A validated metabolomic signature for colorectal cancer: exploration of the clinical value of metabolomics View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-08-25

AUTHORS

Farshad Farshidfar, Aalim M Weljie, Karen A Kopciuk, Robert Hilsden, S Elizabeth McGregor, W Donald Buie, Anthony MacLean, Hans J Vogel, Oliver F Bathe

ABSTRACT

Background:Timely diagnosis and classification of colorectal cancer (CRC) are hindered by unsatisfactory clinical assays. Our aim was to construct a blood-based biomarker series using a single assay, suitable for CRC detection, prognostication and staging.Methods:Serum metabolomic profiles of adenoma (N=31), various stages of CRC (N=320) and healthy matched controls (N=254) were analysed by gas chromatography-mass spectrometry (GC-MS). A diagnostic model for CRC was derived by orthogonal partial least squares-discriminant analysis (OPLS-DA) on a training set, and then validated on an independent data set. Metabolomic models suitable for identifying adenoma, poor prognosis stage II CRC and discriminating various stages were generated.Results:A diagnostic signature for CRC with remarkable multivariate performance (R2Y=0.46, Q2Y=0.39) was constructed, and then validated (sensitivity 85%; specificity 86%). Area under the receiver-operating characteristic curve was 0.91 (95% CI, 0.87–0.96). Adenomas were also detectable (R2Y=0.35, Q2Y=0.26, internal AUROC=0.81, 95% CI, 0.70–0.92). Also of particular interest, we identified models that stratified stage II by prognosis, and classified cases by stage.Conclusions:Using a single assay system, a suite of CRC biomarkers based on circulating metabolites enables early detection, prognostication and preliminary staging information. External population-based studies are required to evaluate the repeatability of our findings and to assess the clinical benefits of these biomarkers. More... »

PAGES

848-857

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.2016.243

DOI

http://dx.doi.org/10.1038/bjc.2016.243

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016876945

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27560555


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenocarcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Case-Control Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colorectal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Progression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Early Detection of Cancer", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Least-Squares Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Metabolome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Metabolomics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Staging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "ROC Curve", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sensitivity and Specificity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcriptome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Oncology, University of Calgary, Calgary, AB, Canada", 
          "id": "http://www.grid.ac/institutes/grid.22072.35", 
          "name": [
            "Department of Surgery, University of Calgary, Calgary, AB, Canada", 
            "Department of Oncology, University of Calgary, Calgary, AB, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Farshidfar", 
        "givenName": "Farshad", 
        "id": "sg:person.01253745362.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253745362.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA, USA", 
          "id": "http://www.grid.ac/institutes/grid.25879.31", 
          "name": [
            "Department of Biological Sciences, University of Calgary, Calgary, AB, Canada", 
            "Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Weljie", 
        "givenName": "Aalim M", 
        "id": "sg:person.01156467457.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156467457.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cancer Epidemiology and Prevention Research, Alberta Health Services, Calgary, AB, Canada", 
          "id": "http://www.grid.ac/institutes/grid.413574.0", 
          "name": [
            "Department of Mathematics and Statistics, University of Calgary, Calgary, AB, Canada", 
            "Cancer Epidemiology and Prevention Research, Alberta Health Services, Calgary, AB, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kopciuk", 
        "givenName": "Karen A", 
        "id": "sg:person.01223356633.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223356633.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Forzani and MacPhail Colon Cancer Screening Centre, Alberta Health Services, Calgary, AB, Canada", 
          "id": "http://www.grid.ac/institutes/grid.413574.0", 
          "name": [
            "Department of Medicine, University of Calgary, Calgary, AB, Canada", 
            "Forzani and MacPhail Colon Cancer Screening Centre, Alberta Health Services, Calgary, AB, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hilsden", 
        "givenName": "Robert", 
        "id": "sg:person.01165640331.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165640331.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cancer Epidemiology and Prevention Research, Alberta Health Services, Calgary, AB, Canada", 
          "id": "http://www.grid.ac/institutes/grid.413574.0", 
          "name": [
            "Department of Oncology, University of Calgary, Calgary, AB, Canada", 
            "Cancer Epidemiology and Prevention Research, Alberta Health Services, Calgary, AB, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "McGregor", 
        "givenName": "S Elizabeth", 
        "id": "sg:person.01261400416.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261400416.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, University of Calgary, Calgary, AB, Canada", 
          "id": "http://www.grid.ac/institutes/grid.22072.35", 
          "name": [
            "Department of Surgery, University of Calgary, Calgary, AB, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Buie", 
        "givenName": "W Donald", 
        "id": "sg:person.01136414614.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136414614.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, University of Calgary, Calgary, AB, Canada", 
          "id": "http://www.grid.ac/institutes/grid.22072.35", 
          "name": [
            "Department of Surgery, University of Calgary, Calgary, AB, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "MacLean", 
        "givenName": "Anthony", 
        "id": "sg:person.0711260173.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711260173.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biological Sciences, University of Calgary, Calgary, AB, Canada", 
          "id": "http://www.grid.ac/institutes/grid.22072.35", 
          "name": [
            "Department of Biological Sciences, University of Calgary, Calgary, AB, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vogel", 
        "givenName": "Hans J", 
        "id": "sg:person.01065466412.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065466412.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Oncology, University of Calgary, Calgary, AB, Canada", 
          "id": "http://www.grid.ac/institutes/grid.22072.35", 
          "name": [
            "Department of Surgery, University of Calgary, Calgary, AB, Canada", 
            "Department of Oncology, University of Calgary, Calgary, AB, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bathe", 
        "givenName": "Oliver F", 
        "id": "sg:person.01057564204.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057564204.51"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/4735_2007_0229", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002758249", 
          "https://doi.org/10.1007/4735_2007_0229"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00216-012-5870-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010437597", 
          "https://doi.org/10.1007/s00216-012-5870-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gm341", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022312204", 
          "https://doi.org/10.1186/gm341"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.2014.170", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048665540", 
          "https://doi.org/10.1038/bjc.2014.170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11306-011-0357-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038023758", 
          "https://doi.org/10.1007/s11306-011-0357-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1016/1044-0305(95)00291-k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001694296", 
          "https://doi.org/10.1016/1044-0305(95)00291-k"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11252", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010619765", 
          "https://doi.org/10.1038/nature11252"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2004-5-10-r80", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018457673", 
          "https://doi.org/10.1186/gb-2004-5-10-r80"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-08-25", 
    "datePublishedReg": "2016-08-25", 
    "description": "Background:Timely diagnosis and classification of colorectal cancer (CRC) are hindered by unsatisfactory clinical assays. Our aim was to construct a blood-based biomarker series using a single assay, suitable for CRC detection, prognostication and staging.Methods:Serum metabolomic profiles of adenoma (N=31), various stages of CRC (N=320) and healthy matched controls (N=254) were analysed by gas chromatography-mass spectrometry (GC-MS). A diagnostic model for CRC was derived by orthogonal partial least squares-discriminant analysis (OPLS-DA) on a training set, and then validated on an independent data set. Metabolomic models suitable for identifying adenoma, poor prognosis stage II CRC and discriminating various stages were generated.Results:A diagnostic signature for CRC with remarkable multivariate performance (R2Y=0.46, Q2Y=0.39) was constructed, and then validated (sensitivity 85%; specificity 86%). Area under the receiver-operating characteristic curve was 0.91 (95% CI, 0.87\u20130.96). Adenomas were also detectable (R2Y=0.35, Q2Y=0.26, internal AUROC=0.81, 95% CI, 0.70\u20130.92). Also of particular interest, we identified models that stratified stage II by prognosis, and classified cases by stage.Conclusions:Using a single assay system, a suite of CRC biomarkers based on circulating metabolites enables early detection, prognostication and preliminary staging information. External population-based studies are required to evaluate the repeatability of our findings and to assess the clinical benefits of these biomarkers.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/bjc.2016.243", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1017082", 
        "issn": [
          "0007-0920", 
          "1532-1827"
        ], 
        "name": "British Journal of Cancer", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "115"
      }
    ], 
    "keywords": [
      "colorectal cancer", 
      "orthogonal partial least squares discriminant analysis", 
      "stage II colorectal cancer", 
      "stage of CRC", 
      "receiver-operating characteristic curve", 
      "population-based study", 
      "serum metabolomic profiles", 
      "clinical benefit", 
      "staging information", 
      "timely diagnosis", 
      "CRC biomarkers", 
      "CRC detection", 
      "clinical value", 
      "metabolomic signature", 
      "stage II", 
      "early detection", 
      "metabolomic profiles", 
      "single assay system", 
      "metabolomics model", 
      "characteristic curve", 
      "clinical assays", 
      "adenomas", 
      "cancer", 
      "prognostication", 
      "biomarkers", 
      "assay system", 
      "partial least squares discriminant analysis", 
      "least squares discriminant analysis", 
      "diagnostic signature", 
      "single assay", 
      "squares discriminant analysis", 
      "assays", 
      "gas chromatography-mass spectrometry", 
      "prognosis", 
      "staging", 
      "diagnosis", 
      "diagnostic model", 
      "chromatography-mass spectrometry", 
      "metabolites", 
      "stage", 
      "multivariate performance", 
      "aim", 
      "metabolomics", 
      "findings", 
      "independent data sets", 
      "control", 
      "cases", 
      "study", 
      "detection", 
      "benefits", 
      "particular interest", 
      "profile", 
      "classification", 
      "model", 
      "curves", 
      "signatures", 
      "analysis", 
      "series", 
      "area", 
      "information", 
      "training set", 
      "values", 
      "spectrometry", 
      "exploration", 
      "interest", 
      "repeatability", 
      "system", 
      "data sets", 
      "set", 
      "performance", 
      "suite"
    ], 
    "name": "A validated metabolomic signature for colorectal cancer: exploration of the clinical value of metabolomics", 
    "pagination": "848-857", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1016876945"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/bjc.2016.243"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27560555"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/bjc.2016.243", 
      "https://app.dimensions.ai/details/publication/pub.1016876945"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T16:00", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_692.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/bjc.2016.243"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/bjc.2016.243'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/bjc.2016.243'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/bjc.2016.243'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/bjc.2016.243'


 

This table displays all metadata directly associated to this object as RDF triples.

332 TRIPLES      21 PREDICATES      128 URIs      112 LITERALS      31 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/bjc.2016.243 schema:about N02891dee1c2949559fa19c364fb2cfe3
2 N044ef8d2f7ec4eb187e082b68f4fe99a
3 N0bb3f3d0ec6349eb8a4c96cd4b0533d5
4 N0bf7d0a24cae449aa5e9fa48a0c51993
5 N0e50195dd5b04f56b56c4a7b7f1c9d10
6 N0ed9691b5b624c17a53ef8b9ee2a10da
7 N146aa65d7cdf4862b65fe3cd6b0c321c
8 N1d9932e3bee64494afdf473e7dbfacce
9 N2312aa716e1c46ff9fe88ebd84ad2bc6
10 N3487b559d92542b281e92bb501d44258
11 N37b38a327ad04626a2b7a67cfc0b9fe4
12 N584a426426a849e4a07d0a9995a69dc7
13 N60575e947c7e4d229f866e82d7c182ca
14 N6d4ee9964b82499fba639db9ef86bab7
15 N8268144972de4dba833d17fe8caac83e
16 N99f0eb3f65c94c08a465101e24be92d1
17 N9c9c25745504445bad4448d56f33a78b
18 Na15282a2c8ed4429adb0978bb92176ae
19 Na4bf8c23789d4f65b7565d2cf5660317
20 Na7659fa46cb84e068ff09d65ae787cbc
21 Nb4eb31cc10894cda93f2dd6702082555
22 Nb6dfe88fa4054760b0212c084c5b76af
23 Nd6ae2b83fba147f19bd593f3b76f55d7
24 Ne69056ee26174e99bf16645c8b26e574
25 anzsrc-for:11
26 anzsrc-for:1112
27 schema:author Na89e63d68d8e470aac303a5f215b4213
28 schema:citation sg:pub.10.1007/4735_2007_0229
29 sg:pub.10.1007/s00216-012-5870-5
30 sg:pub.10.1007/s11306-011-0357-5
31 sg:pub.10.1016/1044-0305(95)00291-k
32 sg:pub.10.1038/bjc.2014.170
33 sg:pub.10.1038/nature11252
34 sg:pub.10.1186/gb-2004-5-10-r80
35 sg:pub.10.1186/gm341
36 schema:datePublished 2016-08-25
37 schema:datePublishedReg 2016-08-25
38 schema:description Background:Timely diagnosis and classification of colorectal cancer (CRC) are hindered by unsatisfactory clinical assays. Our aim was to construct a blood-based biomarker series using a single assay, suitable for CRC detection, prognostication and staging.Methods:Serum metabolomic profiles of adenoma (N=31), various stages of CRC (N=320) and healthy matched controls (N=254) were analysed by gas chromatography-mass spectrometry (GC-MS). A diagnostic model for CRC was derived by orthogonal partial least squares-discriminant analysis (OPLS-DA) on a training set, and then validated on an independent data set. Metabolomic models suitable for identifying adenoma, poor prognosis stage II CRC and discriminating various stages were generated.Results:A diagnostic signature for CRC with remarkable multivariate performance (R2Y=0.46, Q2Y=0.39) was constructed, and then validated (sensitivity 85%; specificity 86%). Area under the receiver-operating characteristic curve was 0.91 (95% CI, 0.87–0.96). Adenomas were also detectable (R2Y=0.35, Q2Y=0.26, internal AUROC=0.81, 95% CI, 0.70–0.92). Also of particular interest, we identified models that stratified stage II by prognosis, and classified cases by stage.Conclusions:Using a single assay system, a suite of CRC biomarkers based on circulating metabolites enables early detection, prognostication and preliminary staging information. External population-based studies are required to evaluate the repeatability of our findings and to assess the clinical benefits of these biomarkers.
39 schema:genre article
40 schema:isAccessibleForFree true
41 schema:isPartOf Na2b37e314f14426bbd9255c92642be30
42 Nb35afcbd6d8a44c3b8358b2fde545504
43 sg:journal.1017082
44 schema:keywords CRC biomarkers
45 CRC detection
46 adenomas
47 aim
48 analysis
49 area
50 assay system
51 assays
52 benefits
53 biomarkers
54 cancer
55 cases
56 characteristic curve
57 chromatography-mass spectrometry
58 classification
59 clinical assays
60 clinical benefit
61 clinical value
62 colorectal cancer
63 control
64 curves
65 data sets
66 detection
67 diagnosis
68 diagnostic model
69 diagnostic signature
70 early detection
71 exploration
72 findings
73 gas chromatography-mass spectrometry
74 independent data sets
75 information
76 interest
77 least squares discriminant analysis
78 metabolites
79 metabolomic profiles
80 metabolomic signature
81 metabolomics
82 metabolomics model
83 model
84 multivariate performance
85 orthogonal partial least squares discriminant analysis
86 partial least squares discriminant analysis
87 particular interest
88 performance
89 population-based study
90 profile
91 prognosis
92 prognostication
93 receiver-operating characteristic curve
94 repeatability
95 series
96 serum metabolomic profiles
97 set
98 signatures
99 single assay
100 single assay system
101 spectrometry
102 squares discriminant analysis
103 stage
104 stage II
105 stage II colorectal cancer
106 stage of CRC
107 staging
108 staging information
109 study
110 suite
111 system
112 timely diagnosis
113 training set
114 values
115 schema:name A validated metabolomic signature for colorectal cancer: exploration of the clinical value of metabolomics
116 schema:pagination 848-857
117 schema:productId N21a04e5fd97d41529ffb85418162f4af
118 N85db66f1c9554a7299a4c58479cfcedb
119 Nfb389715ace54dcb87bdf8157ad96d96
120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016876945
121 https://doi.org/10.1038/bjc.2016.243
122 schema:sdDatePublished 2022-09-02T16:00
123 schema:sdLicense https://scigraph.springernature.com/explorer/license/
124 schema:sdPublisher N4a8fb67ae33a46d1bd857fd570d60edd
125 schema:url https://doi.org/10.1038/bjc.2016.243
126 sgo:license sg:explorer/license/
127 sgo:sdDataset articles
128 rdf:type schema:ScholarlyArticle
129 N02891dee1c2949559fa19c364fb2cfe3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Biomarkers, Tumor
131 rdf:type schema:DefinedTerm
132 N044ef8d2f7ec4eb187e082b68f4fe99a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Neoplasm Staging
134 rdf:type schema:DefinedTerm
135 N0bb3f3d0ec6349eb8a4c96cd4b0533d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Transcriptome
137 rdf:type schema:DefinedTerm
138 N0bf7d0a24cae449aa5e9fa48a0c51993 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Aged, 80 and over
140 rdf:type schema:DefinedTerm
141 N0e50195dd5b04f56b56c4a7b7f1c9d10 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Least-Squares Analysis
143 rdf:type schema:DefinedTerm
144 N0ed9691b5b624c17a53ef8b9ee2a10da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Metabolomics
146 rdf:type schema:DefinedTerm
147 N146aa65d7cdf4862b65fe3cd6b0c321c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Adenocarcinoma
149 rdf:type schema:DefinedTerm
150 N1d9932e3bee64494afdf473e7dbfacce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Humans
152 rdf:type schema:DefinedTerm
153 N21a04e5fd97d41529ffb85418162f4af schema:name doi
154 schema:value 10.1038/bjc.2016.243
155 rdf:type schema:PropertyValue
156 N2312aa716e1c46ff9fe88ebd84ad2bc6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Middle Aged
158 rdf:type schema:DefinedTerm
159 N28c9aec724fe4bf59a113eb03234b669 rdf:first sg:person.01261400416.08
160 rdf:rest N51641af49d064867a81bf956cefe19b0
161 N3487b559d92542b281e92bb501d44258 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Disease Progression
163 rdf:type schema:DefinedTerm
164 N37b38a327ad04626a2b7a67cfc0b9fe4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Metabolome
166 rdf:type schema:DefinedTerm
167 N4a8fb67ae33a46d1bd857fd570d60edd schema:name Springer Nature - SN SciGraph project
168 rdf:type schema:Organization
169 N4fef8a7194704514b7fc1b313c82d5ea rdf:first sg:person.0711260173.53
170 rdf:rest N9bd4608494c343af8810cce685a0cc54
171 N51641af49d064867a81bf956cefe19b0 rdf:first sg:person.01136414614.60
172 rdf:rest N4fef8a7194704514b7fc1b313c82d5ea
173 N584a426426a849e4a07d0a9995a69dc7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Adenoma
175 rdf:type schema:DefinedTerm
176 N60575e947c7e4d229f866e82d7c182ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name ROC Curve
178 rdf:type schema:DefinedTerm
179 N6337794381be4220ab016afbc30ae208 rdf:first sg:person.01223356633.10
180 rdf:rest N83aebee9274e410b86219ab9864d12cb
181 N6d4ee9964b82499fba639db9ef86bab7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Early Detection of Cancer
183 rdf:type schema:DefinedTerm
184 N8268144972de4dba833d17fe8caac83e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Sensitivity and Specificity
186 rdf:type schema:DefinedTerm
187 N83aebee9274e410b86219ab9864d12cb rdf:first sg:person.01165640331.46
188 rdf:rest N28c9aec724fe4bf59a113eb03234b669
189 N85db66f1c9554a7299a4c58479cfcedb schema:name pubmed_id
190 schema:value 27560555
191 rdf:type schema:PropertyValue
192 N8fd89241b90b45dbaa8a9c1e98281d47 rdf:first sg:person.01156467457.26
193 rdf:rest N6337794381be4220ab016afbc30ae208
194 N99f0eb3f65c94c08a465101e24be92d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Male
196 rdf:type schema:DefinedTerm
197 N9bd4608494c343af8810cce685a0cc54 rdf:first sg:person.01065466412.66
198 rdf:rest Nad80f1a078a44e2db2e4f837b6256d5d
199 N9c9c25745504445bad4448d56f33a78b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Neoplasm Proteins
201 rdf:type schema:DefinedTerm
202 Na15282a2c8ed4429adb0978bb92176ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Prognosis
204 rdf:type schema:DefinedTerm
205 Na2b37e314f14426bbd9255c92642be30 schema:issueNumber 7
206 rdf:type schema:PublicationIssue
207 Na4bf8c23789d4f65b7565d2cf5660317 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
208 schema:name Aged
209 rdf:type schema:DefinedTerm
210 Na7659fa46cb84e068ff09d65ae787cbc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
211 schema:name Gene Expression Regulation, Neoplastic
212 rdf:type schema:DefinedTerm
213 Na89e63d68d8e470aac303a5f215b4213 rdf:first sg:person.01253745362.08
214 rdf:rest N8fd89241b90b45dbaa8a9c1e98281d47
215 Nad80f1a078a44e2db2e4f837b6256d5d rdf:first sg:person.01057564204.51
216 rdf:rest rdf:nil
217 Nb35afcbd6d8a44c3b8358b2fde545504 schema:volumeNumber 115
218 rdf:type schema:PublicationVolume
219 Nb4eb31cc10894cda93f2dd6702082555 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
220 schema:name Prospective Studies
221 rdf:type schema:DefinedTerm
222 Nb6dfe88fa4054760b0212c084c5b76af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
223 schema:name Colorectal Neoplasms
224 rdf:type schema:DefinedTerm
225 Nd6ae2b83fba147f19bd593f3b76f55d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
226 schema:name Female
227 rdf:type schema:DefinedTerm
228 Ne69056ee26174e99bf16645c8b26e574 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
229 schema:name Case-Control Studies
230 rdf:type schema:DefinedTerm
231 Nfb389715ace54dcb87bdf8157ad96d96 schema:name dimensions_id
232 schema:value pub.1016876945
233 rdf:type schema:PropertyValue
234 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
235 schema:name Medical and Health Sciences
236 rdf:type schema:DefinedTerm
237 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
238 schema:name Oncology and Carcinogenesis
239 rdf:type schema:DefinedTerm
240 sg:journal.1017082 schema:issn 0007-0920
241 1532-1827
242 schema:name British Journal of Cancer
243 schema:publisher Springer Nature
244 rdf:type schema:Periodical
245 sg:person.01057564204.51 schema:affiliation grid-institutes:grid.22072.35
246 schema:familyName Bathe
247 schema:givenName Oliver F
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057564204.51
249 rdf:type schema:Person
250 sg:person.01065466412.66 schema:affiliation grid-institutes:grid.22072.35
251 schema:familyName Vogel
252 schema:givenName Hans J
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065466412.66
254 rdf:type schema:Person
255 sg:person.01136414614.60 schema:affiliation grid-institutes:grid.22072.35
256 schema:familyName Buie
257 schema:givenName W Donald
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136414614.60
259 rdf:type schema:Person
260 sg:person.01156467457.26 schema:affiliation grid-institutes:grid.25879.31
261 schema:familyName Weljie
262 schema:givenName Aalim M
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156467457.26
264 rdf:type schema:Person
265 sg:person.01165640331.46 schema:affiliation grid-institutes:grid.413574.0
266 schema:familyName Hilsden
267 schema:givenName Robert
268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165640331.46
269 rdf:type schema:Person
270 sg:person.01223356633.10 schema:affiliation grid-institutes:grid.413574.0
271 schema:familyName Kopciuk
272 schema:givenName Karen A
273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223356633.10
274 rdf:type schema:Person
275 sg:person.01253745362.08 schema:affiliation grid-institutes:grid.22072.35
276 schema:familyName Farshidfar
277 schema:givenName Farshad
278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253745362.08
279 rdf:type schema:Person
280 sg:person.01261400416.08 schema:affiliation grid-institutes:grid.413574.0
281 schema:familyName McGregor
282 schema:givenName S Elizabeth
283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261400416.08
284 rdf:type schema:Person
285 sg:person.0711260173.53 schema:affiliation grid-institutes:grid.22072.35
286 schema:familyName MacLean
287 schema:givenName Anthony
288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711260173.53
289 rdf:type schema:Person
290 sg:pub.10.1007/4735_2007_0229 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002758249
291 https://doi.org/10.1007/4735_2007_0229
292 rdf:type schema:CreativeWork
293 sg:pub.10.1007/s00216-012-5870-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010437597
294 https://doi.org/10.1007/s00216-012-5870-5
295 rdf:type schema:CreativeWork
296 sg:pub.10.1007/s11306-011-0357-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038023758
297 https://doi.org/10.1007/s11306-011-0357-5
298 rdf:type schema:CreativeWork
299 sg:pub.10.1016/1044-0305(95)00291-k schema:sameAs https://app.dimensions.ai/details/publication/pub.1001694296
300 https://doi.org/10.1016/1044-0305(95)00291-k
301 rdf:type schema:CreativeWork
302 sg:pub.10.1038/bjc.2014.170 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048665540
303 https://doi.org/10.1038/bjc.2014.170
304 rdf:type schema:CreativeWork
305 sg:pub.10.1038/nature11252 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010619765
306 https://doi.org/10.1038/nature11252
307 rdf:type schema:CreativeWork
308 sg:pub.10.1186/gb-2004-5-10-r80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018457673
309 https://doi.org/10.1186/gb-2004-5-10-r80
310 rdf:type schema:CreativeWork
311 sg:pub.10.1186/gm341 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022312204
312 https://doi.org/10.1186/gm341
313 rdf:type schema:CreativeWork
314 grid-institutes:grid.22072.35 schema:alternateName Department of Biological Sciences, University of Calgary, Calgary, AB, Canada
315 Department of Oncology, University of Calgary, Calgary, AB, Canada
316 Department of Surgery, University of Calgary, Calgary, AB, Canada
317 schema:name Department of Biological Sciences, University of Calgary, Calgary, AB, Canada
318 Department of Oncology, University of Calgary, Calgary, AB, Canada
319 Department of Surgery, University of Calgary, Calgary, AB, Canada
320 rdf:type schema:Organization
321 grid-institutes:grid.25879.31 schema:alternateName Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA, USA
322 schema:name Department of Biological Sciences, University of Calgary, Calgary, AB, Canada
323 Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA, USA
324 rdf:type schema:Organization
325 grid-institutes:grid.413574.0 schema:alternateName Cancer Epidemiology and Prevention Research, Alberta Health Services, Calgary, AB, Canada
326 Forzani and MacPhail Colon Cancer Screening Centre, Alberta Health Services, Calgary, AB, Canada
327 schema:name Cancer Epidemiology and Prevention Research, Alberta Health Services, Calgary, AB, Canada
328 Department of Mathematics and Statistics, University of Calgary, Calgary, AB, Canada
329 Department of Medicine, University of Calgary, Calgary, AB, Canada
330 Department of Oncology, University of Calgary, Calgary, AB, Canada
331 Forzani and MacPhail Colon Cancer Screening Centre, Alberta Health Services, Calgary, AB, Canada
332 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...