Histopathological features of papillary thyroid carcinomas detected during four screening examinations of a Ukrainian-American cohort View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Tetiana I Bogdanova, Liudmyla Yu Zurnadzhy, Yuri E Nikiforov, Rebecca J Leeman-Neill, Mykola D Tronko, Stephen Chanock, Kiyohiko Mabuchi, Ilya A Likhtarov, Leonila M Kovgan, Vladimir Drozdovitch, Mark P Little, Maureen Hatch, Lydia B Zablotska, Viktor M Shpak, Robert J McConnell, Alina V Brenner

ABSTRACT

BACKGROUND: There are limited data on the histopathology of papillary thyroid carcinomas (PTCs) diagnosed in irradiated populations. We evaluated the associations between iodine-131 dose and the histopathological characteristics of post-Chernobyl PTCs, the changes in these characteristics over time, and their associations with selected somatic mutations. METHODS: This study included 115 PTCs diagnosed in a Ukrainian-American cohort (n=13,243) during prescreening and four successive thyroid screenings. Of these PTCs, 65 were subjected to somatic mutation profiling. All individuals were <18 years at the time of the Chernobyl accident and had direct thyroid radioactivity measurements. Statistical analyses included multivariate linear and logistic regression. RESULTS: We identified a borderline significant linear-quadratic association (P=0.063) between iodine-131 dose and overall tumour invasiveness (presence of extrathyroidal extension, lymphatic/vascular invasion, and regional or distant metastases). Irrespective of dose, tumours with chromosomal rearrangements were more likely to have lymphatic/vascular invasion than tumours without chromosomal rearrangements (P=0.020) or tumours with BRAF or RAS point mutations (P=0.008). Controlling for age, there were significant time trends in decreasing tumour size (P<0.001), the extent of lymphatic/vascular invasion (P=0.005), and overall invasiveness (P=0.026). CONCLUSIONS: We determined that the invasive properties of PTCs that develop in iodine-131-exposed children may be associated with radiation dose. In addition, based on a subset of cases, tumours with chromosomal rearrangements appear to have a more invasive phenotype. The increase in small, less invasive PTCs over time is a consequence of repeated screening examinations. More... »

PAGES

1556

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.2015.372

DOI

http://dx.doi.org/10.1038/bjc.2015.372

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032262579

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26625214


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