Effects of microsatellite instability on recurrence patterns and outcomes in colorectal cancers View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-05-26

AUTHORS

Chang Gon Kim, Joong Bae Ahn, Minkyu Jung, Seung Hoon Beom, Chan Kim, Joo Hoon Kim, Su Jin Heo, Hyung Soon Park, Jee Hung Kim, Nam Kyu Kim, Byung Soh Min, Hoguen Kim, Woong Sub Koom, Sang Joon Shin

ABSTRACT

BACKGROUND: Among colorectal cancers (CRCs), high-frequency microsatellite instability (MSI-H) is associated with a better prognosis, compared with low-frequency MSI or microsatellite stability (MSI-L/MSS). However, it is unclear whether MSI affects the prognosis of recurrent CRCs. METHODS: This study included 2940 patients with stage I-III CRC who underwent complete resection. The associations of MSI status with recurrence patterns, disease-free survival (DFS), overall survival from diagnosis to death (OS1), and overall survival from recurrence to death (OS2) were analysed. RESULTS: A total of 261 patients (8.9%) had MSI-H CRC. Patients with MSI-H CRC had better DFS, compared to patients with MSI-L/MSS CRC (hazard ratio (HR): 0.619, P<0.001). High-frequency microsatellite instability CRC was associated with more frequent local recurrence (30.0% vs 12.0%, P=0.032) or peritoneal metastasis (40.0% vs 12.3%, P=0.003), and less frequent lung (10.0% vs 42.5%, P=0.004) or liver metastases (15.0% vs 44.7%, P=0.01). Recurrent MSI-H CRC was associated with worse OS1 (HR: 1.363, P=0.035) and OS2 (HR: 2.667, P<0.001). An analysis of patients with colon cancer yielded similar results. CONCLUSIONS: Recurrence patterns differed between MSI-H CRC and MSI-L/MSS CRC, and recurrent MSI-H CRCs had a worse prognosis. More... »

PAGES

25-33

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.2016.161

DOI

http://dx.doi.org/10.1038/bjc.2016.161

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1006576208

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27228287


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28 schema:description BACKGROUND: Among colorectal cancers (CRCs), high-frequency microsatellite instability (MSI-H) is associated with a better prognosis, compared with low-frequency MSI or microsatellite stability (MSI-L/MSS). However, it is unclear whether MSI affects the prognosis of recurrent CRCs. METHODS: This study included 2940 patients with stage I-III CRC who underwent complete resection. The associations of MSI status with recurrence patterns, disease-free survival (DFS), overall survival from diagnosis to death (OS1), and overall survival from recurrence to death (OS2) were analysed. RESULTS: A total of 261 patients (8.9%) had MSI-H CRC. Patients with MSI-H CRC had better DFS, compared to patients with MSI-L/MSS CRC (hazard ratio (HR): 0.619, P<0.001). High-frequency microsatellite instability CRC was associated with more frequent local recurrence (30.0% vs 12.0%, P=0.032) or peritoneal metastasis (40.0% vs 12.3%, P=0.003), and less frequent lung (10.0% vs 42.5%, P=0.004) or liver metastases (15.0% vs 44.7%, P=0.01). Recurrent MSI-H CRC was associated with worse OS1 (HR: 1.363, P=0.035) and OS2 (HR: 2.667, P<0.001). An analysis of patients with colon cancer yielded similar results. CONCLUSIONS: Recurrence patterns differed between MSI-H CRC and MSI-L/MSS CRC, and recurrent MSI-H CRCs had a worse prognosis.
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36 MSI
37 MSI status
38 MSS colorectal cancers
39 OS1
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41 Recurrent MSI
42 analysis
43 analysis of patients
44 association
45 better disease-free survival
46 better prognosis
47 cancer
48 colon cancer
49 colorectal cancer
50 complete resection
51 death
52 diagnosis
53 disease-free survival
54 effect
55 frequent local recurrence
56 frequent lung
57 high-frequency microsatellite instability
58 instability
59 instability CRC
60 liver metastases
61 local recurrence
62 low-frequency MSI
63 lung
64 metastasis
65 microsatellite instability
66 microsatellite instability colorectal cancer
67 microsatellite stability
68 outcomes
69 overall survival
70 patients
71 patterns
72 peritoneal metastasis
73 prognosis
74 recurrence
75 recurrence patterns
76 recurrent colorectal cancer
77 resection
78 results
79 similar results
80 stability
81 stage I
82 status
83 study
84 survival
85 total
86 worse OS1
87 worse prognosis
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