Nab-paclitaxel plus gemcitabine for metastatic pancreatic adenocarcinoma after Folfirinox failure: an AGEO prospective multicentre cohort View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-09

AUTHORS

Alix Portal, Simon Pernot, David Tougeron, Claire Arbaud, Anne Thirot Bidault, Christelle de la Fouchardière, Pascal Hammel, Thierry Lecomte, Johann Dréanic, Romain Coriat, Jean-Baptiste Bachet, Olivier Dubreuil, Lysiane Marthey, Laetitia Dahan, Belinda Tchoundjeu, Christophe Locher, Céline Lepère, Franck Bonnetain, Julien Taieb

ABSTRACT

BACKGROUND: There is currently no standard second-line treatment for metastatic pancreatic adenocarcinoma (MPA), and progression-free survival is consistently <4 months in this setting. The aim of this study was to evaluate the efficacy and tolerability of Nab-paclitaxel plus gemcitabine (A+G) after Folfirinox failure in MPA. METHODS: From February 2013 to July 2014, all consecutive patients treated with A+G for histologically proven MPA after Folfirinox failure were prospectively enrolled in 12 French centres. A+G was delivered as described in the MPACT trial, until disease progression, patient refusal or unacceptable toxicity. RESULTS: Fifty-seven patients were treated with Nab-paclitaxel plus gemcitabine, for a median of 4 cycles (range 1-12). The disease control rate was 58%, with a 17.5% objective response rate. Median overall survival (OS) was 8.8 months (95% CI: 6.2-9.7) and median progression-free survival was 5.1 months (95% CI: 3.2-6.2). Since the start of first-line chemotherapy, median OS was 18 months (95% CI: 16-21). No toxic deaths occurred. Grade 3-4 toxicities were reported in 40% of patients, consisting of neutropenia (12.5%), neurotoxicity (12.5%), asthenia (9%) and thrombocytopenia (6.5%). CONCLUSIONS: A+G seems to be effective, with a manageable toxicity profile, after Folfirinox failure in patients with MPA. More... »

PAGES

989

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.2015.328

DOI

http://dx.doi.org/10.1038/bjc.2015.328

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010315581

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26372701


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