Erroneous identification of APOBEC3-edited chromosomal DNA in cancer genomics View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-05

AUTHORS

R Suspène, V Caval, M Henry, M S Bouzidi, S Wain-Hobson, J-P Vartanian

ABSTRACT

BACKGROUND: The revolution in cancer genomics shows that the dominant mutations are CG->TA transitions. The sources of these mutations are probably two host cell cytidine deaminases APOBEC3A and APOBEC3B. The former in particular can access nuclear DNA and monotonously introduce phenomenal numbers of C->T mutations in the signature 5'TpC context. These can be copied as G->A transitions in the 5'GpA context. METHODS: DNA hypermutated by an APOBEC3 enzyme can be recovered by a technique called 3DPCR, which stands for differential DNA denaturation PCR. This method exploits the fact that APOBEC3-edited DNA is richer in A+T compared with the reference. We explore explicitly 3DPCR error using cloned DNA. RESULTS: Here we show that the technique has a higher error rate compared with standard PCR and can generate DNA strands containing both C->T and G->A mutations in a 5'GpCpR context. Sequences with similar traits have been recovered from human tumour DNA using 3DPCR. CONCLUSIONS: Differential DNA denaturation PCR cannot be used to identify fixed C->T transitions in cancer genomes. Presently, the overall mutation frequency is ∼10(4)-10(5) base substitutions per cancer genome, or 0.003-0.03 kb(-1). By contrast, the 3DPCR error rate is of the order of 4-20 kb(-1) owing to constant selection for AT DNA and PCR-mediated recombination. Accordingly, sequences recovered by 3DPCR harbouring mixed C->T and G->A mutations associated with the 5'GpC represent artefacts. More... »

PAGES

2615

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.2014.176

DOI

http://dx.doi.org/10.1038/bjc.2014.176

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039442540

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24691422


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CD4-Positive T-Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Hepatocellular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytidine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytosine Deaminase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA, Neoplasm", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hepatitis B, Chronic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hepatitis C, Chronic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interferon-alpha", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nucleic Acid Denaturation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phytohemagglutinins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recombination, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Temperature", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "beta Catenin", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Institut Pasteur", 
          "id": "https://www.grid.ac/institutes/grid.428999.7", 
          "name": [
            "Molecular Retrovirology Unit, Institut Pasteur, 28 rue du Dr. Roux, 75724 Paris, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Susp\u00e8ne", 
        "givenName": "R", 
        "id": "sg:person.01171112422.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171112422.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Pasteur", 
          "id": "https://www.grid.ac/institutes/grid.428999.7", 
          "name": [
            "Molecular Retrovirology Unit, Institut Pasteur, 28 rue du Dr. Roux, 75724 Paris, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Caval", 
        "givenName": "V", 
        "id": "sg:person.01274264236.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274264236.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Pasteur", 
          "id": "https://www.grid.ac/institutes/grid.428999.7", 
          "name": [
            "Molecular Retrovirology Unit, Institut Pasteur, 28 rue du Dr. Roux, 75724 Paris, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Henry", 
        "givenName": "M", 
        "id": "sg:person.01231370414.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231370414.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Pasteur", 
          "id": "https://www.grid.ac/institutes/grid.428999.7", 
          "name": [
            "Molecular Retrovirology Unit, Institut Pasteur, 28 rue du Dr. Roux, 75724 Paris, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bouzidi", 
        "givenName": "M S", 
        "id": "sg:person.01330522050.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330522050.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Pasteur", 
          "id": "https://www.grid.ac/institutes/grid.428999.7", 
          "name": [
            "Molecular Retrovirology Unit, Institut Pasteur, 28 rue du Dr. Roux, 75724 Paris, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wain-Hobson", 
        "givenName": "S", 
        "id": "sg:person.055642406.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.055642406.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Pasteur", 
          "id": "https://www.grid.ac/institutes/grid.428999.7", 
          "name": [
            "Molecular Retrovirology Unit, Institut Pasteur, 28 rue du Dr. Roux, 75724 Paris, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vartanian", 
        "givenName": "J-P", 
        "id": "sg:person.01260647435.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260647435.89"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1093/nar/gkq174", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000987600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.1.1.17", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001511466"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1083338", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001603615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb.1744", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002558962", 
          "https://doi.org/10.1038/nsmb.1744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb.1744", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002558962", 
          "https://doi.org/10.1038/nsmb.1744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/18.7.1687", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004205431"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.01089-09", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004445400"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkh554", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008236318"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1099/vir.0.80426-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008503228"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.celrep.2012.12.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008799776"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(03)00423-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010122284"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1210344", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010363470", 
          "https://doi.org/10.1038/sj.onc.1210344"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1210344", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010363470", 
          "https://doi.org/10.1038/sj.onc.1210344"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/geno.2002.6718", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011191861"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.2701", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012556021", 
          "https://doi.org/10.1038/ng.2701"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature00939", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012721182", 
          "https://doi.org/10.1038/nature00939"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature00939", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012721182", 
          "https://doi.org/10.1038/nature00939"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08658", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014288207", 
          "https://doi.org/10.1038/nature08658"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08658", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014288207", 
          "https://doi.org/10.1038/nature08658"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1000928", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014320823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1009687108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014441277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(03)00515-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017310358"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jmb.2004.01.046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019574917"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/dds513", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021305887"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0004277", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021821176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0408223102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023631355"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0408223102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023631355"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m112.372722", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026629493"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1566", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029313751", 
          "https://doi.org/10.1038/nm1566"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1566", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029313751", 
          "https://doi.org/10.1038/nm1566"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11881", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032796931", 
          "https://doi.org/10.1038/nature11881"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep00806", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032985769", 
          "https://doi.org/10.1038/srep00806"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.23853", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033148049"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.biochem.76.061705.090740", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033286055"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/embor.2011.46", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033286983"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05610", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033482125", 
          "https://doi.org/10.1038/nature05610"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034041413", 
          "https://doi.org/10.1038/nature11017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.21187", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034909568"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0063461", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035667992"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gks685", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039324410"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0073641", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041446057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01709", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042589371", 
          "https://doi.org/10.1038/nature01709"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01709", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042589371", 
          "https://doi.org/10.1038/nature01709"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/molbev/msi026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044612085"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.0030063", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045023132"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.0030063", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045023132"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2012.04.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045709558"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m112.385161", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047104476"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-07-6655", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048034265"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08645", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050729897", 
          "https://doi.org/10.1038/nature08645"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08645", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050729897", 
          "https://doi.org/10.1038/nature08645"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cub.2004.06.057", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051940871"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1153201", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062457319"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.00290-11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062712461"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jb.170.3.1082-1091.1988", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062716746"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077677032", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082786915", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083280357", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-05", 
    "datePublishedReg": "2014-05-01", 
    "description": "BACKGROUND: The revolution in cancer genomics shows that the dominant mutations are CG->TA transitions. The sources of these mutations are probably two host cell cytidine deaminases APOBEC3A and APOBEC3B. The former in particular can access nuclear DNA and monotonously introduce phenomenal numbers of C->T mutations in the signature 5'TpC context. These can be copied as G->A transitions in the 5'GpA context.\nMETHODS: DNA hypermutated by an APOBEC3 enzyme can be recovered by a technique called 3DPCR, which stands for differential DNA denaturation PCR. This method exploits the fact that APOBEC3-edited DNA is richer in A+T compared with the reference. We explore explicitly 3DPCR error using cloned DNA.\nRESULTS: Here we show that the technique has a higher error rate compared with standard PCR and can generate DNA strands containing both C->T and G->A mutations in a 5'GpCpR context. Sequences with similar traits have been recovered from human tumour DNA using 3DPCR.\nCONCLUSIONS: Differential DNA denaturation PCR cannot be used to identify fixed C->T transitions in cancer genomes. Presently, the overall mutation frequency is \u223c10(4)-10(5) base substitutions per cancer genome, or 0.003-0.03\u2009kb(-1). By contrast, the 3DPCR error rate is of the order of 4-20\u2009kb(-1) owing to constant selection for AT DNA and PCR-mediated recombination. Accordingly, sequences recovered by 3DPCR harbouring mixed C->T and G->A mutations associated with the 5'GpC represent artefacts.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/bjc.2014.176", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1017082", 
        "issn": [
          "0007-0920", 
          "1532-1827"
        ], 
        "name": "British Journal of Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "10", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "110"
      }
    ], 
    "name": "Erroneous identification of APOBEC3-edited chromosomal DNA in cancer genomics", 
    "pagination": "2615", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "bbe2cb7441b1f21ba83c4474907a4c54f4575e02329054a6458aba4167059f91"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24691422"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0370635"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/bjc.2014.176"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1039442540"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/bjc.2014.176", 
      "https://app.dimensions.ai/details/publication/pub.1039442540"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T22:20", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000436.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/bjc2014176"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/bjc.2014.176'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/bjc.2014.176'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/bjc.2014.176'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/bjc.2014.176'


 

This table displays all metadata directly associated to this object as RDF triples.

340 TRIPLES      21 PREDICATES      98 URIs      41 LITERALS      29 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/bjc.2014.176 schema:about N05b08df0dd314d4c9d3b8863e8b3964a
2 N093d38eac4a7426892c82f996def24c1
3 N0b04f97a954d4e9ca295783743201335
4 N1adfddf887e644308e1911369a9cd80a
5 N30c8cdf2dcdc4bd89230d543abccc1a6
6 N3887cb916da44b7dbca520e8c75c5f76
7 N3b0442c63722417189b1cd23fcb946a4
8 N3cdb247976864cfab7674e6d9e731e5a
9 N3d28f9f47c7c40cd8b153d11b96b7cc1
10 N660d32871611406da54127602111f5fb
11 N805fb79188ce42a4bad95def49a03701
12 N835412f55a564b68a01f8469ee75821e
13 N8cc9560cb08746d095d2531218b90baf
14 N96977dfe426e48d9b45d12fc8a88d72e
15 N994245add7ab404b8701719cd206ef6d
16 N9f204db7cd734f35a88f284243bc72e2
17 Naf68586f611c4c589dba31fbe3f4cf7f
18 Nbbf2db5daad646ca8776bf7d0c819688
19 Nd7d81567d66b4ad0b0bfd5e68ad463a3
20 Nf54e3857ec584d7cbe7ee7a1d9d82858
21 anzsrc-for:06
22 anzsrc-for:0604
23 schema:author N1f38364732524194864ad6e3998f5e12
24 schema:citation sg:pub.10.1038/nature00939
25 sg:pub.10.1038/nature01709
26 sg:pub.10.1038/nature05610
27 sg:pub.10.1038/nature08645
28 sg:pub.10.1038/nature08658
29 sg:pub.10.1038/nature11017
30 sg:pub.10.1038/nature11881
31 sg:pub.10.1038/ng.2701
32 sg:pub.10.1038/nm1566
33 sg:pub.10.1038/nsmb.1744
34 sg:pub.10.1038/sj.onc.1210344
35 sg:pub.10.1038/srep00806
36 https://app.dimensions.ai/details/publication/pub.1077677032
37 https://app.dimensions.ai/details/publication/pub.1082786915
38 https://app.dimensions.ai/details/publication/pub.1083280357
39 https://doi.org/10.1002/hep.21187
40 https://doi.org/10.1002/ijc.23853
41 https://doi.org/10.1006/geno.2002.6718
42 https://doi.org/10.1016/j.cell.2012.04.024
43 https://doi.org/10.1016/j.celrep.2012.12.008
44 https://doi.org/10.1016/j.cub.2004.06.057
45 https://doi.org/10.1016/j.jmb.2004.01.046
46 https://doi.org/10.1016/s0092-8674(03)00423-9
47 https://doi.org/10.1016/s0092-8674(03)00515-4
48 https://doi.org/10.1038/embor.2011.46
49 https://doi.org/10.1073/pnas.0408223102
50 https://doi.org/10.1073/pnas.1009687108
51 https://doi.org/10.1074/jbc.m112.372722
52 https://doi.org/10.1074/jbc.m112.385161
53 https://doi.org/10.1093/hmg/dds513
54 https://doi.org/10.1093/molbev/msi026
55 https://doi.org/10.1093/nar/18.7.1687
56 https://doi.org/10.1093/nar/gkh554
57 https://doi.org/10.1093/nar/gkq174
58 https://doi.org/10.1093/nar/gks685
59 https://doi.org/10.1099/vir.0.80426-0
60 https://doi.org/10.1101/gr.1.1.17
61 https://doi.org/10.1126/science.1083338
62 https://doi.org/10.1126/science.1153201
63 https://doi.org/10.1128/jb.170.3.1082-1091.1988
64 https://doi.org/10.1128/jvi.00290-11
65 https://doi.org/10.1128/jvi.01089-09
66 https://doi.org/10.1146/annurev.biochem.76.061705.090740
67 https://doi.org/10.1158/0008-5472.can-07-6655
68 https://doi.org/10.1371/journal.pgen.0030063
69 https://doi.org/10.1371/journal.pone.0004277
70 https://doi.org/10.1371/journal.pone.0063461
71 https://doi.org/10.1371/journal.pone.0073641
72 https://doi.org/10.1371/journal.ppat.1000928
73 schema:datePublished 2014-05
74 schema:datePublishedReg 2014-05-01
75 schema:description BACKGROUND: The revolution in cancer genomics shows that the dominant mutations are CG->TA transitions. The sources of these mutations are probably two host cell cytidine deaminases APOBEC3A and APOBEC3B. The former in particular can access nuclear DNA and monotonously introduce phenomenal numbers of C->T mutations in the signature 5'TpC context. These can be copied as G->A transitions in the 5'GpA context. METHODS: DNA hypermutated by an APOBEC3 enzyme can be recovered by a technique called 3DPCR, which stands for differential DNA denaturation PCR. This method exploits the fact that APOBEC3-edited DNA is richer in A+T compared with the reference. We explore explicitly 3DPCR error using cloned DNA. RESULTS: Here we show that the technique has a higher error rate compared with standard PCR and can generate DNA strands containing both C->T and G->A mutations in a 5'GpCpR context. Sequences with similar traits have been recovered from human tumour DNA using 3DPCR. CONCLUSIONS: Differential DNA denaturation PCR cannot be used to identify fixed C->T transitions in cancer genomes. Presently, the overall mutation frequency is ∼10(4)-10(5) base substitutions per cancer genome, or 0.003-0.03 kb(-1). By contrast, the 3DPCR error rate is of the order of 4-20 kb(-1) owing to constant selection for AT DNA and PCR-mediated recombination. Accordingly, sequences recovered by 3DPCR harbouring mixed C->T and G->A mutations associated with the 5'GpC represent artefacts.
76 schema:genre research_article
77 schema:inLanguage en
78 schema:isAccessibleForFree true
79 schema:isPartOf Nad66b2e7f23143728cca4fb47d52cb1e
80 Ndb44267f031545b08fab29cf9d5c7a8c
81 sg:journal.1017082
82 schema:name Erroneous identification of APOBEC3-edited chromosomal DNA in cancer genomics
83 schema:pagination 2615
84 schema:productId N0955e95db9da4a0c914eece1bd47830c
85 N0e694ed452fd4f129c9fc178deb3baec
86 N203cb33818c2469da268fd53a0a139ee
87 N3b39da7a14cc4a17a3f77b97e9287dae
88 N4f95017917a74275911bc5a4bc56f364
89 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039442540
90 https://doi.org/10.1038/bjc.2014.176
91 schema:sdDatePublished 2019-04-10T22:20
92 schema:sdLicense https://scigraph.springernature.com/explorer/license/
93 schema:sdPublisher N9af087387d0f42d5b8357aa9b65c25b1
94 schema:url https://www.nature.com/articles/bjc2014176
95 sgo:license sg:explorer/license/
96 sgo:sdDataset articles
97 rdf:type schema:ScholarlyArticle
98 N05b08df0dd314d4c9d3b8863e8b3964a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Humans
100 rdf:type schema:DefinedTerm
101 N060fe68f5bad4bbbaa3e8315a908c3ec rdf:first sg:person.01274264236.49
102 rdf:rest N83cc90fcda4b4b20afd054a816dd42f7
103 N093d38eac4a7426892c82f996def24c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Polymerase Chain Reaction
105 rdf:type schema:DefinedTerm
106 N0955e95db9da4a0c914eece1bd47830c schema:name pubmed_id
107 schema:value 24691422
108 rdf:type schema:PropertyValue
109 N0b04f97a954d4e9ca295783743201335 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Cytidine
111 rdf:type schema:DefinedTerm
112 N0e694ed452fd4f129c9fc178deb3baec schema:name doi
113 schema:value 10.1038/bjc.2014.176
114 rdf:type schema:PropertyValue
115 N1adfddf887e644308e1911369a9cd80a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Carcinoma, Hepatocellular
117 rdf:type schema:DefinedTerm
118 N1f38364732524194864ad6e3998f5e12 rdf:first sg:person.01171112422.54
119 rdf:rest N060fe68f5bad4bbbaa3e8315a908c3ec
120 N203cb33818c2469da268fd53a0a139ee schema:name dimensions_id
121 schema:value pub.1039442540
122 rdf:type schema:PropertyValue
123 N30c8cdf2dcdc4bd89230d543abccc1a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name DNA, Neoplasm
125 rdf:type schema:DefinedTerm
126 N3887cb916da44b7dbca520e8c75c5f76 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name beta Catenin
128 rdf:type schema:DefinedTerm
129 N3b0442c63722417189b1cd23fcb946a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Mutation
131 rdf:type schema:DefinedTerm
132 N3b39da7a14cc4a17a3f77b97e9287dae schema:name nlm_unique_id
133 schema:value 0370635
134 rdf:type schema:PropertyValue
135 N3cdb247976864cfab7674e6d9e731e5a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Cytosine Deaminase
137 rdf:type schema:DefinedTerm
138 N3d28f9f47c7c40cd8b153d11b96b7cc1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Nucleic Acid Denaturation
140 rdf:type schema:DefinedTerm
141 N4f95017917a74275911bc5a4bc56f364 schema:name readcube_id
142 schema:value bbe2cb7441b1f21ba83c4474907a4c54f4575e02329054a6458aba4167059f91
143 rdf:type schema:PropertyValue
144 N660d32871611406da54127602111f5fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Phytohemagglutinins
146 rdf:type schema:DefinedTerm
147 N805fb79188ce42a4bad95def49a03701 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Temperature
149 rdf:type schema:DefinedTerm
150 N835412f55a564b68a01f8469ee75821e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name CD4-Positive T-Lymphocytes
152 rdf:type schema:DefinedTerm
153 N83cc90fcda4b4b20afd054a816dd42f7 rdf:first sg:person.01231370414.88
154 rdf:rest N9c66dff5a0a94786b03b55b514dfea64
155 N8cc9560cb08746d095d2531218b90baf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Cells, Cultured
157 rdf:type schema:DefinedTerm
158 N96977dfe426e48d9b45d12fc8a88d72e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Hepatitis B, Chronic
160 rdf:type schema:DefinedTerm
161 N994245add7ab404b8701719cd206ef6d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Interleukin-2
163 rdf:type schema:DefinedTerm
164 N9af087387d0f42d5b8357aa9b65c25b1 schema:name Springer Nature - SN SciGraph project
165 rdf:type schema:Organization
166 N9c66dff5a0a94786b03b55b514dfea64 rdf:first sg:person.01330522050.03
167 rdf:rest Nef0bcb115a0849f29b5e04ee68d97b44
168 N9f204db7cd734f35a88f284243bc72e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Hepatitis C, Chronic
170 rdf:type schema:DefinedTerm
171 Nad66b2e7f23143728cca4fb47d52cb1e schema:volumeNumber 110
172 rdf:type schema:PublicationVolume
173 Naf68586f611c4c589dba31fbe3f4cf7f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Liver Neoplasms
175 rdf:type schema:DefinedTerm
176 Nbbf2db5daad646ca8776bf7d0c819688 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Neoplasm Proteins
178 rdf:type schema:DefinedTerm
179 Nccf9304521f94393acb96f14b14d6bc2 rdf:first sg:person.01260647435.89
180 rdf:rest rdf:nil
181 Nd7d81567d66b4ad0b0bfd5e68ad463a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Interferon-alpha
183 rdf:type schema:DefinedTerm
184 Ndb44267f031545b08fab29cf9d5c7a8c schema:issueNumber 10
185 rdf:type schema:PublicationIssue
186 Nef0bcb115a0849f29b5e04ee68d97b44 rdf:first sg:person.055642406.07
187 rdf:rest Nccf9304521f94393acb96f14b14d6bc2
188 Nf54e3857ec584d7cbe7ee7a1d9d82858 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Recombination, Genetic
190 rdf:type schema:DefinedTerm
191 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
192 schema:name Biological Sciences
193 rdf:type schema:DefinedTerm
194 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
195 schema:name Genetics
196 rdf:type schema:DefinedTerm
197 sg:journal.1017082 schema:issn 0007-0920
198 1532-1827
199 schema:name British Journal of Cancer
200 rdf:type schema:Periodical
201 sg:person.01171112422.54 schema:affiliation https://www.grid.ac/institutes/grid.428999.7
202 schema:familyName Suspène
203 schema:givenName R
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171112422.54
205 rdf:type schema:Person
206 sg:person.01231370414.88 schema:affiliation https://www.grid.ac/institutes/grid.428999.7
207 schema:familyName Henry
208 schema:givenName M
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231370414.88
210 rdf:type schema:Person
211 sg:person.01260647435.89 schema:affiliation https://www.grid.ac/institutes/grid.428999.7
212 schema:familyName Vartanian
213 schema:givenName J-P
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260647435.89
215 rdf:type schema:Person
216 sg:person.01274264236.49 schema:affiliation https://www.grid.ac/institutes/grid.428999.7
217 schema:familyName Caval
218 schema:givenName V
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274264236.49
220 rdf:type schema:Person
221 sg:person.01330522050.03 schema:affiliation https://www.grid.ac/institutes/grid.428999.7
222 schema:familyName Bouzidi
223 schema:givenName M S
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330522050.03
225 rdf:type schema:Person
226 sg:person.055642406.07 schema:affiliation https://www.grid.ac/institutes/grid.428999.7
227 schema:familyName Wain-Hobson
228 schema:givenName S
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.055642406.07
230 rdf:type schema:Person
231 sg:pub.10.1038/nature00939 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012721182
232 https://doi.org/10.1038/nature00939
233 rdf:type schema:CreativeWork
234 sg:pub.10.1038/nature01709 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042589371
235 https://doi.org/10.1038/nature01709
236 rdf:type schema:CreativeWork
237 sg:pub.10.1038/nature05610 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033482125
238 https://doi.org/10.1038/nature05610
239 rdf:type schema:CreativeWork
240 sg:pub.10.1038/nature08645 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050729897
241 https://doi.org/10.1038/nature08645
242 rdf:type schema:CreativeWork
243 sg:pub.10.1038/nature08658 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014288207
244 https://doi.org/10.1038/nature08658
245 rdf:type schema:CreativeWork
246 sg:pub.10.1038/nature11017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034041413
247 https://doi.org/10.1038/nature11017
248 rdf:type schema:CreativeWork
249 sg:pub.10.1038/nature11881 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032796931
250 https://doi.org/10.1038/nature11881
251 rdf:type schema:CreativeWork
252 sg:pub.10.1038/ng.2701 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012556021
253 https://doi.org/10.1038/ng.2701
254 rdf:type schema:CreativeWork
255 sg:pub.10.1038/nm1566 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029313751
256 https://doi.org/10.1038/nm1566
257 rdf:type schema:CreativeWork
258 sg:pub.10.1038/nsmb.1744 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002558962
259 https://doi.org/10.1038/nsmb.1744
260 rdf:type schema:CreativeWork
261 sg:pub.10.1038/sj.onc.1210344 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010363470
262 https://doi.org/10.1038/sj.onc.1210344
263 rdf:type schema:CreativeWork
264 sg:pub.10.1038/srep00806 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032985769
265 https://doi.org/10.1038/srep00806
266 rdf:type schema:CreativeWork
267 https://app.dimensions.ai/details/publication/pub.1077677032 schema:CreativeWork
268 https://app.dimensions.ai/details/publication/pub.1082786915 schema:CreativeWork
269 https://app.dimensions.ai/details/publication/pub.1083280357 schema:CreativeWork
270 https://doi.org/10.1002/hep.21187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034909568
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1002/ijc.23853 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033148049
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1006/geno.2002.6718 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011191861
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1016/j.cell.2012.04.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045709558
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1016/j.celrep.2012.12.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008799776
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1016/j.cub.2004.06.057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051940871
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1016/j.jmb.2004.01.046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019574917
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1016/s0092-8674(03)00423-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010122284
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1016/s0092-8674(03)00515-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017310358
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1038/embor.2011.46 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033286983
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1073/pnas.0408223102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023631355
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1073/pnas.1009687108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014441277
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1074/jbc.m112.372722 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026629493
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1074/jbc.m112.385161 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047104476
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1093/hmg/dds513 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021305887
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1093/molbev/msi026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044612085
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1093/nar/18.7.1687 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004205431
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1093/nar/gkh554 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008236318
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1093/nar/gkq174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000987600
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1093/nar/gks685 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039324410
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1099/vir.0.80426-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008503228
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1101/gr.1.1.17 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001511466
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1126/science.1083338 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001603615
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1126/science.1153201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062457319
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1128/jb.170.3.1082-1091.1988 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062716746
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1128/jvi.00290-11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062712461
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1128/jvi.01089-09 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004445400
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1146/annurev.biochem.76.061705.090740 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033286055
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1158/0008-5472.can-07-6655 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048034265
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1371/journal.pgen.0030063 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045023132
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1371/journal.pone.0004277 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021821176
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1371/journal.pone.0063461 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035667992
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1371/journal.pone.0073641 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041446057
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1371/journal.ppat.1000928 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014320823
337 rdf:type schema:CreativeWork
338 https://www.grid.ac/institutes/grid.428999.7 schema:alternateName Institut Pasteur
339 schema:name Molecular Retrovirology Unit, Institut Pasteur, 28 rue du Dr. Roux, 75724 Paris, France.
340 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...