The impact of diabetes mellitus on survival following resection and adjuvant chemotherapy for pancreatic cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-09-01

AUTHORS

Jörg Kleeff, Eithne Costello, Richard Jackson, Chris Halloran, William Greenhalf, Paula Ghaneh, Richard F Lamb, Markus M Lerch, Julia Mayerle, Daniel Palmer, Trevor Cox, Charlotte L Rawcliffe, Oliver Strobel, Markus W Büchler, John P Neoptolemos, for the European Study Group for Pancreatic Cancer

ABSTRACT

Background:Diabetes mellitus is frequently observed in pancreatic cancer patients and is both a risk factor and an early manifestation of the disease.Methods:We analysed the prognostic impact of diabetes on the outcome of pancreatic cancer following resection and adjuvant chemotherapy using individual patient data from three European Study Group for Pancreatic Cancer randomised controlled trials. Analyses were carried out to assess the association between clinical characteristics and the presence of preoperative diabetes, as well as the effect of diabetic status on overall survival.Results:In total, 1105 patients were included in the analysis, of whom 257 (23%) had confirmed diabetes and 848 (77%) did not. Median (95% confidence interval (CI)) unadjusted overall survival in non-diabetic patients was 22.3 (20.8–24.1) months compared with 18.8 (16.9–22.1) months for diabetic patients (P=0.24). Diabetic patients were older, had increased weight and more co-morbidities. Following adjustment, multivariable analysis demonstrated that diabetic patients had an increased risk of death (hazard ratio: 1.19 (95% CI 1.01, 1.40), P=0.034). Maximum tumour size of diabetic patients was larger at randomisation (33.6 vs 29.7 mm, P=0.026).Conclusions:Diabetes mellitus was associated with increased tumour size and reduced survival following pancreatic cancer resection and adjuvant chemotherapy. More... »

PAGES

887-894

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.2016.277

DOI

http://dx.doi.org/10.1038/bjc.2016.277

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030274120

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27584663


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