Ontology type: schema:ScholarlyArticle Open Access: True
2017-09-05
AUTHORSSergey Klimov, Padmashree CG Rida, Mohammed A Aleskandarany, Andrew R Green, Ian O Ellis, Emiel AM Janssen, Emad A Rakha, Ritu Aneja
ABSTRACTBACKGROUND: Although distant metastasis (DM) in breast cancer (BC) is the most lethal form of recurrence and the most common underlying cause of cancer related deaths, the outcome following the development of DM is related to the site of metastasis. Triple negative BC (TNBC) is an aggressive form of BC characterised by early recurrences and high mortality. Athough multiple variables can be used to predict the risk of metastasis, few markers can predict the specific site of metastasis. This study aimed at identifying a biomarker signature to predict particular sites of DM in TNBC. METHODS: A clinically annotated series of 322 TNBC were immunohistochemically stained with 133 biomarkers relevant to BC, to develop multibiomarker models for predicting metastasis to the bone, liver, lung and brain. Patients who experienced metastasis to each site were compared with those who did not, by gradually filtering the biomarker set via a two-tailed t-test and Cox univariate analyses. Biomarker combinations were finally ranked based on statistical significance, and evaluated in multivariable analyses. RESULTS: Our final models were able to stratify TNBC patients into high risk groups that showed over 5, 6, 7 and 8 times higher risk of developing metastasis to the bone, liver, lung and brain, respectively, than low-risk subgroups. These models for predicting site-specific metastasis retained significance following adjustment for tumour size, patient age and chemotherapy status. CONCLUSIONS: Our novel IHC-based biomarkers signatures, when assessed in primary TNBC tumours, enable prediction of specific sites of metastasis, and potentially unravel biomarkers previously unknown in site tropism. More... »
PAGES826
http://scigraph.springernature.com/pub.10.1038/bjc.2017.224
DOIhttp://dx.doi.org/10.1038/bjc.2017.224
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1090746887
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/28720841
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Age Factors",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Biomarkers, Tumor",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Bone Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Brain Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Immunohistochemistry",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Liver Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Lung Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Models, Biological",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Predictive Value of Tests",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Proportional Hazards Models",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Triple Negative Breast Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Tumor Burden",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Georgia State University",
"id": "https://www.grid.ac/institutes/grid.256304.6",
"name": [
"Department of Biology, Georgia State University, Atlanta, GA 30303 USA"
],
"type": "Organization"
},
"familyName": "Klimov",
"givenName": "Sergey",
"id": "sg:person.07662526461.33",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07662526461.33"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Georgia State University",
"id": "https://www.grid.ac/institutes/grid.256304.6",
"name": [
"Department of Biology, Georgia State University, Atlanta, GA 30303 USA"
],
"type": "Organization"
},
"familyName": "Rida",
"givenName": "Padmashree CG",
"id": "sg:person.01133534625.87",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133534625.87"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Nottingham City Hospital",
"id": "https://www.grid.ac/institutes/grid.412920.c",
"name": [
"Department of Cellular Pathology, University of Nottingham and Nottingham University Hospitals NHS Trust, City Hospital Campus, Nottingham NG5 1PB, UK"
],
"type": "Organization"
},
"familyName": "Aleskandarany",
"givenName": "Mohammed A",
"id": "sg:person.0700461537.41",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700461537.41"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Nottingham City Hospital",
"id": "https://www.grid.ac/institutes/grid.412920.c",
"name": [
"Department of Cellular Pathology, University of Nottingham and Nottingham University Hospitals NHS Trust, City Hospital Campus, Nottingham NG5 1PB, UK"
],
"type": "Organization"
},
"familyName": "Green",
"givenName": "Andrew R",
"id": "sg:person.016416665412.02",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016416665412.02"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Nottingham City Hospital",
"id": "https://www.grid.ac/institutes/grid.412920.c",
"name": [
"Department of Cellular Pathology, University of Nottingham and Nottingham University Hospitals NHS Trust, City Hospital Campus, Nottingham NG5 1PB, UK"
],
"type": "Organization"
},
"familyName": "Ellis",
"givenName": "Ian O",
"id": "sg:person.01054612302.65",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054612302.65"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Stavanger University Hospital",
"id": "https://www.grid.ac/institutes/grid.412835.9",
"name": [
"Department of Pathology, Stavanger University Hospital, Stavanger N-4011, Norway"
],
"type": "Organization"
},
"familyName": "Janssen",
"givenName": "Emiel AM",
"id": "sg:person.01310245303.55",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310245303.55"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Nottingham City Hospital",
"id": "https://www.grid.ac/institutes/grid.412920.c",
"name": [
"Department of Cellular Pathology, University of Nottingham and Nottingham University Hospitals NHS Trust, City Hospital Campus, Nottingham NG5 1PB, UK"
],
"type": "Organization"
},
"familyName": "Rakha",
"givenName": "Emad A",
"id": "sg:person.0743637501.84",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743637501.84"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Georgia State University",
"id": "https://www.grid.ac/institutes/grid.256304.6",
"name": [
"Department of Biology, Georgia State University, Atlanta, GA 30303 USA"
],
"type": "Organization"
},
"familyName": "Aneja",
"givenName": "Ritu",
"id": "sg:person.01365356361.20",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365356361.20"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1200/jco.2004.12.149",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001105110"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-06-2854",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001280882"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3816/cbc.2009.s.008",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001900333"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10549-015-3308-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001993992",
"https://doi.org/10.1007/s10549-015-3308-4"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s12032-012-0388-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002468701",
"https://doi.org/10.1007/s12032-012-0388-4"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s12032-012-0388-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002468701",
"https://doi.org/10.1007/s12032-012-0388-4"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2005.03.8802",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003299580"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10549-010-1161-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003412525",
"https://doi.org/10.1007/s10549-010-1161-z"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/npjbcancer.2015.14",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003884064",
"https://doi.org/10.1038/npjbcancer.2015.14"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc1276",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003923555",
"https://doi.org/10.1038/nrc1276"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc1276",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003923555",
"https://doi.org/10.1038/nrc1276"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/path.1916",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003999331"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/path.1916",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003999331"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1083/jcb.148.4.779",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004416817"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0132546",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004817236"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00428-007-0513-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005610870",
"https://doi.org/10.1007/s00428-007-0513-5"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00428-007-0513-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005610870",
"https://doi.org/10.1007/s00428-007-0513-5"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jcb.240530417",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006094664"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jcb.240530417",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006094664"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-07-5644",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007044949"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-13-1255",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007402245"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ejso.2006.02.009",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008973528"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3322/caac.20107",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009055747"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-12-3998",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009130291"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/bjc.2015.165",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009276268",
"https://doi.org/10.1038/bjc.2015.165"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.tem.2007.10.003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010120015"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature08021",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010946448",
"https://doi.org/10.1038/nature08021"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature08021",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010946448",
"https://doi.org/10.1038/nature08021"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1101/sqb.2005.70.018",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014750677"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1101/sqb.2005.70.018",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014750677"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/bcr1384",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014852391",
"https://doi.org/10.1186/bcr1384"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmra030831",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014958480"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc3053",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015420219",
"https://doi.org/10.1038/nrc3053"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/annonc/mdu103",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015672978"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.0709185104",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015936069"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2007.14.4147",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015966665"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc867",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016286671",
"https://doi.org/10.1038/nrc867"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc867",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016286671",
"https://doi.org/10.1038/nrc867"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4048/jbc.2015.18.2.160",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019415346"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.96.24.13920",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019775383"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/jmcb/mjp005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020009159"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0093-7754(03)00233-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020076565"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0093-7754(03)00233-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020076565"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc2622",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020158834",
"https://doi.org/10.1038/nrc2622"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc2622",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020158834",
"https://doi.org/10.1038/nrc2622"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.bjc.6604463",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020604549",
"https://doi.org/10.1038/sj.bjc.6604463"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0002-9440(10)61180-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020963246"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.clon.2007.10.002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021907998"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2006.11.001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024726520"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-08-0436",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024767175"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/annonc/mdn424",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024915934"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0002-9440(10)65628-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025538247"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jso.2930230311",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028249429"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1096/fj.01-0498fje",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028909272"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s13277-013-1461-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030199095",
"https://doi.org/10.1007/s13277-013-1461-0"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2010.30.5037",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032062887"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1172/jci22320",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032627062"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf01840834",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032983382",
"https://doi.org/10.1007/bf01840834"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/pros.21240",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033434804"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc1670",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033699583",
"https://doi.org/10.1038/nrc1670"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc1670",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033699583",
"https://doi.org/10.1038/nrc1670"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/1097-0215(200102)9999:9999<894::aid-ijc1146>3.0.co;2-#",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035222992"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/cncr.22381",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036147682"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s12253-015-9957-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036662101",
"https://doi.org/10.1007/s12253-015-9957-0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s12253-015-9957-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036662101",
"https://doi.org/10.1007/s12253-015-9957-0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10549-014-2927-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036964462",
"https://doi.org/10.1007/s10549-014-2927-5"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/onc.2011.41",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037634816",
"https://doi.org/10.1038/onc.2011.41"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/01.nrl.0000106922.83090.71",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037829958"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/01.nrl.0000106922.83090.71",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037829958"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pbio.1001699",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038129692"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/annonc/mdp411",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038479628"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/ijc.21004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039744402"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(11)61226-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040047584"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1053/sonc.2003.50030",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040983326"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1053/sonc.2003.50030",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040983326"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc1098",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042664529",
"https://doi.org/10.1038/nrc1098"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc1098",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042664529",
"https://doi.org/10.1038/nrc1098"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10549-015-3335-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042865308",
"https://doi.org/10.1007/s10549-015-3335-1"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-05-2090",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043623008"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.tranon.2015.04.004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044907288"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2009.25.9820",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045520644"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1476-4598-7-36",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046060711",
"https://doi.org/10.1186/1476-4598-7-36"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-08-2132",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047937201"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-09-1039",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048199711"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.2634067100",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049404752"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.breast.2012.03.003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050541429"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.semcancer.2012.03.007",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051542366"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncb1507",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051542961",
"https://doi.org/10.1038/ncb1507"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncb1507",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051542961",
"https://doi.org/10.1038/ncb1507"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1053/j.seminoncol.2003.08.005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052381392"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/path.1559",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052755346"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1548-5315(11)70394-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1054717861"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2003.08.017",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064203776"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074575217",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1078044606",
"type": "CreativeWork"
}
],
"datePublished": "2017-09-05",
"datePublishedReg": "2017-09-05",
"description": "BACKGROUND: Although distant metastasis (DM) in breast cancer (BC) is the most lethal form of recurrence and the most common underlying cause of cancer related deaths, the outcome following the development of DM is related to the site of metastasis. Triple negative BC (TNBC) is an aggressive form of BC characterised by early recurrences and high mortality. Athough multiple variables can be used to predict the risk of metastasis, few markers can predict the specific site of metastasis. This study aimed at identifying a biomarker signature to predict particular sites of DM in TNBC.\nMETHODS: A clinically annotated series of 322 TNBC were immunohistochemically stained with 133 biomarkers relevant to BC, to develop multibiomarker models for predicting metastasis to the bone, liver, lung and brain. Patients who experienced metastasis to each site were compared with those who did not, by gradually filtering the biomarker set via a two-tailed t-test and Cox univariate analyses. Biomarker combinations were finally ranked based on statistical significance, and evaluated in multivariable analyses.\nRESULTS: Our final models were able to stratify TNBC patients into high risk groups that showed over 5, 6, 7 and 8 times higher risk of developing metastasis to the bone, liver, lung and brain, respectively, than low-risk subgroups. These models for predicting site-specific metastasis retained significance following adjustment for tumour size, patient age and chemotherapy status.\nCONCLUSIONS: Our novel IHC-based biomarkers signatures, when assessed in primary TNBC tumours, enable prediction of specific sites of metastasis, and potentially unravel biomarkers previously unknown in site tropism.",
"genre": "research_article",
"id": "sg:pub.10.1038/bjc.2017.224",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.3801931",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1017082",
"issn": [
"0007-0920",
"1532-1827"
],
"name": "British Journal of Cancer",
"type": "Periodical"
},
{
"issueNumber": "6",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "117"
}
],
"name": "Novel immunohistochemistry-based signatures to predict metastatic site of triple-negative breast cancers",
"pagination": "826",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"f668c626b6bad40748a787b9f72e4776e12aa16408b0ebf3dda0159f08e9ee9f"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"28720841"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"0370635"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/bjc.2017.224"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1090746887"
]
}
],
"sameAs": [
"https://doi.org/10.1038/bjc.2017.224",
"https://app.dimensions.ai/details/publication/pub.1090746887"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T15:49",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8664_00000502.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/bjc2017224"
}
]Download the RDF metadata as:Â json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/bjc.2017.224'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/bjc.2017.224'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/bjc.2017.224'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/bjc.2017.224'
This table displays all metadata directly associated to this object as RDF triples.
440 TRIPLES
21 PREDICATES
121 URIs
34 LITERALS
23 BLANK NODES