Ontology type: schema:ScholarlyArticle Open Access: True
2015-01
AUTHORSI V Fedorenko, G T Gibney, V K Sondak, K S M Smalley
ABSTRACTIn recent years, melanoma has become a poster-child for the development of oncogene-directed targeted therapies. This approach, which has been exemplified by the development of small-molecule BRAF inhibitors and the BRAF/MEK inhibitor combination for BRAF-mutant melanoma, has brought new hope to patients. Despite these successes, treatment failure seems near inevitable in the majority of cases—even in individuals treated with the BRAF/MEK inhibitor doublet. In the current review, we discuss the future of combination strategies for patients with BRAF-mutant melanoma as well as the emerging therapeutic options for patients with NRAS-mutant and BRAF/NRAS-wild-type melanoma. We also outline some of the newest developments in the in-depth personalisation of therapy that should allow melanoma treatment to continue shaping the field precision cancer medicine. More... »
PAGES217
http://scigraph.springernature.com/pub.10.1038/bjc.2014.476
DOIhttp://dx.doi.org/10.1038/bjc.2014.476
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1028066474
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/25180764
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