Loss of FOXO1 promotes gastric tumour growth and metastasis through upregulation of human epidermal growth factor receptor 2/neu expression View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-10

AUTHORS

Young San Ko, Sung Jin Cho, Jinju Park, Younghoon Kim, Yong Joon Choi, Jung-Soo Pyo, Bo Gun Jang, Jong-Wan Park, Woo Ho Kim, Byung Lan Lee

ABSTRACT

BACKGROUND: The biological significance of FOXO1, a member of the forkhead box O transcription factor family, in gastric cancer (GC) remains unclear. The present study provides direct evidence of the role of FOXO1 in tumour growth and metastasis of GC in relation to human epidermal growth factor receptor 2 (HER2). METHODS: The expressions of FOXO1 and HER2 were modulated in GC cell lines (SNU-638, MKN45, SNU-216 and NCI-N87) by stable transfections. The effects of transfection on GC phenotypes were evaluated in vitro and in animal models. In addition, the relationship between FOXO1 and HER2 was analysed using GC clinical specimens, cell lines and xenografts. RESULTS: FOXO1 silencing in GC cells increased colony formation and mesenchymal transition in vitro, as well as tumour growth and metastasis in nude mice, whereas HER2 silencing induced the opposite results.. Furthermore, an inverse relationship between FOXO1 and HER2 was found in clinical specimens of GC, GC cells and GC xenograft tumours. Although a negative crosstalk between these two molecules was shown, double knockdown of both FOXO1 and HER2 in GC cells revealed that HER2 silencing reversed the FOXO1 shRNA-induced migration and invasion even without the FOXO1 restoration. CONCLUSIONS: Our results indicate that loss of FOXO1 promotes GC growth and metastasis by upregulating HER2 expression and that the HER2 expression is more critical to the induction of GC cell metastasis. The present study provides evidence that the FOXO1/HER2 pathway may regulate GC progression in a subgroup of GC patients. More... »

PAGES

1186

References to SciGraph publications

  • 2014-07. RETRACTED ARTICLE: MMP9 activation triggered by epidermal growth factor induced FoxO1 nuclear exclusion in non-small cell lung cancer in TUMOR BIOLOGY
  • 2011-01. A hypoxia-dependent upregulation of hypoxia-inducible factor-1 by nuclear factor-κB promotes gastric tumour growth and angiogenesis in BRITISH JOURNAL OF CANCER
  • 2014-07. The forkhead transcription factor FOXO1 mediates cisplatin resistance in gastric cancer cells by activating phosphoinositide 3-kinase/Akt pathway in GASTRIC CANCER
  • 2013-12. A synergistic interaction between transcription factors nuclear factor-κB and signal transducers and activators of transcription 3 promotes gastric cancer cell migration and invasion in BMC GASTROENTEROLOGY
  • 2000-11. Tyrosine kinases and gastric cancer in ONCOGENE
  • 2014-06. Testican-1-mediated epithelial–mesenchymal transition signaling confers acquired resistance to lapatinib in HER2-positive gastric cancer in ONCOGENE
  • 2014-10. RETRACTED ARTICLE: Epidermal growth factor induces FoxO1 nuclear exclusion to activate MMP7-mediated metastasis of larynx carcinoma in TUMOR BIOLOGY
  • 2007-06. Stressing the role of FoxO proteins in lifespan and disease in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2014-07. RETRACTED ARTICLE: Inhibition of FoxO1 nuclear exclusion prevents metastasis of Glioblastoma in TUMOR BIOLOGY
  • 2007-08. Constitutive phosphorylation of the FOXO1A transcription factor as a prognostic variable in gastric cancer in MODERN PATHOLOGY
  • 2012-07. In vitro and in vivo antitumor activity of cetuximab in human gastric cancer cell lines in relation to epidermal growth factor receptor (EGFR) expression and mutational phenotype in GASTRIC CANCER
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/bjc.2015.273

    DOI

    http://dx.doi.org/10.1038/bjc.2015.273

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1002868789

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26448177


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