Tumoral CD105 is a novel independent prognostic marker for prognosis in clear-cell renal cell carcinoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-04

AUTHORS

A Saroufim, Y Messai, M Hasmim, N Rioux, R Iacovelli, G Verhoest, K Bensalah, J-J Patard, L Albiges, B Azzarone, B Escudier, S Chouaib

ABSTRACT

BACKGROUND: Angiogenesis is essential for tumour growth and metastasis. There are conflicting reports as to whether microvessel density (MVD) using the endothelial marker CD105 (cluster of differentiation molecule 105) in clear-cell renal cell carcinomas (ccRCC) is associated with prognosis. Recently, CD105 has been described as a RCC cancer stem cell marker. METHODS: A total of 102 ccRCC were analysed. Representative tumour sections were stained for CD105. Vascularity (endothelial CD105) was quantified by MVD. The immunohistochemistry analysis detected positive (if present) or negative (if absent) CD105 tumoral staining. This retrospective population-based study was evaluated using Kaplan-Meier method, t-test and Cox proportional hazard model. RESULTS: We found that the expression of endothelial CD105 (MVD) negatively correlated with nuclear grade (P<0.001), tumour stage (P<0.001) and Leibovitch score (P<0.001), whereas the expression of tumoral CD105 positively correlated with these three clinicopathological factors (P<0.001). In multivariate analysis, tumoral CD105 was found to be an independent predictor of poor overall survival (P=0.002). CONCLUSIONS: We have shown for the first time that tumoral CD105 is an independent predictive marker for death risk and unfavourable prognosis in patients with ccRCC after curative resection. More... »

PAGES

1778

References to SciGraph publications

  • 2010-06. Prognostic factors in renal cell carcinoma in WORLD JOURNAL OF UROLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/bjc.2014.71

    DOI

    http://dx.doi.org/10.1038/bjc.2014.71

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1038325628

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24594997


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