B-RAF mutation and accumulated gene methylation in aberrant crypt foci (ACF), sessile serrated adenoma/polyp (SSA/P) and cancer in SSA/P View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-10-14

AUTHORS

A Inoue, K Okamoto, Y Fujino, T Nakagawa, N Muguruma, K Sannomiya, Y Mitsui, T Takaoka, S Kitamura, H Miyamoto, T Okahisa, T Fujimori, I Imoto, T Takayama

ABSTRACT

BACKGROUND: Sessile serrated adenomas/polyps (SSA/Ps) are a putative precursor of colon cancer with microsatellite instability (MSI). However, the developmental mechanism of SSA/P remains unknown. We performed genetic analysis and genome-wide DNA methylation analysis in aberrant crypt foci (ACF), SSA/P, and cancer in SSA/P specimens to show a close association between ACF and the SSA/P-cancer sequence. We also evaluated the prevalence and number of ACF in SSA/P patients. METHODS: ACF in the right-side colon were observed in 36 patients with SSA/Ps alone, 2 with cancers in SSA/P, and 20 normal subjects and biopsied under magnifying endoscopy. B-RAF mutation and MSI were analysed by PCR-restriction fragment length polymorphism (RFLP) and PCR-SSCP, respectively, in 15 ACF, 20 SSA/P, and 2 cancer specimens. DNA methylation array analysis of seven ACF, seven SSA/P, and two cancer in SSA/P specimens was performed using the microarray-based integrated analysis of methylation by isochizomers (MIAMI) method. RESULTS: B-RAF mutations were frequently detected in ACF, SSA/P, and cancer in SSA/P tissues. The number of methylated genes increased significantly in the order of ACF More... »

PAGES

403-412

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.2014.545

DOI

http://dx.doi.org/10.1038/bjc.2014.545

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023669180

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25314065


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92 mutations
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96 order
97 order of ACF
98 patients
99 polymorphism
100 polyps
101 precursor lesions
102 precursors
103 prevalence
104 putative precursor
105 results
106 right-side colon
107 sequence
108 sessile
109 significant correlation
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