Major histocompatibility complex class I expression impacts on patient survival and type and density of immune cells in biliary tract ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-11

AUTHORS

Benjamin Goeppert, Lena Frauenschuh, Manuela Zucknick, Stephanie Roessler, Arianeb Mehrabi, Mohammadreza Hafezi, Albrecht Stenzinger, Arne Warth, Anita Pathil, Marcus Renner, Peter Schirmacher, Wilko Weichert

ABSTRACT

BACKGROUND: Biliary tract cancers (BTC) are rare malignant tumours with a poor prognosis. Previously, we have presented a detailed characterisation of the inflammatory infiltrate in BTC. Here, we analysed the impact of the expression of major histocompatibility complex class I (MHC I) on patient survival and the quantity, as well as the quality of tumour-infiltrating immune cell types in BTC. METHODS: MHC I expression was assessed semi-quantitatively in 334 BTC, including extrahepatic (n=129) and intrahepatic cholangiocarcinomas (n=146), as well as adenocarcinomas of the gallbladder (n=59). In addition, 71 high-grade biliary intraepithelial lesions (BilIN 3) were included. Results were correlated with data on antitumour inflammation and investigated with respect to their association with clinicopathological variables and patient survival. RESULTS: BTC showed a wide spectrum of different MHC I expression patterns ranging from complete negativity in some tumours to strong homogenous expression in others. In BilIN 3, significantly higher MHC I expression levels were seen compared to invasive tumours (P=0.004). Patients with strong tumoural MHC I expression had a significantly higher overall survival probability (median survival benefit: 8 months; P=0.006). MHC I expression strongly correlated with the number of tumour-infiltrating T-lymphocytes (CD4(+) and CD8(+)) and macrophages. CONCLUSIONS: Differences of MHC I expression predict patient outcome and show correlations with specific components of the inflammatory infiltrate in BTC. These findings contribute to a better understanding of immune response and immune escape phenomena in cholangiocarcinogenesis. More... »

PAGES

1343

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.2015.337

DOI

http://dx.doi.org/10.1038/bjc.2015.337

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1000656763

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26461054


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