B-RAF mutation and accumulated gene methylation in aberrant crypt foci (ACF), sessile serrated adenoma/polyp (SSA/P) and cancer in SSA/P View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-10-14

AUTHORS

A Inoue, K Okamoto, Y Fujino, T Nakagawa, N Muguruma, K Sannomiya, Y Mitsui, T Takaoka, S Kitamura, H Miyamoto, T Okahisa, T Fujimori, I Imoto, T Takayama

ABSTRACT

BACKGROUND: Sessile serrated adenomas/polyps (SSA/Ps) are a putative precursor of colon cancer with microsatellite instability (MSI). However, the developmental mechanism of SSA/P remains unknown. We performed genetic analysis and genome-wide DNA methylation analysis in aberrant crypt foci (ACF), SSA/P, and cancer in SSA/P specimens to show a close association between ACF and the SSA/P-cancer sequence. We also evaluated the prevalence and number of ACF in SSA/P patients. METHODS: ACF in the right-side colon were observed in 36 patients with SSA/Ps alone, 2 with cancers in SSA/P, and 20 normal subjects and biopsied under magnifying endoscopy. B-RAF mutation and MSI were analysed by PCR-restriction fragment length polymorphism (RFLP) and PCR-SSCP, respectively, in 15 ACF, 20 SSA/P, and 2 cancer specimens. DNA methylation array analysis of seven ACF, seven SSA/P, and two cancer in SSA/P specimens was performed using the microarray-based integrated analysis of methylation by isochizomers (MIAMI) method. RESULTS: B-RAF mutations were frequently detected in ACF, SSA/P, and cancer in SSA/P tissues. The number of methylated genes increased significantly in the order of ACF More... »

PAGES

403-412

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.2014.545

DOI

http://dx.doi.org/10.1038/bjc.2014.545

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023669180

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25314065


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81 isochizomers (MIAMI) method
82 length polymorphism
83 lesions
84 magnifying endoscopy
85 mechanism
86 method
87 methylation
88 methylation analysis
89 methylation array analysis
90 microarray-based integrated analysis
91 microsatellite instability
92 mutations
93 normal subjects
94 number
95 number of ACF
96 order
97 order of ACF
98 patients
99 polymorphism
100 polyps
101 precursor lesions
102 precursors
103 prevalence
104 putative precursor
105 results
106 right-side colon
107 sequence
108 sessile
109 significant correlation
110 specimens
111 subjects
112 tissue
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