Prognostic value of histopathological regression in 850 neoadjuvantly treated oesophagogastric adenocarcinomas View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-04

AUTHORS

T Schmidt, L Sicic, S Blank, K Becker, W Weichert, T Bruckner, T Parakonthun, R Langer, M W Büchler, J-R Siewert, F Lordick, K Ott

ABSTRACT

BACKGROUND: Recently, histopathological tumour regression, prevalence of signet ring cells, and localisation were reported as prognostic factors in neoadjuvantly treated oesophagogastric (junctional and gastric) cancer. This exploratory retrospective study analyses independent prognostic factors within a large patient cohort after preoperative chemotherapy including clinical and histopathological factors. METHODS: In all, 850 patients presenting with oesophagogastric cancer staged cT3/4 Nany cM0/x were treated with neoadjuvant chemotherapy followed by resection in two academic centres. Patient data were documented in a prospective database and retrospectively analysed. RESULTS: Of all factors prognostic on univariate analysis, only clinical response, complications, ypTNM stage, and R category were independently prognostic (P<0.01) on multivariate analysis. Tumour localisation and signet ring cells were independently prognostic only when investigator-dependent clinical response evaluation was excluded from the multivariate model. Histopathological tumour regression correlates with tumour grading, Laurén classification, clinical response, ypT, ypN, and R categories but was not identified as an independent prognostic factor. Within R0-resected patients only surgical complications and ypTNM stage were independent prognostic factors. CONCLUSIONS: Only established prognostic factors like ypTNM stage, R category, and complications were identified as independent prognostic factors in resected patients after neoadjuvant chemotherapy. In contrast, histopathological tumour regression was not found as an independent prognostic marker. More... »

PAGES

1712

References to SciGraph publications

  • 2011-06. Recurrence and survival after pathologic complete response to preoperative therapy followed by surgery for gastric or gastrooesophageal adenocarcinoma in BRITISH JOURNAL OF CANCER
  • 2013-02. Preoperative therapy of esophagogastric cancer: the problem of nonresponding patients in LANGENBECK'S ARCHIVES OF SURGERY
  • 2012-07. Adenocarcinomas of the Esophagogastric Junction Are More Likely to Respond to Preoperative Chemotherapy than Distal Gastric Cancer in ANNALS OF SURGICAL ONCOLOGY
  • 2009-04. Surgical Factors Influence the Outcome After Ivor-Lewis Esophagectomy with Intrathoracic Anastomosis for Adenocarcinoma of the Esophagogastric Junction: A Consecutive Series of 240 Patients at an Experienced Center in ANNALS OF SURGICAL ONCOLOGY
  • 2008-03. The new credo: induction chemotherapy in locally advanced gastric cancer: consequences for surgical strategies in GASTRIC CANCER
  • 2013-10. Prognostic impact of lymph node involvement and the extent of lymphadenectomy (LAD) in adenocarcinoma of the esophagogastric junction (AEG) in LANGENBECK'S ARCHIVES OF SURGERY
  • 2007-12. Does Graded Histologic Response After Neoadjuvant Chemotherapy Predict Survival for Completely Resected Gastric Cancer? in ANNALS OF SURGICAL ONCOLOGY
  • 2009-12. Prognostic significance of histopathological tumor regression after neoadjuvant chemotherapy in esophageal adenocarcinomas in MODERN PATHOLOGY
  • 2012-07. Prediction of Response and Prognosis by a Score Including Only Pretherapeutic Parameters in 410 Neoadjuvant Treated Gastric Cancer Patients in ANNALS OF SURGICAL ONCOLOGY
  • 2012-06. Posttherapy Nodal Status, Not Graded Histologic Response, Predicts Survival after Neoadjuvant Chemotherapy for Advanced Gastric Cancer in ANNALS OF SURGICAL ONCOLOGY
  • 2012-01. Impact of pretherapeutic routine clinical staging for the individualization of treatment in gastric cancer patients in LANGENBECK'S ARCHIVES OF SURGERY
  • 2001-06. The new Japanese Classification of Gastric Carcinoma: Revised explanation of "Response assessment of chemotherapy and radiotherapy for gastric carcinoma" in GASTRIC CANCER
  • 2003-09. Neoadjuvant chemotherapy with cisplatin, 5-FU, and leucovorin (PLF) in locally advanced gastric cancer: a prospective phase II study in GASTRIC CANCER
  • 2013-02. Factors predicting prognosis and recurrence in patients with esophago-gastric adenocarcinoma and histopathological response with less than 10 % residual tumor in LANGENBECK'S ARCHIVES OF SURGERY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/bjc.2014.94

    DOI

    http://dx.doi.org/10.1038/bjc.2014.94

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1022808419

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24569472


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adenocarcinoma", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adolescent", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged, 80 and over", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Esophageal Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoadjuvant Therapy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm Staging", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Predictive Value of Tests", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prognosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Remission Induction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Retrospective Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Stomach Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tumor Burden", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Young Adult", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Heidelberg University", 
              "id": "https://www.grid.ac/institutes/grid.7700.0", 
              "name": [
                "Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schmidt", 
            "givenName": "T", 
            "id": "sg:person.0605741476.97", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605741476.97"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Heidelberg University", 
              "id": "https://www.grid.ac/institutes/grid.7700.0", 
              "name": [
                "Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sicic", 
            "givenName": "L", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Heidelberg University", 
              "id": "https://www.grid.ac/institutes/grid.7700.0", 
              "name": [
                "Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Blank", 
            "givenName": "S", 
            "id": "sg:person.0677475742.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677475742.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Technical University Munich", 
              "id": "https://www.grid.ac/institutes/grid.6936.a", 
              "name": [
                "Department of Pathology, Technische Universitaet Muenchen, 81675 Munich, Germany."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Becker", 
            "givenName": "K", 
            "id": "sg:person.07443336642.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07443336642.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Heidelberg University", 
              "id": "https://www.grid.ac/institutes/grid.7700.0", 
              "name": [
                "Department of Pathology, University of Heidelberg, 69120 Heidelberg, Germany."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Weichert", 
            "givenName": "W", 
            "id": "sg:person.0657434205.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657434205.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Heidelberg University", 
              "id": "https://www.grid.ac/institutes/grid.7700.0", 
              "name": [
                "Institute of Medical Biometry and Informatics (IMBI), University of Heidelberg, 69120 Heidelberg, Germany."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bruckner", 
            "givenName": "T", 
            "id": "sg:person.0703170701.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703170701.53"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Heidelberg University", 
              "id": "https://www.grid.ac/institutes/grid.7700.0", 
              "name": [
                "Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Parakonthun", 
            "givenName": "T", 
            "id": "sg:person.01176677754.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176677754.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Bern", 
              "id": "https://www.grid.ac/institutes/grid.5734.5", 
              "name": [
                "Department of Pathology, University of Bern, 3010 Bern, Switzerland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Langer", 
            "givenName": "R", 
            "id": "sg:person.01125611417.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125611417.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Heidelberg University", 
              "id": "https://www.grid.ac/institutes/grid.7700.0", 
              "name": [
                "Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany."
              ], 
              "type": "Organization"
            }, 
            "familyName": "B\u00fcchler", 
            "givenName": "M W", 
            "id": "sg:person.07610347412.52", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07610347412.52"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Freiburg", 
              "id": "https://www.grid.ac/institutes/grid.5963.9", 
              "name": [
                "Directorate, University of Freiburg, 79095 Freiburg, Germany."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Siewert", 
            "givenName": "J-R", 
            "id": "sg:person.01277540464.64", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277540464.64"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "University Cancer Center Leipzig (UCCL), University of Leipzig, 04103 Leipzig, Germany."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lordick", 
            "givenName": "F", 
            "id": "sg:person.01242313310.55", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242313310.55"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Heidelberg University", 
              "id": "https://www.grid.ac/institutes/grid.7700.0", 
              "name": [
                "Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ott", 
            "givenName": "K", 
            "id": "sg:person.01214055342.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214055342.00"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/j.ejca.2012.07.029", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000080879"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0b013e318216f449", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001928488"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0b013e318216f449", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001928488"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0360-3016(03)00751-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003408231"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.semradonc.2006.09.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005238661"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0b013e3181fb8dde", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006671917"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0b013e3181fb8dde", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006671917"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0b013e3181fb8dde", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006671917"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejca.2010.09.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006818677"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.athoracsur.2011.06.091", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007789082"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2010.33.0597", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011221078"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10120-007-0448-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011643575", 
              "https://doi.org/10.1007/s10120-007-0448-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10120-007-0448-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011643575", 
              "https://doi.org/10.1007/s10120-007-0448-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/modpathol.2009.123", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012578327", 
              "https://doi.org/10.1038/modpathol.2009.123"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/modpathol.2009.123", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012578327", 
              "https://doi.org/10.1038/modpathol.2009.123"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa073149", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014019609"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10120-003-0245-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014719114", 
              "https://doi.org/10.1007/s10120-003-0245-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2005.12.151", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015500287"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000135515", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015970254"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pas.0b013e31828778fd", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017528254"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pas.0b013e31828778fd", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017528254"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pas.0b013e31828778fd", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017528254"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2012.42.6635", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017574383"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1245/s10434-011-2165-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020458849", 
              "https://doi.org/10.1245/s10434-011-2165-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0b013e31818f3afb", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022005965"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0b013e31818f3afb", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022005965"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1112088", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024545289"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0b013e3182352647", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025383944"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0b013e3182352647", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025383944"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1245/s10434-011-2147-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026036748", 
              "https://doi.org/10.1245/s10434-011-2147-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0b013e31821111b5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026179512"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0b013e31821111b5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026179512"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00000658-200109000-00010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026747798"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00000658-200109000-00010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026747798"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.2011.175", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027236372", 
              "https://doi.org/10.1038/bjc.2011.175"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1245/s10434-009-0336-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027762959", 
              "https://doi.org/10.1245/s10434-009-0336-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1245/s10434-012-2254-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029615752", 
              "https://doi.org/10.1245/s10434-012-2254-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00423-013-1101-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030119507", 
              "https://doi.org/10.1007/s00423-013-1101-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2011.35.8028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031513445"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00423-011-0805-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033879748", 
              "https://doi.org/10.1007/s00423-011-0805-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00423-012-1034-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034359745", 
              "https://doi.org/10.1007/s00423-012-1034-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1067/msy.2002.127166", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037155478"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1067/msy.2002.127166", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037155478"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00423-012-1039-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038356319", 
              "https://doi.org/10.1007/s00423-012-1039-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa022343", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041730457"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cncr.11660", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041969186"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2008.17.0506", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042415261"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s101200100010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042915183", 
              "https://doi.org/10.1007/s101200100010"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1245/s10434-007-9574-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045953387", 
              "https://doi.org/10.1245/s10434-007-9574-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1470-2045(11)70142-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049054354"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa055531", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050751169"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2009.26.6114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051366045"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2012.44.4315", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052963336"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00000658-199903000-00001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060134968"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00000658-199903000-00001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060134968"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00000658-199903000-00001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060134968"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2003.12.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064203986"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2014-04", 
        "datePublishedReg": "2014-04-01", 
        "description": "BACKGROUND: Recently, histopathological tumour regression, prevalence of signet ring cells, and localisation were reported as prognostic factors in neoadjuvantly treated oesophagogastric (junctional and gastric) cancer. This exploratory retrospective study analyses independent prognostic factors within a large patient cohort after preoperative chemotherapy including clinical and histopathological factors.\nMETHODS: In all, 850 patients presenting with oesophagogastric cancer staged cT3/4 Nany cM0/x were treated with neoadjuvant chemotherapy followed by resection in two academic centres. Patient data were documented in a prospective database and retrospectively analysed.\nRESULTS: Of all factors prognostic on univariate analysis, only clinical response, complications, ypTNM stage, and R category were independently prognostic (P<0.01) on multivariate analysis. Tumour localisation and signet ring cells were independently prognostic only when investigator-dependent clinical response evaluation was excluded from the multivariate model. Histopathological tumour regression correlates with tumour grading, Laur\u00e9n classification, clinical response, ypT, ypN, and R categories but was not identified as an independent prognostic factor. Within R0-resected patients only surgical complications and ypTNM stage were independent prognostic factors.\nCONCLUSIONS: Only established prognostic factors like ypTNM stage, R category, and complications were identified as independent prognostic factors in resected patients after neoadjuvant chemotherapy. In contrast, histopathological tumour regression was not found as an independent prognostic marker.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/bjc.2014.94", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1017082", 
            "issn": [
              "0007-0920", 
              "1532-1827"
            ], 
            "name": "British Journal of Cancer", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "7", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "110"
          }
        ], 
        "name": "Prognostic value of histopathological regression in 850 neoadjuvantly treated oesophagogastric adenocarcinomas", 
        "pagination": "1712", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "6caa052d7e538920eedf9aa0972680c6ace63228b73e5cf970c2de24dc9dec76"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "24569472"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "0370635"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/bjc.2014.94"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1022808419"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/bjc.2014.94", 
          "https://app.dimensions.ai/details/publication/pub.1022808419"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T14:48", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8663_00000434.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/bjc201494"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/bjc.2014.94'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/bjc.2014.94'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/bjc.2014.94'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/bjc.2014.94'


     

    This table displays all metadata directly associated to this object as RDF triples.

    377 TRIPLES      21 PREDICATES      91 URIs      40 LITERALS      28 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/bjc.2014.94 schema:about N0c6997bb298f4c2c9dc5781b2cd7ab0f
    2 N0fd9531667c346b292051d95eda792d1
    3 N10117367f8704c8aad45d08fadc7dba5
    4 N3494650e440c44b2a73fbf4b22ff4dae
    5 N3573aefc73eb46e7925ace1c0dc52e56
    6 N52f8dd01a6fb476693d069148f2d4d60
    7 N530113553329475a8aa2e8d407a01104
    8 N5cd8a7c6adca46b1bfcdf13d29779ff0
    9 N728c3dba024f4b5b948c981a67fca125
    10 N7346efe0929644cf9bc348caf0ba0cfd
    11 N8b8bd55c8a8745a4ba5a3e58dc4849ca
    12 N8d05f75325e145e8ab0865326f61b77d
    13 Nad095a94d91746cb80ca1e1b6769bbe6
    14 Nae2e705e88aa468fb1b17fd4c45122b2
    15 Nb1cedd6258414f9998f19f49cb4af6cc
    16 Nb30de32909e54e4cbf20392358d84224
    17 Nb7a7dfe3c512451b8fea74e7d170bc3d
    18 Nbe915bd5543f42b285869bcdb8d476da
    19 Ndf122167288e4e46ba980687b097b8b7
    20 anzsrc-for:11
    21 anzsrc-for:1112
    22 schema:author N9b85062e6331423ebfca92a53ecaf169
    23 schema:citation sg:pub.10.1007/s00423-011-0805-8
    24 sg:pub.10.1007/s00423-012-1034-5
    25 sg:pub.10.1007/s00423-012-1039-0
    26 sg:pub.10.1007/s00423-013-1101-6
    27 sg:pub.10.1007/s10120-003-0245-4
    28 sg:pub.10.1007/s10120-007-0448-1
    29 sg:pub.10.1007/s101200100010
    30 sg:pub.10.1038/bjc.2011.175
    31 sg:pub.10.1038/modpathol.2009.123
    32 sg:pub.10.1245/s10434-007-9574-6
    33 sg:pub.10.1245/s10434-009-0336-5
    34 sg:pub.10.1245/s10434-011-2147-8
    35 sg:pub.10.1245/s10434-011-2165-6
    36 sg:pub.10.1245/s10434-012-2254-1
    37 https://doi.org/10.1002/cncr.11660
    38 https://doi.org/10.1016/j.athoracsur.2011.06.091
    39 https://doi.org/10.1016/j.ejca.2010.09.009
    40 https://doi.org/10.1016/j.ejca.2012.07.029
    41 https://doi.org/10.1016/j.semradonc.2006.09.007
    42 https://doi.org/10.1016/s0360-3016(03)00751-x
    43 https://doi.org/10.1016/s1470-2045(11)70142-5
    44 https://doi.org/10.1056/nejmoa022343
    45 https://doi.org/10.1056/nejmoa055531
    46 https://doi.org/10.1056/nejmoa073149
    47 https://doi.org/10.1056/nejmoa1112088
    48 https://doi.org/10.1067/msy.2002.127166
    49 https://doi.org/10.1097/00000658-199903000-00001
    50 https://doi.org/10.1097/00000658-200109000-00010
    51 https://doi.org/10.1097/pas.0b013e31828778fd
    52 https://doi.org/10.1097/sla.0b013e31818f3afb
    53 https://doi.org/10.1097/sla.0b013e3181fb8dde
    54 https://doi.org/10.1097/sla.0b013e31821111b5
    55 https://doi.org/10.1097/sla.0b013e318216f449
    56 https://doi.org/10.1097/sla.0b013e3182352647
    57 https://doi.org/10.1159/000135515
    58 https://doi.org/10.1200/jco.2003.12.004
    59 https://doi.org/10.1200/jco.2005.12.151
    60 https://doi.org/10.1200/jco.2008.17.0506
    61 https://doi.org/10.1200/jco.2009.26.6114
    62 https://doi.org/10.1200/jco.2010.33.0597
    63 https://doi.org/10.1200/jco.2011.35.8028
    64 https://doi.org/10.1200/jco.2012.42.6635
    65 https://doi.org/10.1200/jco.2012.44.4315
    66 schema:datePublished 2014-04
    67 schema:datePublishedReg 2014-04-01
    68 schema:description BACKGROUND: Recently, histopathological tumour regression, prevalence of signet ring cells, and localisation were reported as prognostic factors in neoadjuvantly treated oesophagogastric (junctional and gastric) cancer. This exploratory retrospective study analyses independent prognostic factors within a large patient cohort after preoperative chemotherapy including clinical and histopathological factors. METHODS: In all, 850 patients presenting with oesophagogastric cancer staged cT3/4 Nany cM0/x were treated with neoadjuvant chemotherapy followed by resection in two academic centres. Patient data were documented in a prospective database and retrospectively analysed. RESULTS: Of all factors prognostic on univariate analysis, only clinical response, complications, ypTNM stage, and R category were independently prognostic (P<0.01) on multivariate analysis. Tumour localisation and signet ring cells were independently prognostic only when investigator-dependent clinical response evaluation was excluded from the multivariate model. Histopathological tumour regression correlates with tumour grading, Laurén classification, clinical response, ypT, ypN, and R categories but was not identified as an independent prognostic factor. Within R0-resected patients only surgical complications and ypTNM stage were independent prognostic factors. CONCLUSIONS: Only established prognostic factors like ypTNM stage, R category, and complications were identified as independent prognostic factors in resected patients after neoadjuvant chemotherapy. In contrast, histopathological tumour regression was not found as an independent prognostic marker.
    69 schema:genre research_article
    70 schema:inLanguage en
    71 schema:isAccessibleForFree true
    72 schema:isPartOf Ne07ed5e50b59454893bcbc16860492ce
    73 Nf4c8c002a21d45d89becce66919caecf
    74 sg:journal.1017082
    75 schema:name Prognostic value of histopathological regression in 850 neoadjuvantly treated oesophagogastric adenocarcinomas
    76 schema:pagination 1712
    77 schema:productId N1a5408d7be3240198a849ddd5f10e7c2
    78 N2658ed1337644940b4bdb6b4fa4cb889
    79 N360116e10d3e41e89c44397aa40f8cf8
    80 N44dd388a42a3498f9001b01895bb4dce
    81 Nba54797c3c6344e291e69cc7178de8e1
    82 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022808419
    83 https://doi.org/10.1038/bjc.2014.94
    84 schema:sdDatePublished 2019-04-10T14:48
    85 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    86 schema:sdPublisher N2686fab4eb444141bb0e51007595230a
    87 schema:url https://www.nature.com/articles/bjc201494
    88 sgo:license sg:explorer/license/
    89 sgo:sdDataset articles
    90 rdf:type schema:ScholarlyArticle
    91 N05df760fbf584f2bbe4c7fcb77962657 rdf:first sg:person.07443336642.41
    92 rdf:rest N8568639931f4425ca175c62187e982f5
    93 N0c6997bb298f4c2c9dc5781b2cd7ab0f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    94 schema:name Retrospective Studies
    95 rdf:type schema:DefinedTerm
    96 N0fd9531667c346b292051d95eda792d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    97 schema:name Aged, 80 and over
    98 rdf:type schema:DefinedTerm
    99 N10117367f8704c8aad45d08fadc7dba5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    100 schema:name Stomach Neoplasms
    101 rdf:type schema:DefinedTerm
    102 N1a5408d7be3240198a849ddd5f10e7c2 schema:name dimensions_id
    103 schema:value pub.1022808419
    104 rdf:type schema:PropertyValue
    105 N2658ed1337644940b4bdb6b4fa4cb889 schema:name readcube_id
    106 schema:value 6caa052d7e538920eedf9aa0972680c6ace63228b73e5cf970c2de24dc9dec76
    107 rdf:type schema:PropertyValue
    108 N2686fab4eb444141bb0e51007595230a schema:name Springer Nature - SN SciGraph project
    109 rdf:type schema:Organization
    110 N3494650e440c44b2a73fbf4b22ff4dae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    111 schema:name Female
    112 rdf:type schema:DefinedTerm
    113 N3573aefc73eb46e7925ace1c0dc52e56 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    114 schema:name Young Adult
    115 rdf:type schema:DefinedTerm
    116 N360116e10d3e41e89c44397aa40f8cf8 schema:name nlm_unique_id
    117 schema:value 0370635
    118 rdf:type schema:PropertyValue
    119 N3e9bf8e1f18a4cb2b2b565371a122cf8 rdf:first Nb198b6f866964b19b45405b118a17801
    120 rdf:rest Nc120b76c8706460fab949e026f3854af
    121 N44dd388a42a3498f9001b01895bb4dce schema:name pubmed_id
    122 schema:value 24569472
    123 rdf:type schema:PropertyValue
    124 N4f5a2d2a254d4f6086e674efc0f75ab0 rdf:first sg:person.01214055342.00
    125 rdf:rest rdf:nil
    126 N52f8dd01a6fb476693d069148f2d4d60 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    127 schema:name Adult
    128 rdf:type schema:DefinedTerm
    129 N530113553329475a8aa2e8d407a01104 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    130 schema:name Humans
    131 rdf:type schema:DefinedTerm
    132 N5cd8a7c6adca46b1bfcdf13d29779ff0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    133 schema:name Neoplasm Staging
    134 rdf:type schema:DefinedTerm
    135 N6d6b64858e6642a087429ca2801f80ca rdf:first sg:person.01242313310.55
    136 rdf:rest N4f5a2d2a254d4f6086e674efc0f75ab0
    137 N728c3dba024f4b5b948c981a67fca125 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Prognosis
    139 rdf:type schema:DefinedTerm
    140 N7346efe0929644cf9bc348caf0ba0cfd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    141 schema:name Adenocarcinoma
    142 rdf:type schema:DefinedTerm
    143 N8568639931f4425ca175c62187e982f5 rdf:first sg:person.0657434205.21
    144 rdf:rest Nc97bdced54524bfc98cb2e1f3696c15c
    145 N8b8bd55c8a8745a4ba5a3e58dc4849ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    146 schema:name Esophageal Neoplasms
    147 rdf:type schema:DefinedTerm
    148 N8d05f75325e145e8ab0865326f61b77d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    149 schema:name Tumor Burden
    150 rdf:type schema:DefinedTerm
    151 N8d9f6c3b829d40b89c144a20e4f3fe53 rdf:first sg:person.01277540464.64
    152 rdf:rest N6d6b64858e6642a087429ca2801f80ca
    153 N9b85062e6331423ebfca92a53ecaf169 rdf:first sg:person.0605741476.97
    154 rdf:rest N3e9bf8e1f18a4cb2b2b565371a122cf8
    155 N9e93a5a242034a358f7b4c697270fafa rdf:first sg:person.07610347412.52
    156 rdf:rest N8d9f6c3b829d40b89c144a20e4f3fe53
    157 Nad095a94d91746cb80ca1e1b6769bbe6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    158 schema:name Adolescent
    159 rdf:type schema:DefinedTerm
    160 Nae2e705e88aa468fb1b17fd4c45122b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    161 schema:name Neoadjuvant Therapy
    162 rdf:type schema:DefinedTerm
    163 Nb198b6f866964b19b45405b118a17801 schema:affiliation https://www.grid.ac/institutes/grid.7700.0
    164 schema:familyName Sicic
    165 schema:givenName L
    166 rdf:type schema:Person
    167 Nb1cedd6258414f9998f19f49cb4af6cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    168 schema:name Remission Induction
    169 rdf:type schema:DefinedTerm
    170 Nb30de32909e54e4cbf20392358d84224 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    171 schema:name Aged
    172 rdf:type schema:DefinedTerm
    173 Nb3cf31b4b6704b39809ea58172b4fd12 rdf:first sg:person.01125611417.35
    174 rdf:rest N9e93a5a242034a358f7b4c697270fafa
    175 Nb7a7dfe3c512451b8fea74e7d170bc3d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    176 schema:name Male
    177 rdf:type schema:DefinedTerm
    178 Nba54797c3c6344e291e69cc7178de8e1 schema:name doi
    179 schema:value 10.1038/bjc.2014.94
    180 rdf:type schema:PropertyValue
    181 Nbe915bd5543f42b285869bcdb8d476da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    182 schema:name Middle Aged
    183 rdf:type schema:DefinedTerm
    184 Nc120b76c8706460fab949e026f3854af rdf:first sg:person.0677475742.17
    185 rdf:rest N05df760fbf584f2bbe4c7fcb77962657
    186 Nc97bdced54524bfc98cb2e1f3696c15c rdf:first sg:person.0703170701.53
    187 rdf:rest Nd651ced77b3549709aae65005c4fced0
    188 Nd651ced77b3549709aae65005c4fced0 rdf:first sg:person.01176677754.42
    189 rdf:rest Nb3cf31b4b6704b39809ea58172b4fd12
    190 Nd95a525d76e148749b98b91c33dd1774 schema:name University Cancer Center Leipzig (UCCL), University of Leipzig, 04103 Leipzig, Germany.
    191 rdf:type schema:Organization
    192 Ndf122167288e4e46ba980687b097b8b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    193 schema:name Predictive Value of Tests
    194 rdf:type schema:DefinedTerm
    195 Ne07ed5e50b59454893bcbc16860492ce schema:issueNumber 7
    196 rdf:type schema:PublicationIssue
    197 Nf4c8c002a21d45d89becce66919caecf schema:volumeNumber 110
    198 rdf:type schema:PublicationVolume
    199 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    200 schema:name Medical and Health Sciences
    201 rdf:type schema:DefinedTerm
    202 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    203 schema:name Oncology and Carcinogenesis
    204 rdf:type schema:DefinedTerm
    205 sg:journal.1017082 schema:issn 0007-0920
    206 1532-1827
    207 schema:name British Journal of Cancer
    208 rdf:type schema:Periodical
    209 sg:person.01125611417.35 schema:affiliation https://www.grid.ac/institutes/grid.5734.5
    210 schema:familyName Langer
    211 schema:givenName R
    212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125611417.35
    213 rdf:type schema:Person
    214 sg:person.01176677754.42 schema:affiliation https://www.grid.ac/institutes/grid.7700.0
    215 schema:familyName Parakonthun
    216 schema:givenName T
    217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176677754.42
    218 rdf:type schema:Person
    219 sg:person.01214055342.00 schema:affiliation https://www.grid.ac/institutes/grid.7700.0
    220 schema:familyName Ott
    221 schema:givenName K
    222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214055342.00
    223 rdf:type schema:Person
    224 sg:person.01242313310.55 schema:affiliation Nd95a525d76e148749b98b91c33dd1774
    225 schema:familyName Lordick
    226 schema:givenName F
    227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242313310.55
    228 rdf:type schema:Person
    229 sg:person.01277540464.64 schema:affiliation https://www.grid.ac/institutes/grid.5963.9
    230 schema:familyName Siewert
    231 schema:givenName J-R
    232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277540464.64
    233 rdf:type schema:Person
    234 sg:person.0605741476.97 schema:affiliation https://www.grid.ac/institutes/grid.7700.0
    235 schema:familyName Schmidt
    236 schema:givenName T
    237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605741476.97
    238 rdf:type schema:Person
    239 sg:person.0657434205.21 schema:affiliation https://www.grid.ac/institutes/grid.7700.0
    240 schema:familyName Weichert
    241 schema:givenName W
    242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657434205.21
    243 rdf:type schema:Person
    244 sg:person.0677475742.17 schema:affiliation https://www.grid.ac/institutes/grid.7700.0
    245 schema:familyName Blank
    246 schema:givenName S
    247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677475742.17
    248 rdf:type schema:Person
    249 sg:person.0703170701.53 schema:affiliation https://www.grid.ac/institutes/grid.7700.0
    250 schema:familyName Bruckner
    251 schema:givenName T
    252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703170701.53
    253 rdf:type schema:Person
    254 sg:person.07443336642.41 schema:affiliation https://www.grid.ac/institutes/grid.6936.a
    255 schema:familyName Becker
    256 schema:givenName K
    257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07443336642.41
    258 rdf:type schema:Person
    259 sg:person.07610347412.52 schema:affiliation https://www.grid.ac/institutes/grid.7700.0
    260 schema:familyName Büchler
    261 schema:givenName M W
    262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07610347412.52
    263 rdf:type schema:Person
    264 sg:pub.10.1007/s00423-011-0805-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033879748
    265 https://doi.org/10.1007/s00423-011-0805-8
    266 rdf:type schema:CreativeWork
    267 sg:pub.10.1007/s00423-012-1034-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034359745
    268 https://doi.org/10.1007/s00423-012-1034-5
    269 rdf:type schema:CreativeWork
    270 sg:pub.10.1007/s00423-012-1039-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038356319
    271 https://doi.org/10.1007/s00423-012-1039-0
    272 rdf:type schema:CreativeWork
    273 sg:pub.10.1007/s00423-013-1101-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030119507
    274 https://doi.org/10.1007/s00423-013-1101-6
    275 rdf:type schema:CreativeWork
    276 sg:pub.10.1007/s10120-003-0245-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014719114
    277 https://doi.org/10.1007/s10120-003-0245-4
    278 rdf:type schema:CreativeWork
    279 sg:pub.10.1007/s10120-007-0448-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011643575
    280 https://doi.org/10.1007/s10120-007-0448-1
    281 rdf:type schema:CreativeWork
    282 sg:pub.10.1007/s101200100010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042915183
    283 https://doi.org/10.1007/s101200100010
    284 rdf:type schema:CreativeWork
    285 sg:pub.10.1038/bjc.2011.175 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027236372
    286 https://doi.org/10.1038/bjc.2011.175
    287 rdf:type schema:CreativeWork
    288 sg:pub.10.1038/modpathol.2009.123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012578327
    289 https://doi.org/10.1038/modpathol.2009.123
    290 rdf:type schema:CreativeWork
    291 sg:pub.10.1245/s10434-007-9574-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045953387
    292 https://doi.org/10.1245/s10434-007-9574-6
    293 rdf:type schema:CreativeWork
    294 sg:pub.10.1245/s10434-009-0336-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027762959
    295 https://doi.org/10.1245/s10434-009-0336-5
    296 rdf:type schema:CreativeWork
    297 sg:pub.10.1245/s10434-011-2147-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026036748
    298 https://doi.org/10.1245/s10434-011-2147-8
    299 rdf:type schema:CreativeWork
    300 sg:pub.10.1245/s10434-011-2165-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020458849
    301 https://doi.org/10.1245/s10434-011-2165-6
    302 rdf:type schema:CreativeWork
    303 sg:pub.10.1245/s10434-012-2254-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029615752
    304 https://doi.org/10.1245/s10434-012-2254-1
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1002/cncr.11660 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041969186
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1016/j.athoracsur.2011.06.091 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007789082
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1016/j.ejca.2010.09.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006818677
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1016/j.ejca.2012.07.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000080879
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1016/j.semradonc.2006.09.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005238661
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1016/s0360-3016(03)00751-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1003408231
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1016/s1470-2045(11)70142-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049054354
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1056/nejmoa022343 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041730457
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1056/nejmoa055531 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050751169
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1056/nejmoa073149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014019609
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1056/nejmoa1112088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024545289
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1067/msy.2002.127166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037155478
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1097/00000658-199903000-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060134968
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1097/00000658-200109000-00010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026747798
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1097/pas.0b013e31828778fd schema:sameAs https://app.dimensions.ai/details/publication/pub.1017528254
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.1097/sla.0b013e31818f3afb schema:sameAs https://app.dimensions.ai/details/publication/pub.1022005965
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1097/sla.0b013e3181fb8dde schema:sameAs https://app.dimensions.ai/details/publication/pub.1006671917
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1097/sla.0b013e31821111b5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026179512
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.1097/sla.0b013e318216f449 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001928488
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.1097/sla.0b013e3182352647 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025383944
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.1159/000135515 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015970254
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.1200/jco.2003.12.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203986
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.1200/jco.2005.12.151 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015500287
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.1200/jco.2008.17.0506 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042415261
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.1200/jco.2009.26.6114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051366045
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.1200/jco.2010.33.0597 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011221078
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.1200/jco.2011.35.8028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031513445
    359 rdf:type schema:CreativeWork
    360 https://doi.org/10.1200/jco.2012.42.6635 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017574383
    361 rdf:type schema:CreativeWork
    362 https://doi.org/10.1200/jco.2012.44.4315 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052963336
    363 rdf:type schema:CreativeWork
    364 https://www.grid.ac/institutes/grid.5734.5 schema:alternateName University of Bern
    365 schema:name Department of Pathology, University of Bern, 3010 Bern, Switzerland.
    366 rdf:type schema:Organization
    367 https://www.grid.ac/institutes/grid.5963.9 schema:alternateName University of Freiburg
    368 schema:name Directorate, University of Freiburg, 79095 Freiburg, Germany.
    369 rdf:type schema:Organization
    370 https://www.grid.ac/institutes/grid.6936.a schema:alternateName Technical University Munich
    371 schema:name Department of Pathology, Technische Universitaet Muenchen, 81675 Munich, Germany.
    372 rdf:type schema:Organization
    373 https://www.grid.ac/institutes/grid.7700.0 schema:alternateName Heidelberg University
    374 schema:name Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany.
    375 Department of Pathology, University of Heidelberg, 69120 Heidelberg, Germany.
    376 Institute of Medical Biometry and Informatics (IMBI), University of Heidelberg, 69120 Heidelberg, Germany.
    377 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...