Cell line and patient-derived xenograft models reveal elevated CDCP1 as a target in high-grade serous ovarian cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-02

AUTHORS

Brittney S Harrington, Yaowu He, Claire M Davies, Sarah J Wallace, Mark N Adams, Elizabeth A Beaven, Deborah K Roche, Catherine Kennedy, Naven P Chetty, Alexander J Crandon, Christopher Flatley, Niara B Oliveira, Catherine M Shannon, Anna deFazio, Anna V Tinker, C Blake Gilks, Brian Gabrielli, Donal J Brennan, Jermaine I Coward, Jane E Armes, Lewis C Perrin, John D Hooper

ABSTRACT

BACKGROUND: Development of targeted therapies for high-grade serous ovarian cancer (HGSC) remains challenging, as contributing molecular pathways are poorly defined or expressed heterogeneously. CUB-domain containing protein 1 (CDCP1) is a cell-surface protein elevated in lung, colorectal, pancreas, renal and clear cell ovarian cancer. METHODS: CUB-domain containing protein 1 was examined by immunohistochemistry in HGSC and fallopian tube. The impact of targeting CDCP1 on cell growth and migration in vitro, and intraperitoneal xenograft growth in mice was examined. Three patient-derived xenograft (PDX) mouse models were developed and characterised for CDCP1 expression. The effect of a monoclonal anti-CDCP1 antibody on PDX growth was examined. Src activation was assessed by western blot analysis. RESULTS: Elevated CDCP1 was observed in 77% of HGSC cases. Silencing of CDCP1 reduced migration and non-adherent cell growth in vitro and tumour burden in vivo. Expression of CDCP1 in patient samples was maintained in PDX models. Antibody blockade of CDCP1 significantly reduced growth of an HGSC PDX. The CDCP1-mediated activation of Src was observed in cultured cells and mouse xenografts. CONCLUSIONS: CUB-domain containing protein 1 is over-expressed by the majority of HGSCs. In vitro and mouse model data indicate that CDCP1 has a role in HGSC and that it can be targeted to inhibit progression of this cancer. More... »

PAGES

417

References to SciGraph publications

  • 1975. New Human Tumor Cell Lines in HUMAN TUMOR CELLS IN VITRO
  • 2008-12. Microarray-based identification of CUB-domain containing protein 1 as a potential prognostic marker in conventional renal cell carcinoma in JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • 2000-06. Characterization of four novel epithelial ovarian cancer cell lines in IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY - ANIMAL
  • 2000-06. CHARACTERIZATION OF FOUR NOVEL EPITHELIAL OVARIAN CANCER CELL LINES in IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY - ANIMAL
  • 2012-08. Blocking of CDCP1 cleavage in vivo prevents Akt-dependent survival and inhibits metastatic colonization through PARP1-mediated apoptosis of cancer cells in ONCOGENE
  • 2013-12. Evaluating cell lines as tumour models by comparison of genomic profiles in NATURE COMMUNICATIONS
  • 2016-01. Elevated CDCP1 predicts poor patient outcome and mediates ovarian clear cell carcinoma by promoting tumor spheroid formation, cell migration and chemoresistance in ONCOGENE
  • 2015-03. EGF inhibits constitutive internalization and palmitoylation-dependent degradation of membrane-spanning procancer CDCP1 promoting its availability on the cell surface in ONCOGENE
  • 2014-01. In vivo cleaved CDCP1 promotes early tumor dissemination via complexing with activated β1 integrin and induction of FAK/PI3K/Akt motility signaling in ONCOGENE
  • 2011-10. Rethinking ovarian cancer: recommendations for improving outcomes in NATURE REVIEWS CANCER
  • 2013-04. Latest research and treatment of advanced-stage epithelial ovarian cancer in NATURE REVIEWS CLINICAL ONCOLOGY
  • 2003-03. Subtractive immunization using highly metastatic human tumor cells identifies SIMA135/CDCP1, a 135 kDa cell surface phosphorylated glycoprotein antigen in ONCOGENE
  • 2015-10. CUB-domain-containing protein 1 overexpression in solid cancers promotes cancer cell growth by activating Src family kinases in ONCOGENE
  • 2012-02. The SRC-associated protein CUB Domain-Containing Protein-1 regulates adhesion and motility in ONCOGENE
  • 2015-06. Anoikis resistance is a critical feature of highly aggressive ovarian cancer cells in ONCOGENE
  • 2011-09. Immunohistochemical staining patterns of p53 can serve as a surrogate marker for TP53 mutations in ovarian carcinoma: an immunohistochemical and nucleotide sequencing analysis in MODERN PATHOLOGY
  • 2014-12. Versican regulates metastasis of epithelial ovarian carcinoma cells and spheroids in JOURNAL OF OVARIAN RESEARCH
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/bjc.2015.471

    DOI

    http://dx.doi.org/10.1038/bjc.2015.471

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1040752675

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26882065


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antigens, CD", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Biomarkers, Tumor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Adhesion Molecules", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Line, Tumor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Movement", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Proliferation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cystadenocarcinoma, Serous", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Disease Models, Animal", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Heterografts", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm Grading", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Ovarian Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA, Small Interfering", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Survival Analysis", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Mater Adult Hospital", 
              "id": "https://www.grid.ac/institutes/grid.416528.c", 
              "name": [
                "Mater Research Institute, University of Queensland, Translational Research Institute, Woolloongabba, QLD 4102, Australia", 
                "Mater Ovarian Cancer Research Collaborative, Mater Adult Hospital, South Brisbane, QLD 4101, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Harrington", 
            "givenName": "Brittney S", 
            "id": "sg:person.01363113572.91", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363113572.91"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mater Adult Hospital", 
              "id": "https://www.grid.ac/institutes/grid.416528.c", 
              "name": [
                "Mater Research Institute, University of Queensland, Translational Research Institute, Woolloongabba, QLD 4102, Australia", 
                "Mater Ovarian Cancer Research Collaborative, Mater Adult Hospital, South Brisbane, QLD 4101, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "He", 
            "givenName": "Yaowu", 
            "id": "sg:person.0664040424.95", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664040424.95"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mater Health Services", 
              "id": "https://www.grid.ac/institutes/grid.1491.d", 
              "name": [
                "Mater Research Institute, University of Queensland, Translational Research Institute, Woolloongabba, QLD 4102, Australia", 
                "Mater Ovarian Cancer Research Collaborative, Mater Adult Hospital, South Brisbane, QLD 4101, Australia", 
                "Mater Health Services, South Brisbane, QLD 4101, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Davies", 
            "givenName": "Claire M", 
            "id": "sg:person.01062574751.76", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062574751.76"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mater Health Services", 
              "id": "https://www.grid.ac/institutes/grid.1491.d", 
              "name": [
                "Mater Ovarian Cancer Research Collaborative, Mater Adult Hospital, South Brisbane, QLD 4101, Australia", 
                "Mater Health Services, South Brisbane, QLD 4101, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wallace", 
            "givenName": "Sarah J", 
            "id": "sg:person.0753736072.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753736072.22"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Translational Research Institute", 
              "id": "https://www.grid.ac/institutes/grid.489335.0", 
              "name": [
                "Mater Research Institute, University of Queensland, Translational Research Institute, Woolloongabba, QLD 4102, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Adams", 
            "givenName": "Mark N", 
            "id": "sg:person.01340253532.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340253532.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mater Health Services", 
              "id": "https://www.grid.ac/institutes/grid.1491.d", 
              "name": [
                "Mater Ovarian Cancer Research Collaborative, Mater Adult Hospital, South Brisbane, QLD 4101, Australia", 
                "Mater Health Services, South Brisbane, QLD 4101, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Beaven", 
            "givenName": "Elizabeth A", 
            "id": "sg:person.01077577577.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077577577.12"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mater Adult Hospital", 
              "id": "https://www.grid.ac/institutes/grid.416528.c", 
              "name": [
                "Mater Research Institute, University of Queensland, Translational Research Institute, Woolloongabba, QLD 4102, Australia", 
                "Mater Ovarian Cancer Research Collaborative, Mater Adult Hospital, South Brisbane, QLD 4101, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Roche", 
            "givenName": "Deborah K", 
            "id": "sg:person.0614271406.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0614271406.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Westmead Institute for Medical Research", 
              "id": "https://www.grid.ac/institutes/grid.452919.2", 
              "name": [
                "Department of Gynaecological Oncology, Westmead Hospital and Centre for Cancer Research, Westmead Millennium Institute, Westmead, NSW 2145, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kennedy", 
            "givenName": "Catherine", 
            "id": "sg:person.013103524532.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013103524532.49"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mater Health Services", 
              "id": "https://www.grid.ac/institutes/grid.1491.d", 
              "name": [
                "Mater Ovarian Cancer Research Collaborative, Mater Adult Hospital, South Brisbane, QLD 4101, Australia", 
                "Mater Health Services, South Brisbane, QLD 4101, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chetty", 
            "givenName": "Naven P", 
            "id": "sg:person.0575674157.75", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0575674157.75"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mater Health Services", 
              "id": "https://www.grid.ac/institutes/grid.1491.d", 
              "name": [
                "Mater Ovarian Cancer Research Collaborative, Mater Adult Hospital, South Brisbane, QLD 4101, Australia", 
                "Mater Health Services, South Brisbane, QLD 4101, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Crandon", 
            "givenName": "Alexander J", 
            "id": "sg:person.010043675414.78", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010043675414.78"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Translational Research Institute", 
              "id": "https://www.grid.ac/institutes/grid.489335.0", 
              "name": [
                "Mater Research Institute, University of Queensland, Translational Research Institute, Woolloongabba, QLD 4102, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Flatley", 
            "givenName": "Christopher", 
            "id": "sg:person.01323143321.88", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323143321.88"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mater Health Services", 
              "id": "https://www.grid.ac/institutes/grid.1491.d", 
              "name": [
                "Mater Ovarian Cancer Research Collaborative, Mater Adult Hospital, South Brisbane, QLD 4101, Australia", 
                "Mater Health Services, South Brisbane, QLD 4101, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Oliveira", 
            "givenName": "Niara B", 
            "id": "sg:person.011062244552.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011062244552.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mater Health Services", 
              "id": "https://www.grid.ac/institutes/grid.1491.d", 
              "name": [
                "Mater Ovarian Cancer Research Collaborative, Mater Adult Hospital, South Brisbane, QLD 4101, Australia", 
                "Mater Health Services, South Brisbane, QLD 4101, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shannon", 
            "givenName": "Catherine M", 
            "id": "sg:person.01204413072.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204413072.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Westmead Institute for Medical Research", 
              "id": "https://www.grid.ac/institutes/grid.452919.2", 
              "name": [
                "Department of Gynaecological Oncology, Westmead Hospital and Centre for Cancer Research, Westmead Millennium Institute, Westmead, NSW 2145, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "deFazio", 
            "givenName": "Anna", 
            "id": "sg:person.0671761151.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671761151.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "BC Cancer Agency", 
              "id": "https://www.grid.ac/institutes/grid.248762.d", 
              "name": [
                "Cheryl Brown Ovarian Cancer Outcomes Unit, Division of Medical Oncology and Vancouver Centre, British Columbia Cancer Agency, Vancouver, BC, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tinker", 
            "givenName": "Anna V", 
            "id": "sg:person.01106472247.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106472247.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of British Columbia", 
              "id": "https://www.grid.ac/institutes/grid.17091.3e", 
              "name": [
                "Department of Pathology and Laboratory Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gilks", 
            "givenName": "C Blake", 
            "id": "sg:person.01120560217.98", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120560217.98"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Queensland", 
              "id": "https://www.grid.ac/institutes/grid.1003.2", 
              "name": [
                "The University of Queensland Diamantina Institute, Translational Research Institute, Woolloongabba, QLD 4102, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gabrielli", 
            "givenName": "Brian", 
            "id": "sg:person.0603311623.57", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603311623.57"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mater Health Services", 
              "id": "https://www.grid.ac/institutes/grid.1491.d", 
              "name": [
                "Mater Ovarian Cancer Research Collaborative, Mater Adult Hospital, South Brisbane, QLD 4101, Australia", 
                "Mater Health Services, South Brisbane, QLD 4101, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Brennan", 
            "givenName": "Donal J", 
            "id": "sg:person.01143415300.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143415300.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mater Health Services", 
              "id": "https://www.grid.ac/institutes/grid.1491.d", 
              "name": [
                "Mater Research Institute, University of Queensland, Translational Research Institute, Woolloongabba, QLD 4102, Australia", 
                "Mater Ovarian Cancer Research Collaborative, Mater Adult Hospital, South Brisbane, QLD 4101, Australia", 
                "Mater Health Services, South Brisbane, QLD 4101, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Coward", 
            "givenName": "Jermaine I", 
            "id": "sg:person.0771731317.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771731317.49"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mater Health Services", 
              "id": "https://www.grid.ac/institutes/grid.1491.d", 
              "name": [
                "Mater Ovarian Cancer Research Collaborative, Mater Adult Hospital, South Brisbane, QLD 4101, Australia", 
                "Mater Health Services, South Brisbane, QLD 4101, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Armes", 
            "givenName": "Jane E", 
            "id": "sg:person.01367244620.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367244620.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mater Health Services", 
              "id": "https://www.grid.ac/institutes/grid.1491.d", 
              "name": [
                "Mater Ovarian Cancer Research Collaborative, Mater Adult Hospital, South Brisbane, QLD 4101, Australia", 
                "Mater Health Services, South Brisbane, QLD 4101, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Perrin", 
            "givenName": "Lewis C", 
            "id": "sg:person.0721425415.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721425415.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mater Adult Hospital", 
              "id": "https://www.grid.ac/institutes/grid.416528.c", 
              "name": [
                "Mater Research Institute, University of Queensland, Translational Research Institute, Woolloongabba, QLD 4102, Australia", 
                "Mater Ovarian Cancer Research Collaborative, Mater Adult Hospital, South Brisbane, QLD 4101, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hooper", 
            "givenName": "John D", 
            "id": "sg:person.01215515222.80", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215515222.80"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/onc.2011.262", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000420328", 
              "https://doi.org/10.1038/onc.2011.262"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pat.0b013e32835bd561", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000443975"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pat.0b013e32835bd561", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000443975"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pat.0b013e32835bd561", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000443975"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1290/1071-2690(2000)036<0357:cofneo>2.0.co;2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000451104", 
              "https://doi.org/10.1290/1071-2690(2000)036<0357:cofneo>2.0.co;2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pas.0000000000000353", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000484914"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pas.0000000000000353", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000484914"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pas.0000000000000353", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000484914"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pat.0b013e328348a6e7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000654232"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pat.0b013e328348a6e7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000654232"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pat.0b013e328348a6e7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000654232"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2013.05.049", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001425400"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2014.88", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004935530", 
              "https://doi.org/10.1038/onc.2014.88"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1541-7786.mcr-09-0100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005445829"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrclinonc.2013.5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006139455", 
              "https://doi.org/10.1038/nrclinonc.2013.5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrclinonc.2013.5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006139455", 
              "https://doi.org/10.1038/nrclinonc.2013.5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/path.2696", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006485690"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2559.2004.01787.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008911407"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1222435110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010316361"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0024420", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012716774"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0103988", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013924787"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0103988", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013924787"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molonc.2013.08.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014200991"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00432-008-0412-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015868176", 
              "https://doi.org/10.1007/s00432-008-0412-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00432-008-0412-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015868176", 
              "https://doi.org/10.1007/s00432-008-0412-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-10-0220", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016728613"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.29210", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018963471"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1117135109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019036331"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2012.547", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020731179", 
              "https://doi.org/10.1038/onc.2012.547"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2012.547", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020731179", 
              "https://doi.org/10.1038/onc.2012.547"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/path.2744", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021005164"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/path.2744", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021005164"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/0471142905.hg1011s57", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021035685"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-14-1292", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021464776"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3322/caac.21166", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021817259"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-07-1657", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021899361"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2353/ajpath.2008.070981", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022397602"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/00313020410001721555", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023065499"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/00313020410001721555", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023065499"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2353/ajpath.2010.100105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024928264"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2011.555", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028010034", 
              "https://doi.org/10.1038/onc.2011.555"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0072162", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028870459"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0072162", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028870459"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2013.10.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029297219"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m111.335448", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030248029"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1309/ajcpgxk0fr4mhihb", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033344012"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/modpathol.2011.85", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034842843", 
              "https://doi.org/10.1038/modpathol.2011.85"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/gyno.2001.6353", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034887715"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2014.264", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035051786", 
              "https://doi.org/10.1038/onc.2014.264"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2014.264", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035051786", 
              "https://doi.org/10.1038/onc.2014.264"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1206220", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036369351", 
              "https://doi.org/10.1038/sj.onc.1206220"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1206220", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036369351", 
              "https://doi.org/10.1038/sj.onc.1206220"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m111.227462", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036551929"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m109.096453", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037449687"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4757-1647-4_5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039518345", 
              "https://doi.org/10.1007/978-1-4757-1647-4_5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2015.19", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039519132", 
              "https://doi.org/10.1038/onc.2015.19"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0053050", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043492183"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms3126", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043513580", 
              "https://doi.org/10.1038/ncomms3126"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pmed.0050232", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043679611"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/path.4353", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045003770"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ygyno.2015.08.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046281352"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1017228108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047040096"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1757-2215-7-70", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047364375", 
              "https://doi.org/10.1186/1757-2215-7-70"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1757-2215-7-70", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047364375", 
              "https://doi.org/10.1186/1757-2215-7-70"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2015.101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050170603", 
              "https://doi.org/10.1038/onc.2015.101"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/his.12651", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051285559"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/iub.198", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052985483"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/iub.198", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052985483"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc3144", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053036406", 
              "https://doi.org/10.1038/nrc3144"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1011777108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053322910"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1011777108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053322910"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1349-7006.2008.01066.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053705427"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/mp900236t", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056214170"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/mp900236t", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056214170"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1290/1071-2690(2000)036<0357:cofneo>2.3.co;2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064748507", 
              "https://doi.org/10.1290/1071-2690(2000)036<0357:cofneo>2.3.co;2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.14694/edbook_am.2014.34.e258", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1067344602"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1043/1543-2165(2008)132[402:aoitgp]2.0.co;2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077615502"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1080083733", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082929650", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2016-02", 
        "datePublishedReg": "2016-02-01", 
        "description": "BACKGROUND: Development of targeted therapies for high-grade serous ovarian cancer (HGSC) remains challenging, as contributing molecular pathways are poorly defined or expressed heterogeneously. CUB-domain containing protein 1 (CDCP1) is a cell-surface protein elevated in lung, colorectal, pancreas, renal and clear cell ovarian cancer.\nMETHODS: CUB-domain containing protein 1 was examined by immunohistochemistry in HGSC and fallopian tube. The impact of targeting CDCP1 on cell growth and migration in vitro, and intraperitoneal xenograft growth in mice was examined. Three patient-derived xenograft (PDX) mouse models were developed and characterised for CDCP1 expression. The effect of a monoclonal anti-CDCP1 antibody on PDX growth was examined. Src activation was assessed by western blot analysis.\nRESULTS: Elevated CDCP1 was observed in 77% of HGSC cases. Silencing of CDCP1 reduced migration and non-adherent cell growth in vitro and tumour burden in vivo. Expression of CDCP1 in patient samples was maintained in PDX models. Antibody blockade of CDCP1 significantly reduced growth of an HGSC PDX. The CDCP1-mediated activation of Src was observed in cultured cells and mouse xenografts.\nCONCLUSIONS: CUB-domain containing protein 1 is over-expressed by the majority of HGSCs. In vitro and mouse model data indicate that CDCP1 has a role in HGSC and that it can be targeted to inhibit progression of this cancer.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/bjc.2015.471", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.6729330", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6715700", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1017082", 
            "issn": [
              "0007-0920", 
              "1532-1827"
            ], 
            "name": "British Journal of Cancer", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "4", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "114"
          }
        ], 
        "name": "Cell line and patient-derived xenograft models reveal elevated CDCP1 as a target in high-grade serous ovarian cancer", 
        "pagination": "417", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "c220ffb744bf82db9b9cd76058f1623f349e19ca72a3b5632023199c58edc89d"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "26882065"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "0370635"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/bjc.2015.471"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1040752675"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/bjc.2015.471", 
          "https://app.dimensions.ai/details/publication/pub.1040752675"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T16:30", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000434.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/bjc2015471"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/bjc.2015.471'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/bjc.2015.471'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/bjc.2015.471'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/bjc.2015.471'


     

    This table displays all metadata directly associated to this object as RDF triples.

    508 TRIPLES      21 PREDICATES      107 URIs      39 LITERALS      27 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/bjc.2015.471 schema:about N1971d790945b48b9b58a27d2238b2f71
    2 N2b20f4745ea345e98af891fc191fc741
    3 N2c076d1132084013a1c0b4b8c6c46bd9
    4 N399cd2cec2f74283860158e2412e5d74
    5 N40cd16574c4a4b4cab9265a7acd547ed
    6 N63e8c39f726649e88cb10575033b7ef7
    7 N83883e9da5384252926ea6ff1054b67d
    8 N8642a053cdc24b23bd42961d63f5b364
    9 N97dfcb87cb6346209b12942a2001b215
    10 N9c85d8676da9445691314ff491e51280
    11 Na670f348cc6c420c85fb737013c4f00e
    12 Naeb66b2603774684a464548e3c76b390
    13 Naf3518a030c04c13a4833e9f9a45d808
    14 Nb7cb3d4a4fd845b2b5f80a4c42b78e17
    15 Nb804c033bedf4dc899ecb451d1ec6f26
    16 Nc56b0fb7c55c4304886e7fe481e1e5d2
    17 Nf8c76471236841c4bdc910c7fe6a541c
    18 Nf9bce22da6134d80ada9f5ebcc60249e
    19 anzsrc-for:11
    20 anzsrc-for:1112
    21 schema:author N24f30881d4e345b5839e704e645d326c
    22 schema:citation sg:pub.10.1007/978-1-4757-1647-4_5
    23 sg:pub.10.1007/s00432-008-0412-4
    24 sg:pub.10.1038/modpathol.2011.85
    25 sg:pub.10.1038/ncomms3126
    26 sg:pub.10.1038/nrc3144
    27 sg:pub.10.1038/nrclinonc.2013.5
    28 sg:pub.10.1038/onc.2011.262
    29 sg:pub.10.1038/onc.2011.555
    30 sg:pub.10.1038/onc.2012.547
    31 sg:pub.10.1038/onc.2014.264
    32 sg:pub.10.1038/onc.2014.88
    33 sg:pub.10.1038/onc.2015.101
    34 sg:pub.10.1038/onc.2015.19
    35 sg:pub.10.1038/sj.onc.1206220
    36 sg:pub.10.1186/1757-2215-7-70
    37 sg:pub.10.1290/1071-2690(2000)036<0357:cofneo>2.0.co;2
    38 sg:pub.10.1290/1071-2690(2000)036<0357:cofneo>2.3.co;2
    39 https://app.dimensions.ai/details/publication/pub.1080083733
    40 https://app.dimensions.ai/details/publication/pub.1082929650
    41 https://doi.org/10.1002/0471142905.hg1011s57
    42 https://doi.org/10.1002/ijc.29210
    43 https://doi.org/10.1002/iub.198
    44 https://doi.org/10.1002/path.2696
    45 https://doi.org/10.1002/path.2744
    46 https://doi.org/10.1002/path.4353
    47 https://doi.org/10.1006/gyno.2001.6353
    48 https://doi.org/10.1016/j.ccr.2013.10.013
    49 https://doi.org/10.1016/j.molonc.2013.08.009
    50 https://doi.org/10.1016/j.ygyno.2015.08.017
    51 https://doi.org/10.1021/mp900236t
    52 https://doi.org/10.1043/1543-2165(2008)132[402:aoitgp]2.0.co;2
    53 https://doi.org/10.1053/j.gastro.2013.05.049
    54 https://doi.org/10.1073/pnas.1011777108
    55 https://doi.org/10.1073/pnas.1017228108
    56 https://doi.org/10.1073/pnas.1117135109
    57 https://doi.org/10.1073/pnas.1222435110
    58 https://doi.org/10.1074/jbc.m109.096453
    59 https://doi.org/10.1074/jbc.m111.227462
    60 https://doi.org/10.1074/jbc.m111.335448
    61 https://doi.org/10.1080/00313020410001721555
    62 https://doi.org/10.1097/pas.0000000000000353
    63 https://doi.org/10.1097/pat.0b013e328348a6e7
    64 https://doi.org/10.1097/pat.0b013e32835bd561
    65 https://doi.org/10.1111/his.12651
    66 https://doi.org/10.1111/j.1349-7006.2008.01066.x
    67 https://doi.org/10.1111/j.1365-2559.2004.01787.x
    68 https://doi.org/10.1158/0008-5472.can-07-1657
    69 https://doi.org/10.1158/0008-5472.can-10-0220
    70 https://doi.org/10.1158/1078-0432.ccr-14-1292
    71 https://doi.org/10.1158/1541-7786.mcr-09-0100
    72 https://doi.org/10.1309/ajcpgxk0fr4mhihb
    73 https://doi.org/10.1371/journal.pmed.0050232
    74 https://doi.org/10.1371/journal.pone.0024420
    75 https://doi.org/10.1371/journal.pone.0053050
    76 https://doi.org/10.1371/journal.pone.0072162
    77 https://doi.org/10.1371/journal.pone.0103988
    78 https://doi.org/10.14694/edbook_am.2014.34.e258
    79 https://doi.org/10.2353/ajpath.2008.070981
    80 https://doi.org/10.2353/ajpath.2010.100105
    81 https://doi.org/10.3322/caac.21166
    82 schema:datePublished 2016-02
    83 schema:datePublishedReg 2016-02-01
    84 schema:description BACKGROUND: Development of targeted therapies for high-grade serous ovarian cancer (HGSC) remains challenging, as contributing molecular pathways are poorly defined or expressed heterogeneously. CUB-domain containing protein 1 (CDCP1) is a cell-surface protein elevated in lung, colorectal, pancreas, renal and clear cell ovarian cancer. METHODS: CUB-domain containing protein 1 was examined by immunohistochemistry in HGSC and fallopian tube. The impact of targeting CDCP1 on cell growth and migration in vitro, and intraperitoneal xenograft growth in mice was examined. Three patient-derived xenograft (PDX) mouse models were developed and characterised for CDCP1 expression. The effect of a monoclonal anti-CDCP1 antibody on PDX growth was examined. Src activation was assessed by western blot analysis. RESULTS: Elevated CDCP1 was observed in 77% of HGSC cases. Silencing of CDCP1 reduced migration and non-adherent cell growth in vitro and tumour burden in vivo. Expression of CDCP1 in patient samples was maintained in PDX models. Antibody blockade of CDCP1 significantly reduced growth of an HGSC PDX. The CDCP1-mediated activation of Src was observed in cultured cells and mouse xenografts. CONCLUSIONS: CUB-domain containing protein 1 is over-expressed by the majority of HGSCs. In vitro and mouse model data indicate that CDCP1 has a role in HGSC and that it can be targeted to inhibit progression of this cancer.
    85 schema:genre research_article
    86 schema:inLanguage en
    87 schema:isAccessibleForFree true
    88 schema:isPartOf N496b924e945c499683dd4646a8985ad1
    89 N69d0334937664898be0fb6ae82c7433a
    90 sg:journal.1017082
    91 schema:name Cell line and patient-derived xenograft models reveal elevated CDCP1 as a target in high-grade serous ovarian cancer
    92 schema:pagination 417
    93 schema:productId N1aa86ab0c78d44629ad3834ab6903ab1
    94 N23545f6fb78f469b9d33e44909b4b18c
    95 N29b6a8ec0bcd416f9319533cca45039d
    96 N54958fbb154c466494442c654370b8ff
    97 N6fdf75998ed245acb814839e5a1df214
    98 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040752675
    99 https://doi.org/10.1038/bjc.2015.471
    100 schema:sdDatePublished 2019-04-10T16:30
    101 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    102 schema:sdPublisher N9191f4bbe0cb4460a53f3f4f0901749f
    103 schema:url https://www.nature.com/articles/bjc2015471
    104 sgo:license sg:explorer/license/
    105 sgo:sdDataset articles
    106 rdf:type schema:ScholarlyArticle
    107 N02f60ec37f8e45289f6cf1e486f7e9e0 rdf:first sg:person.01340253532.05
    108 rdf:rest N1752633b6ec14c7b9b0f9a2a5ffc7a01
    109 N0c4a26811c01425e9ff0ccc57d28e0c8 rdf:first sg:person.0771731317.49
    110 rdf:rest N17891db8d4104a24af76bfc0e44cc345
    111 N0dba90fe7b2c417ab950703b6b78bd8a rdf:first sg:person.0575674157.75
    112 rdf:rest N6038acd3a3734fad966674da90ca3d25
    113 N1752633b6ec14c7b9b0f9a2a5ffc7a01 rdf:first sg:person.01077577577.12
    114 rdf:rest Nb6eb45c6832f453494b410f89bf23a44
    115 N17891db8d4104a24af76bfc0e44cc345 rdf:first sg:person.01367244620.37
    116 rdf:rest N9aa3e0a81beb44b7951965d589b64df3
    117 N1971d790945b48b9b58a27d2238b2f71 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    118 schema:name RNA, Small Interfering
    119 rdf:type schema:DefinedTerm
    120 N1aa86ab0c78d44629ad3834ab6903ab1 schema:name doi
    121 schema:value 10.1038/bjc.2015.471
    122 rdf:type schema:PropertyValue
    123 N1dc1d95faf43451ab93d6277136552af rdf:first sg:person.01062574751.76
    124 rdf:rest N40cbaab834d5470eb6845c7fbfb49b5e
    125 N23545f6fb78f469b9d33e44909b4b18c schema:name readcube_id
    126 schema:value c220ffb744bf82db9b9cd76058f1623f349e19ca72a3b5632023199c58edc89d
    127 rdf:type schema:PropertyValue
    128 N24f30881d4e345b5839e704e645d326c rdf:first sg:person.01363113572.91
    129 rdf:rest Na64aef2ed2d64edea891d52b3ebb7d77
    130 N29b6a8ec0bcd416f9319533cca45039d schema:name pubmed_id
    131 schema:value 26882065
    132 rdf:type schema:PropertyValue
    133 N2b20f4745ea345e98af891fc191fc741 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    134 schema:name Neoplasm Grading
    135 rdf:type schema:DefinedTerm
    136 N2b91cc3170144d8692efdead3b5ad86e rdf:first sg:person.01204413072.31
    137 rdf:rest N8a946bfd01d845c0a06b7e17e22fcc33
    138 N2c076d1132084013a1c0b4b8c6c46bd9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    139 schema:name Disease Models, Animal
    140 rdf:type schema:DefinedTerm
    141 N399cd2cec2f74283860158e2412e5d74 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    142 schema:name Cell Proliferation
    143 rdf:type schema:DefinedTerm
    144 N3c69298916004edea3521926d9497b83 rdf:first sg:person.0603311623.57
    145 rdf:rest Ne2e464a1e9fe4115beae9f4d7be4f02a
    146 N40cbaab834d5470eb6845c7fbfb49b5e rdf:first sg:person.0753736072.22
    147 rdf:rest N02f60ec37f8e45289f6cf1e486f7e9e0
    148 N40cd16574c4a4b4cab9265a7acd547ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    149 schema:name Biomarkers, Tumor
    150 rdf:type schema:DefinedTerm
    151 N496b924e945c499683dd4646a8985ad1 schema:volumeNumber 114
    152 rdf:type schema:PublicationVolume
    153 N54958fbb154c466494442c654370b8ff schema:name nlm_unique_id
    154 schema:value 0370635
    155 rdf:type schema:PropertyValue
    156 N55e58ffd63384a0f8ffa58e3ba5094c6 rdf:first sg:person.01120560217.98
    157 rdf:rest N3c69298916004edea3521926d9497b83
    158 N5a08eb8af6da44fa958979a5a3dfd0c5 rdf:first sg:person.011062244552.34
    159 rdf:rest N2b91cc3170144d8692efdead3b5ad86e
    160 N6038acd3a3734fad966674da90ca3d25 rdf:first sg:person.010043675414.78
    161 rdf:rest N9698c47358dd4fd28de9c1b376afe9fd
    162 N63e8c39f726649e88cb10575033b7ef7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    163 schema:name Cell Line, Tumor
    164 rdf:type schema:DefinedTerm
    165 N69d0334937664898be0fb6ae82c7433a schema:issueNumber 4
    166 rdf:type schema:PublicationIssue
    167 N6fdf75998ed245acb814839e5a1df214 schema:name dimensions_id
    168 schema:value pub.1040752675
    169 rdf:type schema:PropertyValue
    170 N7313c752fb6f4cff8312d35412429dd7 rdf:first sg:person.013103524532.49
    171 rdf:rest N0dba90fe7b2c417ab950703b6b78bd8a
    172 N83883e9da5384252926ea6ff1054b67d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    173 schema:name Humans
    174 rdf:type schema:DefinedTerm
    175 N8642a053cdc24b23bd42961d63f5b364 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    176 schema:name Neoplasm Proteins
    177 rdf:type schema:DefinedTerm
    178 N8a946bfd01d845c0a06b7e17e22fcc33 rdf:first sg:person.0671761151.05
    179 rdf:rest N9affac51194d4f32ac1c5979b3b59c6d
    180 N9191f4bbe0cb4460a53f3f4f0901749f schema:name Springer Nature - SN SciGraph project
    181 rdf:type schema:Organization
    182 N9698c47358dd4fd28de9c1b376afe9fd rdf:first sg:person.01323143321.88
    183 rdf:rest N5a08eb8af6da44fa958979a5a3dfd0c5
    184 N97dfcb87cb6346209b12942a2001b215 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    185 schema:name Heterografts
    186 rdf:type schema:DefinedTerm
    187 N9aa3e0a81beb44b7951965d589b64df3 rdf:first sg:person.0721425415.23
    188 rdf:rest Ne8ec789aed9a4b968a1e9a79fc56aa09
    189 N9affac51194d4f32ac1c5979b3b59c6d rdf:first sg:person.01106472247.46
    190 rdf:rest N55e58ffd63384a0f8ffa58e3ba5094c6
    191 N9c85d8676da9445691314ff491e51280 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    192 schema:name Female
    193 rdf:type schema:DefinedTerm
    194 Na64aef2ed2d64edea891d52b3ebb7d77 rdf:first sg:person.0664040424.95
    195 rdf:rest N1dc1d95faf43451ab93d6277136552af
    196 Na670f348cc6c420c85fb737013c4f00e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    197 schema:name Animals
    198 rdf:type schema:DefinedTerm
    199 Naeb66b2603774684a464548e3c76b390 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    200 schema:name Cell Movement
    201 rdf:type schema:DefinedTerm
    202 Naf3518a030c04c13a4833e9f9a45d808 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    203 schema:name Antigens, CD
    204 rdf:type schema:DefinedTerm
    205 Nb6eb45c6832f453494b410f89bf23a44 rdf:first sg:person.0614271406.38
    206 rdf:rest N7313c752fb6f4cff8312d35412429dd7
    207 Nb7cb3d4a4fd845b2b5f80a4c42b78e17 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    208 schema:name Mice
    209 rdf:type schema:DefinedTerm
    210 Nb804c033bedf4dc899ecb451d1ec6f26 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    211 schema:name Cell Adhesion Molecules
    212 rdf:type schema:DefinedTerm
    213 Nc56b0fb7c55c4304886e7fe481e1e5d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    214 schema:name Ovarian Neoplasms
    215 rdf:type schema:DefinedTerm
    216 Ne2e464a1e9fe4115beae9f4d7be4f02a rdf:first sg:person.01143415300.42
    217 rdf:rest N0c4a26811c01425e9ff0ccc57d28e0c8
    218 Ne8ec789aed9a4b968a1e9a79fc56aa09 rdf:first sg:person.01215515222.80
    219 rdf:rest rdf:nil
    220 Nf8c76471236841c4bdc910c7fe6a541c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    221 schema:name Cystadenocarcinoma, Serous
    222 rdf:type schema:DefinedTerm
    223 Nf9bce22da6134d80ada9f5ebcc60249e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    224 schema:name Survival Analysis
    225 rdf:type schema:DefinedTerm
    226 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    227 schema:name Medical and Health Sciences
    228 rdf:type schema:DefinedTerm
    229 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    230 schema:name Oncology and Carcinogenesis
    231 rdf:type schema:DefinedTerm
    232 sg:grant.6715700 http://pending.schema.org/fundedItem sg:pub.10.1038/bjc.2015.471
    233 rdf:type schema:MonetaryGrant
    234 sg:grant.6729330 http://pending.schema.org/fundedItem sg:pub.10.1038/bjc.2015.471
    235 rdf:type schema:MonetaryGrant
    236 sg:journal.1017082 schema:issn 0007-0920
    237 1532-1827
    238 schema:name British Journal of Cancer
    239 rdf:type schema:Periodical
    240 sg:person.010043675414.78 schema:affiliation https://www.grid.ac/institutes/grid.1491.d
    241 schema:familyName Crandon
    242 schema:givenName Alexander J
    243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010043675414.78
    244 rdf:type schema:Person
    245 sg:person.01062574751.76 schema:affiliation https://www.grid.ac/institutes/grid.1491.d
    246 schema:familyName Davies
    247 schema:givenName Claire M
    248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062574751.76
    249 rdf:type schema:Person
    250 sg:person.01077577577.12 schema:affiliation https://www.grid.ac/institutes/grid.1491.d
    251 schema:familyName Beaven
    252 schema:givenName Elizabeth A
    253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077577577.12
    254 rdf:type schema:Person
    255 sg:person.011062244552.34 schema:affiliation https://www.grid.ac/institutes/grid.1491.d
    256 schema:familyName Oliveira
    257 schema:givenName Niara B
    258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011062244552.34
    259 rdf:type schema:Person
    260 sg:person.01106472247.46 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
    261 schema:familyName Tinker
    262 schema:givenName Anna V
    263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106472247.46
    264 rdf:type schema:Person
    265 sg:person.01120560217.98 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
    266 schema:familyName Gilks
    267 schema:givenName C Blake
    268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120560217.98
    269 rdf:type schema:Person
    270 sg:person.01143415300.42 schema:affiliation https://www.grid.ac/institutes/grid.1491.d
    271 schema:familyName Brennan
    272 schema:givenName Donal J
    273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143415300.42
    274 rdf:type schema:Person
    275 sg:person.01204413072.31 schema:affiliation https://www.grid.ac/institutes/grid.1491.d
    276 schema:familyName Shannon
    277 schema:givenName Catherine M
    278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204413072.31
    279 rdf:type schema:Person
    280 sg:person.01215515222.80 schema:affiliation https://www.grid.ac/institutes/grid.416528.c
    281 schema:familyName Hooper
    282 schema:givenName John D
    283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215515222.80
    284 rdf:type schema:Person
    285 sg:person.013103524532.49 schema:affiliation https://www.grid.ac/institutes/grid.452919.2
    286 schema:familyName Kennedy
    287 schema:givenName Catherine
    288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013103524532.49
    289 rdf:type schema:Person
    290 sg:person.01323143321.88 schema:affiliation https://www.grid.ac/institutes/grid.489335.0
    291 schema:familyName Flatley
    292 schema:givenName Christopher
    293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323143321.88
    294 rdf:type schema:Person
    295 sg:person.01340253532.05 schema:affiliation https://www.grid.ac/institutes/grid.489335.0
    296 schema:familyName Adams
    297 schema:givenName Mark N
    298 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340253532.05
    299 rdf:type schema:Person
    300 sg:person.01363113572.91 schema:affiliation https://www.grid.ac/institutes/grid.416528.c
    301 schema:familyName Harrington
    302 schema:givenName Brittney S
    303 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363113572.91
    304 rdf:type schema:Person
    305 sg:person.01367244620.37 schema:affiliation https://www.grid.ac/institutes/grid.1491.d
    306 schema:familyName Armes
    307 schema:givenName Jane E
    308 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367244620.37
    309 rdf:type schema:Person
    310 sg:person.0575674157.75 schema:affiliation https://www.grid.ac/institutes/grid.1491.d
    311 schema:familyName Chetty
    312 schema:givenName Naven P
    313 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0575674157.75
    314 rdf:type schema:Person
    315 sg:person.0603311623.57 schema:affiliation https://www.grid.ac/institutes/grid.1003.2
    316 schema:familyName Gabrielli
    317 schema:givenName Brian
    318 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603311623.57
    319 rdf:type schema:Person
    320 sg:person.0614271406.38 schema:affiliation https://www.grid.ac/institutes/grid.416528.c
    321 schema:familyName Roche
    322 schema:givenName Deborah K
    323 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0614271406.38
    324 rdf:type schema:Person
    325 sg:person.0664040424.95 schema:affiliation https://www.grid.ac/institutes/grid.416528.c
    326 schema:familyName He
    327 schema:givenName Yaowu
    328 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664040424.95
    329 rdf:type schema:Person
    330 sg:person.0671761151.05 schema:affiliation https://www.grid.ac/institutes/grid.452919.2
    331 schema:familyName deFazio
    332 schema:givenName Anna
    333 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671761151.05
    334 rdf:type schema:Person
    335 sg:person.0721425415.23 schema:affiliation https://www.grid.ac/institutes/grid.1491.d
    336 schema:familyName Perrin
    337 schema:givenName Lewis C
    338 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721425415.23
    339 rdf:type schema:Person
    340 sg:person.0753736072.22 schema:affiliation https://www.grid.ac/institutes/grid.1491.d
    341 schema:familyName Wallace
    342 schema:givenName Sarah J
    343 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753736072.22
    344 rdf:type schema:Person
    345 sg:person.0771731317.49 schema:affiliation https://www.grid.ac/institutes/grid.1491.d
    346 schema:familyName Coward
    347 schema:givenName Jermaine I
    348 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771731317.49
    349 rdf:type schema:Person
    350 sg:pub.10.1007/978-1-4757-1647-4_5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039518345
    351 https://doi.org/10.1007/978-1-4757-1647-4_5
    352 rdf:type schema:CreativeWork
    353 sg:pub.10.1007/s00432-008-0412-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015868176
    354 https://doi.org/10.1007/s00432-008-0412-4
    355 rdf:type schema:CreativeWork
    356 sg:pub.10.1038/modpathol.2011.85 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034842843
    357 https://doi.org/10.1038/modpathol.2011.85
    358 rdf:type schema:CreativeWork
    359 sg:pub.10.1038/ncomms3126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043513580
    360 https://doi.org/10.1038/ncomms3126
    361 rdf:type schema:CreativeWork
    362 sg:pub.10.1038/nrc3144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053036406
    363 https://doi.org/10.1038/nrc3144
    364 rdf:type schema:CreativeWork
    365 sg:pub.10.1038/nrclinonc.2013.5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006139455
    366 https://doi.org/10.1038/nrclinonc.2013.5
    367 rdf:type schema:CreativeWork
    368 sg:pub.10.1038/onc.2011.262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000420328
    369 https://doi.org/10.1038/onc.2011.262
    370 rdf:type schema:CreativeWork
    371 sg:pub.10.1038/onc.2011.555 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028010034
    372 https://doi.org/10.1038/onc.2011.555
    373 rdf:type schema:CreativeWork
    374 sg:pub.10.1038/onc.2012.547 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020731179
    375 https://doi.org/10.1038/onc.2012.547
    376 rdf:type schema:CreativeWork
    377 sg:pub.10.1038/onc.2014.264 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035051786
    378 https://doi.org/10.1038/onc.2014.264
    379 rdf:type schema:CreativeWork
    380 sg:pub.10.1038/onc.2014.88 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004935530
    381 https://doi.org/10.1038/onc.2014.88
    382 rdf:type schema:CreativeWork
    383 sg:pub.10.1038/onc.2015.101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050170603
    384 https://doi.org/10.1038/onc.2015.101
    385 rdf:type schema:CreativeWork
    386 sg:pub.10.1038/onc.2015.19 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039519132
    387 https://doi.org/10.1038/onc.2015.19
    388 rdf:type schema:CreativeWork
    389 sg:pub.10.1038/sj.onc.1206220 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036369351
    390 https://doi.org/10.1038/sj.onc.1206220
    391 rdf:type schema:CreativeWork
    392 sg:pub.10.1186/1757-2215-7-70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047364375
    393 https://doi.org/10.1186/1757-2215-7-70
    394 rdf:type schema:CreativeWork
    395 sg:pub.10.1290/1071-2690(2000)036<0357:cofneo>2.0.co;2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000451104
    396 https://doi.org/10.1290/1071-2690(2000)036<0357:cofneo>2.0.co;2
    397 rdf:type schema:CreativeWork
    398 sg:pub.10.1290/1071-2690(2000)036<0357:cofneo>2.3.co;2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064748507
    399 https://doi.org/10.1290/1071-2690(2000)036<0357:cofneo>2.3.co;2
    400 rdf:type schema:CreativeWork
    401 https://app.dimensions.ai/details/publication/pub.1080083733 schema:CreativeWork
    402 https://app.dimensions.ai/details/publication/pub.1082929650 schema:CreativeWork
    403 https://doi.org/10.1002/0471142905.hg1011s57 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021035685
    404 rdf:type schema:CreativeWork
    405 https://doi.org/10.1002/ijc.29210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018963471
    406 rdf:type schema:CreativeWork
    407 https://doi.org/10.1002/iub.198 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052985483
    408 rdf:type schema:CreativeWork
    409 https://doi.org/10.1002/path.2696 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006485690
    410 rdf:type schema:CreativeWork
    411 https://doi.org/10.1002/path.2744 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021005164
    412 rdf:type schema:CreativeWork
    413 https://doi.org/10.1002/path.4353 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045003770
    414 rdf:type schema:CreativeWork
    415 https://doi.org/10.1006/gyno.2001.6353 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034887715
    416 rdf:type schema:CreativeWork
    417 https://doi.org/10.1016/j.ccr.2013.10.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029297219
    418 rdf:type schema:CreativeWork
    419 https://doi.org/10.1016/j.molonc.2013.08.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014200991
    420 rdf:type schema:CreativeWork
    421 https://doi.org/10.1016/j.ygyno.2015.08.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046281352
    422 rdf:type schema:CreativeWork
    423 https://doi.org/10.1021/mp900236t schema:sameAs https://app.dimensions.ai/details/publication/pub.1056214170
    424 rdf:type schema:CreativeWork
    425 https://doi.org/10.1043/1543-2165(2008)132[402:aoitgp]2.0.co;2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077615502
    426 rdf:type schema:CreativeWork
    427 https://doi.org/10.1053/j.gastro.2013.05.049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001425400
    428 rdf:type schema:CreativeWork
    429 https://doi.org/10.1073/pnas.1011777108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053322910
    430 rdf:type schema:CreativeWork
    431 https://doi.org/10.1073/pnas.1017228108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047040096
    432 rdf:type schema:CreativeWork
    433 https://doi.org/10.1073/pnas.1117135109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019036331
    434 rdf:type schema:CreativeWork
    435 https://doi.org/10.1073/pnas.1222435110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010316361
    436 rdf:type schema:CreativeWork
    437 https://doi.org/10.1074/jbc.m109.096453 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037449687
    438 rdf:type schema:CreativeWork
    439 https://doi.org/10.1074/jbc.m111.227462 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036551929
    440 rdf:type schema:CreativeWork
    441 https://doi.org/10.1074/jbc.m111.335448 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030248029
    442 rdf:type schema:CreativeWork
    443 https://doi.org/10.1080/00313020410001721555 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023065499
    444 rdf:type schema:CreativeWork
    445 https://doi.org/10.1097/pas.0000000000000353 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000484914
    446 rdf:type schema:CreativeWork
    447 https://doi.org/10.1097/pat.0b013e328348a6e7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000654232
    448 rdf:type schema:CreativeWork
    449 https://doi.org/10.1097/pat.0b013e32835bd561 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000443975
    450 rdf:type schema:CreativeWork
    451 https://doi.org/10.1111/his.12651 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051285559
    452 rdf:type schema:CreativeWork
    453 https://doi.org/10.1111/j.1349-7006.2008.01066.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1053705427
    454 rdf:type schema:CreativeWork
    455 https://doi.org/10.1111/j.1365-2559.2004.01787.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008911407
    456 rdf:type schema:CreativeWork
    457 https://doi.org/10.1158/0008-5472.can-07-1657 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021899361
    458 rdf:type schema:CreativeWork
    459 https://doi.org/10.1158/0008-5472.can-10-0220 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016728613
    460 rdf:type schema:CreativeWork
    461 https://doi.org/10.1158/1078-0432.ccr-14-1292 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021464776
    462 rdf:type schema:CreativeWork
    463 https://doi.org/10.1158/1541-7786.mcr-09-0100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005445829
    464 rdf:type schema:CreativeWork
    465 https://doi.org/10.1309/ajcpgxk0fr4mhihb schema:sameAs https://app.dimensions.ai/details/publication/pub.1033344012
    466 rdf:type schema:CreativeWork
    467 https://doi.org/10.1371/journal.pmed.0050232 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043679611
    468 rdf:type schema:CreativeWork
    469 https://doi.org/10.1371/journal.pone.0024420 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012716774
    470 rdf:type schema:CreativeWork
    471 https://doi.org/10.1371/journal.pone.0053050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043492183
    472 rdf:type schema:CreativeWork
    473 https://doi.org/10.1371/journal.pone.0072162 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028870459
    474 rdf:type schema:CreativeWork
    475 https://doi.org/10.1371/journal.pone.0103988 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013924787
    476 rdf:type schema:CreativeWork
    477 https://doi.org/10.14694/edbook_am.2014.34.e258 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067344602
    478 rdf:type schema:CreativeWork
    479 https://doi.org/10.2353/ajpath.2008.070981 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022397602
    480 rdf:type schema:CreativeWork
    481 https://doi.org/10.2353/ajpath.2010.100105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024928264
    482 rdf:type schema:CreativeWork
    483 https://doi.org/10.3322/caac.21166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021817259
    484 rdf:type schema:CreativeWork
    485 https://www.grid.ac/institutes/grid.1003.2 schema:alternateName University of Queensland
    486 schema:name The University of Queensland Diamantina Institute, Translational Research Institute, Woolloongabba, QLD 4102, Australia
    487 rdf:type schema:Organization
    488 https://www.grid.ac/institutes/grid.1491.d schema:alternateName Mater Health Services
    489 schema:name Mater Health Services, South Brisbane, QLD 4101, Australia
    490 Mater Ovarian Cancer Research Collaborative, Mater Adult Hospital, South Brisbane, QLD 4101, Australia
    491 Mater Research Institute, University of Queensland, Translational Research Institute, Woolloongabba, QLD 4102, Australia
    492 rdf:type schema:Organization
    493 https://www.grid.ac/institutes/grid.17091.3e schema:alternateName University of British Columbia
    494 schema:name Department of Pathology and Laboratory Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada
    495 rdf:type schema:Organization
    496 https://www.grid.ac/institutes/grid.248762.d schema:alternateName BC Cancer Agency
    497 schema:name Cheryl Brown Ovarian Cancer Outcomes Unit, Division of Medical Oncology and Vancouver Centre, British Columbia Cancer Agency, Vancouver, BC, Canada
    498 rdf:type schema:Organization
    499 https://www.grid.ac/institutes/grid.416528.c schema:alternateName Mater Adult Hospital
    500 schema:name Mater Ovarian Cancer Research Collaborative, Mater Adult Hospital, South Brisbane, QLD 4101, Australia
    501 Mater Research Institute, University of Queensland, Translational Research Institute, Woolloongabba, QLD 4102, Australia
    502 rdf:type schema:Organization
    503 https://www.grid.ac/institutes/grid.452919.2 schema:alternateName Westmead Institute for Medical Research
    504 schema:name Department of Gynaecological Oncology, Westmead Hospital and Centre for Cancer Research, Westmead Millennium Institute, Westmead, NSW 2145, Australia
    505 rdf:type schema:Organization
    506 https://www.grid.ac/institutes/grid.489335.0 schema:alternateName Translational Research Institute
    507 schema:name Mater Research Institute, University of Queensland, Translational Research Institute, Woolloongabba, QLD 4102, Australia
    508 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...