Beyond BRAF: where next for melanoma therapy? View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-01

AUTHORS

I V Fedorenko, G T Gibney, V K Sondak, K S M Smalley

ABSTRACT

In recent years, melanoma has become a poster-child for the development of oncogene-directed targeted therapies. This approach, which has been exemplified by the development of small-molecule BRAF inhibitors and the BRAF/MEK inhibitor combination for BRAF-mutant melanoma, has brought new hope to patients. Despite these successes, treatment failure seems near inevitable in the majority of cases—even in individuals treated with the BRAF/MEK inhibitor doublet. In the current review, we discuss the future of combination strategies for patients with BRAF-mutant melanoma as well as the emerging therapeutic options for patients with NRAS-mutant and BRAF/NRAS-wild-type melanoma. We also outline some of the newest developments in the in-depth personalisation of therapy that should allow melanoma treatment to continue shaping the field precision cancer medicine. More... »

PAGES

217

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/bjc.2014.476

    DOI

    http://dx.doi.org/10.1038/bjc.2014.476

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1028066474

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25180764


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