MicroRNA profiling in clear cell renal cell carcinoma tissues potentially links tumorigenesis and recurrence with obesity View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12-01

AUTHORS

X Shu, M A Hildebrandt, J Gu, N M Tannir, S F Matin, J A Karam, C G Wood, X Wu

ABSTRACT

Background:Twenty to 40% localised RCC patients may experience recurrence after curative surgery. Limited miRNA predictors have been identified for ccRCC recurrence.Methods:Through a multi-phase study design, we analysed miRNAs in tissues obtained from 203 ccRCC patients. Paired t-test was used for tumour–normal comparisons and Cox regression model was performed to compute hazard ratios (HRs) and corresponding 95% CIs.Results:A 17-miRNA signature was identified that can concordantly classify >95% of tumour/adjacent normal samples. Significant enrichment was found as 6 out of 17 miRNAs were associated with obesity (binomial probability=0.001). Decreased levels of miR-204-5p and miR-139-5p were each associated with an approximately three-fold increased risk of recurrence (P<0.01). Risk score was generated based on expressions of miR-204-5p and miR-139-5p, and the trend test was significant in both discovery and validation sets (Pfor trend<0.05). Striking MST reduction was observed for patients with a high-risk score (high vs low: discovery, 9.4 vs >97.7 months; validation, 20.8 vs >70.3 months). Expressions of miR-204-5p were also associated with body mass index (β=5.64, P<0.001). Significant inverse correlations were observed and validated between miR-204-5p and 13 obesity-related genes (r<0, P<0.01).Conclusions:We identified 17 miRNAs dysregulated in ccRCC tissues and showed that low expressions of miR-204-5p and miR-139-5p were associated with the higher risk of recurrence. The link between miR-204-5p and ccRCC recurrence may be partially mediated by regulating the expression of targeted obesity-related genes. More... »

PAGES

77-84

References to SciGraph publications

  • 2013-06-23. Comprehensive molecular characterization of clear cell renal cell carcinoma in NATURE
  • 2005-01-01. ADAM12 in THE ADAM FAMILY OF PROTEASES
  • 2010-05. Epidemiology and risk factors for kidney cancer in NATURE REVIEWS UROLOGY
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    URI

    http://scigraph.springernature.com/pub.10.1038/bjc.2016.392

    DOI

    http://dx.doi.org/10.1038/bjc.2016.392

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1022144139

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27907930


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