Ontology type: schema:ScholarlyArticle Open Access: True
2015-09
AUTHORSL Rossi, E Laas, P Mallon, A Vincent-Salomon, J-M Guinebretiere, F Lerebours, R Rouzier, J-Y Pierga, F Reyal
ABSTRACTBACKGROUND: Inconsistencies between mitotic index (MI) and Ki67 measures have been identified in many breast tumour samples. The aim of this study was to describe the prognosis of hormone receptor-positive (HR+) HER2- tumours having discrepant MI and Ki67. METHODS: We included a cohort of breast cancer patients initially treated by surgery between 2001 and 2005 in the Institut Curie. Breast cancer-specific survival (BCSS) and disease-free survival (DFS) were analysed according to three proliferation groups: high MI/high Ki67 (MI=3, Ki67>20%), low MI/low Ki67 (MI<3, Ki67⩽20%) and discrepant (high MI/low Ki67 or low MI/high Ki67). RESULTS: Among the 1430 patients, 19.6% had discrepant Ki67 and MI, 11.6% had high markers and 68.8% had low markers. The 5-year BCSS was 95.8%, 95% CI (0.93-0.98) in the discrepant group, 99.3%, 95% CI (0.993-0.999) in the low-proliferation group and 91.8%, 95% CI (0.88-0.96) in the high-proliferation group. In multivariate analysis, the survival of the discrepant group was lower than that of the low-proliferation group: BCSS hazard ratio (HR)=3.01 (1.32-6.84; P=0.008) and DFS HR=2.07, 95% CI (1.31-3.26; P=0.002). Among grade 2 tumours in multivariate analysis, DFS of the discrepant group was lower than that of the low MI/low Ki67 group: HR=1.98, 95% CI (1.14-3.46), P=0.02. Regarding BCSS, the obtained results were similar. CONCLUSION: The prognosis of patients with discrepant MI and Ki67 appears intermediate between that of low MI/low Ki67 and high MI/high Ki67 groups. These markers should be jointly analysed to clarify prognosis. More... »
PAGES996
http://scigraph.springernature.com/pub.10.1038/bjc.2015.239
DOIhttp://dx.doi.org/10.1038/bjc.2015.239
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1001002484
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/26379080
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Breast Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Ki-67 Antigen",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mitotic Index",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Prognosis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Receptor, ErbB-2",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Receptors, Steroid",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Survival Analysis",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Institute Curie",
"id": "https://www.grid.ac/institutes/grid.418596.7",
"name": [
"D\u00e9partement de chirurgie, Institut Curie, 75005 Paris, France."
],
"type": "Organization"
},
"familyName": "Rossi",
"givenName": "L",
"id": "sg:person.0606402350.36",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606402350.36"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Tenon Hospital",
"id": "https://www.grid.ac/institutes/grid.413483.9",
"name": [
"Service de Gyn\u00e9cologie-Obst\u00e9trique, H\u00f4pital Tenon, 75020 Paris, France."
],
"type": "Organization"
},
"familyName": "Laas",
"givenName": "E",
"id": "sg:person.01347132026.83",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347132026.83"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Craigavon Area Hospital",
"id": "https://www.grid.ac/institutes/grid.413258.9",
"name": [
"Craigavon Area Hospital Breast Unit BT63 5QQ, Portadown, Northern Ireland."
],
"type": "Organization"
},
"familyName": "Mallon",
"givenName": "P",
"id": "sg:person.01221233570.94",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221233570.94"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Institute Curie",
"id": "https://www.grid.ac/institutes/grid.418596.7",
"name": [
"D\u00e9partement de biologie des tumeurs, Institut Curie, 75005 Paris, France."
],
"type": "Organization"
},
"familyName": "Vincent-Salomon",
"givenName": "A",
"id": "sg:person.01306222052.48",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306222052.48"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Institute Curie",
"id": "https://www.grid.ac/institutes/grid.418596.7",
"name": [
"D\u00e9partement de biologie des tumeurs, Institut Curie, 75005 Paris, France."
],
"type": "Organization"
},
"familyName": "Guinebretiere",
"givenName": "J-M",
"id": "sg:person.01244162220.06",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244162220.06"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Institute Curie",
"id": "https://www.grid.ac/institutes/grid.418596.7",
"name": [
"D\u00e9partement d'oncologie m\u00e9dicale, Institut Curie, 75005 Paris, France."
],
"type": "Organization"
},
"familyName": "Lerebours",
"givenName": "F",
"id": "sg:person.01075435727.26",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075435727.26"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Institute Curie",
"id": "https://www.grid.ac/institutes/grid.418596.7",
"name": [
"D\u00e9partement de chirurgie, Institut Curie, 75005 Paris, France.",
"Equipe d'Accueil 7285, 'Risk and Safety in Clinical Medicine for women and Perinatal Health', University Versailles-Saint-Quentin, 78180 Montigny-le-Bretonneux, France."
],
"type": "Organization"
},
"familyName": "Rouzier",
"givenName": "R",
"id": "sg:person.01101754741.17",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101754741.17"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Institute Curie",
"id": "https://www.grid.ac/institutes/grid.418596.7",
"name": [
"D\u00e9partement d'oncologie m\u00e9dicale, Institut Curie, 75005 Paris, France."
],
"type": "Organization"
},
"familyName": "Pierga",
"givenName": "J-Y",
"id": "sg:person.0711334140.14",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711334140.14"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Institute Curie",
"id": "https://www.grid.ac/institutes/grid.418596.7",
"name": [
"D\u00e9partement de chirurgie, Institut Curie, 75005 Paris, France.",
"D\u00e9partement de recherche translationnelle, Equipe r\u00e9sidu tumoral et r\u00e9ponse au traitement, Institut Curie, 75005 Paris, France.",
"INSERM U932 Immunity and Cancer, Institut Curie, 75005 Paris, France."
],
"type": "Organization"
},
"familyName": "Reyal",
"givenName": "F",
"id": "sg:person.01104374270.94",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104374270.94"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1155/2006/152341",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000734926"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/bcr1618",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000765469",
"https://doi.org/10.1186/bcr1618"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/cyto.990120107",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001679047"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/cyto.990120107",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001679047"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/cncr.11188",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001711822"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ejca.2004.03.014",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002203769"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/jnci/djt319",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003667172"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.clbc.2014.12.007",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005719115"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/modpathol.2013.60",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007928096",
"https://doi.org/10.1038/modpathol.2013.60"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1365-2559.1991.tb00229.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010222506"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1365-2559.1991.tb00229.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010222506"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1470-2045(09)70262-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011020813"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.annpat.2010.07.001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011050402"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1470-2045(09)70314-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011515750"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1634/theoncologist.2008-0073",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013710026"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10549-010-1028-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016276726",
"https://doi.org/10.1007/s10549-010-1028-3"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2005.08.046",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018553672"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/jnci/djp082",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020655992"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1365-2559.2006.02402.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021910635"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/cyto.990110210",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023702923"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/cyto.990110210",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023702923"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/jnci/djr393",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024075504"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1365-2559.2003.01745.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024991457"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.bjc.6603756",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030523104",
"https://doi.org/10.1038/sj.bjc.6603756"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.breast.2008.02.002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032864891"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0046-8177(92)90313-r",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034293001"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/annonc/mdm535",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035355209"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/jnci/djm289",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041663946"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/cncr.10458",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044689120"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/annonc/mdt303",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045949725"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2012.43.4134",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046496198"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0055901",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047160777"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2007.14.2364",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049142592"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2005.05.511",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052242373"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/ijc.27539",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053189613"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.5114/pjp.2013.34596",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1072591437"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1076958084",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082946270",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1083173461",
"type": "CreativeWork"
}
],
"datePublished": "2015-09",
"datePublishedReg": "2015-09-01",
"description": "BACKGROUND: Inconsistencies between mitotic index (MI) and Ki67 measures have been identified in many breast tumour samples. The aim of this study was to describe the prognosis of hormone receptor-positive (HR+) HER2- tumours having discrepant MI and Ki67.\nMETHODS: We included a cohort of breast cancer patients initially treated by surgery between 2001 and 2005 in the Institut Curie. Breast cancer-specific survival (BCSS) and disease-free survival (DFS) were analysed according to three proliferation groups: high MI/high Ki67 (MI=3, Ki67>20%), low MI/low Ki67 (MI<3, Ki67\u2a7d20%) and discrepant (high MI/low Ki67 or low MI/high Ki67).\nRESULTS: Among the 1430 patients, 19.6% had discrepant Ki67 and MI, 11.6% had high markers and 68.8% had low markers. The 5-year BCSS was 95.8%, 95% CI (0.93-0.98) in the discrepant group, 99.3%, 95% CI (0.993-0.999) in the low-proliferation group and 91.8%, 95% CI (0.88-0.96) in the high-proliferation group. In multivariate analysis, the survival of the discrepant group was lower than that of the low-proliferation group: BCSS hazard ratio (HR)=3.01 (1.32-6.84; P=0.008) and DFS HR=2.07, 95% CI (1.31-3.26; P=0.002). Among grade 2 tumours in multivariate analysis, DFS of the discrepant group was lower than that of the low MI/low Ki67 group: HR=1.98, 95% CI (1.14-3.46), P=0.02. Regarding BCSS, the obtained results were similar.\nCONCLUSION: The prognosis of patients with discrepant MI and Ki67 appears intermediate between that of low MI/low Ki67 and high MI/high Ki67 groups. These markers should be jointly analysed to clarify prognosis.",
"genre": "research_article",
"id": "sg:pub.10.1038/bjc.2015.239",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1017082",
"issn": [
"0007-0920",
"1532-1827"
],
"name": "British Journal of Cancer",
"type": "Periodical"
},
{
"issueNumber": "7",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "113"
}
],
"name": "Prognostic impact of discrepant Ki67 and mitotic index on hormone receptor-positive, HER2-negative breast carcinoma",
"pagination": "996",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"04c6dfb2aa1d95dac0e19b14b4b8f2caa38765d39d2cd792435ccacb93e55e8d"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"26379080"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"0370635"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/bjc.2015.239"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1001002484"
]
}
],
"sameAs": [
"https://doi.org/10.1038/bjc.2015.239",
"https://app.dimensions.ai/details/publication/pub.1001002484"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T20:35",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000434.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/bjc2015239"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/bjc.2015.239'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/bjc.2015.239'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/bjc.2015.239'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/bjc.2015.239'
This table displays all metadata directly associated to this object as RDF triples.
281 TRIPLES
21 PREDICATES
74 URIs
30 LITERALS
18 BLANK NODES