MicroRNA expression profiling in male and female familial breast cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-11-13

AUTHORS

R Pinto, S De Summa, K Danza, O Popescu, A Paradiso, L Micale, G Merla, O Palumbo, M Carella, S Tommasi

ABSTRACT

BACKGROUND: Gender-associated epigenetic alterations are poorly investigated in male and female familial breast cancer (fBC). MicroRNAs may contribute to the different biology in men and women particularly related to RASSF1A pathways. METHODS: Microarray technology was used to evaluate miRNA profile in 24 male and 43 female fBC. Key results were validated using RT-qPCR in an external samples set. In vitro studies were carried out to verify microRNA-target gene interaction. RESULTS: Pathway enrichment analysis with the 287 differentially expressed microRNAs revealed several signalling pathways differently regulated in male and female cases. Because we previously hypothesised a peculiar involvement of RASSF1A in male fBC pathogenesis, we focussed on the MAPK and the Hippo signalling pathways that are regulated by RASSF1A. Male miR-152 and miR-497 upregulation and RASSF1A and NORE1A interacting gene downregulation were observed, confirming a possible indirect interaction between miRNAs and the two genes. CONCLUSIONS: For the first time, a different microRNA expression pattern in male and female fBC has been shown. Moreover, the importance of RASSF1A pathway in male fBC carcinogenesis has been confirmed, highlighting a possible role for miR-152 and miR-497 in controlling MAPK and Hippo signalling pathways, regulated by RASSF1A. More... »

PAGES

2361-2368

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.2014.535

DOI

http://dx.doi.org/10.1038/bjc.2014.535

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008661555

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25393370


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81 miR-152
82 miR-497
83 miR-497 upregulation
84 miRNA profiles
85 miRNAs
86 microRNA - target gene interactions
87 microRNA expression patterns
88 microRNAs
89 microarray technology
90 pathogenesis
91 pathway
92 pathway enrichment analysis
93 patterns
94 peculiar involvement
95 possible indirect interactions
96 possible role
97 profile
98 profiling
99 results
100 role
101 samples
102 study
103 technology
104 time
105 upregulation
106 women
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