Ipilimumab retreatment in patients with pretreated advanced melanoma: the expanded access programme in Italy View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-04

AUTHORS

V Chiarion-Sileni, J Pigozzo, P A Ascierto, E Simeone, M Maio, L Calabrò, P Marchetti, F De Galitiis, A Testori, P F Ferrucci, P Queirolo, F Spagnolo, P Quaglino, F Carnevale Schianca, M Mandalà, L Di Guardo, M Del Vecchio

ABSTRACT

BACKGROUND: Retreatment with ipilimumab has been shown to re-establish disease control in some patients with disease progression. Here, we report the efficacy and safety of retreatment with ipilimumab 3 mg kg(-1) among patients participating in an expanded access programme in Italy. METHODS: Patients who achieved disease control during induction therapy were retreated with ipilimumab upon progression (3 mg kg(-1) every 3 weeks for up to four doses), providing they had not experienced toxicity that precluded further dosing. Tumour assessments were conducted after retreatment, and patients were monitored throughout for adverse events. RESULTS: Of 855 patients treated with ipilimumab, 51 were retreated upon disease progression. Of these, 28 (55%) regained disease control upon retreatment and 42% were alive 2 years after the first induction dose of ipilimumab; median overall survival was 21 months. Eleven patients (22%) had a treatment-related adverse event of any grade during retreatment. These were generally mild-to-moderate and resolved within a median of 4 days. No new types of toxicity were reported. CONCLUSIONS: For patients who meet predefined criteria, retreatment with ipilimumab is generally well tolerated and can translate into clinical benefit. This strategy should be compared with other therapeutic options in randomised controlled trials. More... »

PAGES

1721

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bjc.2014.126

DOI

http://dx.doi.org/10.1038/bjc.2014.126

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014968763

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24619072


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Monoclonal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Progression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Health Plan Implementation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Health Services Accessibility", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunotherapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ipilimumab", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Italy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Melanoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Program Development", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Remission Induction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retreatment", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Skin Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Melanoma Cancer Unit, Veneto Institute of Oncology IOV-IRCCS, Via Gattamelata, 64, 35128 Padua, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chiarion-Sileni", 
        "givenName": "V", 
        "id": "sg:person.0707113743.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707113743.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Melanoma Cancer Unit, Veneto Institute of Oncology IOV-IRCCS, Via Gattamelata, 64, 35128 Padua, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pigozzo", 
        "givenName": "J", 
        "id": "sg:person.01076711104.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076711104.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Melanoma, Cancer Immunotherapy and Innovative Therapy Unit, Istituto Nazionale Tumori Fondazione \u2018G Pascale\u2019, Via Cappella dei Cangiani, 1, 80131 Naples, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ascierto", 
        "givenName": "P A", 
        "id": "sg:person.01212502023.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212502023.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Melanoma, Cancer Immunotherapy and Innovative Therapy Unit, Istituto Nazionale Tumori Fondazione \u2018G Pascale\u2019, Via Cappella dei Cangiani, 1, 80131 Naples, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Simeone", 
        "givenName": "E", 
        "id": "sg:person.01127536021.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127536021.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Azienda Ospedaliera Universitaria Senese", 
          "id": "https://www.grid.ac/institutes/grid.411477.0", 
          "name": [
            "Medical Oncology and Immunotherapy Unit, University Hospital of Siena, Istituto Toscano Tumori, Strada delle Scotte, 14, 53100 Siena, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maio", 
        "givenName": "M", 
        "id": "sg:person.01061427172.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061427172.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Azienda Ospedaliera Universitaria Senese", 
          "id": "https://www.grid.ac/institutes/grid.411477.0", 
          "name": [
            "Medical Oncology and Immunotherapy Unit, University Hospital of Siena, Istituto Toscano Tumori, Strada delle Scotte, 14, 53100 Siena, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Calabr\u00f2", 
        "givenName": "L", 
        "id": "sg:person.01050657054.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050657054.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sapienza University of Rome", 
          "id": "https://www.grid.ac/institutes/grid.7841.a", 
          "name": [
            "Medical Oncology, Dermopathic Institute of the Immaculate IDI-IRCCS, Via dei Monti di Creta, 104, 00167 Rome, Italy", 
            "Medical Oncology, Sant\u2019Andrea Hospital, Sapienza University of Rome, Via di Grottarossa, 1035-39, 00189 Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marchetti", 
        "givenName": "P", 
        "id": "sg:person.0641150074.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641150074.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Medical Oncology, Dermopathic Institute of the Immaculate IDI-IRCCS, Via dei Monti di Creta, 104, 00167 Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "De Galitiis", 
        "givenName": "F", 
        "id": "sg:person.01274530176.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274530176.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "European Institute of Oncology", 
          "id": "https://www.grid.ac/institutes/grid.15667.33", 
          "name": [
            "Divisione Melanoma, Istituto Europeo di Oncologia, Via Ripamonti, 435, 20141 Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Testori", 
        "givenName": "A", 
        "id": "sg:person.01021072757.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021072757.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "European Institute of Oncology", 
          "id": "https://www.grid.ac/institutes/grid.15667.33", 
          "name": [
            "Oncology of Melanoma Unit, Istituto Europeo di Oncologia, Via Ripamonti, 435, 20141 Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ferrucci", 
        "givenName": "P F", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ospedale San Martino", 
          "id": "https://www.grid.ac/institutes/grid.410345.7", 
          "name": [
            "Department of Medical Oncology A, San Martino Hospital, National Institute for Cancer Research, L.go R. Benzi, 10, 16132 Genoa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Queirolo", 
        "givenName": "P", 
        "id": "sg:person.01102114523.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102114523.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ospedale San Martino", 
          "id": "https://www.grid.ac/institutes/grid.410345.7", 
          "name": [
            "Department of Medical Oncology A, San Martino Hospital, National Institute for Cancer Research, L.go R. Benzi, 10, 16132 Genoa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Spagnolo", 
        "givenName": "F", 
        "id": "sg:person.01261247072.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261247072.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Turin", 
          "id": "https://www.grid.ac/institutes/grid.7605.4", 
          "name": [
            "Dermatologic Clinic, Department of Medical Sciences, University of Torino, San Giovanni Battista di Torino, Via Cherasco, 23, 10126 Turin, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Quaglino", 
        "givenName": "P", 
        "id": "sg:person.0776042506.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776042506.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Candiolo Cancer Institute", 
          "id": "https://www.grid.ac/institutes/grid.419555.9", 
          "name": [
            "Division of Medical Oncology, Institute for Cancer Research and Treatment, IRCC, Piedmont Oncology Foundation, Strada Provinciale, 142, 10060 Candiolo, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schianca", 
        "givenName": "F Carnevale", 
        "id": "sg:person.0610724345.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610724345.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ospedale Papa Giovanni XXIII", 
          "id": "https://www.grid.ac/institutes/grid.460094.f", 
          "name": [
            "Unit of Medical Oncology, Papa Giovanni XXIII Hospital, Piazza OMS-Organizzazione Mondiale della Sanit\u00e0, 1, 24127 Bergamo, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mandal\u00e0", 
        "givenName": "M", 
        "id": "sg:person.01157622404.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157622404.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Nazionale dei Tumori", 
          "id": "https://www.grid.ac/institutes/grid.417893.0", 
          "name": [
            "Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian, 1, 20133 Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Di Guardo", 
        "givenName": "L", 
        "id": "sg:person.0625237211.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625237211.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Nazionale dei Tumori", 
          "id": "https://www.grid.ac/institutes/grid.417893.0", 
          "name": [
            "Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian, 1, 20133 Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Del Vecchio", 
        "givenName": "M", 
        "id": "sg:person.0600120704.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600120704.85"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.semcancer.2007.06.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001693325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1479-5876-9-204", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002969174", 
          "https://doi.org/10.1186/1479-5876-9-204"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-11-1823", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010268280"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.0105-2896.2006.00391.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012853788"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-09-1024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016716683"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2012.41.6750", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019320335"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2012.41.6115", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019659802"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10637-009-9376-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021055401", 
          "https://doi.org/10.1007/s10637-009-9376-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-12-3080", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021277346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2009.12.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021779666"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdq013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025653897"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1529-8019.2005.00052.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026701684"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1529-8019.2005.00052.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026701684"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-09-1624", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028571226"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1586/era.09.25", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030498193"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1131078", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034203142"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2008.17.8954", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034543033"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1104621", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036355137"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0065-2776(06)90008-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037003471"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2133.2004.05708.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037745378"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdr584", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039421158"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/theoncologist.2009-0028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040649902"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/j.0818-9641.2004.01273.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041030125", 
          "https://doi.org/10.1111/j.0818-9641.2004.01273.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2007.12.7837", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046075678"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.seminoncol.2010.09.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052040775"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1003466", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052212829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.coi.2006.01.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052941380"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(09)70334-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053423975"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.174.11.6863", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077054825"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-04", 
    "datePublishedReg": "2014-04-01", 
    "description": "BACKGROUND: Retreatment with ipilimumab has been shown to re-establish disease control in some patients with disease progression. Here, we report the efficacy and safety of retreatment with ipilimumab 3 mg kg(-1) among patients participating in an expanded access programme in Italy.\nMETHODS: Patients who achieved disease control during induction therapy were retreated with ipilimumab upon progression (3 mg kg(-1) every 3 weeks for up to four doses), providing they had not experienced toxicity that precluded further dosing. Tumour assessments were conducted after retreatment, and patients were monitored throughout for adverse events.\nRESULTS: Of 855 patients treated with ipilimumab, 51 were retreated upon disease progression. Of these, 28 (55%) regained disease control upon retreatment and 42% were alive 2 years after the first induction dose of ipilimumab; median overall survival was 21 months. Eleven patients (22%) had a treatment-related adverse event of any grade during retreatment. These were generally mild-to-moderate and resolved within a median of 4 days. No new types of toxicity were reported.\nCONCLUSIONS: For patients who meet predefined criteria, retreatment with ipilimumab is generally well tolerated and can translate into clinical benefit. This strategy should be compared with other therapeutic options in randomised controlled trials.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/bjc.2014.126", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1017082", 
        "issn": [
          "0007-0920", 
          "1532-1827"
        ], 
        "name": "British Journal of Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "110"
      }
    ], 
    "name": "Ipilimumab retreatment in patients with pretreated advanced melanoma: the expanded access programme in Italy", 
    "pagination": "1721", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "475112d898d1276a3d14e0f2563206acb464ffbfade6610e97c57bed4b8da7f6"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24619072"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0370635"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/bjc.2014.126"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1014968763"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/bjc.2014.126", 
      "https://app.dimensions.ai/details/publication/pub.1014968763"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T22:20", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000434.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/bjc2014126"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/bjc.2014.126'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/bjc.2014.126'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/bjc.2014.126'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/bjc.2014.126'


 

This table displays all metadata directly associated to this object as RDF triples.

384 TRIPLES      21 PREDICATES      78 URIs      42 LITERALS      30 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/bjc.2014.126 schema:about N06145b13b3ae458db6176e6716d03afe
2 N0876e2abb1644facb8f03612b2c49e19
3 N1fe75a9d155b48ae88e560106dbb5f0b
4 N2398c9e08054411e9d4332ba5b480e26
5 N4be22c1a35af450bafddde30d2e5eab5
6 N50dc24cd344d4736a5a60f96d005974a
7 N587ad9113bcd45b99e3a402814ddc21b
8 N5bcf6619cf72422c843915071881a588
9 N764fd9ed413b453dab5115e3c1e21d85
10 N7fb7efcf960d4372907420f9b7677249
11 N895380d931d647e9b54064e4f31e9f82
12 N8b3e937d1eff421c965a9dee849d2b12
13 N96528f7867ae455496b5334b295b2433
14 Na1539cfca1504f53a3f41ed160ff908b
15 Naa4d85ae4faf4bb3aa9fffb639f68505
16 Nc5afabb8be8047b185487bc5e6d522c6
17 Ncd1a5a2546824b3faac525ef22c78004
18 Nd6eff258fbd24b83bb5121d2277d5187
19 Nde18fedf921943eabc6147612c438748
20 Nea8f752ddaeb4937b3cbb6b71f8a8ef6
21 Nff8c30f15a9e417f90dc34be14568227
22 anzsrc-for:11
23 anzsrc-for:1103
24 schema:author Neca94f477f0644ce9cf416243b24cb17
25 schema:citation sg:pub.10.1007/s10637-009-9376-8
26 sg:pub.10.1111/j.0818-9641.2004.01273.x
27 sg:pub.10.1186/1479-5876-9-204
28 https://doi.org/10.1016/j.coi.2006.01.011
29 https://doi.org/10.1016/j.ejca.2009.12.014
30 https://doi.org/10.1016/j.semcancer.2007.06.009
31 https://doi.org/10.1016/s0065-2776(06)90008-x
32 https://doi.org/10.1016/s1470-2045(09)70334-1
33 https://doi.org/10.1053/j.seminoncol.2010.09.015
34 https://doi.org/10.1056/nejmoa1003466
35 https://doi.org/10.1056/nejmoa1104621
36 https://doi.org/10.1093/annonc/mdq013
37 https://doi.org/10.1093/annonc/mdr584
38 https://doi.org/10.1111/j.0105-2896.2006.00391.x
39 https://doi.org/10.1111/j.1365-2133.2004.05708.x
40 https://doi.org/10.1111/j.1529-8019.2005.00052.x
41 https://doi.org/10.1126/science.1131078
42 https://doi.org/10.1158/1078-0432.ccr-09-1024
43 https://doi.org/10.1158/1078-0432.ccr-09-1624
44 https://doi.org/10.1158/1078-0432.ccr-11-1823
45 https://doi.org/10.1158/1078-0432.ccr-12-3080
46 https://doi.org/10.1200/jco.2007.12.7837
47 https://doi.org/10.1200/jco.2008.17.8954
48 https://doi.org/10.1200/jco.2012.41.6115
49 https://doi.org/10.1200/jco.2012.41.6750
50 https://doi.org/10.1586/era.09.25
51 https://doi.org/10.1634/theoncologist.2009-0028
52 https://doi.org/10.4049/jimmunol.174.11.6863
53 schema:datePublished 2014-04
54 schema:datePublishedReg 2014-04-01
55 schema:description BACKGROUND: Retreatment with ipilimumab has been shown to re-establish disease control in some patients with disease progression. Here, we report the efficacy and safety of retreatment with ipilimumab 3 mg kg(-1) among patients participating in an expanded access programme in Italy. METHODS: Patients who achieved disease control during induction therapy were retreated with ipilimumab upon progression (3 mg kg(-1) every 3 weeks for up to four doses), providing they had not experienced toxicity that precluded further dosing. Tumour assessments were conducted after retreatment, and patients were monitored throughout for adverse events. RESULTS: Of 855 patients treated with ipilimumab, 51 were retreated upon disease progression. Of these, 28 (55%) regained disease control upon retreatment and 42% were alive 2 years after the first induction dose of ipilimumab; median overall survival was 21 months. Eleven patients (22%) had a treatment-related adverse event of any grade during retreatment. These were generally mild-to-moderate and resolved within a median of 4 days. No new types of toxicity were reported. CONCLUSIONS: For patients who meet predefined criteria, retreatment with ipilimumab is generally well tolerated and can translate into clinical benefit. This strategy should be compared with other therapeutic options in randomised controlled trials.
56 schema:genre research_article
57 schema:inLanguage en
58 schema:isAccessibleForFree true
59 schema:isPartOf N00d180bac89c424a82a3043b2e58f2ac
60 Nea28f32c05cf447ca17507d94d834dd3
61 sg:journal.1017082
62 schema:name Ipilimumab retreatment in patients with pretreated advanced melanoma: the expanded access programme in Italy
63 schema:pagination 1721
64 schema:productId N459201a8843f4de8912ed0ca96c1639a
65 N51b9e0ff4a544828abf4d90424eaddc7
66 Nc985d7d996b64ebe8e20ab3355f445c6
67 Nd90ae20e8d354bda81f48f1042ba858c
68 Ndb01d37c96b7483084f159b449dd1040
69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014968763
70 https://doi.org/10.1038/bjc.2014.126
71 schema:sdDatePublished 2019-04-10T22:20
72 schema:sdLicense https://scigraph.springernature.com/explorer/license/
73 schema:sdPublisher N520986b269ba4607a9e645b14a249e3b
74 schema:url https://www.nature.com/articles/bjc2014126
75 sgo:license sg:explorer/license/
76 sgo:sdDataset articles
77 rdf:type schema:ScholarlyArticle
78 N00d180bac89c424a82a3043b2e58f2ac schema:volumeNumber 110
79 rdf:type schema:PublicationVolume
80 N06145b13b3ae458db6176e6716d03afe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Italy
82 rdf:type schema:DefinedTerm
83 N0876e2abb1644facb8f03612b2c49e19 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Antibodies, Monoclonal
85 rdf:type schema:DefinedTerm
86 N14ae8656e791499eacd035c12542bd90 rdf:first sg:person.0776042506.09
87 rdf:rest Nb76777eb490e4a0cb8f7bf74a72f4e23
88 N1dd499d13d9c4606a03693ffb22bc933 rdf:first sg:person.01261247072.50
89 rdf:rest N14ae8656e791499eacd035c12542bd90
90 N1e77b2068c86401597d91ad2ceada2ca schema:name Melanoma Cancer Unit, Veneto Institute of Oncology IOV-IRCCS, Via Gattamelata, 64, 35128 Padua, Italy
91 rdf:type schema:Organization
92 N1fdc84b2823f49639cd70a503331a511 rdf:first sg:person.01076711104.26
93 rdf:rest N7dfe903fc4004820aa26103f51db5b20
94 N1fe75a9d155b48ae88e560106dbb5f0b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Young Adult
96 rdf:type schema:DefinedTerm
97 N2398c9e08054411e9d4332ba5b480e26 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Survival Analysis
99 rdf:type schema:DefinedTerm
100 N23a9797ebaa24c0fbdc22cc58558537d rdf:first Ndaf668b94fd240a8a017156f77ccb1f1
101 rdf:rest Nf372d9d5f166460da2ab9bd87aae158b
102 N337560edf963469ba62f8f8d8b1660eb rdf:first sg:person.0641150074.04
103 rdf:rest Nd4064127d8594227874d9c29b553105a
104 N39ce398bf27c4faeb893fab74f2a7ff9 rdf:first sg:person.01050657054.88
105 rdf:rest N337560edf963469ba62f8f8d8b1660eb
106 N459201a8843f4de8912ed0ca96c1639a schema:name pubmed_id
107 schema:value 24619072
108 rdf:type schema:PropertyValue
109 N4be22c1a35af450bafddde30d2e5eab5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Female
111 rdf:type schema:DefinedTerm
112 N50dc24cd344d4736a5a60f96d005974a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Retreatment
114 rdf:type schema:DefinedTerm
115 N51b9e0ff4a544828abf4d90424eaddc7 schema:name doi
116 schema:value 10.1038/bjc.2014.126
117 rdf:type schema:PropertyValue
118 N520986b269ba4607a9e645b14a249e3b schema:name Springer Nature - SN SciGraph project
119 rdf:type schema:Organization
120 N56de9e676b8f48f48ff53cf658d898c9 rdf:first sg:person.01127536021.40
121 rdf:rest Nac226b5bc4864d7d902147621c6c6f6b
122 N587ad9113bcd45b99e3a402814ddc21b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Melanoma
124 rdf:type schema:DefinedTerm
125 N5bcf6619cf72422c843915071881a588 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Adult
127 rdf:type schema:DefinedTerm
128 N6ba9de4fd09a45aea523113adf921e1b rdf:first sg:person.01157622404.07
129 rdf:rest Ne620c287b1ab4b5da7ea7a6ac97a8a15
130 N764fd9ed413b453dab5115e3c1e21d85 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Disease Progression
132 rdf:type schema:DefinedTerm
133 N77d23928ed4041a38167ae621ae2588f schema:name Melanoma, Cancer Immunotherapy and Innovative Therapy Unit, Istituto Nazionale Tumori Fondazione ‘G Pascale’, Via Cappella dei Cangiani, 1, 80131 Naples, Italy
134 rdf:type schema:Organization
135 N7dfe903fc4004820aa26103f51db5b20 rdf:first sg:person.01212502023.44
136 rdf:rest N56de9e676b8f48f48ff53cf658d898c9
137 N7fb7efcf960d4372907420f9b7677249 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Ipilimumab
139 rdf:type schema:DefinedTerm
140 N895380d931d647e9b54064e4f31e9f82 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Immunotherapy
142 rdf:type schema:DefinedTerm
143 N8b3e937d1eff421c965a9dee849d2b12 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Aged, 80 and over
145 rdf:type schema:DefinedTerm
146 N96528f7867ae455496b5334b295b2433 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Remission Induction
148 rdf:type schema:DefinedTerm
149 N9c43b9dc78a74926b6b064aa57ac4844 rdf:first sg:person.0600120704.85
150 rdf:rest rdf:nil
151 Na1539cfca1504f53a3f41ed160ff908b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Program Development
153 rdf:type schema:DefinedTerm
154 Na4b2f0f0f5e3474c86c1bd26e02bf197 schema:name Medical Oncology, Dermopathic Institute of the Immaculate IDI-IRCCS, Via dei Monti di Creta, 104, 00167 Rome, Italy
155 rdf:type schema:Organization
156 Naa4d85ae4faf4bb3aa9fffb639f68505 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Health Plan Implementation
158 rdf:type schema:DefinedTerm
159 Nac226b5bc4864d7d902147621c6c6f6b rdf:first sg:person.01061427172.10
160 rdf:rest N39ce398bf27c4faeb893fab74f2a7ff9
161 Nb0661dffb8bf4f7ab0b489f38b588ab8 schema:name Melanoma, Cancer Immunotherapy and Innovative Therapy Unit, Istituto Nazionale Tumori Fondazione ‘G Pascale’, Via Cappella dei Cangiani, 1, 80131 Naples, Italy
162 rdf:type schema:Organization
163 Nb76777eb490e4a0cb8f7bf74a72f4e23 rdf:first sg:person.0610724345.49
164 rdf:rest N6ba9de4fd09a45aea523113adf921e1b
165 Nbd83e6e6bd3247bcb5ba67fc2f22b80d schema:name Melanoma Cancer Unit, Veneto Institute of Oncology IOV-IRCCS, Via Gattamelata, 64, 35128 Padua, Italy
166 rdf:type schema:Organization
167 Nc536762486cd4ab29c89000643e488b6 rdf:first sg:person.01021072757.16
168 rdf:rest N23a9797ebaa24c0fbdc22cc58558537d
169 Nc5afabb8be8047b185487bc5e6d522c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Humans
171 rdf:type schema:DefinedTerm
172 Nc985d7d996b64ebe8e20ab3355f445c6 schema:name dimensions_id
173 schema:value pub.1014968763
174 rdf:type schema:PropertyValue
175 Ncd1a5a2546824b3faac525ef22c78004 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Health Services Accessibility
177 rdf:type schema:DefinedTerm
178 Nd4064127d8594227874d9c29b553105a rdf:first sg:person.01274530176.31
179 rdf:rest Nc536762486cd4ab29c89000643e488b6
180 Nd6eff258fbd24b83bb5121d2277d5187 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Aged
182 rdf:type schema:DefinedTerm
183 Nd90ae20e8d354bda81f48f1042ba858c schema:name nlm_unique_id
184 schema:value 0370635
185 rdf:type schema:PropertyValue
186 Ndaf668b94fd240a8a017156f77ccb1f1 schema:affiliation https://www.grid.ac/institutes/grid.15667.33
187 schema:familyName Ferrucci
188 schema:givenName P F
189 rdf:type schema:Person
190 Ndb01d37c96b7483084f159b449dd1040 schema:name readcube_id
191 schema:value 475112d898d1276a3d14e0f2563206acb464ffbfade6610e97c57bed4b8da7f6
192 rdf:type schema:PropertyValue
193 Nde18fedf921943eabc6147612c438748 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Male
195 rdf:type schema:DefinedTerm
196 Ne620c287b1ab4b5da7ea7a6ac97a8a15 rdf:first sg:person.0625237211.06
197 rdf:rest N9c43b9dc78a74926b6b064aa57ac4844
198 Nea28f32c05cf447ca17507d94d834dd3 schema:issueNumber 7
199 rdf:type schema:PublicationIssue
200 Nea8f752ddaeb4937b3cbb6b71f8a8ef6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
201 schema:name Skin Neoplasms
202 rdf:type schema:DefinedTerm
203 Neca94f477f0644ce9cf416243b24cb17 rdf:first sg:person.0707113743.39
204 rdf:rest N1fdc84b2823f49639cd70a503331a511
205 Nf372d9d5f166460da2ab9bd87aae158b rdf:first sg:person.01102114523.12
206 rdf:rest N1dd499d13d9c4606a03693ffb22bc933
207 Nff8c30f15a9e417f90dc34be14568227 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
208 schema:name Middle Aged
209 rdf:type schema:DefinedTerm
210 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
211 schema:name Medical and Health Sciences
212 rdf:type schema:DefinedTerm
213 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
214 schema:name Clinical Sciences
215 rdf:type schema:DefinedTerm
216 sg:journal.1017082 schema:issn 0007-0920
217 1532-1827
218 schema:name British Journal of Cancer
219 rdf:type schema:Periodical
220 sg:person.01021072757.16 schema:affiliation https://www.grid.ac/institutes/grid.15667.33
221 schema:familyName Testori
222 schema:givenName A
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021072757.16
224 rdf:type schema:Person
225 sg:person.01050657054.88 schema:affiliation https://www.grid.ac/institutes/grid.411477.0
226 schema:familyName Calabrò
227 schema:givenName L
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050657054.88
229 rdf:type schema:Person
230 sg:person.01061427172.10 schema:affiliation https://www.grid.ac/institutes/grid.411477.0
231 schema:familyName Maio
232 schema:givenName M
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061427172.10
234 rdf:type schema:Person
235 sg:person.01076711104.26 schema:affiliation N1e77b2068c86401597d91ad2ceada2ca
236 schema:familyName Pigozzo
237 schema:givenName J
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076711104.26
239 rdf:type schema:Person
240 sg:person.01102114523.12 schema:affiliation https://www.grid.ac/institutes/grid.410345.7
241 schema:familyName Queirolo
242 schema:givenName P
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102114523.12
244 rdf:type schema:Person
245 sg:person.01127536021.40 schema:affiliation Nb0661dffb8bf4f7ab0b489f38b588ab8
246 schema:familyName Simeone
247 schema:givenName E
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127536021.40
249 rdf:type schema:Person
250 sg:person.01157622404.07 schema:affiliation https://www.grid.ac/institutes/grid.460094.f
251 schema:familyName Mandalà
252 schema:givenName M
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157622404.07
254 rdf:type schema:Person
255 sg:person.01212502023.44 schema:affiliation N77d23928ed4041a38167ae621ae2588f
256 schema:familyName Ascierto
257 schema:givenName P A
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212502023.44
259 rdf:type schema:Person
260 sg:person.01261247072.50 schema:affiliation https://www.grid.ac/institutes/grid.410345.7
261 schema:familyName Spagnolo
262 schema:givenName F
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261247072.50
264 rdf:type schema:Person
265 sg:person.01274530176.31 schema:affiliation Na4b2f0f0f5e3474c86c1bd26e02bf197
266 schema:familyName De Galitiis
267 schema:givenName F
268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274530176.31
269 rdf:type schema:Person
270 sg:person.0600120704.85 schema:affiliation https://www.grid.ac/institutes/grid.417893.0
271 schema:familyName Del Vecchio
272 schema:givenName M
273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600120704.85
274 rdf:type schema:Person
275 sg:person.0610724345.49 schema:affiliation https://www.grid.ac/institutes/grid.419555.9
276 schema:familyName Schianca
277 schema:givenName F Carnevale
278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610724345.49
279 rdf:type schema:Person
280 sg:person.0625237211.06 schema:affiliation https://www.grid.ac/institutes/grid.417893.0
281 schema:familyName Di Guardo
282 schema:givenName L
283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625237211.06
284 rdf:type schema:Person
285 sg:person.0641150074.04 schema:affiliation https://www.grid.ac/institutes/grid.7841.a
286 schema:familyName Marchetti
287 schema:givenName P
288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641150074.04
289 rdf:type schema:Person
290 sg:person.0707113743.39 schema:affiliation Nbd83e6e6bd3247bcb5ba67fc2f22b80d
291 schema:familyName Chiarion-Sileni
292 schema:givenName V
293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707113743.39
294 rdf:type schema:Person
295 sg:person.0776042506.09 schema:affiliation https://www.grid.ac/institutes/grid.7605.4
296 schema:familyName Quaglino
297 schema:givenName P
298 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776042506.09
299 rdf:type schema:Person
300 sg:pub.10.1007/s10637-009-9376-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021055401
301 https://doi.org/10.1007/s10637-009-9376-8
302 rdf:type schema:CreativeWork
303 sg:pub.10.1111/j.0818-9641.2004.01273.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041030125
304 https://doi.org/10.1111/j.0818-9641.2004.01273.x
305 rdf:type schema:CreativeWork
306 sg:pub.10.1186/1479-5876-9-204 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002969174
307 https://doi.org/10.1186/1479-5876-9-204
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1016/j.coi.2006.01.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052941380
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1016/j.ejca.2009.12.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021779666
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1016/j.semcancer.2007.06.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001693325
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1016/s0065-2776(06)90008-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037003471
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1016/s1470-2045(09)70334-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053423975
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1053/j.seminoncol.2010.09.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052040775
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1056/nejmoa1003466 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052212829
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1056/nejmoa1104621 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036355137
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1093/annonc/mdq013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025653897
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1093/annonc/mdr584 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039421158
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1111/j.0105-2896.2006.00391.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012853788
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1111/j.1365-2133.2004.05708.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037745378
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1111/j.1529-8019.2005.00052.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1026701684
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1126/science.1131078 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034203142
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1158/1078-0432.ccr-09-1024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016716683
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1158/1078-0432.ccr-09-1624 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028571226
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1158/1078-0432.ccr-11-1823 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010268280
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1158/1078-0432.ccr-12-3080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021277346
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1200/jco.2007.12.7837 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046075678
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1200/jco.2008.17.8954 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034543033
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1200/jco.2012.41.6115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019659802
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1200/jco.2012.41.6750 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019320335
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1586/era.09.25 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030498193
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1634/theoncologist.2009-0028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040649902
356 rdf:type schema:CreativeWork
357 https://doi.org/10.4049/jimmunol.174.11.6863 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077054825
358 rdf:type schema:CreativeWork
359 https://www.grid.ac/institutes/grid.15667.33 schema:alternateName European Institute of Oncology
360 schema:name Divisione Melanoma, Istituto Europeo di Oncologia, Via Ripamonti, 435, 20141 Milan, Italy
361 Oncology of Melanoma Unit, Istituto Europeo di Oncologia, Via Ripamonti, 435, 20141 Milan, Italy
362 rdf:type schema:Organization
363 https://www.grid.ac/institutes/grid.410345.7 schema:alternateName Ospedale San Martino
364 schema:name Department of Medical Oncology A, San Martino Hospital, National Institute for Cancer Research, L.go R. Benzi, 10, 16132 Genoa, Italy
365 rdf:type schema:Organization
366 https://www.grid.ac/institutes/grid.411477.0 schema:alternateName Azienda Ospedaliera Universitaria Senese
367 schema:name Medical Oncology and Immunotherapy Unit, University Hospital of Siena, Istituto Toscano Tumori, Strada delle Scotte, 14, 53100 Siena, Italy
368 rdf:type schema:Organization
369 https://www.grid.ac/institutes/grid.417893.0 schema:alternateName Istituto Nazionale dei Tumori
370 schema:name Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian, 1, 20133 Milan, Italy
371 rdf:type schema:Organization
372 https://www.grid.ac/institutes/grid.419555.9 schema:alternateName Candiolo Cancer Institute
373 schema:name Division of Medical Oncology, Institute for Cancer Research and Treatment, IRCC, Piedmont Oncology Foundation, Strada Provinciale, 142, 10060 Candiolo, Italy
374 rdf:type schema:Organization
375 https://www.grid.ac/institutes/grid.460094.f schema:alternateName Ospedale Papa Giovanni XXIII
376 schema:name Unit of Medical Oncology, Papa Giovanni XXIII Hospital, Piazza OMS-Organizzazione Mondiale della Sanità, 1, 24127 Bergamo, Italy
377 rdf:type schema:Organization
378 https://www.grid.ac/institutes/grid.7605.4 schema:alternateName University of Turin
379 schema:name Dermatologic Clinic, Department of Medical Sciences, University of Torino, San Giovanni Battista di Torino, Via Cherasco, 23, 10126 Turin, Italy
380 rdf:type schema:Organization
381 https://www.grid.ac/institutes/grid.7841.a schema:alternateName Sapienza University of Rome
382 schema:name Medical Oncology, Dermopathic Institute of the Immaculate IDI-IRCCS, Via dei Monti di Creta, 104, 00167 Rome, Italy
383 Medical Oncology, Sant’Andrea Hospital, Sapienza University of Rome, Via di Grottarossa, 1035-39, 00189 Rome, Italy
384 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...