Tailoring heated intraperitoneal mitomycin C for peritoneal metastases originating from colorectal carcinoma: a translational approach to improve survival View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-03

AUTHORS

R Kwakman, E M V de Cuba, J P de Winter, I H J T de Hingh, P M Delis-van Diemen, M Tijssen, M A Rooimans, O Krijgsman, B Carvalho, G J Peters, H J Bonjer, G A Meijer, E A te Velde

ABSTRACT

BACKGROUND: Patients with peritoneal metastases (PMs) originating from colorectal carcinoma (CRC) are curatively treated by cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) with mitomycin C (MMC). We aim to improve patient selection for HIPEC by predicting MMC sensitivity. METHODS: The MMC sensitivity was determined for 12 CRC cell lines and correlated to mRNA expression of 37 genes related to the Fanconi anaemia (FA)-BRCA pathway, ATM-ATR pathway and enzymatic activation of MMC. Functionality of the FA-BRCA pathway in cell lines was assessed using a chromosomal breakage assay and western blot for key protein FANCD2. Bloom syndrome protein (BLM) was further analysed by staining for the corresponding protein with immunohistochemistry (IHC) on both CRC cell lines (n=12) and patient material (n=20). RESULTS: High sensitivity correlated with a low BLM (P=0.01) and BRCA2 (P=0.02) at mRNA expression level. However, FA-BRCA pathway functionality demonstrated no correlation to MMC sensitivity. In cell lines, weak intensity staining of BLM by IHC correlated to high sensitivity (P=0.04) to MMC. Low BLM protein expression was significantly associated with an improved survival in patients after CRS and HIPEC (P=0.04). CONCLUSIONS: Low BLM levels are associated with high MMC sensitivity and an improved survival after HIPEC. More... »

PAGES

851

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.2015.18

DOI

http://dx.doi.org/10.1038/bjc.2015.18

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011775354

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25668003


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibiotics, Antineoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Caco-2 Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colorectal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fanconi Anemia Complementation Group D2 Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HCT116 Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HT29 Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hyperthermia, Induced", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitomycin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peritoneal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RecQ Helicases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Translational Medical Research", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Department of Surgical Oncology, Cancer Center Amsterdam and VU University Medical Center, De Boelelaan 1117, Amsterdam 1081 HV, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kwakman", 
        "givenName": "R", 
        "id": "sg:person.01331525327.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331525327.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Surgical Oncology, Cancer Center Amsterdam and VU University Medical Center, De Boelelaan 1117, Amsterdam 1081 HV, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de Cuba", 
        "givenName": "E M V", 
        "id": "sg:person.01263412127.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263412127.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Clinical Genetics, Cancer Center Amsterdam and VU University Medical Center, De Boelelaan 1117, Amsterdam 1081 HV, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de Winter", 
        "givenName": "J P", 
        "id": "sg:person.01127433351.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127433351.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Catharina Ziekenhuis", 
          "id": "https://www.grid.ac/institutes/grid.413532.2", 
          "name": [
            "Department of Surgery, Catharina Ziekenhuis Eindhoven, Eindhoven, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de Hingh", 
        "givenName": "I H J T", 
        "id": "sg:person.016552664644.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016552664644.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Pathology and Tumour Profiling Unit, Cancer Center Amsterdam and VU University Medical Center, De Boelelaan 1117, Amsterdam 1081 HV, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Diemen", 
        "givenName": "P M Delis-van", 
        "id": "sg:person.014746167407.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014746167407.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Pathology and Tumour Profiling Unit, Cancer Center Amsterdam and VU University Medical Center, De Boelelaan 1117, Amsterdam 1081 HV, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tijssen", 
        "givenName": "M", 
        "id": "sg:person.01031672443.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031672443.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Clinical Genetics, Cancer Center Amsterdam and VU University Medical Center, De Boelelaan 1117, Amsterdam 1081 HV, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rooimans", 
        "givenName": "M A", 
        "id": "sg:person.01055457051.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055457051.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Pathology and Tumour Profiling Unit, Cancer Center Amsterdam and VU University Medical Center, De Boelelaan 1117, Amsterdam 1081 HV, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Krijgsman", 
        "givenName": "O", 
        "id": "sg:person.01013142175.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013142175.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Pathology and Tumour Profiling Unit, Cancer Center Amsterdam and VU University Medical Center, De Boelelaan 1117, Amsterdam 1081 HV, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Carvalho", 
        "givenName": "B", 
        "id": "sg:person.01224175623.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224175623.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Oncology, Cancer Center Amsterdam and VU University Medical Center, De Boelelaan 1117, Amsterdam 1081 HV, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Peters", 
        "givenName": "G J", 
        "id": "sg:person.01255301342.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255301342.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Surgical Oncology, Cancer Center Amsterdam and VU University Medical Center, De Boelelaan 1117, Amsterdam 1081 HV, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bonjer", 
        "givenName": "H J", 
        "id": "sg:person.07445411004.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07445411004.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Pathology and Tumour Profiling Unit, Cancer Center Amsterdam and VU University Medical Center, De Boelelaan 1117, Amsterdam 1081 HV, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Meijer", 
        "givenName": "G A", 
        "id": "sg:person.01343465105.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343465105.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Surgical Oncology, Cancer Center Amsterdam and VU University Medical Center, De Boelelaan 1117, Amsterdam 1081 HV, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Velde", 
        "givenName": "E A te", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1101/gad.195248.112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001256503"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jamasurg.2013.1006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001283323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc970", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001754654", 
          "https://doi.org/10.1038/nrc970"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc970", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001754654", 
          "https://doi.org/10.1038/nrc970"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cgt.7700430", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006040247", 
          "https://doi.org/10.1038/sj.cgt.7700430"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cgt.7700430", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006040247", 
          "https://doi.org/10.1038/sj.cgt.7700430"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2004.10.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007908968"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.153.2.367", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008700703"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12094-010-0531-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008946844", 
          "https://doi.org/10.1007/s12094-010-0531-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12094-010-0531-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008946844", 
          "https://doi.org/10.1007/s12094-010-0531-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/sqb.2005.70.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009155809"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jso.21051", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012592276"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1179/joc.2005.17.6.668", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012882006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.2003811", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013673802"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.2910560124", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013756932"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.2910560124", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013756932"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/genesandcancer.13", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015166933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1593/tlo.13238", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016884883"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.2001.5387", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017551323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ymeth.2010.02.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019057171"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ymeth.2010.02.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019057171"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jso.23189", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019161436"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2217/pgs.12.137", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020363247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-2952(98)00073-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020436099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/00015458.2006.11679897", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021508324"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/bti270", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024039594"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1055-3207(03)00031-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026325222"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2012/836425", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027925083"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(95)90105-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029355541"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-008-9966-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030091417", 
          "https://doi.org/10.1245/s10434-008-9966-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-009-0487-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030183343", 
          "https://doi.org/10.1245/s10434-009-0487-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-009-0487-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030183343", 
          "https://doi.org/10.1245/s10434-009-0487-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cgt.7700734", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030873876", 
          "https://doi.org/10.1038/sj.cgt.7700734"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cgt.7700734", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030873876", 
          "https://doi.org/10.1038/sj.cgt.7700734"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/cdg114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031436651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/88.5.259", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033563954"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00428-012-1287-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033609099", 
          "https://doi.org/10.1007/s00428-012-1287-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.2009.01375.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034899346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.2009.01375.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034899346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.soc.2012.07.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037317257"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mrfmmm.2009.01.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038206967"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cub.2009.02.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038228349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ctrv.2012.11.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039663666"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-10-0475", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043497946"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.272.49.30611", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044179445"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.emboj.7600277", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044946367"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ppo.0b013e3181a58d95", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047540081"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ppo.0b013e3181a58d95", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047540081"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ppo.0b013e3181a58d95", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047540081"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/00365521.2012.640825", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048464351"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m603747200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049747468"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2012/238731", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051910695"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cc.3.12.1286", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072297792"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074630046", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/mol.58.5.1146", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074715319"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074735200", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075055337", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076341113", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077653754", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079826313", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083326056", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-03", 
    "datePublishedReg": "2015-03-01", 
    "description": "BACKGROUND: Patients with peritoneal metastases (PMs) originating from colorectal carcinoma (CRC) are curatively treated by cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) with mitomycin C (MMC). We aim to improve patient selection for HIPEC by predicting MMC sensitivity.\nMETHODS: The MMC sensitivity was determined for 12 CRC cell lines and correlated to mRNA expression of 37 genes related to the Fanconi anaemia (FA)-BRCA pathway, ATM-ATR pathway and enzymatic activation of MMC. Functionality of the FA-BRCA pathway in cell lines was assessed using a chromosomal breakage assay and western blot for key protein FANCD2. Bloom syndrome protein (BLM) was further analysed by staining for the corresponding protein with immunohistochemistry (IHC) on both CRC cell lines (n=12) and patient material (n=20).\nRESULTS: High sensitivity correlated with a low BLM (P=0.01) and BRCA2 (P=0.02) at mRNA expression level. However, FA-BRCA pathway functionality demonstrated no correlation to MMC sensitivity. In cell lines, weak intensity staining of BLM by IHC correlated to high sensitivity (P=0.04) to MMC. Low BLM protein expression was significantly associated with an improved survival in patients after CRS and HIPEC (P=0.04).\nCONCLUSIONS: Low BLM levels are associated with high MMC sensitivity and an improved survival after HIPEC.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/bjc.2015.18", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1017082", 
        "issn": [
          "0007-0920", 
          "1532-1827"
        ], 
        "name": "British Journal of Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "112"
      }
    ], 
    "name": "Tailoring heated intraperitoneal mitomycin C for peritoneal metastases originating from colorectal carcinoma: a translational approach to improve survival", 
    "pagination": "851", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "381abe24b23d4bb015bf37df384dae740a44bc47238b51cb42d8d1400885ab7f"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25668003"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0370635"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/bjc.2015.18"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1011775354"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/bjc.2015.18", 
      "https://app.dimensions.ai/details/publication/pub.1011775354"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T13:57", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000435.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/bjc201518"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/bjc.2015.18'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/bjc.2015.18'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/bjc.2015.18'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/bjc.2015.18'


 

This table displays all metadata directly associated to this object as RDF triples.

397 TRIPLES      21 PREDICATES      97 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/bjc.2015.18 schema:about N054bfaf81ca94a939573bd133116b59c
2 N0df6d348343241f0af1af5722e201194
3 N10e1aeb8e4f14a348462af8a367dafa6
4 N117e9b4ce99f4ff2a463319ce2d5bb09
5 N35f9940257db4ac78ed8a06f23e1be0c
6 N3aa0f3f67d14426bb71d6e825b92318a
7 N3d8d4f80e63e4bcea243061c0c8b575c
8 N5a04c6765b6547df8f25cf4c9f6b89a4
9 N71da6eb9d5dc4b658af8a3c3db6203fa
10 N7246073cfc65458b87b3dcd0d8943cab
11 N7a78153ce67e419a9fa982967bb5b0ba
12 N9233598fc6c04068ac00437c28abd802
13 Na788d8780d304a3c8a44ed08fce5fc52
14 Na90d8a2d4830491ca69c1f507fe364cc
15 Naec9ecfe854646998cf282c1fc99408c
16 Nb4173fd138da4beda254318e1f81f9e0
17 Nb4ea6c4a13a0479b96901830fa969866
18 anzsrc-for:11
19 anzsrc-for:1112
20 schema:author Nb8032a02c5044867a66233738cf01c14
21 schema:citation sg:pub.10.1007/s00428-012-1287-y
22 sg:pub.10.1007/s12094-010-0531-7
23 sg:pub.10.1038/nrc970
24 sg:pub.10.1038/sj.cgt.7700430
25 sg:pub.10.1038/sj.cgt.7700734
26 sg:pub.10.1245/s10434-008-9966-2
27 sg:pub.10.1245/s10434-009-0487-4
28 https://app.dimensions.ai/details/publication/pub.1074630046
29 https://app.dimensions.ai/details/publication/pub.1074735200
30 https://app.dimensions.ai/details/publication/pub.1075055337
31 https://app.dimensions.ai/details/publication/pub.1076341113
32 https://app.dimensions.ai/details/publication/pub.1077653754
33 https://app.dimensions.ai/details/publication/pub.1079826313
34 https://app.dimensions.ai/details/publication/pub.1083326056
35 https://doi.org/10.1001/jamasurg.2013.1006
36 https://doi.org/10.1002/ijc.2910560124
37 https://doi.org/10.1002/jso.21051
38 https://doi.org/10.1002/jso.23189
39 https://doi.org/10.1006/bbrc.2001.5387
40 https://doi.org/10.1016/0092-8674(95)90105-1
41 https://doi.org/10.1016/j.ctrv.2012.11.003
42 https://doi.org/10.1016/j.cub.2009.02.018
43 https://doi.org/10.1016/j.mrfmmm.2009.01.013
44 https://doi.org/10.1016/j.soc.2012.07.014
45 https://doi.org/10.1016/j.ymeth.2010.02.009
46 https://doi.org/10.1016/s0006-2952(98)00073-2
47 https://doi.org/10.1016/s1055-3207(03)00031-0
48 https://doi.org/10.1038/sj.emboj.7600277
49 https://doi.org/10.1074/jbc.272.49.30611
50 https://doi.org/10.1074/jbc.m603747200
51 https://doi.org/10.1080/00015458.2006.11679897
52 https://doi.org/10.1083/jcb.153.2.367
53 https://doi.org/10.1093/bioinformatics/bti270
54 https://doi.org/10.1093/emboj/cdg114
55 https://doi.org/10.1093/jnci/88.5.259
56 https://doi.org/10.1097/ppo.0b013e3181a58d95
57 https://doi.org/10.1101/gad.195248.112
58 https://doi.org/10.1101/gad.2003811
59 https://doi.org/10.1101/sqb.2005.70.002
60 https://doi.org/10.1111/j.1349-7006.2009.01375.x
61 https://doi.org/10.1124/mol.58.5.1146
62 https://doi.org/10.1155/2012/238731
63 https://doi.org/10.1155/2012/836425
64 https://doi.org/10.1158/0008-5472.can-10-0475
65 https://doi.org/10.1179/joc.2005.17.6.668
66 https://doi.org/10.1200/jco.2004.10.012
67 https://doi.org/10.1593/tlo.13238
68 https://doi.org/10.18632/genesandcancer.13
69 https://doi.org/10.2217/pgs.12.137
70 https://doi.org/10.3109/00365521.2012.640825
71 https://doi.org/10.4161/cc.3.12.1286
72 schema:datePublished 2015-03
73 schema:datePublishedReg 2015-03-01
74 schema:description BACKGROUND: Patients with peritoneal metastases (PMs) originating from colorectal carcinoma (CRC) are curatively treated by cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) with mitomycin C (MMC). We aim to improve patient selection for HIPEC by predicting MMC sensitivity. METHODS: The MMC sensitivity was determined for 12 CRC cell lines and correlated to mRNA expression of 37 genes related to the Fanconi anaemia (FA)-BRCA pathway, ATM-ATR pathway and enzymatic activation of MMC. Functionality of the FA-BRCA pathway in cell lines was assessed using a chromosomal breakage assay and western blot for key protein FANCD2. Bloom syndrome protein (BLM) was further analysed by staining for the corresponding protein with immunohistochemistry (IHC) on both CRC cell lines (n=12) and patient material (n=20). RESULTS: High sensitivity correlated with a low BLM (P=0.01) and BRCA2 (P=0.02) at mRNA expression level. However, FA-BRCA pathway functionality demonstrated no correlation to MMC sensitivity. In cell lines, weak intensity staining of BLM by IHC correlated to high sensitivity (P=0.04) to MMC. Low BLM protein expression was significantly associated with an improved survival in patients after CRS and HIPEC (P=0.04). CONCLUSIONS: Low BLM levels are associated with high MMC sensitivity and an improved survival after HIPEC.
75 schema:genre research_article
76 schema:inLanguage en
77 schema:isAccessibleForFree true
78 schema:isPartOf N41bb6ff684ac4c8f9ab1099479c3fca5
79 N6eb382d535434c44839e59aafe63b7a0
80 sg:journal.1017082
81 schema:name Tailoring heated intraperitoneal mitomycin C for peritoneal metastases originating from colorectal carcinoma: a translational approach to improve survival
82 schema:pagination 851
83 schema:productId N203ec595213a42e583a56e96a4f6271e
84 N33cd98ff8e5d4a85a9f50f16c48b49fa
85 N880cb015bbef4947993dfc0b638eb93a
86 Na6149135b676495ba2ebf876286f2e71
87 Nd85486810e024d43af912a6c7d3dbbea
88 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011775354
89 https://doi.org/10.1038/bjc.2015.18
90 schema:sdDatePublished 2019-04-10T13:57
91 schema:sdLicense https://scigraph.springernature.com/explorer/license/
92 schema:sdPublisher N83559e4dd66c4799936e1cb625d4c838
93 schema:url https://www.nature.com/articles/bjc201518
94 sgo:license sg:explorer/license/
95 sgo:sdDataset articles
96 rdf:type schema:ScholarlyArticle
97 N054bfaf81ca94a939573bd133116b59c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Signal Transduction
99 rdf:type schema:DefinedTerm
100 N0df6d348343241f0af1af5722e201194 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Antibiotics, Antineoplastic
102 rdf:type schema:DefinedTerm
103 N0e6717e4c7dc41819da7b0c8e5d29447 rdf:first sg:person.01224175623.35
104 rdf:rest N5be8f092b4a4448eb2d10375ab6c51d9
105 N0ee04f6d5e98488d8f7fac877107091e rdf:first sg:person.014746167407.52
106 rdf:rest Ncfc943a7728146eb9184ff2927d5c26d
107 N10990734773d47fbbde7d37a387df185 schema:name Department of Pathology and Tumour Profiling Unit, Cancer Center Amsterdam and VU University Medical Center, De Boelelaan 1117, Amsterdam 1081 HV, The Netherlands
108 rdf:type schema:Organization
109 N10e1aeb8e4f14a348462af8a367dafa6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Peritoneal Neoplasms
111 rdf:type schema:DefinedTerm
112 N117e9b4ce99f4ff2a463319ce2d5bb09 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name HT29 Cells
114 rdf:type schema:DefinedTerm
115 N203ec595213a42e583a56e96a4f6271e schema:name doi
116 schema:value 10.1038/bjc.2015.18
117 rdf:type schema:PropertyValue
118 N33cd98ff8e5d4a85a9f50f16c48b49fa schema:name nlm_unique_id
119 schema:value 0370635
120 rdf:type schema:PropertyValue
121 N35f9940257db4ac78ed8a06f23e1be0c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name HCT116 Cells
123 rdf:type schema:DefinedTerm
124 N3aa0f3f67d14426bb71d6e825b92318a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Translational Medical Research
126 rdf:type schema:DefinedTerm
127 N3d8d4f80e63e4bcea243061c0c8b575c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name RecQ Helicases
129 rdf:type schema:DefinedTerm
130 N41bb6ff684ac4c8f9ab1099479c3fca5 schema:volumeNumber 112
131 rdf:type schema:PublicationVolume
132 N41f5db99d5b54d3e8a4725763676de83 schema:name Department of Pathology and Tumour Profiling Unit, Cancer Center Amsterdam and VU University Medical Center, De Boelelaan 1117, Amsterdam 1081 HV, The Netherlands
133 rdf:type schema:Organization
134 N48335736fe15457bb3dda3cc9c44bd33 schema:name Department of Clinical Genetics, Cancer Center Amsterdam and VU University Medical Center, De Boelelaan 1117, Amsterdam 1081 HV, The Netherlands
135 rdf:type schema:Organization
136 N555c2fd67c9b4a879e2feb75b488edf3 rdf:first sg:person.016552664644.41
137 rdf:rest N0ee04f6d5e98488d8f7fac877107091e
138 N58b66f372a8348bd8e595a0efa29a3e3 rdf:first sg:person.01343465105.24
139 rdf:rest Neb284ba2983144fd96b7167b2cc25389
140 N5a04c6765b6547df8f25cf4c9f6b89a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Humans
142 rdf:type schema:DefinedTerm
143 N5be8f092b4a4448eb2d10375ab6c51d9 rdf:first sg:person.01255301342.17
144 rdf:rest N93d9bfd1f4f74bd2af746151d13829e5
145 N5cd2cf6df79047049c0ce21dedbcf0c7 schema:name Department of Pathology and Tumour Profiling Unit, Cancer Center Amsterdam and VU University Medical Center, De Boelelaan 1117, Amsterdam 1081 HV, The Netherlands
146 rdf:type schema:Organization
147 N6c8f4ad11fd243209fa75a8e9ee593dd schema:name Department of Surgical Oncology, Cancer Center Amsterdam and VU University Medical Center, De Boelelaan 1117, Amsterdam 1081 HV, The Netherlands
148 rdf:type schema:Organization
149 N6eb382d535434c44839e59aafe63b7a0 schema:issueNumber 5
150 rdf:type schema:PublicationIssue
151 N7005025389e643a28111a96c47578502 rdf:first sg:person.01127433351.24
152 rdf:rest N555c2fd67c9b4a879e2feb75b488edf3
153 N71da6eb9d5dc4b658af8a3c3db6203fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Fanconi Anemia Complementation Group D2 Protein
155 rdf:type schema:DefinedTerm
156 N7246073cfc65458b87b3dcd0d8943cab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Biomarkers, Tumor
158 rdf:type schema:DefinedTerm
159 N7643e0aa5cfb4afea51400c431eb7d4f schema:name Department of Surgical Oncology, Cancer Center Amsterdam and VU University Medical Center, De Boelelaan 1117, Amsterdam 1081 HV, The Netherlands
160 rdf:type schema:Organization
161 N7a78153ce67e419a9fa982967bb5b0ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Hyperthermia, Induced
163 rdf:type schema:DefinedTerm
164 N83559e4dd66c4799936e1cb625d4c838 schema:name Springer Nature - SN SciGraph project
165 rdf:type schema:Organization
166 N880cb015bbef4947993dfc0b638eb93a schema:name pubmed_id
167 schema:value 25668003
168 rdf:type schema:PropertyValue
169 N9233598fc6c04068ac00437c28abd802 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Survival Analysis
171 rdf:type schema:DefinedTerm
172 N93d9bfd1f4f74bd2af746151d13829e5 rdf:first sg:person.07445411004.86
173 rdf:rest N58b66f372a8348bd8e595a0efa29a3e3
174 N9537e552bc674ebfb649eaaf9c9399a4 schema:name Department of Pathology and Tumour Profiling Unit, Cancer Center Amsterdam and VU University Medical Center, De Boelelaan 1117, Amsterdam 1081 HV, The Netherlands
175 rdf:type schema:Organization
176 N9e69fe5b20a54399b19abc6c35078be4 rdf:first sg:person.01013142175.10
177 rdf:rest N0e6717e4c7dc41819da7b0c8e5d29447
178 Na465ce94e4604aca8aa9c4b117d5cac3 schema:name Department of Clinical Genetics, Cancer Center Amsterdam and VU University Medical Center, De Boelelaan 1117, Amsterdam 1081 HV, The Netherlands
179 rdf:type schema:Organization
180 Na6149135b676495ba2ebf876286f2e71 schema:name readcube_id
181 schema:value 381abe24b23d4bb015bf37df384dae740a44bc47238b51cb42d8d1400885ab7f
182 rdf:type schema:PropertyValue
183 Na788d8780d304a3c8a44ed08fce5fc52 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Colorectal Neoplasms
185 rdf:type schema:DefinedTerm
186 Na90d8a2d4830491ca69c1f507fe364cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Mitomycin
188 rdf:type schema:DefinedTerm
189 Naec9ecfe854646998cf282c1fc99408c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Cell Line, Tumor
191 rdf:type schema:DefinedTerm
192 Nb132150db81c4affbb0dacf35f1354cf schema:name Department of Pathology and Tumour Profiling Unit, Cancer Center Amsterdam and VU University Medical Center, De Boelelaan 1117, Amsterdam 1081 HV, The Netherlands
193 rdf:type schema:Organization
194 Nb3509b9d84ff4af995a1ae6de53f22eb rdf:first sg:person.01055457051.07
195 rdf:rest N9e69fe5b20a54399b19abc6c35078be4
196 Nb4173fd138da4beda254318e1f81f9e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Caco-2 Cells
198 rdf:type schema:DefinedTerm
199 Nb4ea6c4a13a0479b96901830fa969866 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Gene Expression Regulation, Neoplastic
201 rdf:type schema:DefinedTerm
202 Nb8032a02c5044867a66233738cf01c14 rdf:first sg:person.01331525327.32
203 rdf:rest Nef3f6889a6004d50a1779c315a788ac7
204 Nbe3bc6f6794d4461aa71388564f9ccec schema:affiliation Ne6ee769ab5b44938ba6ab515b4ab4b89
205 schema:familyName Velde
206 schema:givenName E A te
207 rdf:type schema:Person
208 Ncfc943a7728146eb9184ff2927d5c26d rdf:first sg:person.01031672443.64
209 rdf:rest Nb3509b9d84ff4af995a1ae6de53f22eb
210 Nd85486810e024d43af912a6c7d3dbbea schema:name dimensions_id
211 schema:value pub.1011775354
212 rdf:type schema:PropertyValue
213 Ne2713b713105424dba789c4524282c1b schema:name Department of Surgical Oncology, Cancer Center Amsterdam and VU University Medical Center, De Boelelaan 1117, Amsterdam 1081 HV, The Netherlands
214 rdf:type schema:Organization
215 Ne6ee769ab5b44938ba6ab515b4ab4b89 schema:name Department of Surgical Oncology, Cancer Center Amsterdam and VU University Medical Center, De Boelelaan 1117, Amsterdam 1081 HV, The Netherlands
216 rdf:type schema:Organization
217 Neb284ba2983144fd96b7167b2cc25389 rdf:first Nbe3bc6f6794d4461aa71388564f9ccec
218 rdf:rest rdf:nil
219 Nef3f6889a6004d50a1779c315a788ac7 rdf:first sg:person.01263412127.08
220 rdf:rest N7005025389e643a28111a96c47578502
221 Nf4b25a6306184515beef34c062aca563 schema:name Department of Oncology, Cancer Center Amsterdam and VU University Medical Center, De Boelelaan 1117, Amsterdam 1081 HV, The Netherlands
222 rdf:type schema:Organization
223 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
224 schema:name Medical and Health Sciences
225 rdf:type schema:DefinedTerm
226 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
227 schema:name Oncology and Carcinogenesis
228 rdf:type schema:DefinedTerm
229 sg:journal.1017082 schema:issn 0007-0920
230 1532-1827
231 schema:name British Journal of Cancer
232 rdf:type schema:Periodical
233 sg:person.01013142175.10 schema:affiliation N9537e552bc674ebfb649eaaf9c9399a4
234 schema:familyName Krijgsman
235 schema:givenName O
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013142175.10
237 rdf:type schema:Person
238 sg:person.01031672443.64 schema:affiliation Nb132150db81c4affbb0dacf35f1354cf
239 schema:familyName Tijssen
240 schema:givenName M
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031672443.64
242 rdf:type schema:Person
243 sg:person.01055457051.07 schema:affiliation Na465ce94e4604aca8aa9c4b117d5cac3
244 schema:familyName Rooimans
245 schema:givenName M A
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055457051.07
247 rdf:type schema:Person
248 sg:person.01127433351.24 schema:affiliation N48335736fe15457bb3dda3cc9c44bd33
249 schema:familyName de Winter
250 schema:givenName J P
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127433351.24
252 rdf:type schema:Person
253 sg:person.01224175623.35 schema:affiliation N10990734773d47fbbde7d37a387df185
254 schema:familyName Carvalho
255 schema:givenName B
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224175623.35
257 rdf:type schema:Person
258 sg:person.01255301342.17 schema:affiliation Nf4b25a6306184515beef34c062aca563
259 schema:familyName Peters
260 schema:givenName G J
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255301342.17
262 rdf:type schema:Person
263 sg:person.01263412127.08 schema:affiliation Ne2713b713105424dba789c4524282c1b
264 schema:familyName de Cuba
265 schema:givenName E M V
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263412127.08
267 rdf:type schema:Person
268 sg:person.01331525327.32 schema:affiliation N6c8f4ad11fd243209fa75a8e9ee593dd
269 schema:familyName Kwakman
270 schema:givenName R
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331525327.32
272 rdf:type schema:Person
273 sg:person.01343465105.24 schema:affiliation N41f5db99d5b54d3e8a4725763676de83
274 schema:familyName Meijer
275 schema:givenName G A
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343465105.24
277 rdf:type schema:Person
278 sg:person.014746167407.52 schema:affiliation N5cd2cf6df79047049c0ce21dedbcf0c7
279 schema:familyName Diemen
280 schema:givenName P M Delis-van
281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014746167407.52
282 rdf:type schema:Person
283 sg:person.016552664644.41 schema:affiliation https://www.grid.ac/institutes/grid.413532.2
284 schema:familyName de Hingh
285 schema:givenName I H J T
286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016552664644.41
287 rdf:type schema:Person
288 sg:person.07445411004.86 schema:affiliation N7643e0aa5cfb4afea51400c431eb7d4f
289 schema:familyName Bonjer
290 schema:givenName H J
291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07445411004.86
292 rdf:type schema:Person
293 sg:pub.10.1007/s00428-012-1287-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1033609099
294 https://doi.org/10.1007/s00428-012-1287-y
295 rdf:type schema:CreativeWork
296 sg:pub.10.1007/s12094-010-0531-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008946844
297 https://doi.org/10.1007/s12094-010-0531-7
298 rdf:type schema:CreativeWork
299 sg:pub.10.1038/nrc970 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001754654
300 https://doi.org/10.1038/nrc970
301 rdf:type schema:CreativeWork
302 sg:pub.10.1038/sj.cgt.7700430 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006040247
303 https://doi.org/10.1038/sj.cgt.7700430
304 rdf:type schema:CreativeWork
305 sg:pub.10.1038/sj.cgt.7700734 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030873876
306 https://doi.org/10.1038/sj.cgt.7700734
307 rdf:type schema:CreativeWork
308 sg:pub.10.1245/s10434-008-9966-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030091417
309 https://doi.org/10.1245/s10434-008-9966-2
310 rdf:type schema:CreativeWork
311 sg:pub.10.1245/s10434-009-0487-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030183343
312 https://doi.org/10.1245/s10434-009-0487-4
313 rdf:type schema:CreativeWork
314 https://app.dimensions.ai/details/publication/pub.1074630046 schema:CreativeWork
315 https://app.dimensions.ai/details/publication/pub.1074735200 schema:CreativeWork
316 https://app.dimensions.ai/details/publication/pub.1075055337 schema:CreativeWork
317 https://app.dimensions.ai/details/publication/pub.1076341113 schema:CreativeWork
318 https://app.dimensions.ai/details/publication/pub.1077653754 schema:CreativeWork
319 https://app.dimensions.ai/details/publication/pub.1079826313 schema:CreativeWork
320 https://app.dimensions.ai/details/publication/pub.1083326056 schema:CreativeWork
321 https://doi.org/10.1001/jamasurg.2013.1006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001283323
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1002/ijc.2910560124 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013756932
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1002/jso.21051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012592276
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1002/jso.23189 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019161436
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1006/bbrc.2001.5387 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017551323
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1016/0092-8674(95)90105-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029355541
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1016/j.ctrv.2012.11.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039663666
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1016/j.cub.2009.02.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038228349
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1016/j.mrfmmm.2009.01.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038206967
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1016/j.soc.2012.07.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037317257
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1016/j.ymeth.2010.02.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019057171
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1016/s0006-2952(98)00073-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020436099
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1016/s1055-3207(03)00031-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026325222
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1038/sj.emboj.7600277 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044946367
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1074/jbc.272.49.30611 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044179445
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1074/jbc.m603747200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049747468
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1080/00015458.2006.11679897 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021508324
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1083/jcb.153.2.367 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008700703
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1093/bioinformatics/bti270 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024039594
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1093/emboj/cdg114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031436651
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1093/jnci/88.5.259 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033563954
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1097/ppo.0b013e3181a58d95 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047540081
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1101/gad.195248.112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001256503
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1101/gad.2003811 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013673802
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1101/sqb.2005.70.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009155809
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1111/j.1349-7006.2009.01375.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1034899346
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1124/mol.58.5.1146 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074715319
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1155/2012/238731 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051910695
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1155/2012/836425 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027925083
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1158/0008-5472.can-10-0475 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043497946
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1179/joc.2005.17.6.668 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012882006
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1200/jco.2004.10.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007908968
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1593/tlo.13238 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016884883
386 rdf:type schema:CreativeWork
387 https://doi.org/10.18632/genesandcancer.13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015166933
388 rdf:type schema:CreativeWork
389 https://doi.org/10.2217/pgs.12.137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020363247
390 rdf:type schema:CreativeWork
391 https://doi.org/10.3109/00365521.2012.640825 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048464351
392 rdf:type schema:CreativeWork
393 https://doi.org/10.4161/cc.3.12.1286 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072297792
394 rdf:type schema:CreativeWork
395 https://www.grid.ac/institutes/grid.413532.2 schema:alternateName Catharina Ziekenhuis
396 schema:name Department of Surgery, Catharina Ziekenhuis Eindhoven, Eindhoven, The Netherlands
397 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...