Evaluation of FLT-PET-CT as an imaging biomarker of proliferation in primary breast cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-06

AUTHORS

D K Woolf, M Beresford, S P Li, M Dowsett, B Sanghera, W L Wong, L Sonoda, S Detre, V Amin, M-L Ah-See, D Miles, A Makris

ABSTRACT

BACKGROUND: [(18)F]fluorothymidine (FLT) has been proposed as a positron emission tomography (PET)-imaging biomarker of proliferation for breast cancer. The aim of this prospective study was to assess the feasibility of FLT-PET-CT as a technique for predicting the response to neoadjuvant chemotherapy (NAC) in primary breast cancer and to compare baseline FLT with Ki-67. METHODS: Twenty women with primary breast cancer had a baseline FLT-PET-CT scan that was repeated before the second cycle of chemotherapy. Expression of Ki-67 in the diagnostic biopsy was quantified. From the FLT-PET-CT scans lesion maximum and mean standardised uptake values (SUVmax, SUVmean) were calculated. RESULTS: Mean baseline SUVmax was 7.3, and 4.62 post one cycle of NAC, representing a drop of 2.68 (36.3%). There was no significant association between baseline, post chemotherapy, or change in SUVmax and pathological response to NAC. There was a significant correlation between pre-chemotherapy Ki-67 and SUVmax of 0.604 (P=0.006). CONCLUSIONS: Baseline SUVmax measurements of FLT-PET-CT were significantly related to Ki-67 suggesting that it is a proliferation biomarker. However, in this series neither the baseline value nor the change in SUVmax after one cycle of NAC were able to predict response as most patients had a sizeable SUVmax reduction. More... »

PAGES

2847

References to SciGraph publications

  • 2009-03. Reproducibility of quantitative 18F-3′-deoxy-3′-fluorothymidine measurements using positron emission tomography in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2008-08. [18F]FDG and [18F]FLT uptake in human breast cancer cells in relation to the effects of chemotherapy: an in vitro study in BRITISH JOURNAL OF CANCER
  • 1998-11. Imaging proliferation in vivo with [F-18]FLT and positron emission tomography in NATURE MEDICINE
  • 2012-12. Validity of Simplified 3′-Deoxy-3′-[18F]Fluorothymidine Uptake Measures for Monitoring Response to Chemotherapy in Locally Advanced Breast Cancer in MOLECULAR IMAGING AND BIOLOGY
  • 2009-07. The prognostic significance of Ki67 before and after neoadjuvant chemotherapy in breast cancer in BREAST CANCER RESEARCH AND TREATMENT
  • 2013-06. Ki-67 is a prognostic parameter in breast cancer patients: results of a large population-based cohort of a cancer registry in BREAST CANCER RESEARCH AND TREATMENT
  • 2004-05. PET with [18F]fluorothymidine for imaging of primary breast cancer: a pilot study in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2006-01. Usefulness of 3′-[F-18]Fluoro-3′-deoxythymidine with Positron Emission Tomography in Predicting Breast Cancer Response to Therapy in MOLECULAR IMAGING AND BIOLOGY
  • 2011-07. The prognostic value of functional tumor volume and total lesion glycolysis in patients with colorectal cancer liver metastases undergoing 90Y selective internal radiation therapy plus chemotherapy in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2007-09. Imaging early changes in proliferation at 1 week post chemotherapy: a pilot study in breast cancer patients with 3′-deoxy-3′-[18F]fluorothymidine positron emission tomography in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/bjc.2014.207

    DOI

    http://dx.doi.org/10.1038/bjc.2014.207

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1034338732

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24832174


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antineoplastic Agents", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Biomarkers, Tumor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Breast Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Proliferation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Dideoxynucleosides", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Ki-67 Antigen", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mastectomy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoadjuvant Therapy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Positron-Emission Tomography", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prospective Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Radiopharmaceuticals", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Mount Vernon Cancer Centre", 
              "id": "https://www.grid.ac/institutes/grid.477623.3", 
              "name": [
                "Breast Research Unit, Mount Vernon Cancer Centre, Rickmansworth Road, Northwood, HA6 2RN, UK."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Woolf", 
            "givenName": "D K", 
            "id": "sg:person.01022614412.09", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022614412.09"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Oncology, Royal United Hospital Bath, Avon, Bath, BA1 3NG, UK."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Beresford", 
            "givenName": "M", 
            "id": "sg:person.01261437400.82", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261437400.82"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mount Vernon Cancer Centre", 
              "id": "https://www.grid.ac/institutes/grid.477623.3", 
              "name": [
                "Breast Research Unit, Mount Vernon Cancer Centre, Rickmansworth Road, Northwood, HA6 2RN, UK."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Li", 
            "givenName": "S P", 
            "id": "sg:person.01206134665.58", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206134665.58"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Royal Marsden Hospital", 
              "id": "https://www.grid.ac/institutes/grid.424926.f", 
              "name": [
                "Academic Department of Biochemistry, Royal Marsden Hospital, Fulham Road, London, SW3 6JJ, UK."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dowsett", 
            "givenName": "M", 
            "id": "sg:person.015776405257.84", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015776405257.84"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mount Vernon Hospital", 
              "id": "https://www.grid.ac/institutes/grid.416188.2", 
              "name": [
                "Paul Strickland Scanner Centre, Mount Vernon Hospital, Rickmansworth Road, Northwood, HA6 2RN, UK."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sanghera", 
            "givenName": "B", 
            "id": "sg:person.01253271412.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253271412.54"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mount Vernon Hospital", 
              "id": "https://www.grid.ac/institutes/grid.416188.2", 
              "name": [
                "Paul Strickland Scanner Centre, Mount Vernon Hospital, Rickmansworth Road, Northwood, HA6 2RN, UK."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wong", 
            "givenName": "W L", 
            "id": "sg:person.0627725367.69", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627725367.69"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mount Vernon Hospital", 
              "id": "https://www.grid.ac/institutes/grid.416188.2", 
              "name": [
                "Paul Strickland Scanner Centre, Mount Vernon Hospital, Rickmansworth Road, Northwood, HA6 2RN, UK."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sonoda", 
            "givenName": "L", 
            "id": "sg:person.01004357363.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004357363.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Royal Marsden Hospital", 
              "id": "https://www.grid.ac/institutes/grid.424926.f", 
              "name": [
                "Academic Department of Biochemistry, Royal Marsden Hospital, Fulham Road, London, SW3 6JJ, UK."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Detre", 
            "givenName": "S", 
            "id": "sg:person.01255315707.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255315707.07"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mount Vernon Cancer Centre", 
              "id": "https://www.grid.ac/institutes/grid.477623.3", 
              "name": [
                "Breast Research Unit, Mount Vernon Cancer Centre, Rickmansworth Road, Northwood, HA6 2RN, UK."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Amin", 
            "givenName": "V", 
            "id": "sg:person.0644417152.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644417152.12"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mount Vernon Cancer Centre", 
              "id": "https://www.grid.ac/institutes/grid.477623.3", 
              "name": [
                "Breast Research Unit, Mount Vernon Cancer Centre, Rickmansworth Road, Northwood, HA6 2RN, UK."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ah-See", 
            "givenName": "M-L", 
            "id": "sg:person.0774613253.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774613253.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mount Vernon Cancer Centre", 
              "id": "https://www.grid.ac/institutes/grid.477623.3", 
              "name": [
                "Breast Research Unit, Mount Vernon Cancer Centre, Rickmansworth Road, Northwood, HA6 2RN, UK."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Miles", 
            "givenName": "D", 
            "id": "sg:person.01043410075.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043410075.28"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mount Vernon Cancer Centre", 
              "id": "https://www.grid.ac/institutes/grid.477623.3", 
              "name": [
                "Breast Research Unit, Mount Vernon Cancer Centre, Rickmansworth Road, Northwood, HA6 2RN, UK."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Makris", 
            "givenName": "A", 
            "id": "sg:person.01213324200.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213324200.08"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1080/10428190601113568", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001718583"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2967/jnumed.110.078501", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002768569"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/3337", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004161257", 
              "https://doi.org/10.1038/3337"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/3337", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004161257", 
              "https://doi.org/10.1038/3337"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-04-4297", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004752219"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1378/chest.129.2.393", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005864112"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mnm.0b013e328349567b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005875710"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mnm.0b013e328349567b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005875710"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2967/jnumed.108.057307", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009233958"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-07-5243", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010146815"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1470-2045(09)70262-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011020813"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2967/jnumed.112.112201", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012067028"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00259-011-1758-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013515892", 
              "https://doi.org/10.1007/s00259-011-1758-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ijrobp.2007.10.055", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014325717"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00259-004-1462-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014342296", 
              "https://doi.org/10.1007/s00259-004-1462-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-008-0081-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014658591", 
              "https://doi.org/10.1007/s10549-008-0081-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-008-0081-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014658591", 
              "https://doi.org/10.1007/s10549-008-0081-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2967/jnumed.111.094458", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017438010"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejca.2012.05.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018554931"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1095-0397(99)00016-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021919420"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00259-007-0379-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022458148", 
              "https://doi.org/10.1007/s00259-007-0379-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00259-007-0379-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022458148", 
              "https://doi.org/10.1007/s00259-007-0379-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.semnuclmed.2007.08.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023154509"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/djr393", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024075504"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11307-005-0029-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036734971", 
              "https://doi.org/10.1007/s11307-005-0029-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11307-005-0029-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036734971", 
              "https://doi.org/10.1007/s11307-005-0029-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00259-008-0960-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037413540", 
              "https://doi.org/10.1007/s00259-008-0960-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ymeth.2009.03.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037720865"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ymeth.2009.03.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037720865"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1677/erc-10-0136", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038033241"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-013-2560-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038911248", 
              "https://doi.org/10.1007/s10549-013-2560-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-013-2560-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038911248", 
              "https://doi.org/10.1007/s10549-013-2560-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2967/jnumed.112.113332", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039035219"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jlcr.25804401306", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039924295"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2967/jnumed.111.088914", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040091269"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/rlu.0b013e3182639747", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042490148"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-06-0898", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044111952"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11307-012-0547-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046928063", 
              "https://doi.org/10.1007/s11307-012-0547-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6604523", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049257356", 
              "https://doi.org/10.1038/sj.bjc.6604523"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2010.32.4939", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053639601"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1109/42.363108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1061170278"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.20.6.1456", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064202868"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2005.07.501", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064204282"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/138161209787581977", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069166864"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075344818", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077003950", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2014-06", 
        "datePublishedReg": "2014-06-01", 
        "description": "BACKGROUND: [(18)F]fluorothymidine (FLT) has been proposed as a positron emission tomography (PET)-imaging biomarker of proliferation for breast cancer. The aim of this prospective study was to assess the feasibility of FLT-PET-CT as a technique for predicting the response to neoadjuvant chemotherapy (NAC) in primary breast cancer and to compare baseline FLT with Ki-67.\nMETHODS: Twenty women with primary breast cancer had a baseline FLT-PET-CT scan that was repeated before the second cycle of chemotherapy. Expression of Ki-67 in the diagnostic biopsy was quantified. From the FLT-PET-CT scans lesion maximum and mean standardised uptake values (SUVmax, SUVmean) were calculated.\nRESULTS: Mean baseline SUVmax was 7.3, and 4.62 post one cycle of NAC, representing a drop of 2.68 (36.3%). There was no significant association between baseline, post chemotherapy, or change in SUVmax and pathological response to NAC. There was a significant correlation between pre-chemotherapy Ki-67 and SUVmax of 0.604 (P=0.006).\nCONCLUSIONS: Baseline SUVmax measurements of FLT-PET-CT were significantly related to Ki-67 suggesting that it is a proliferation biomarker. However, in this series neither the baseline value nor the change in SUVmax after one cycle of NAC were able to predict response as most patients had a sizeable SUVmax reduction.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/bjc.2014.207", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1017082", 
            "issn": [
              "0007-0920", 
              "1532-1827"
            ], 
            "name": "British Journal of Cancer", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "12", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "110"
          }
        ], 
        "name": "Evaluation of FLT-PET-CT as an imaging biomarker of proliferation in primary breast cancer", 
        "pagination": "2847", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "a3932ac8d9ad27e083150788698ec5828c76eaf820f7fe22465948f6b5d635ab"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "24832174"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "0370635"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/bjc.2014.207"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1034338732"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/bjc.2014.207", 
          "https://app.dimensions.ai/details/publication/pub.1034338732"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T14:48", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8663_00000434.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/bjc2014207"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/bjc.2014.207'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/bjc.2014.207'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/bjc.2014.207'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/bjc.2014.207'


     

    This table displays all metadata directly associated to this object as RDF triples.

    343 TRIPLES      21 PREDICATES      84 URIs      37 LITERALS      25 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/bjc.2014.207 schema:about N0fe199239fec4ba9bee22c05fa4b2186
    2 N1a7cf4361e864c978b19a57e5a991951
    3 N23900ad2abd445b2b8d4c7beb80af219
    4 N2db4ae424e9647249b05d0cadddee5bb
    5 N4e914593e2344fe5b972426b7ce7cbd9
    6 N70554e0966a44990ab55b08ecbf5e584
    7 N719b4f41f66441e7a451b4289f6cfe6b
    8 N94cb5463a5744f7f8001440118376acf
    9 N97ffc6429e11488faff37392aa1179d3
    10 Nd2c140628ddf4fd39872e80117064a32
    11 Ne44ded52eb564eb5aa57a229f090f71d
    12 Nf011956ea89c4f448ed11835b4753a57
    13 Nf0214f2e5ddd4c35bea45f316f0a7e4f
    14 Nf0b34db0400f4df9abe3caa93e7335fe
    15 Nf9a26575a59346f69a1c2acf7ef0a046
    16 Nfe7654fe56db4859b8816941c8ed0ff1
    17 anzsrc-for:11
    18 anzsrc-for:1112
    19 schema:author N5da19b7c72fb47a7b04bcc67c477bf20
    20 schema:citation sg:pub.10.1007/s00259-004-1462-8
    21 sg:pub.10.1007/s00259-007-0379-4
    22 sg:pub.10.1007/s00259-008-0960-5
    23 sg:pub.10.1007/s00259-011-1758-4
    24 sg:pub.10.1007/s10549-008-0081-7
    25 sg:pub.10.1007/s10549-013-2560-8
    26 sg:pub.10.1007/s11307-005-0029-9
    27 sg:pub.10.1007/s11307-012-0547-1
    28 sg:pub.10.1038/3337
    29 sg:pub.10.1038/sj.bjc.6604523
    30 https://app.dimensions.ai/details/publication/pub.1075344818
    31 https://app.dimensions.ai/details/publication/pub.1077003950
    32 https://doi.org/10.1002/jlcr.25804401306
    33 https://doi.org/10.1016/j.ejca.2012.05.001
    34 https://doi.org/10.1016/j.ijrobp.2007.10.055
    35 https://doi.org/10.1016/j.ymeth.2009.03.009
    36 https://doi.org/10.1016/s1095-0397(99)00016-3
    37 https://doi.org/10.1016/s1470-2045(09)70262-1
    38 https://doi.org/10.1053/j.semnuclmed.2007.08.004
    39 https://doi.org/10.1080/10428190601113568
    40 https://doi.org/10.1093/jnci/djr393
    41 https://doi.org/10.1097/mnm.0b013e328349567b
    42 https://doi.org/10.1097/rlu.0b013e3182639747
    43 https://doi.org/10.1109/42.363108
    44 https://doi.org/10.1158/0008-5472.can-04-4297
    45 https://doi.org/10.1158/0008-5472.can-06-0898
    46 https://doi.org/10.1158/1078-0432.ccr-07-5243
    47 https://doi.org/10.1200/jco.20.6.1456
    48 https://doi.org/10.1200/jco.2005.07.501
    49 https://doi.org/10.1200/jco.2010.32.4939
    50 https://doi.org/10.1378/chest.129.2.393
    51 https://doi.org/10.1677/erc-10-0136
    52 https://doi.org/10.2174/138161209787581977
    53 https://doi.org/10.2967/jnumed.108.057307
    54 https://doi.org/10.2967/jnumed.110.078501
    55 https://doi.org/10.2967/jnumed.111.088914
    56 https://doi.org/10.2967/jnumed.111.094458
    57 https://doi.org/10.2967/jnumed.112.112201
    58 https://doi.org/10.2967/jnumed.112.113332
    59 schema:datePublished 2014-06
    60 schema:datePublishedReg 2014-06-01
    61 schema:description BACKGROUND: [(18)F]fluorothymidine (FLT) has been proposed as a positron emission tomography (PET)-imaging biomarker of proliferation for breast cancer. The aim of this prospective study was to assess the feasibility of FLT-PET-CT as a technique for predicting the response to neoadjuvant chemotherapy (NAC) in primary breast cancer and to compare baseline FLT with Ki-67. METHODS: Twenty women with primary breast cancer had a baseline FLT-PET-CT scan that was repeated before the second cycle of chemotherapy. Expression of Ki-67 in the diagnostic biopsy was quantified. From the FLT-PET-CT scans lesion maximum and mean standardised uptake values (SUVmax, SUVmean) were calculated. RESULTS: Mean baseline SUVmax was 7.3, and 4.62 post one cycle of NAC, representing a drop of 2.68 (36.3%). There was no significant association between baseline, post chemotherapy, or change in SUVmax and pathological response to NAC. There was a significant correlation between pre-chemotherapy Ki-67 and SUVmax of 0.604 (P=0.006). CONCLUSIONS: Baseline SUVmax measurements of FLT-PET-CT were significantly related to Ki-67 suggesting that it is a proliferation biomarker. However, in this series neither the baseline value nor the change in SUVmax after one cycle of NAC were able to predict response as most patients had a sizeable SUVmax reduction.
    62 schema:genre research_article
    63 schema:inLanguage en
    64 schema:isAccessibleForFree true
    65 schema:isPartOf N143e7a134207401e9447f9d70fb83bc2
    66 N78ec6a12a9b24f00b2726ad489c0dfb1
    67 sg:journal.1017082
    68 schema:name Evaluation of FLT-PET-CT as an imaging biomarker of proliferation in primary breast cancer
    69 schema:pagination 2847
    70 schema:productId N1273ef9e706f47c4b2032d2b1491ce88
    71 N807a8f30ed5548e1856c7d2c0beaf8ec
    72 Na733930b351a439e835dfe943c9d5211
    73 Nb0bbee2f39334e4a99c85023f9f03edd
    74 Nef56c73346da469f859618344cd8dfdd
    75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034338732
    76 https://doi.org/10.1038/bjc.2014.207
    77 schema:sdDatePublished 2019-04-10T14:48
    78 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    79 schema:sdPublisher Na3d27168742f433cbd8806693ef69bf9
    80 schema:url https://www.nature.com/articles/bjc2014207
    81 sgo:license sg:explorer/license/
    82 sgo:sdDataset articles
    83 rdf:type schema:ScholarlyArticle
    84 N0de645a230864f6bbda099901941a1ec rdf:first sg:person.015776405257.84
    85 rdf:rest N526c8d635b644faeb1d2c945f255ec38
    86 N0fe199239fec4ba9bee22c05fa4b2186 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    87 schema:name Prospective Studies
    88 rdf:type schema:DefinedTerm
    89 N1273ef9e706f47c4b2032d2b1491ce88 schema:name pubmed_id
    90 schema:value 24832174
    91 rdf:type schema:PropertyValue
    92 N143e7a134207401e9447f9d70fb83bc2 schema:volumeNumber 110
    93 rdf:type schema:PublicationVolume
    94 N1a7cf4361e864c978b19a57e5a991951 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    95 schema:name Antineoplastic Agents
    96 rdf:type schema:DefinedTerm
    97 N23900ad2abd445b2b8d4c7beb80af219 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    98 schema:name Cell Proliferation
    99 rdf:type schema:DefinedTerm
    100 N242b1c1444f740aea366e9f36d869837 rdf:first sg:person.0774613253.13
    101 rdf:rest Nc691049ce8bc4705a2b6b24f83145b82
    102 N2db4ae424e9647249b05d0cadddee5bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    103 schema:name Middle Aged
    104 rdf:type schema:DefinedTerm
    105 N38e1777aa87244c59a74579069cf5dce rdf:first sg:person.01213324200.08
    106 rdf:rest rdf:nil
    107 N3a56782382584ff49e7875334b32eeb4 rdf:first sg:person.01004357363.45
    108 rdf:rest N88a7c2e095024a8181a2192b8cedae27
    109 N3a7e76f18f3a43639d65a8fb6caa22d5 rdf:first sg:person.01206134665.58
    110 rdf:rest N0de645a230864f6bbda099901941a1ec
    111 N4e914593e2344fe5b972426b7ce7cbd9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    112 schema:name Mastectomy
    113 rdf:type schema:DefinedTerm
    114 N526c8d635b644faeb1d2c945f255ec38 rdf:first sg:person.01253271412.54
    115 rdf:rest N6f6a4a9c53d94db195d560ec44d381cd
    116 N5da19b7c72fb47a7b04bcc67c477bf20 rdf:first sg:person.01022614412.09
    117 rdf:rest N8f17864cd93044928bad53a5785c4962
    118 N6f6a4a9c53d94db195d560ec44d381cd rdf:first sg:person.0627725367.69
    119 rdf:rest N3a56782382584ff49e7875334b32eeb4
    120 N70554e0966a44990ab55b08ecbf5e584 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    121 schema:name Dideoxynucleosides
    122 rdf:type schema:DefinedTerm
    123 N719b4f41f66441e7a451b4289f6cfe6b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    124 schema:name Neoadjuvant Therapy
    125 rdf:type schema:DefinedTerm
    126 N748b732555f3484eaee88a343b231458 rdf:first sg:person.0644417152.12
    127 rdf:rest N242b1c1444f740aea366e9f36d869837
    128 N78ec6a12a9b24f00b2726ad489c0dfb1 schema:issueNumber 12
    129 rdf:type schema:PublicationIssue
    130 N807a8f30ed5548e1856c7d2c0beaf8ec schema:name nlm_unique_id
    131 schema:value 0370635
    132 rdf:type schema:PropertyValue
    133 N88a7c2e095024a8181a2192b8cedae27 rdf:first sg:person.01255315707.07
    134 rdf:rest N748b732555f3484eaee88a343b231458
    135 N8f17864cd93044928bad53a5785c4962 rdf:first sg:person.01261437400.82
    136 rdf:rest N3a7e76f18f3a43639d65a8fb6caa22d5
    137 N94cb5463a5744f7f8001440118376acf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Positron-Emission Tomography
    139 rdf:type schema:DefinedTerm
    140 N97ffc6429e11488faff37392aa1179d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    141 schema:name Aged
    142 rdf:type schema:DefinedTerm
    143 Na3d27168742f433cbd8806693ef69bf9 schema:name Springer Nature - SN SciGraph project
    144 rdf:type schema:Organization
    145 Na733930b351a439e835dfe943c9d5211 schema:name readcube_id
    146 schema:value a3932ac8d9ad27e083150788698ec5828c76eaf820f7fe22465948f6b5d635ab
    147 rdf:type schema:PropertyValue
    148 Nb0bbee2f39334e4a99c85023f9f03edd schema:name dimensions_id
    149 schema:value pub.1034338732
    150 rdf:type schema:PropertyValue
    151 Nc691049ce8bc4705a2b6b24f83145b82 rdf:first sg:person.01043410075.28
    152 rdf:rest N38e1777aa87244c59a74579069cf5dce
    153 Nd2c140628ddf4fd39872e80117064a32 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    154 schema:name Biomarkers, Tumor
    155 rdf:type schema:DefinedTerm
    156 Ne44ded52eb564eb5aa57a229f090f71d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    157 schema:name Adult
    158 rdf:type schema:DefinedTerm
    159 Ne54c2a6c49db4182a19ed8bfc52c6019 schema:name Department of Oncology, Royal United Hospital Bath, Avon, Bath, BA1 3NG, UK.
    160 rdf:type schema:Organization
    161 Nef56c73346da469f859618344cd8dfdd schema:name doi
    162 schema:value 10.1038/bjc.2014.207
    163 rdf:type schema:PropertyValue
    164 Nf011956ea89c4f448ed11835b4753a57 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    165 schema:name Female
    166 rdf:type schema:DefinedTerm
    167 Nf0214f2e5ddd4c35bea45f316f0a7e4f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    168 schema:name Ki-67 Antigen
    169 rdf:type schema:DefinedTerm
    170 Nf0b34db0400f4df9abe3caa93e7335fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    171 schema:name Breast Neoplasms
    172 rdf:type schema:DefinedTerm
    173 Nf9a26575a59346f69a1c2acf7ef0a046 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    174 schema:name Radiopharmaceuticals
    175 rdf:type schema:DefinedTerm
    176 Nfe7654fe56db4859b8816941c8ed0ff1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    177 schema:name Humans
    178 rdf:type schema:DefinedTerm
    179 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    180 schema:name Medical and Health Sciences
    181 rdf:type schema:DefinedTerm
    182 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    183 schema:name Oncology and Carcinogenesis
    184 rdf:type schema:DefinedTerm
    185 sg:journal.1017082 schema:issn 0007-0920
    186 1532-1827
    187 schema:name British Journal of Cancer
    188 rdf:type schema:Periodical
    189 sg:person.01004357363.45 schema:affiliation https://www.grid.ac/institutes/grid.416188.2
    190 schema:familyName Sonoda
    191 schema:givenName L
    192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004357363.45
    193 rdf:type schema:Person
    194 sg:person.01022614412.09 schema:affiliation https://www.grid.ac/institutes/grid.477623.3
    195 schema:familyName Woolf
    196 schema:givenName D K
    197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022614412.09
    198 rdf:type schema:Person
    199 sg:person.01043410075.28 schema:affiliation https://www.grid.ac/institutes/grid.477623.3
    200 schema:familyName Miles
    201 schema:givenName D
    202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043410075.28
    203 rdf:type schema:Person
    204 sg:person.01206134665.58 schema:affiliation https://www.grid.ac/institutes/grid.477623.3
    205 schema:familyName Li
    206 schema:givenName S P
    207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206134665.58
    208 rdf:type schema:Person
    209 sg:person.01213324200.08 schema:affiliation https://www.grid.ac/institutes/grid.477623.3
    210 schema:familyName Makris
    211 schema:givenName A
    212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213324200.08
    213 rdf:type schema:Person
    214 sg:person.01253271412.54 schema:affiliation https://www.grid.ac/institutes/grid.416188.2
    215 schema:familyName Sanghera
    216 schema:givenName B
    217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253271412.54
    218 rdf:type schema:Person
    219 sg:person.01255315707.07 schema:affiliation https://www.grid.ac/institutes/grid.424926.f
    220 schema:familyName Detre
    221 schema:givenName S
    222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255315707.07
    223 rdf:type schema:Person
    224 sg:person.01261437400.82 schema:affiliation Ne54c2a6c49db4182a19ed8bfc52c6019
    225 schema:familyName Beresford
    226 schema:givenName M
    227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261437400.82
    228 rdf:type schema:Person
    229 sg:person.015776405257.84 schema:affiliation https://www.grid.ac/institutes/grid.424926.f
    230 schema:familyName Dowsett
    231 schema:givenName M
    232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015776405257.84
    233 rdf:type schema:Person
    234 sg:person.0627725367.69 schema:affiliation https://www.grid.ac/institutes/grid.416188.2
    235 schema:familyName Wong
    236 schema:givenName W L
    237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627725367.69
    238 rdf:type schema:Person
    239 sg:person.0644417152.12 schema:affiliation https://www.grid.ac/institutes/grid.477623.3
    240 schema:familyName Amin
    241 schema:givenName V
    242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644417152.12
    243 rdf:type schema:Person
    244 sg:person.0774613253.13 schema:affiliation https://www.grid.ac/institutes/grid.477623.3
    245 schema:familyName Ah-See
    246 schema:givenName M-L
    247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774613253.13
    248 rdf:type schema:Person
    249 sg:pub.10.1007/s00259-004-1462-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014342296
    250 https://doi.org/10.1007/s00259-004-1462-8
    251 rdf:type schema:CreativeWork
    252 sg:pub.10.1007/s00259-007-0379-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022458148
    253 https://doi.org/10.1007/s00259-007-0379-4
    254 rdf:type schema:CreativeWork
    255 sg:pub.10.1007/s00259-008-0960-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037413540
    256 https://doi.org/10.1007/s00259-008-0960-5
    257 rdf:type schema:CreativeWork
    258 sg:pub.10.1007/s00259-011-1758-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013515892
    259 https://doi.org/10.1007/s00259-011-1758-4
    260 rdf:type schema:CreativeWork
    261 sg:pub.10.1007/s10549-008-0081-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014658591
    262 https://doi.org/10.1007/s10549-008-0081-7
    263 rdf:type schema:CreativeWork
    264 sg:pub.10.1007/s10549-013-2560-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038911248
    265 https://doi.org/10.1007/s10549-013-2560-8
    266 rdf:type schema:CreativeWork
    267 sg:pub.10.1007/s11307-005-0029-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036734971
    268 https://doi.org/10.1007/s11307-005-0029-9
    269 rdf:type schema:CreativeWork
    270 sg:pub.10.1007/s11307-012-0547-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046928063
    271 https://doi.org/10.1007/s11307-012-0547-1
    272 rdf:type schema:CreativeWork
    273 sg:pub.10.1038/3337 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004161257
    274 https://doi.org/10.1038/3337
    275 rdf:type schema:CreativeWork
    276 sg:pub.10.1038/sj.bjc.6604523 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049257356
    277 https://doi.org/10.1038/sj.bjc.6604523
    278 rdf:type schema:CreativeWork
    279 https://app.dimensions.ai/details/publication/pub.1075344818 schema:CreativeWork
    280 https://app.dimensions.ai/details/publication/pub.1077003950 schema:CreativeWork
    281 https://doi.org/10.1002/jlcr.25804401306 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039924295
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1016/j.ejca.2012.05.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018554931
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1016/j.ijrobp.2007.10.055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014325717
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1016/j.ymeth.2009.03.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037720865
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1016/s1095-0397(99)00016-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021919420
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1016/s1470-2045(09)70262-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011020813
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1053/j.semnuclmed.2007.08.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023154509
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1080/10428190601113568 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001718583
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1093/jnci/djr393 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024075504
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1097/mnm.0b013e328349567b schema:sameAs https://app.dimensions.ai/details/publication/pub.1005875710
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1097/rlu.0b013e3182639747 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042490148
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1109/42.363108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1061170278
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1158/0008-5472.can-04-4297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004752219
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1158/0008-5472.can-06-0898 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044111952
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1158/1078-0432.ccr-07-5243 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010146815
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1200/jco.20.6.1456 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064202868
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1200/jco.2005.07.501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064204282
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1200/jco.2010.32.4939 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053639601
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1378/chest.129.2.393 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005864112
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1677/erc-10-0136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038033241
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.2174/138161209787581977 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069166864
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.2967/jnumed.108.057307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009233958
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.2967/jnumed.110.078501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002768569
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.2967/jnumed.111.088914 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040091269
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.2967/jnumed.111.094458 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017438010
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.2967/jnumed.112.112201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012067028
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.2967/jnumed.112.113332 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039035219
    334 rdf:type schema:CreativeWork
    335 https://www.grid.ac/institutes/grid.416188.2 schema:alternateName Mount Vernon Hospital
    336 schema:name Paul Strickland Scanner Centre, Mount Vernon Hospital, Rickmansworth Road, Northwood, HA6 2RN, UK.
    337 rdf:type schema:Organization
    338 https://www.grid.ac/institutes/grid.424926.f schema:alternateName Royal Marsden Hospital
    339 schema:name Academic Department of Biochemistry, Royal Marsden Hospital, Fulham Road, London, SW3 6JJ, UK.
    340 rdf:type schema:Organization
    341 https://www.grid.ac/institutes/grid.477623.3 schema:alternateName Mount Vernon Cancer Centre
    342 schema:name Breast Research Unit, Mount Vernon Cancer Centre, Rickmansworth Road, Northwood, HA6 2RN, UK.
    343 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...