type schema:DefinedTerm
123 N304c66e3f93642298d2336121f1d6b46 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Membrane Proteins
125 rdf:type schema:DefinedTerm
126 N33b84da030614428a089eb3af6fa711a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Neoplasm Staging
128 rdf:type schema:DefinedTerm
129 N43f0585b7c4944ff83193c41d88bd889 rdf:first sg:person.01137103576.21
130 rdf:rest Nece2abb68f1b4f429333eb5b41220ee8
131 N4793684244a94e2ea0a25a70f3651ae9 rdf:first sg:person.01012174047.40
132 rdf:rest N0c9856d1ab0a43fb82deb07320c4ede8
133 N519e9aba27df41eb91f2b270080846d4 schema:issueNumber 9
134 rdf:type schema:PublicationIssue
135 N52bd474291814214be289d35cc6e6465 rdf:first sg:person.011373215124.06
136 rdf:rest N1d24a5074613488fa40e7f29b0ec1f79
137 N5346dc7734ee4a01b27b86f0fcf698b1 schema:name St Luke’s Cancer Centre, Egerton Road, Guildford GU2 7XX, UK
138 rdf:type schema:Organization
139 N597fd4af43034ce5be7052317a8db2cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Rectal Neoplasms
141 rdf:type schema:DefinedTerm
142 N5b441345cf1d4d1693702ad75d760ec3 rdf:first sg:person.01111333556.71
143 rdf:rest rdf:nil
144 N5df2924cc93c44ba9b2712769c19508a schema:name Department of Oncology, North Wales Cancer Treatment Centre, Bodelwyddan, Denbighshire LL18 5UJ, UK
145 rdf:type schema:Organization
146 N60cf7100848a4d0b8f90b80c32c33225 rdf:first sg:person.01262037576.18
147 rdf:rest N0bfbb7c304e2461e98bf7d4b915140b6
148 N6aab35ed75474e2cbcccff33b1e35b3e rdf:first sg:person.0603260617.15
149 rdf:rest N5b441345cf1d4d1693702ad75d760ec3
150 N6d724788a7a04e58bafeb46893232ca0 rdf:first sg:person.01030061632.62
151 rdf:rest N7a50c4cf31c24a94b19e63d28cd015b1
152 N70474c67e614487c9a748b83ab44faa4 schema:name dimensions_id
153 schema:value pub.1091400472
154 rdf:type schema:PropertyValue
155 N7506a15dbe194427a4c5aed74103c23f rdf:first sg:person.01002663565.33
156 rdf:rest N76cd7a813de744d3b30059cf8ba3c0d6
157 N76cd7a813de744d3b30059cf8ba3c0d6 rdf:first Na7a2f7869352439c9b8c4ea493f21c65
158 rdf:rest N43f0585b7c4944ff83193c41d88bd889
159 N7a50c4cf31c24a94b19e63d28cd015b1 rdf:first sg:person.01231610504.23
160 rdf:rest N9b597a11da5d47c1a4be0af8277e5454
161 N7bc5e7c89811407ca5c1aecbf9871418 rdf:first sg:person.01257026230.01
162 rdf:rest Nebbb663cac5f430583a9a660dce25540
163 N81e23d05fa1a4f93be0f531d08b66cf7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Retrospective Studies
165 rdf:type schema:DefinedTerm
166 N8511dbf0babd444b8689bd4bb20b815c schema:name nlm_unique_id
167 schema:value 0370635
168 rdf:type schema:PropertyValue
169 N89f95f078bd04acc86f0e4fb87f07094 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Prospective Studies
171 rdf:type schema:DefinedTerm
172 N8b0f57e6d7c44e5c84999202d958e02c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Prognosis
174 rdf:type schema:DefinedTerm
175 N92101d8e94f346119784169518695d9b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Male
177 rdf:type schema:DefinedTerm
178 N93f7f6b3c35b42cfbf2be1ba831827d0 schema:name readcube_id
179 schema:value 9633ee8f36bdc59cf47db469d821e341e9d79fee6773edf26c3b6532e0be058f
180 rdf:type schema:PropertyValue
181 N9b597a11da5d47c1a4be0af8277e5454 rdf:first sg:person.0645520032.49
182 rdf:rest Nb2f29be13c6441dcb1d4ff9c92323a81
183 N9eb9da1c1e0749b1a65d65a3bee53eb5 schema:volumeNumber 117
184 rdf:type schema:PublicationVolume
185 Na03a53c8a2324a0c9bfd23355d2a159f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Proto-Oncogene Proteins p21(ras)
187 rdf:type schema:DefinedTerm
188 Na56c276af3294534be5299a0a549ffce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Camptothecin
190 rdf:type schema:DefinedTerm
191 Na7a2f7869352439c9b8c4ea493f21c65 schema:affiliation https://www.grid.ac/institutes/grid.9909.9
192 schema:familyName Bottomley
193 schema:givenName Daniel
194 rdf:type schema:Person
195 Nac5faf730057492d8c8427a8826647d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
196 schema:name GTP Phosphohydrolases
197 rdf:type schema:DefinedTerm
198 Nad62badc15b644d886457313c7bb55a5 schema:affiliation https://www.grid.ac/institutes/grid.15628.38
199 schema:familyName Worlding
200 schema:givenName Jane
201 rdf:type schema:Person
202 Naede48c4867049c6a6e17defbc3f0a57 schema:name pubmed_id
203 schema:value 28859058
204 rdf:type schema:PropertyValue
205 Nb2f29be13c6441dcb1d4ff9c92323a81 rdf:first sg:person.01307134474.81
206 rdf:rest N7bc5e7c89811407ca5c1aecbf9871418
207 Nbc4284969e3a4159a38f1e679e453195 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
208 schema:name Aged
209 rdf:type schema:DefinedTerm
210 Nbe2aef1af52449a582007e690f964e57 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
211 schema:name Proto-Oncogene Proteins B-raf
212 rdf:type schema:DefinedTerm
213 Nbe59553005d64e5dab5c8905e862982d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
214 schema:name Follow-Up Studies
215 rdf:type schema:DefinedTerm
216 Nc95937c0ffee4cf9b706d2e0cde52b29 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
217 schema:name Adult
218 rdf:type schema:DefinedTerm
219 Ncf28394cae4e4ccbaf319f5ceedf1bcb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
220 schema:name Female
221 rdf:type schema:DefinedTerm
222 Nd12e139a6ec548049fb3b5f5530459ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
223 schema:name Adenocarcinoma
224 rdf:type schema:DefinedTerm
225 Ndd08139b6b3940d6967b08b9d4c30ae4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
226 schema:name Cetuximab
227 rdf:type schema:DefinedTerm
228 Ne751cba59e6245718486a8b507608947 schema:name doi
229 schema:value 10.1038/bjc.2017.294
230 rdf:type schema:PropertyValue
231 Nebbb663cac5f430583a9a660dce25540 rdf:first sg:person.01371433471.82
232 rdf:rest N52bd474291814214be289d35cc6e6465
233 Nece2abb68f1b4f429333eb5b41220ee8 rdf:first sg:person.015444120047.28
234 rdf:rest N6aab35ed75474e2cbcccff33b1e35b3e
235 Nf1ea5f05102643b9a1863a94d0f69ff1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
236 schema:name Chemoradiotherapy
237 rdf:type schema:DefinedTerm
238 Nfe6633c15bad40eaa31dd1de55588384 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
239 schema:name Class I Phosphatidylinositol 3-Kinases
240 rdf:type schema:DefinedTerm
241 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
242 schema:name Medical and Health Sciences
243 rdf:type schema:DefinedTerm
244 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
245 schema:name Clinical Sciences
246 rdf:type schema:DefinedTerm
247 sg:journal.1017082 schema:issn 0007-0920
248 1532-1827
249 schema:name British Journal of Cancer
250 rdf:type schema:Periodical
251 sg:person.01002663565.33 schema:affiliation https://www.grid.ac/institutes/grid.9909.9
252 schema:familyName Taylor
253 schema:givenName Morag
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002663565.33
255 rdf:type schema:Person
256 sg:person.01012174047.40 schema:affiliation https://www.grid.ac/institutes/grid.9909.9
257 schema:familyName Southward
258 schema:givenName Katie
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012174047.40
260 rdf:type schema:Person
261 sg:person.01020376324.61 schema:affiliation N5346dc7734ee4a01b27b86f0fcf698b1
262 schema:familyName Essapen
263 schema:givenName Sharadah
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020376324.61
265 rdf:type schema:Person
266 sg:person.01030061632.62 schema:affiliation N5df2924cc93c44ba9b2712769c19508a
267 schema:familyName Gollins
268 schema:givenName Simon
269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030061632.62
270 rdf:type schema:Person
271 sg:person.01111333556.71 schema:affiliation https://www.grid.ac/institutes/grid.83440.3b
272 schema:familyName Beare
273 schema:givenName Sandy
274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111333556.71
275 rdf:type schema:Person
276 sg:person.01124556725.90 schema:affiliation https://www.grid.ac/institutes/grid.9909.9
277 schema:familyName Tinkler-Hundal
278 schema:givenName Emma
279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124556725.90
280 rdf:type schema:Person
281 sg:person.01137103576.21 schema:affiliation https://www.grid.ac/institutes/grid.9909.9
282 schema:familyName Chambers
283 schema:givenName Philip
284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137103576.21
285 rdf:type schema:Person
286 sg:person.011373215124.06 schema:affiliation https://www.grid.ac/institutes/grid.443984.6
287 schema:familyName Quirke
288 schema:givenName Phil
289 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011373215124.06
290 rdf:type schema:Person
291 sg:person.01231610504.23 schema:affiliation https://www.grid.ac/institutes/grid.9909.9
292 schema:familyName West
293 schema:givenName Nick
294 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231610504.23
295 rdf:type schema:Person
296 sg:person.01257026230.01 schema:affiliation https://www.grid.ac/institutes/grid.412917.8
297 schema:familyName Saunders
298 schema:givenName Mark
299 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257026230.01
300 rdf:type schema:Person
301 sg:person.01262037576.18 schema:affiliation https://www.grid.ac/institutes/grid.414586.a
302 schema:familyName Sizer
303 schema:givenName Bruce
304 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262037576.18
305 rdf:type schema:Person
306 sg:person.01307134474.81 schema:affiliation https://www.grid.ac/institutes/grid.418624.d
307 schema:familyName Myint
308 schema:givenName Arthur Sun
309 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307134474.81
310 rdf:type schema:Person
311 sg:person.01370160323.58 schema:affiliation https://www.grid.ac/institutes/grid.9909.9
312 schema:familyName Hemmings
313 schema:givenName Gemma
314 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370160323.58
315 rdf:type schema:Person
316 sg:person.01371433471.82 schema:affiliation https://www.grid.ac/institutes/grid.416204.5
317 schema:familyName Susnerwala
318 schema:givenName Shabbir
319 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371433471.82
320 rdf:type schema:Person
321 sg:person.015444120047.28 schema:affiliation https://www.grid.ac/institutes/grid.83440.3b
322 schema:familyName Lawrie
323 schema:givenName Emma
324 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015444120047.28
325 rdf:type schema:Person
326 sg:person.0603260617.15 schema:affiliation https://www.grid.ac/institutes/grid.83440.3b
327 schema:familyName Lopes
328 schema:givenName Andre
329 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603260617.15
330 rdf:type schema:Person
331 sg:person.0645520032.49 schema:affiliation https://www.grid.ac/institutes/grid.9909.9
332 schema:familyName Sebag-Montefiore
333 schema:givenName David
334 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645520032.49
335 rdf:type schema:Person
336 sg:person.0774106122.06 schema:affiliation https://www.grid.ac/institutes/grid.417581.e
337 schema:familyName Samuel
338 schema:givenName Leslie
339 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774106122.06
340 rdf:type schema:Person
341 sg:pub.10.1038/nature11219 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004846070
342 https://doi.org/10.1038/nature11219
343 rdf:type schema:CreativeWork
344 sg:pub.10.1038/ng.3214 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008423455
345 https://doi.org/10.1038/ng.3214
346 rdf:type schema:CreativeWork
347 sg:pub.10.1038/nm.3870 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035726640
348 https://doi.org/10.1038/nm.3870
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1016/j.clon.2015.11.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042194971
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1016/j.hoc.2006.01.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042960688
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1016/j.ijrobp.2010.06.043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011463050
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1016/j.ijrobp.2012.03.048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031516034
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1016/j.radonc.2004.12.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031841398
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1016/j.suronc.2013.02.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011316789
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1016/s1470-2045(10)70130-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038656599
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1016/s1470-2045(13)70136-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045300754
365 rdf:type schema:CreativeWork
366 https://doi.org/10.1016/s1470-2045(13)70599-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013224241
367 rdf:type schema:CreativeWork
368 https://doi.org/10.1056/nejmoa033025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035161767
369 rdf:type schema:CreativeWork
370 https://doi.org/10.1056/nejmoa053422 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005630380
371 rdf:type schema:CreativeWork
372 https://doi.org/10.1056/nejmoa0805019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045468727
373 rdf:type schema:CreativeWork
374 https://doi.org/10.1093/annonc/mds236 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034294500
375 rdf:type schema:CreativeWork
376 https://doi.org/10.1126/science.1235122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035954369
377 rdf:type schema:CreativeWork
378 https://doi.org/10.1155/2011/393521 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063203728
379 rdf:type schema:CreativeWork
380 https://doi.org/10.1158/1078-0432.ccr-16-0032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063225319
381 rdf:type schema:CreativeWork
382 https://doi.org/10.1200/jco.2005.02.1329 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042089423
383 rdf:type schema:CreativeWork
384 https://doi.org/10.1200/jco.2006.06.7629 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040853793
385 rdf:type schema:CreativeWork
386 https://doi.org/10.1200/jco.2009.22.4295 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027962078
387 rdf:type schema:CreativeWork
388 https://doi.org/10.1200/jco.2010.29.7697 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004927382
389 rdf:type schema:CreativeWork
390 https://doi.org/10.1200/jco.2011.39.6036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022439548
391 rdf:type schema:CreativeWork
392 https://doi.org/10.1200/jco.2014.59.4812 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026384267
393 rdf:type schema:CreativeWork
394 https://doi.org/10.1371/journal.pone.0108247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029745203
395 rdf:type schema:CreativeWork
396 https://doi.org/10.3233/acp-2011-0005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017368181
397 rdf:type schema:CreativeWork
398 https://www.grid.ac/institutes/grid.15628.38 schema:alternateName University Hospitals Coventry and Warwickshire NHS Trust
399 schema:name University Hospitals Coventry and Warwickshire NHS Trust, Clifford Bridge Road, Coventry CV2 2DX, UK
400 rdf:type schema:Organization
401 https://www.grid.ac/institutes/grid.412917.8 schema:alternateName Christie Hospital NHS Foundation Trust
402 schema:name The Christie NHS Foundation Trust, Withington, Manchester M20 4BX, UK
403 rdf:type schema:Organization
404 https://www.grid.ac/institutes/grid.414586.a schema:alternateName Colchester General Hospital
405 schema:name Colchester General Hospital, Turner Road, Colchester CO4 5JL, UK
406 rdf:type schema:Organization
407 https://www.grid.ac/institutes/grid.416204.5 schema:alternateName Royal Preston Hospital
408 schema:name Royal Preston Hospital, Fulwood, Preston PR2 9HT, UK
409 rdf:type schema:Organization
410 https://www.grid.ac/institutes/grid.417581.e schema:alternateName Aberdeen Royal Infirmary
411 schema:name Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZN, UK
412 rdf:type schema:Organization
413 https://www.grid.ac/institutes/grid.418624.d schema:alternateName Clatterbridge Cancer Centre NHS Foundation Trust
414 schema:name Clatterbridge Cancer Centre, Clatterbridge Road, Wirral CH63 4JY, UK
415 rdf:type schema:Organization
416 https://www.grid.ac/institutes/grid.443984.6 schema:alternateName St James's University Hospital
417 schema:name Pathology and Tumour Biology, Level 4 Wellcome Trust Brenner Building, St James University Hospital, Beckett Street, Leeds LS9 7TF, UK
418 rdf:type schema:Organization
419 https://www.grid.ac/institutes/grid.83440.3b schema:alternateName University College London
420 schema:name Cancer Research UK & UCL Cancer Trials Centre, University College London, 90 Tottenham Court Road, London W1T 4TJ, UK
421 rdf:type schema:Organization
422 https://www.grid.ac/institutes/grid.9909.9 schema:alternateName University of Leeds
423 schema:name Leeds Institute of Cancer and Pathology, University of Leeds, Leeds LS9 7TF, UK
424 St James’ Institute of Oncology, University of Leeds, Leeds LS9 7TF, UK
425 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...