Effect of oral anticoagulants on the outcome of faecal immunochemical test View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-02-04

AUTHORS

L Bujanda, C Sarasqueta, Á Lanas, E Quintero, J Cubiella, V Hernandez, J D Morillas, T Perez-Fernández, D Salas, M Andreu, F Carballo, X Bessa, I Portillo, R Jover, F Balaguer, A Cosme, A Castells

ABSTRACT

BACKGROUND: We aimed to evaluate whether oral anticoagulants (OACs) alter faecal immunochemical test (FIT) performance in average-risk colorectal cancer (CRC) screening. METHODS: Individuals aged 50-69 years were invited to receive one FIT sample (cutoff 75 ng ml(-1)) between November 2008 and June 2011. RESULTS: Faecal immunochemical test was positive in 9.3% (21 out of 224) of users of OAC and 6.2% (365 out of 5821) of non-users (P-trend=0.07). The positive predictive value (PPV) for advanced neoplasia (AN) in non-users was 50.4% vs 47.6% in users (odds ratio, 0.70; 95% CI, 0.3-1.8; P=0.5). The PPV for AN in OAC more antiplatelets (aspirin or clopidogrel) was 75% (odds ratio, 2; 95% CI, 0.4-10.8; P=0.4). CONCLUSIONS: Oral anticoagulant did not significantly modify the PPV for AN in this population-based colorectal screening program. The detection rate of advanced adenoma was higher in the combination OAC more antiplatelets. More... »

PAGES

1334-1337

Journal

TITLE

British Journal of Cancer

ISSUE

5

VOLUME

110

Author Affiliations

  • Department of Gastroenterology, Hospital Universitario Donostia, Instituto Biodonostia, Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBERehd), Universidad del País Vasco (UPV/EHU), San Sebastián, Spain.
  • Hospital Universitario Donostia, Instituto Biodonostia, Red de Investigación en Servicios de Salud en Enfermedades Crónicas (REDISSEC), San Sebastián, Spain.
  • Department of Gastroenterology, University of Zaragoza, IIS Aragón, CIBERehd, Zaragoza, Spain.
  • Department of Gastroenterology, Hospital Universitario de Canarias, Universidad de La Laguna, Tenerife, Spain.
  • Department of Gastroenterology, Complexo Hospitalario Universitario de Ourense, Ourense, Spain.
  • Servicio de Aparato Digestivo, Complexo Hospitalario Universitario de Vigo, Vigo, Spain.
  • Department of Gastroenterology, Hospital Clínico San Carlos, Madrid, Spain.
  • Department of Gastroenterology, Hospital Fundación Alcorcón, Madrid, Spain.
  • Programa de Cribado de Cáncer Colorrectal, Dirección General de Salud Pública, Conselleria de Sanitat, Valencia, Spain.
  • Department of Gastroenterology, Hospital del Mar, IMIM, Barcelona, Catalonia, Spain.
  • Unidad de Gestión Clínica de Digestivo, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain.
  • Centro Coordinador del Programa de Cribado Cáncer Colorrectal, Organización Central de Osakidetza-Servicio Vasco de Salud, Bilbao, Spain.
  • Department of Gastroenterology, Hospital General Universitario de Alicante, Alicante, Spain.
  • Department of Gastroenterology, Hospital Clínic, Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBERehd), IDIBAPS, University of Barcelona, Barcelona, Catalonia, Spain.
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/bjc.2014.38

    DOI

    http://dx.doi.org/10.1038/bjc.2014.38

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1045696108

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24496455


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