Prognostic value of the KRAS G12V mutation in 841 surgically resected Caucasian lung adenocarcinoma cases View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-10

AUTHORS

Stéphane Renaud, Pierre-Emmanuel Falcoz, Mickaël Schaëffer, Dominique Guenot, Benoit Romain, Anne Olland, Jérémie Reeb, Nicola Santelmo, Marie-Pierre Chenard, Michèle Legrain, Anne-Claire Voegeli, Michèle Beau-Faller, Gilbert Massard

ABSTRACT

BACKGROUND: Identifying patients who will experience lung cancer recurrence after surgery remains a challenge. We aimed to evaluate whether mutant forms of epidermal growth factor receptor (EGFR) and Kirsten rat sarcoma viral oncogene homolog (KRAS) (mEGFR and mKRAS) are useful biomarkers in resected non-small cell lung cancer (NSCLC). METHODS: We retrospectively reviewed data from 841 patients who underwent surgery and molecular testing for NSCLC between 2007 and 2012. RESULTS: mEGFR was observed in 103 patients (12.2%), and mKRAS in 265 (31.5%). The median overall survival (OS) and time to recurrence (TTR) were significantly lower for mKRAS (OS: 43 months; TTR: 19 months) compared with mEGFR (OS: 67 months; TTR: 24 months) and wild-type patients (OS: 55 months; disease-free survival (DFS): 24 months). Patients with KRAS G12V exhibited worse OS and TTR compared with the entire cohort (OS: KRAS G12V: 26 months vs COHORT: 60 months; DFS: KRAS G12V: 15 months vs COHORT: 24 months). These results were confirmed using multivariate analyses (non-G12V status, hazard ratio (HR): 0.43 (confidence interval: 0.28-0.65), P<0.0001 for OS; HR: 0.67 (0.48-0.92), P=0.01 for TTR). Risk of recurrence was significantly lower for non-KRAS G12V (HR: 0.01, (0.001-0.08), P<0.0001). CONCLUSIONS: mKRAS and mEGFR may predict survival and recurrence in early stages of NSCLC. Patients with KRAS G12V exhibited worse OS and higher recurrence incidences. More... »

PAGES

1206

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.2015.327

DOI

http://dx.doi.org/10.1038/bjc.2015.327

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019887568

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26372703


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    "description": "BACKGROUND: Identifying patients who will experience lung cancer recurrence after surgery remains a challenge. We aimed to evaluate whether mutant forms of epidermal growth factor receptor (EGFR) and Kirsten rat sarcoma viral oncogene homolog (KRAS) (mEGFR and mKRAS) are useful biomarkers in resected non-small cell lung cancer (NSCLC).\nMETHODS: We retrospectively reviewed data from 841 patients who underwent surgery and molecular testing for NSCLC between 2007 and 2012.\nRESULTS: mEGFR was observed in 103 patients (12.2%), and mKRAS in 265 (31.5%). The median overall survival (OS) and time to recurrence (TTR) were significantly lower for mKRAS (OS: 43 months; TTR: 19 months) compared with mEGFR (OS: 67 months; TTR: 24 months) and wild-type patients (OS: 55 months; disease-free survival (DFS): 24 months). Patients with KRAS G12V exhibited worse OS and TTR compared with the entire cohort (OS: KRAS G12V: 26 months vs\nCOHORT: 60 months; DFS: KRAS G12V: 15 months vs\nCOHORT: 24 months). These results were confirmed using multivariate analyses (non-G12V status, hazard ratio (HR): 0.43 (confidence interval: 0.28-0.65), P<0.0001 for OS; HR: 0.67 (0.48-0.92), P=0.01 for TTR). Risk of recurrence was significantly lower for non-KRAS G12V (HR: 0.01, (0.001-0.08), P<0.0001).\nCONCLUSIONS: mKRAS and mEGFR may predict survival and recurrence in early stages of NSCLC. Patients with KRAS G12V exhibited worse OS and higher recurrence incidences.", 
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302 Department of Molecular Biology, Oncobiology Laboratory, Regional Institute of Cancer Strasbourg University Hospital, Hôpital de Hautepierre, Strasbourg, France
303 Reasearch Unit EA3430: Tumoral Progression and Micro-environment, Translational and Epidemiological Approaches, Translational Medicine Federation, Strasbourg University. 67000 Strasbourg, France
304 rdf:type schema:Organization
305 https://www.grid.ac/institutes/grid.413866.e schema:alternateName Hôpital Civil, Strasbourg
306 schema:name Department of Thoracic Surgery, Strasbourg University Hospital, Nouvel Hôpital Civil, 67000 Strasbourg, France
307 rdf:type schema:Organization
 




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