Mutational profiling of familial male breast cancers reveals similarities with luminal A female breast cancer with rare TP53 mutations View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-12

AUTHORS

S Deb, S Q Wong, J Li, H Do, J Weiss, D Byrne, A Chakrabarti, T Bosma, , A Fellowes, A Dobrovic, S B Fox

ABSTRACT

BACKGROUND: Male breast cancer (MBC) is still poorly understood with a large proportion arising in families with a history of breast cancer. Genomic studies have focused on germline determinants of MBC risk, with minimal knowledge of somatic changes in these cancers. METHODS: Using a TruSeq amplicon cancer panel, this study evaluated 48 familial MBCs (3 BRCA1 germline mutant, 17 BRCA2 germline mutant and 28 BRCAX) for hotspot somatic mutations and copy number changes in 48 common cancer genes. RESULTS: Twelve missense mutations included nine PIK3CA mutations (seven in BRCAX patients), two TP53 mutations (both in BRCA2 patients) and one PTEN mutation. Common gains were seen in GNAS (34.1%) and losses were seen in GNAQ (36.4%), ABL1 (47.7%) and ATM (34.1%). Gains of HRAS (37.5% vs 3%, P=0.006), STK11 (25.0% vs 0%, P=0.01) and SMARCB1 (18.8% vs 0%, P=0.04) and the loss of RB1 (43.8% vs 13%, P=0.03) were specific to BRCA2 tumours. CONCLUSIONS: This study is the first to perform high-throughput somatic sequencing on familial MBCs. Overall, PIK3CA mutations are most commonly seen, with fewer TP53 and PTEN mutations, similar to the profile seen in luminal A female breast cancers. Differences in mutation profiles and patterns of gene gains/losses are seen between BRCA2 (associated with TP53/PTEN mutations, loss of RB1 and gain of HRAS, STK11 and SMARCB1) and BRCAX (associated with PIK3CA mutations) tumours, suggesting that BRCA2 and BRCAX MBCs may be distinct and arise from different tumour pathways. This has implications on potential therapies, depending on the BRCA status of MBC patients. More... »

PAGES

2351

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.2014.511

DOI

http://dx.doi.org/10.1038/bjc.2014.511

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048774910

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25490678


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "BRCA1 Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "BRCA2 Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms, Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Mutational Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, p53", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Predisposition to Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "High-Throughput Nucleotide Sequencing", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "PTEN Phosphohydrolase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Suppressor Protein p53", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "Department of Molecular Pathology, Peter MacCallum Cancer Centre, East Melbourne, VIC 3002, Australia", 
            "Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC 3010, Australia", 
            "Department of Pathology, University of Melbourne, Parkville, VIC 3010, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Deb", 
        "givenName": "S", 
        "id": "sg:person.0632562530.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632562530.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Peter MacCallum Cancer Centre", 
          "id": "https://www.grid.ac/institutes/grid.1055.1", 
          "name": [
            "Department of Molecular Pathology, Peter MacCallum Cancer Centre, East Melbourne, VIC 3002, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wong", 
        "givenName": "S Q", 
        "id": "sg:person.0735351471.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735351471.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Peter MacCallum Cancer Centre", 
          "id": "https://www.grid.ac/institutes/grid.1055.1", 
          "name": [
            "Department of Bioinformatics, Cancer Research Division, Peter MacCallum Cancer Centre, East Melbourne, VIC 3002, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "J", 
        "id": "sg:person.01351705470.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351705470.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ludwig Institute for Cancer Research", 
          "id": "https://www.grid.ac/institutes/grid.482095.2", 
          "name": [
            "Translational Genomics and Epigenomics Laboratory, Ludwig Institute for Cancer Research, Olivia Newton-John Cancer and Wellness Centre, Heidelberg, VIC 3084, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Do", 
        "givenName": "H", 
        "id": "sg:person.0744527633.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744527633.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ludwig Institute for Cancer Research", 
          "id": "https://www.grid.ac/institutes/grid.482095.2", 
          "name": [
            "Translational Genomics and Epigenomics Laboratory, Ludwig Institute for Cancer Research, Olivia Newton-John Cancer and Wellness Centre, Heidelberg, VIC 3084, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Weiss", 
        "givenName": "J", 
        "id": "sg:person.0736177172.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736177172.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Peter MacCallum Cancer Centre", 
          "id": "https://www.grid.ac/institutes/grid.1055.1", 
          "name": [
            "Department of Molecular Pathology, Peter MacCallum Cancer Centre, East Melbourne, VIC 3002, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Byrne", 
        "givenName": "D", 
        "id": "sg:person.01301663750.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301663750.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Peter MacCallum Cancer Centre", 
          "id": "https://www.grid.ac/institutes/grid.1055.1", 
          "name": [
            "Metastasis Research Laboratory, Peter MacCallum Cancer Centre, East Melbourne, VIC 3002, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chakrabarti", 
        "givenName": "A", 
        "id": "sg:person.013004401577.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013004401577.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Peter MacCallum Cancer Centre", 
          "id": "https://www.grid.ac/institutes/grid.1055.1", 
          "name": [
            "Molecular Diagnostics, Department of Pathology, Peter MacCallum Cancer Centre, East Melbourne, VIC 3002, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bosma", 
        "givenName": "T", 
        "id": "sg:person.01120540772.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120540772.37"
        ], 
        "type": "Person"
      }, 
      {}, 
      {
        "affiliation": {
          "alternateName": "Peter MacCallum Cancer Centre", 
          "id": "https://www.grid.ac/institutes/grid.1055.1", 
          "name": [
            "Molecular Diagnostics, Department of Pathology, Peter MacCallum Cancer Centre, East Melbourne, VIC 3002, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fellowes", 
        "givenName": "A", 
        "id": "sg:person.01240334322.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240334322.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ludwig Institute for Cancer Research", 
          "id": "https://www.grid.ac/institutes/grid.482095.2", 
          "name": [
            "Department of Molecular Pathology, Peter MacCallum Cancer Centre, East Melbourne, VIC 3002, Australia", 
            "Translational Genomics and Epigenomics Laboratory, Ludwig Institute for Cancer Research, Olivia Newton-John Cancer and Wellness Centre, Heidelberg, VIC 3084, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dobrovic", 
        "givenName": "A", 
        "id": "sg:person.01123554371.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123554371.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "Department of Molecular Pathology, Peter MacCallum Cancer Centre, East Melbourne, VIC 3002, Australia", 
            "Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC 3010, Australia", 
            "Department of Pathology, University of Melbourne, Parkville, VIC 3010, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fox", 
        "givenName": "S B", 
        "id": "sg:person.014574012772.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014574012772.14"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/humu.20648", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000429812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s13402-011-0041-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003496599", 
          "https://doi.org/10.1007/s13402-011-0041-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1373/clinchem.2012.202390", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007467043"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-012-2051-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012093048", 
          "https://doi.org/10.1007/s10549-012-2051-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1055-9965.epi-05-0414", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014951084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/bcr3463", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015382223", 
          "https://doi.org/10.1186/bcr3463"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9610(01)00733-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015991873"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-04-1992", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016954304"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19950501)75:9<2233::aid-cncr2820750907>3.0.co;2-s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018558607"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.95.25.14863", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020882317"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2559.2004.01766.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022312462"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/00313020802035899", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023333757"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/00313020802035899", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023333757"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11412", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024942368", 
          "https://doi.org/10.1038/nature11412"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2006.09.2775", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026719751"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.10289", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030723190"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-04-0220", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031810883"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1098-2264(199901)24:1<56::aid-gcc8>3.0.co;2-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033338206"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.21646", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034048154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.21646", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034048154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2009.25.5729", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035637150"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/bts146", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036656207"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2407-12-510", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037087235", 
          "https://doi.org/10.1186/1471-2407-12-510"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1995.493", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039219995", 
          "https://doi.org/10.1038/bjc.1995.493"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1995.493", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039219995", 
          "https://doi.org/10.1038/bjc.1995.493"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-010-1262-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041308069", 
          "https://doi.org/10.1007/s10549-010-1262-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.2417", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043786104", 
          "https://doi.org/10.1038/ng.2417"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-04-0429", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045344967"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2407-12-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053240527", 
          "https://doi.org/10.1186/1471-2407-12-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jcem.81.9.8784104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064320527"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-137-8-200210150-00013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073705841"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1999.17.5.1474", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074460868"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074816011", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075215992", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075223338", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076997911", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082929638", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-12", 
    "datePublishedReg": "2014-12-01", 
    "description": "BACKGROUND: Male breast cancer (MBC) is still poorly understood with a large proportion arising in families with a history of breast cancer. Genomic studies have focused on germline determinants of MBC risk, with minimal knowledge of somatic changes in these cancers.\nMETHODS: Using a TruSeq amplicon cancer panel, this study evaluated 48 familial MBCs (3 BRCA1 germline mutant, 17 BRCA2 germline mutant and 28 BRCAX) for hotspot somatic mutations and copy number changes in 48 common cancer genes.\nRESULTS: Twelve missense mutations included nine PIK3CA mutations (seven in BRCAX patients), two TP53 mutations (both in BRCA2 patients) and one PTEN mutation. Common gains were seen in GNAS (34.1%) and losses were seen in GNAQ (36.4%), ABL1 (47.7%) and ATM (34.1%). Gains of HRAS (37.5% vs 3%, P=0.006), STK11 (25.0% vs 0%, P=0.01) and SMARCB1 (18.8% vs 0%, P=0.04) and the loss of RB1 (43.8% vs 13%, P=0.03) were specific to BRCA2 tumours.\nCONCLUSIONS: This study is the first to perform high-throughput somatic sequencing on familial MBCs. Overall, PIK3CA mutations are most commonly seen, with fewer TP53 and PTEN mutations, similar to the profile seen in luminal A female breast cancers. Differences in mutation profiles and patterns of gene gains/losses are seen between BRCA2 (associated with TP53/PTEN mutations, loss of RB1 and gain of HRAS, STK11 and SMARCB1) and BRCAX (associated with PIK3CA mutations) tumours, suggesting that BRCA2 and BRCAX MBCs may be distinct and arise from different tumour pathways. This has implications on potential therapies, depending on the BRCA status of MBC patients.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/bjc.2014.511", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1017082", 
        "issn": [
          "0007-0920", 
          "1532-1827"
        ], 
        "name": "British Journal of Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "12", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "111"
      }
    ], 
    "name": "Mutational profiling of familial male breast cancers reveals similarities with luminal A female breast cancer with rare TP53 mutations", 
    "pagination": "2351", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "e85aabc293505f9bd1b9112543be00305a1b99f03459df7ab12c0c239b0b9410"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25490678"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0370635"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/bjc.2014.511"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1048774910"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/bjc.2014.511", 
      "https://app.dimensions.ai/details/publication/pub.1048774910"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T22:20", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000434.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/bjc2014511"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/bjc.2014.511'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/bjc.2014.511'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/bjc.2014.511'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/bjc.2014.511'


 

This table displays all metadata directly associated to this object as RDF triples.

311 TRIPLES      21 PREDICATES      76 URIs      34 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/bjc.2014.511 schema:about N2a8fc13619c3443f962503a511ba2488
2 N3c7e8070ea694fb28f05266c69d55d48
3 N6ba3e8083c714ba7b179f813d291c4cb
4 N864ae58ee91a417b96bfb4bc79106495
5 N9683331948df422d998c34386a668a66
6 Na4fe1a27006e4ec79a83485ac3079286
7 Na5257f53ead04df7b476fe9c336e1868
8 Na7f4101ce203439b8e8f1ed9a1dba462
9 Nbcd67ac44ec943c5a4b76045f25653e4
10 Nbedbbdc48ae0417d9b49db8019d9638b
11 Nc0a67b15d9cb49cbba70f8830cc22dd1
12 Nda61d14db48a44319e617daec8c7b74f
13 Nec7dfca1c53e4bc594afc42cf5d8775c
14 anzsrc-for:11
15 anzsrc-for:1112
16 schema:author Nb14b45f4e326442386a6577fdd6d229f
17 schema:citation sg:pub.10.1007/s10549-010-1262-8
18 sg:pub.10.1007/s10549-012-2051-3
19 sg:pub.10.1007/s13402-011-0041-9
20 sg:pub.10.1038/bjc.1995.493
21 sg:pub.10.1038/nature11412
22 sg:pub.10.1038/ng.2417
23 sg:pub.10.1186/1471-2407-12-510
24 sg:pub.10.1186/1471-2407-12-8
25 sg:pub.10.1186/bcr3463
26 https://app.dimensions.ai/details/publication/pub.1074816011
27 https://app.dimensions.ai/details/publication/pub.1075215992
28 https://app.dimensions.ai/details/publication/pub.1075223338
29 https://app.dimensions.ai/details/publication/pub.1076997911
30 https://app.dimensions.ai/details/publication/pub.1082929638
31 https://doi.org/10.1002/(sici)1098-2264(199901)24:1<56::aid-gcc8>3.0.co;2-x
32 https://doi.org/10.1002/1097-0142(19950501)75:9<2233::aid-cncr2820750907>3.0.co;2-s
33 https://doi.org/10.1002/humu.20648
34 https://doi.org/10.1002/ijc.10289
35 https://doi.org/10.1002/ijc.21646
36 https://doi.org/10.1016/s0002-9610(01)00733-4
37 https://doi.org/10.1073/pnas.95.25.14863
38 https://doi.org/10.1080/00313020802035899
39 https://doi.org/10.1093/bioinformatics/bts146
40 https://doi.org/10.1111/j.1365-2559.2004.01766.x
41 https://doi.org/10.1158/0008-5472.can-04-1992
42 https://doi.org/10.1158/1055-9965.epi-05-0414
43 https://doi.org/10.1158/1078-0432.ccr-04-0220
44 https://doi.org/10.1158/1078-0432.ccr-04-0429
45 https://doi.org/10.1200/jco.1999.17.5.1474
46 https://doi.org/10.1200/jco.2006.09.2775
47 https://doi.org/10.1200/jco.2009.25.5729
48 https://doi.org/10.1210/jcem.81.9.8784104
49 https://doi.org/10.1373/clinchem.2012.202390
50 https://doi.org/10.7326/0003-4819-137-8-200210150-00013
51 schema:datePublished 2014-12
52 schema:datePublishedReg 2014-12-01
53 schema:description BACKGROUND: Male breast cancer (MBC) is still poorly understood with a large proportion arising in families with a history of breast cancer. Genomic studies have focused on germline determinants of MBC risk, with minimal knowledge of somatic changes in these cancers. METHODS: Using a TruSeq amplicon cancer panel, this study evaluated 48 familial MBCs (3 BRCA1 germline mutant, 17 BRCA2 germline mutant and 28 BRCAX) for hotspot somatic mutations and copy number changes in 48 common cancer genes. RESULTS: Twelve missense mutations included nine PIK3CA mutations (seven in BRCAX patients), two TP53 mutations (both in BRCA2 patients) and one PTEN mutation. Common gains were seen in GNAS (34.1%) and losses were seen in GNAQ (36.4%), ABL1 (47.7%) and ATM (34.1%). Gains of HRAS (37.5% vs 3%, P=0.006), STK11 (25.0% vs 0%, P=0.01) and SMARCB1 (18.8% vs 0%, P=0.04) and the loss of RB1 (43.8% vs 13%, P=0.03) were specific to BRCA2 tumours. CONCLUSIONS: This study is the first to perform high-throughput somatic sequencing on familial MBCs. Overall, PIK3CA mutations are most commonly seen, with fewer TP53 and PTEN mutations, similar to the profile seen in luminal A female breast cancers. Differences in mutation profiles and patterns of gene gains/losses are seen between BRCA2 (associated with TP53/PTEN mutations, loss of RB1 and gain of HRAS, STK11 and SMARCB1) and BRCAX (associated with PIK3CA mutations) tumours, suggesting that BRCA2 and BRCAX MBCs may be distinct and arise from different tumour pathways. This has implications on potential therapies, depending on the BRCA status of MBC patients.
54 schema:genre research_article
55 schema:inLanguage en
56 schema:isAccessibleForFree true
57 schema:isPartOf N56b9832d4bbb447789390d7bea56b236
58 Nf66d7f658a514d268069496210ac75a3
59 sg:journal.1017082
60 schema:name Mutational profiling of familial male breast cancers reveals similarities with luminal A female breast cancer with rare TP53 mutations
61 schema:pagination 2351
62 schema:productId N182ab59ff9ff433a99f9da5e409d7b64
63 N3d5e2e6f99c842b9adcd6923270e14c7
64 N750dcc5127294919b2e369fa345b72ed
65 Nc09634c6a9664ccd97c24a7630582e36
66 Nc44a385e80504418900660f76cdcf6a7
67 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048774910
68 https://doi.org/10.1038/bjc.2014.511
69 schema:sdDatePublished 2019-04-10T22:20
70 schema:sdLicense https://scigraph.springernature.com/explorer/license/
71 schema:sdPublisher N10a296a8ed6941b5ad44d0d38745446d
72 schema:url https://www.nature.com/articles/bjc2014511
73 sgo:license sg:explorer/license/
74 sgo:sdDataset articles
75 rdf:type schema:ScholarlyArticle
76 N10a296a8ed6941b5ad44d0d38745446d schema:name Springer Nature - SN SciGraph project
77 rdf:type schema:Organization
78 N182ab59ff9ff433a99f9da5e409d7b64 schema:name nlm_unique_id
79 schema:value 0370635
80 rdf:type schema:PropertyValue
81 N1c025846c5824dcd8c1a030e348811a1 rdf:first sg:person.013004401577.40
82 rdf:rest N79cb17acfd2e45c2bda55ec30988ed5b
83 N20008a4f787246b78b404baca4fc98eb rdf:first sg:person.01351705470.18
84 rdf:rest N52cb3e93ae5943c4b003bc1ac2b3098a
85 N2a8fc13619c3443f962503a511ba2488 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Male
87 rdf:type schema:DefinedTerm
88 N3a2f3ccda95b49cebc4f5ff7d037591b rdf:first sg:person.01301663750.40
89 rdf:rest N1c025846c5824dcd8c1a030e348811a1
90 N3c7e8070ea694fb28f05266c69d55d48 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Female
92 rdf:type schema:DefinedTerm
93 N3d5e2e6f99c842b9adcd6923270e14c7 schema:name doi
94 schema:value 10.1038/bjc.2014.511
95 rdf:type schema:PropertyValue
96 N52cb3e93ae5943c4b003bc1ac2b3098a rdf:first sg:person.0744527633.23
97 rdf:rest Nb0cbf6cd017a4f639aa447a29a1170d3
98 N56b9832d4bbb447789390d7bea56b236 schema:issueNumber 12
99 rdf:type schema:PublicationIssue
100 N5ac6b53b71cc401792c202890a0d5de1 rdf:first sg:person.01123554371.82
101 rdf:rest Ndad2ddbc748c4382bddc97a12358cad5
102 N6ba3e8083c714ba7b179f813d291c4cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name BRCA2 Protein
104 rdf:type schema:DefinedTerm
105 N750dcc5127294919b2e369fa345b72ed schema:name readcube_id
106 schema:value e85aabc293505f9bd1b9112543be00305a1b99f03459df7ab12c0c239b0b9410
107 rdf:type schema:PropertyValue
108 N79cb17acfd2e45c2bda55ec30988ed5b rdf:first sg:person.01120540772.37
109 rdf:rest Ne554e32a50cf4f24a5605b5c754f47e9
110 N864ae58ee91a417b96bfb4bc79106495 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Genetic Predisposition to Disease
112 rdf:type schema:DefinedTerm
113 N91fc6b72cf36451b97390f078e93a2d3 rdf:first sg:person.0735351471.77
114 rdf:rest N20008a4f787246b78b404baca4fc98eb
115 N9683331948df422d998c34386a668a66 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Humans
117 rdf:type schema:DefinedTerm
118 Na4fe1a27006e4ec79a83485ac3079286 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name DNA Mutational Analysis
120 rdf:type schema:DefinedTerm
121 Na5257f53ead04df7b476fe9c336e1868 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name BRCA1 Protein
123 rdf:type schema:DefinedTerm
124 Na7f4101ce203439b8e8f1ed9a1dba462 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Tumor Suppressor Protein p53
126 rdf:type schema:DefinedTerm
127 Nb0cbf6cd017a4f639aa447a29a1170d3 rdf:first sg:person.0736177172.15
128 rdf:rest N3a2f3ccda95b49cebc4f5ff7d037591b
129 Nb14b45f4e326442386a6577fdd6d229f rdf:first sg:person.0632562530.13
130 rdf:rest N91fc6b72cf36451b97390f078e93a2d3
131 Nbcd67ac44ec943c5a4b76045f25653e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Mutation
133 rdf:type schema:DefinedTerm
134 Nbedbbdc48ae0417d9b49db8019d9638b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name PTEN Phosphohydrolase
136 rdf:type schema:DefinedTerm
137 Nc09634c6a9664ccd97c24a7630582e36 schema:name pubmed_id
138 schema:value 25490678
139 rdf:type schema:PropertyValue
140 Nc0a67b15d9cb49cbba70f8830cc22dd1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Genes, p53
142 rdf:type schema:DefinedTerm
143 Nc44a385e80504418900660f76cdcf6a7 schema:name dimensions_id
144 schema:value pub.1048774910
145 rdf:type schema:PropertyValue
146 Nd9bb6e75387f4d3185e4a48a48f99eba rdf:first sg:person.01240334322.05
147 rdf:rest N5ac6b53b71cc401792c202890a0d5de1
148 Nda61d14db48a44319e617daec8c7b74f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name High-Throughput Nucleotide Sequencing
150 rdf:type schema:DefinedTerm
151 Ndad2ddbc748c4382bddc97a12358cad5 rdf:first sg:person.014574012772.14
152 rdf:rest rdf:nil
153 Ne554e32a50cf4f24a5605b5c754f47e9 rdf:first Nc9784c96cc7d4e83aa98bf64e2ebdf30
154 rdf:rest Nd9bb6e75387f4d3185e4a48a48f99eba
155 Nec7dfca1c53e4bc594afc42cf5d8775c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Breast Neoplasms, Male
157 rdf:type schema:DefinedTerm
158 Nf66d7f658a514d268069496210ac75a3 schema:volumeNumber 111
159 rdf:type schema:PublicationVolume
160 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
161 schema:name Medical and Health Sciences
162 rdf:type schema:DefinedTerm
163 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
164 schema:name Oncology and Carcinogenesis
165 rdf:type schema:DefinedTerm
166 sg:journal.1017082 schema:issn 0007-0920
167 1532-1827
168 schema:name British Journal of Cancer
169 rdf:type schema:Periodical
170 sg:person.01120540772.37 schema:affiliation https://www.grid.ac/institutes/grid.1055.1
171 schema:familyName Bosma
172 schema:givenName T
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120540772.37
174 rdf:type schema:Person
175 sg:person.01123554371.82 schema:affiliation https://www.grid.ac/institutes/grid.482095.2
176 schema:familyName Dobrovic
177 schema:givenName A
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123554371.82
179 rdf:type schema:Person
180 sg:person.01240334322.05 schema:affiliation https://www.grid.ac/institutes/grid.1055.1
181 schema:familyName Fellowes
182 schema:givenName A
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240334322.05
184 rdf:type schema:Person
185 sg:person.013004401577.40 schema:affiliation https://www.grid.ac/institutes/grid.1055.1
186 schema:familyName Chakrabarti
187 schema:givenName A
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013004401577.40
189 rdf:type schema:Person
190 sg:person.01301663750.40 schema:affiliation https://www.grid.ac/institutes/grid.1055.1
191 schema:familyName Byrne
192 schema:givenName D
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301663750.40
194 rdf:type schema:Person
195 sg:person.01351705470.18 schema:affiliation https://www.grid.ac/institutes/grid.1055.1
196 schema:familyName Li
197 schema:givenName J
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351705470.18
199 rdf:type schema:Person
200 sg:person.014574012772.14 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
201 schema:familyName Fox
202 schema:givenName S B
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014574012772.14
204 rdf:type schema:Person
205 sg:person.0632562530.13 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
206 schema:familyName Deb
207 schema:givenName S
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632562530.13
209 rdf:type schema:Person
210 sg:person.0735351471.77 schema:affiliation https://www.grid.ac/institutes/grid.1055.1
211 schema:familyName Wong
212 schema:givenName S Q
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735351471.77
214 rdf:type schema:Person
215 sg:person.0736177172.15 schema:affiliation https://www.grid.ac/institutes/grid.482095.2
216 schema:familyName Weiss
217 schema:givenName J
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736177172.15
219 rdf:type schema:Person
220 sg:person.0744527633.23 schema:affiliation https://www.grid.ac/institutes/grid.482095.2
221 schema:familyName Do
222 schema:givenName H
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744527633.23
224 rdf:type schema:Person
225 sg:pub.10.1007/s10549-010-1262-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041308069
226 https://doi.org/10.1007/s10549-010-1262-8
227 rdf:type schema:CreativeWork
228 sg:pub.10.1007/s10549-012-2051-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012093048
229 https://doi.org/10.1007/s10549-012-2051-3
230 rdf:type schema:CreativeWork
231 sg:pub.10.1007/s13402-011-0041-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003496599
232 https://doi.org/10.1007/s13402-011-0041-9
233 rdf:type schema:CreativeWork
234 sg:pub.10.1038/bjc.1995.493 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039219995
235 https://doi.org/10.1038/bjc.1995.493
236 rdf:type schema:CreativeWork
237 sg:pub.10.1038/nature11412 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024942368
238 https://doi.org/10.1038/nature11412
239 rdf:type schema:CreativeWork
240 sg:pub.10.1038/ng.2417 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043786104
241 https://doi.org/10.1038/ng.2417
242 rdf:type schema:CreativeWork
243 sg:pub.10.1186/1471-2407-12-510 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037087235
244 https://doi.org/10.1186/1471-2407-12-510
245 rdf:type schema:CreativeWork
246 sg:pub.10.1186/1471-2407-12-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053240527
247 https://doi.org/10.1186/1471-2407-12-8
248 rdf:type schema:CreativeWork
249 sg:pub.10.1186/bcr3463 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015382223
250 https://doi.org/10.1186/bcr3463
251 rdf:type schema:CreativeWork
252 https://app.dimensions.ai/details/publication/pub.1074816011 schema:CreativeWork
253 https://app.dimensions.ai/details/publication/pub.1075215992 schema:CreativeWork
254 https://app.dimensions.ai/details/publication/pub.1075223338 schema:CreativeWork
255 https://app.dimensions.ai/details/publication/pub.1076997911 schema:CreativeWork
256 https://app.dimensions.ai/details/publication/pub.1082929638 schema:CreativeWork
257 https://doi.org/10.1002/(sici)1098-2264(199901)24:1<56::aid-gcc8>3.0.co;2-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1033338206
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1002/1097-0142(19950501)75:9<2233::aid-cncr2820750907>3.0.co;2-s schema:sameAs https://app.dimensions.ai/details/publication/pub.1018558607
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1002/humu.20648 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000429812
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1002/ijc.10289 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030723190
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1002/ijc.21646 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034048154
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1016/s0002-9610(01)00733-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015991873
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1073/pnas.95.25.14863 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020882317
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1080/00313020802035899 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023333757
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1093/bioinformatics/bts146 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036656207
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1111/j.1365-2559.2004.01766.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022312462
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1158/0008-5472.can-04-1992 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016954304
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1158/1055-9965.epi-05-0414 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014951084
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1158/1078-0432.ccr-04-0220 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031810883
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1158/1078-0432.ccr-04-0429 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045344967
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1200/jco.1999.17.5.1474 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074460868
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1200/jco.2006.09.2775 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026719751
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1200/jco.2009.25.5729 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035637150
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1210/jcem.81.9.8784104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064320527
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1373/clinchem.2012.202390 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007467043
294 rdf:type schema:CreativeWork
295 https://doi.org/10.7326/0003-4819-137-8-200210150-00013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073705841
296 rdf:type schema:CreativeWork
297 https://www.grid.ac/institutes/grid.1008.9 schema:alternateName University of Melbourne
298 schema:name Department of Molecular Pathology, Peter MacCallum Cancer Centre, East Melbourne, VIC 3002, Australia
299 Department of Pathology, University of Melbourne, Parkville, VIC 3010, Australia
300 Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC 3010, Australia
301 rdf:type schema:Organization
302 https://www.grid.ac/institutes/grid.1055.1 schema:alternateName Peter MacCallum Cancer Centre
303 schema:name Department of Bioinformatics, Cancer Research Division, Peter MacCallum Cancer Centre, East Melbourne, VIC 3002, Australia
304 Department of Molecular Pathology, Peter MacCallum Cancer Centre, East Melbourne, VIC 3002, Australia
305 Metastasis Research Laboratory, Peter MacCallum Cancer Centre, East Melbourne, VIC 3002, Australia
306 Molecular Diagnostics, Department of Pathology, Peter MacCallum Cancer Centre, East Melbourne, VIC 3002, Australia
307 rdf:type schema:Organization
308 https://www.grid.ac/institutes/grid.482095.2 schema:alternateName Ludwig Institute for Cancer Research
309 schema:name Department of Molecular Pathology, Peter MacCallum Cancer Centre, East Melbourne, VIC 3002, Australia
310 Translational Genomics and Epigenomics Laboratory, Ludwig Institute for Cancer Research, Olivia Newton-John Cancer and Wellness Centre, Heidelberg, VIC 3084, Australia
311 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...